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E-CBIL-22 - Transcription profiling by array of wild type and PGC-1alpha knock-out mice liver and skeletal muscle

Released on 6 April 2007, last updated on 13 May 2014
Mus musculus
Samples (21)
Array (1)
Protocols (6)
PGC-1alpha; is a coactivator of nuclear receptors and other transcription factors that regulates several metabolic processes, including mitochondrial biogenesis and respiration, hepatic gluconeogenesis, and muscle fiber-type switching. We show here that, while hepatocytes lacking PGC-1alpha; are defective in the program of hormone-stimulated gluconeogenesis, the mice have constitutively activated gluconeogenic gene expression that is completely insensitive to normal feeding controls. C/EBPbeta; is elevated in the livers of these mice and activates the gluconeogenic genes in a PGC-1α-independent manner. Despite having reduced mitochondrial function, PGC-1alpha; null mice are paradoxically lean and resistant to diet-induced obesity. This is largely due to a profound hyperactivity displayed by the null animals and is associated with lesions in the striatal region of the brain that controls movement. These data illustrate a central role for PGC-1alpha; in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis.
Experiment types
transcription profiling by array, genetic modification design, growth condition design, organism part comparison design
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. , PMID:15454086
Investigation descriptionE-CBIL-22.idf.txt
Sample and data relationshipE-CBIL-22.sdrf.txt
Raw data (1)
Processed data (1)
Array designA-AFFY-6.adf.txt