IntAct Update: May 2014

Interactors of the palmitoyl acyltransferase protein, HIP14

IntAct Update: May 2014

30 Apr 2014 - 16:23

This month we feature a dataset by Butland and colleagues exploring a role for the palmitoyl acyltransferase protein, HIP14, in the pathogenesis of Huntington Disease.

HIP14 and Huntingtin protein (the mutation of which is causative for the condition) share an unusually large number of interactors, suggesting defective palmitoylation of key substrates by HIP14 may be important in disease progression. This was published in Butland, S.L. et al. (2014) The Palmitoyl acyltransferase HIP14 Shares a High Proportion of Interactors with Huntingtin: Implications for a Role in the Pathogenesis of Huntington Disease. Human Molecular Genetics, doi: 10.1093/hmg/ddu137

The data were submitted directly to IntAct as part of the publication process, and can be searched using IMEx ID IM-21827 on the IntAct website and the IMEx Consortium pages.

Updates for this release

There was one release in April: R179. The IntAct database now contains 12,670 publications, 32,922 experiments and 445,813 binary interactions.

The Complex Portal

A poster describing the Complex Portal was presented at the recent Biocuration conference. You are welcome to download the poster from our website.

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