IntAct dataset of the month: the Human Proteostasis network

The Human Proteostasis network, by Taipale et al

IntAct dataset of the month: the Human Proteostasis network

5 Aug 2014 - 09:31

Perturbation of the proteostasis network has been implicated in many diseases, spanning neurodegeneration, cancer and Mendelian disorders. Chaperones are the most prominent class of proteins that shape this network. In their paper, A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways, Taipale and colleagues use a combination of mass spectrometry and quantitative LUMIER assays to characterise the client specificity of cochaperones, and begin to decipher the proteostasis network as a whole by identifying interactors of all known Hsp90 cochaperones and several known Hsp70 cochaperones.

The data were submitted directly to IntAct as part of the publication process, and can be searched using IMEx ID IM-22301 on the IntAct website and the IMEx Consortium pages.

Updates for release R182

There was one release in July: R182. The IntAct database now contains 12,947 publications, 33,742 experiments and 454,515 binary interactions.

The Complex Portal  currently describes 917 stable biological complexes.

The Complex Portal

Biocurators from the Saccharomyces Genome Database are joining the IntAct curators in work to provide an encyclopaedic resource of protein complexes. With their help, over 300 of the macromolecular complexes that can be found in Saccharomyces cerevisiae can be accessed via the Complex Portal. We will now be able to increase this number rapidly.

Network and Pathways 2014

Thirty biologists (pictured below) recently attended the 2014 Networks and Pathways course, where they learned about how to analyse large datasets using molecular interaction data and related pathway resources with selected Cytoscape apps. Thanks to all who attended, and to the trainers, for making this such a successful event. You can find details of the 2015 course on our Training pages.

2014 Networks and Pathways course

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