ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 18-JUN-2025, entry version 139. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR FunCoup; P01174; 77. DR STRING; 10116.ENSRNOP00000073381; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 6060011at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR InterPro; IPR050514; WAP_four-disulfide_core. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR PANTHER; PTHR19441:SF96; WHEY ACIDIC PROTEIN; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 05-FEB-2025, entry version 138. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000073381; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 6060011at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR InterPro; IPR050514; WAP_four-disulfide_core. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR PANTHER; PTHR19441:SF96; WHEY ACIDIC PROTEIN; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 27-NOV-2024, entry version 137. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000073381; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR InterPro; IPR050514; WAP_four-disulfide_core. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR PANTHER; PTHR19441:SF96; WHEY ACIDIC PROTEIN; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 24-JUL-2024, entry version 136. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000073381; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR InterPro; IPR050514; WAP_four-disulfide_core. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR PANTHER; PTHR19441:SF96; WHEY ACIDIC PROTEIN; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 27-MAR-2024, entry version 135. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000073381; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR PANTHER; PTHR19441:SF96; WHEY ACIDIC PROTEIN; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 24-JAN-2024, entry version 134. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000073381; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441:SF95; WAP DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 08-NOV-2023, entry version 133. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; 10116-ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441:SF95; WAP DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 13-SEP-2023, entry version 132. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441:SF95; WAP DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 03-MAY-2023, entry version 131. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441:SF95; WAP DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 22-FEB-2023, entry version 130. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 4306065at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW. DR CDD; cd00199; WAP; 1. DR Gene3D; 4.10.75.10; Elafin-like; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR PANTHER; PTHR19441:SF95; WAP DOMAIN-CONTAINING PROTEIN; 1. DR PANTHER; PTHR19441; WHEY ACDIC PROTEIN WAP; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 14-DEC-2022, entry version 129. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR AGR; RGD:621851; -. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; Elafin-like; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 25-MAY-2022, entry version 128. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR AlphaFoldDB; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 29-SEP-2021, entry version 127. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 02-DEC-2020, entry version 126. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 12-AUG-2020, entry version 125. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG502RXHY; Eukaryota. DR InParanoid; P01174; -. DR KO; K17106; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central. DR GO; GO:0019731; P:antibacterial humoral response; IBA:GO_Central. DR GO; GO:0045087; P:innate immune response; IBA:GO_Central. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 26-FEB-2020, entry version 124. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR InParanoid; P01174; -. DR KO; K17106; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 11-DEC-2019, entry version 123. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat whey RT protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Reference proteome; Repeat; Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000269|PubMed:6955785" FT CHAIN 20..137 FT /note="Whey acidic protein" FT /id="PRO_0000041353" FT DOMAIN 27..73 FT /note="WAP 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DOMAIN 76..127 FT /note="WAP 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00722" FT DISULFID 34..61 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 45..65 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 48..60 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 54..69 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 83..115 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 96..119 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 102..114 FT /evidence="ECO:0000305|PubMed:6955785" FT DISULFID 108..123 FT /evidence="ECO:0000305|PubMed:6955785" FT CONFLICT 4 FT /note="S -> F (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 35 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 39 FT /note="F -> S (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 47 FT /note="N -> K (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 68 FT /note="S -> P (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 99 FT /note="D -> G (in Ref. 2; AAA42346)" FT /evidence="ECO:0000305" FT CONFLICT 116 FT /note="K -> N (in Ref. 2 and 3)" FT /evidence="ECO:0000305" FT CONFLICT 127 FT /note="E -> K (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> D (in Ref. 2)" FT /evidence="ECO:0000305" FT CONFLICT 129 FT /note="K -> E (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" FT CONFLICT 134 FT /note="I -> V (in Ref. 3; AAA42347)" FT /evidence="ECO:0000305" SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 08-MAY-2019, entry version 122. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 16-JAN-2019, entry version 121. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR OrthoDB; 1409658at2759; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 28-FEB-2018, entry version 120. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 25-OCT-2017, entry version 119. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 2. DR InterPro; IPR036645; Elafin-like_sf. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 10-MAY-2017, entry version 118. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 12-APR-2017, entry version 117. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 2. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 15-MAR-2017, entry version 116. