Associate Director of EMBL-EBI Services, Senior Scientist and Head of Genes, Genomes & Variation Services
Paul was appointed Associate Director of EMBL-EBI Services in 2019 with responsibility for data resources and related activities. He has been an EMBL Senior Scientist since 2011 and Team Leader for Vertebrate Genomics at EMBL-EBI since 2007. His team develops the Ensembl genome annotation resources and analysis infrastructure.He joined EMBL-EBI in 2005 to undertake postdoctoral research with Ewan Birney.
Paul has worked on aspects of genome annotation, comparative genomics, and large-scale biological data generation projects for more than two decades, initially with sequencing of the mouse genome. More recently he has been involved with ENCODE, the 1000 Genomes Project, the International Human Epigenome Consortium, and numerous genome projects.
Before that, Paul completed MSc degrees in both Biomedical Engineering and Computer Science and a DSc in Biomedical Engineering at Washington University in St Louis. Paul graduated from Drake University with a BS in Physics.
flicek [at] ebi.ac.uk
ORCID iD: 0000-0002-3897-7955
Tel:+44 (0)1223 49 4231 / Fax:+44 (0)1223 494 468
The Vertebrate Genomics team develops the Ensembl genome annotation resources and analysis infrastructure in collaboration with the Wellcome Trust Sanger Institute; creates informatics resources as part of worldwide efforts to distribute data and materials for mouse models, phenotyping and related research and leads data management activities for several large-scale genomics projects, including the 1000 Genomes Project and Blueprint as part of the International Human Epigenome Consortium (IHEC). The resources and services of the Vertebrate Genomics team are made publicly available to ensure widest possible use by the scientific community.
We also have an active research effort focused on the evolution of transcriptional regulation with an ultimate goal of understanding mechanisms and maintenance of cell-type specificity. Our major research collaboration with Duncan Odom’s group at the University of Cambridge continues to pioneer methods of comparative regulatory genomics for biological discovery across a wide range of mammalian and vertebrate species. We are also interested in integrated analysis techniques to assess the interaction of ubiquitously expressed proteins and tissue-specific factors in tissue-specific gene regulation.
The Flicek Research Group focuses on computational models for genome annotation and evolution based on models incorporating DNA-protein interactions, epigenetic modifications, and the DNA sequence itself. The group is also interested in the large-scale infrastructure required for modern bioinformatics including storage and access methods for high-throughput sequencing data.