Modelling signalling events in dendritic spines
University of Edinburgh
Dendritic spines are specialised neuronal compartments that house the receiving end of synaptic connections in the hippocampus. When we form memories, snyaptic connections change in strength, and this involves both biochemical signalling and structural changes in dendritic spines.
Modelling this system computationally is complicated by the fact that spines are small compartments with low copy numbers of each individual molecular species, that many of the signalling proteins can exist in a vast number of functional states, and that biochemical signalling interacts both with electrical signalling and with structural changes at synapses. In this talk, I will present some of our recent work in addressing these challenges.
Speaker Biography: Melanie Stefan is a lecturer at the University of Edinburgh, and an adjunct assistant professor at the Zhejiang University - University of Edinburgh Institute in Haining, China. Her research interests lie in using computational models to understand learning and memory. She completed her PhD at EMBL-EBI in 2009, and worked as a postdoc at the University of Tokyo and the California Institute of Technology, and as a Curriculum Fellow for Quantitative Biology at Harvard Medical School, before joining the University of Edinburgh in 2015.
Type: Ad hoc talk
When: Thursday 24 January 2019; 3:00pm
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