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 15-FEB-2017, entry version 115. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 08-JUN-2016, entry version 114. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 09-DEC-2015, entry version 113. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 11-NOV-2015, entry version 112. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PaxDb; P01174; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; ENOG410JG7V; Eukaryota. DR eggNOG; ENOG411160P; LUCA. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 16-SEP-2015, entry version 111. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR Genevisible; P01174; RN. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP_dom. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 24-JUN-2015, entry version 110. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR Genevisible; P01174; RN. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 27-MAY-2015, entry version 109. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 29-APR-2015, entry version 108. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR PRO; PR:P01174; -. DR Proteomes; UP000002494; Unplaced. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 01-APR-2015, entry version 107. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR Proteomes; UP000002494; Unplaced. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 07-JAN-2015, entry version 106. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR Proteomes; UP000002494; Unplaced. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 29-OCT-2014, entry version 105. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR InParanoid; P01174; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 01-OCT-2014, entry version 104. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. {ECO:0000255|PROSITE- CC ProRule:PRU00722}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 {ECO:0000269|PubMed:6955785}. FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DOMAIN 76 127 WAP 2. {ECO:0000255|PROSITE- FT ProRule:PRU00722}. FT DISULFID 34 61 {ECO:0000305|PubMed:6955785}. FT DISULFID 45 65 {ECO:0000305|PubMed:6955785}. FT DISULFID 48 60 {ECO:0000305|PubMed:6955785}. FT DISULFID 54 69 {ECO:0000305|PubMed:6955785}. FT DISULFID 83 115 {ECO:0000305|PubMed:6955785}. FT DISULFID 96 119 {ECO:0000305|PubMed:6955785}. FT DISULFID 102 114 {ECO:0000305|PubMed:6955785}. FT DISULFID 108 123 {ECO:0000305|PubMed:6955785}. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT {ECO:0000305}. FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). {ECO:0000305}. FT CONFLICT 127 127 E -> K (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> D (in Ref. 2). {ECO:0000305}. FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT {ECO:0000305}. FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). FT {ECO:0000305}. SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 03-SEP-2014, entry version 103. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 16-APR-2014, entry version 102. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR KO; K17106; -. DR PhylomeDB; P01174; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP-type_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 22-JAN-2014, entry version 101. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR KO; K17106; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP-type_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 13-NOV-2013, entry version 100. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR KO; K17106; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP-type_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 16-OCT-2013, entry version 99. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR KO; K17106; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP-type_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; SSF57256; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 24-JUL-2013, entry version 98. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR PRIDE; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR KO; K17106; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP-type_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 01-MAY-2013, entry version 97. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR008197; WAP-type_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 03-APR-2013, entry version 96. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; 10116.ENSRNOP00000010744; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 06-MAR-2013, entry version 95. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0045735; F:nutrient reservoir activity; IEA:Compara. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; -; 1. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 28-NOV-2012, entry version 94. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0045735; F:nutrient reservoir activity; IEA:Compara. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; 4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 11-JUL-2012, entry version 93. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; RGD:621851; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0045735; F:nutrient reservoir activity; IEA:Compara. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 16-MAY-2012, entry version 92. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOGENOM; HOG000133035; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 18-APR-2012, entry version 91. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 22-FEB-2012, entry version 90. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; NOG122061; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 21-SEP-2011, entry version 89. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR GeneTree; ENSGT00530000063227; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Reference proteome; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 28-JUN-2011, entry version 88. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 22373; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR GeneTree; ENSGT00530000063227; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Complete proteome; Direct protein sequencing; Disulfide bond; KW Milk protein; Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 31-MAY-2011, entry version 87. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR GeneTree; ENSGT00530000063227; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 08-MAR-2011, entry version 86. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR GeneTree; ENSGT00530000063227; -. DR HOVERGEN; HBG098607; -. DR OrthoDB; EOG4R23WG; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 08-FEB-2011, entry version 85. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR GeneTree; ENSGT00530000063227; -. DR HOVERGEN; HBG098607; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 30-NOV-2010, entry version 84. