Enzyme Portal: Facilitating enzyme research

Enzyme portal logo

Enzyme Portal: Facilitating enzyme research

20 May 2019 - 11:20

EMBL-EBI has relaunched the Enzyme Portal, a unified public data resource for scientists who are interested in the biological function and biochemistry of enzymes. The primary objective of the Enzyme Portal is to allow scientists to navigate available knowledge about enzymes and utilise exploratory tools that facilitate novel discoveries and enzyme design.

Enzyme Portal

The Enzyme Portal integrates major public resources, including the UniProt Knowledgebase (UniProt KB), the Protein Data Bank in Europe (PDBe), Rhea, M-CSA (Mechanism and Catalytic Site Atlas), Reactome, IntEnz, ChEBI and ChEMBL, to provide a summary of enzyme taxonomy, sequences, structural and functional information, biochemical pathways, catalytic activities, reaction mechanisms, and small molecule/drug interactions. It also provides cross-references to the underlying data resources, making it easier to explore the data further.

The relaunched Enzyme Portal offers a number of new features which include:

  • New search entry points by enzyme family, taxonomy and cofactors in addition to existing ones (disease, enzyme classification, and pathway)
  • A new analysis tool from Prof. Janet Thornton’s research group, Transform-MinER, which enables users to find enzymes that act on a specific molecule or enzymes that could catalyse the transformation of a substrate into the desired product
  • A new dedicated enzyme page that describes enzyme activities, cofactors, reaction mechanisms and available publications
  • An improved user interface that is more intuitive and easier to navigate

Future work on the Enzyme Portal will include enhancing existing functionalities, developing relevant tools for enzyme search and analysis, and extending international collaborations for enzyme prediction systems.

The Enzyme Portal team is available to help with your research needs, so please get in touch with any questions or comments using the feedback form on the website.

Visit the Enzyme Portal to learn more - https://www.ebi.ac.uk/enzymeportal/

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