Research Group Leader
John Marioni obtained his PhD in Applied Mathematics in the University of Cambridge in 2008 and did his postdoctoral research in the Department of Human Genetics, University of Chicago. He joined EMBL-EBI as Research Group Leader in Computational and Evolutionary Genomics in 2010. His group develops the computational and statistical tools necessary to exploit high-throughput genomics data, with the aim of understanding the regulation of gene expression and modelling developmental and evolutionary processes. Within this context, the Marioni group focuses on understanding how the divergence of gene expression levels is regulated, using gene expression as a definition of the molecular fingerprint of individual cells to study the evolution of cell types, and modelling spatial variability in gene-expression levels within a tissue or organism. These three strands of research are brought together by single-cell sequencing technologies. John has a joint appointment at the Wellcome Trust Sanger Institute and the University of Cambridge.
marioni [at] ebi.ac.uk
ORCID iD: 0000-0001-9092-0852
Tel:+ 44 (0) 1223 494 583 / Fax:+ 44 (0) 1223 492 621
Human Cell Atlas
EMBL-EBI, the Broad Institute, the UCSC Genomics Institute and the Chan Zuckerberg Initiative are building a Data Coordination Platform for the Human Cell Atlas, an ambitious international collaboration led by the Sanger Institute and the Broad Institute.
The Human Cell Atlas is an open, data-intensive endeavour to chart the specific genetic properties of all human cells, across all tissues and organs, and build a new reference map of the healthy human body. EMBL-EBI is contributing its experience coordinating large-scale, open science initiatives, and is creating the new data-sharing and analysis platform collaboratively using cloud-based technologies.