Bone remodelling - BioModels Model of the Month

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Bone remodelling - BioModels Model of the Month

22 Nov 2018 - 15:58

Bone is an organ undergoing a continuous remodelling process where old bone cells get absorbed and replaced with new bone cells. Osteoclasts are cells that absorb old bone tissue during growth to repair bones with micro-fractures. Osteoblasts secrete the substance of bone which forms the bone matrix.

Proctor et al. (2016) created a mathematical model, including the mechanisms of multiple signalling pathways that regulates osteoclast and osteoblast. The authors then simulated the effects of varying loads of exercise on the bone mass.

The results showed how decrease in physical activity with age affects bone remodelling and leads to diseases such as osteoporosis and arthritis. Scientists can use this model to explore new strategies to tackle bone diseases. Read more about this model at BioModels Model of the Month article for November 2018

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