ID   WAP$RAT        STANDARD;      PRT;   137 AA.
AC   P01174;
DT   21-JUL-1986  (REL. 01, CREATED)
DT   01-OCT-1989  (REL. 12, LAST SEQUENCE UPDATE)
DT   01-OCT-1989  (REL. 12, LAST ANNOTATION UPDATE)
DE   WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP).
OS   RAT (RATTUS NORVEGICUS).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; RODENTIA.
RN   [1] (SEQUENCE FROM N.A.)
RA   CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U.,
RA   SIPPEL A.E.;
RL   NUCLEIC ACIDS RES. 12:8685-8697(1984).
RN   [2] (SEQUENCE FROM N.A.)
RA   HENNIGHAUSEN L.G., SIPPEL A.E.;
RL   NUCLEIC ACIDS RES. 10:3733-3744(1982).
RN   [3] (SEQUENCE FROM N.A.)
RA   DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.;
RL   PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982).
CC   -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE
CC       MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES
CC       WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN,
CC       AS YET UNDESCRIBED, INHIBITORY FUNCTION.
CC   -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE
CC       ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS
CC       DUPLICATED IN THE REGION OF RESIDUES 102-131.
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DR   PIR; A01228; WYRT.
DR   EMBL; X01153; RNWAP1.
DR   EMBL; X01154; RNWAP2.
DR   EMBL; X01155; RNWAP3.
DR   EMBL; X01156; RNWAP4.
DR   EMBL; J00802; RNWAP52.
DR   EMBL; J00801; RNWAP.
KW   MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL.
FT   SIGNAL        1     19
FT   CHAIN        20    137       WHEY ACIDIC PROTEIN.
FT   MOD_RES      39     39       PHOSPHORYLATION (PUTATIVE).
FT   MOD_RES      40     40       PHOSPHORYLATION (PUTATIVE).
FT   MOD_RES      50     50       PHOSPHORYLATION (PUTATIVE).
FT   MOD_RES     103    103       PHOSPHORYLATION (PUTATIVE).
FT   SIMILAR     102    131       WITH THE 2ND DOMAIN OF BASIC PROTEASE
FT                                INHIBITOR FROM RED SEA TURTLE; 14 OF 31
FT                                POSITIONS ARE IDENTICAL.
FT   REPEAT       20     72
FT   REPEAT       73    137
FT   CONFLICT      4      4       S -> F (IN REF. 3).
FT   CONFLICT     35     35       S -> P (IN REF. 2 AND 3).
FT   CONFLICT     39     39       F -> S (IN REF. 2 AND 3).
FT   CONFLICT     47     47       N -> K (IN REF. 2).
FT   CONFLICT     68     68       S -> P (IN REF. 2 AND 3).
FT   CONFLICT     99     99       D -> G (IN REF. 3).
FT   CONFLICT    127    127       E -> K (IN REF. 3).
FT   CONFLICT    129    129       K -> E (IN REF. 2).
FT   CONFLICT    129    129       K -> D (IN REF. 3).
FT   CONFLICT    134    134       I -> V (IN REF. 2).
SQ   SEQUENCE   137 AA;  14827 MW;  93803 CN;