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; NM_053751.4. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR HOVERGEN; HBG098607; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 05-OCT-2010, entry version 83. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR HOVERGEN; HBG098607; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 10-AUG-2010, entry version 82. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR ProteinModelPortal; P01174; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR HOVERGEN; HBG098607; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 02-MAR-2010, entry version 81. DE RecName: Full=Whey acidic protein; DE Short=WAP; DE AltName: Full=Whey phosphoprotein; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR HOVERGEN; HBG098607; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR SUPFAM; SSF57256; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 19-JAN-2010, entry version 80. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR SMR; P01174; 78-128. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR eggNOG; maNOG23928; -. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 1. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 24-NOV-2009, entry version 79. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 13-OCT-2009, entry version 78. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR Ensembl; ENSRNOT00000057142; ENSRNOP00000053970; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR Genevestigator; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR018069; Whey_acidic_4-diS_core_CS. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 22-SEP-2009, entry version 77. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR Ensembl; ENSRNOT00000057142; ENSRNOP00000053970; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0030414; F:peptidase inhibitor activity; NAS:RGD. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR018069; Whey_acidic_4-diS_core_CS. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 01-SEP-2009, entry version 76. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR STRING; P01174; -. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR Ensembl; ENSRNOT00000057142; ENSRNOP00000053970; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR CTD; 114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR018069; Whey_acidic_4-diS_core_CS. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 28-JUL-2009, entry version 75. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOT00000010744; ENSRNOP00000010744; ENSRNOG00000008097; Rattus norvegicus. DR Ensembl; ENSRNOT00000057142; ENSRNOP00000053970; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR UCSC; NM_053751; rat. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR018069; Whey_acidic_4-diS_core_CS. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 16-JUN-2009, entry version 74. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR018069; Whey_acidic_4-diS_core_CS. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 05-MAY-2009, entry version 73. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; DOI=10.1073/pnas.79.13.3987; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR018069; Whey_acidic_4-diS_core_CS. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 03-MAR-2009, entry version 72. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR018069; Whey_acidic_4-diS_core_CS. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Disulfide bond; Milk protein; KW Protease inhibitor; Repeat; Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 10-FEB-2009, entry version 71. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR IPI; IPI00210939; -. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 25-NOV-2008, entry version 70. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 04-NOV-2008, entry version 69. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR NextBio; 618763; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:UniProtKB-KW. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 02-SEP-2008, entry version 68. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS51390; WAP; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 27 73 WAP 1. FT DOMAIN 76 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 22-JUL-2008, entry version 67. DE RecName: Full=Whey acidic protein; DE AltName: Full=Whey phosphoprotein; DE AltName: Full=WAP; DE Flags: Precursor; GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 10-JUN-2008, entry version 66. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR HOVERGEN; P01174; -. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 08-APR-2008, entry version 65. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3; AAA42347). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2; AAA42346). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2; AAA42346). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3; AAA42347). FT CONFLICT 134 134 I -> V (in Ref. 3; AAA42347). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 26-FEB-2008, entry version 64. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR015874; 4-disulphide_core. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; Whey_acidic_protein_4-diS_core; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 02-OCT-2007, entry version 63. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR RefSeq; NP_446203.1; -. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR GeneID; 114596; -. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; Whey_acidic_protein_4-diS_core. DR Gene3D; G3DSA:4.10.75.10; G3DSA:4.10.75.10; 1. DR Pfam; PF00095; WAP; 2. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 24-JUL-2007, entry version 62. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. PE 1: Evidence at protein level; KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 10-JUL-2007, entry version 61. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Secreted; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 12-JUN-2007, entry version 60. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 01-MAY-2007, entry version 59. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Gene3D; G3DSA:4.10.75.10; G3DSA:4.10.75.10; 1. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 03-APR-2007, entry version 58. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-41, AND DISULFIDE RP BONDS. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- PTM: Contains 8 disulfide bonds. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Direct protein sequencing; Milk protein; Protease inhibitor; Repeat; KW Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 Probable. FT DISULFID 45 65 Probable. FT DISULFID 48 60 Probable. FT DISULFID 54 69 Probable. FT DISULFID 83 115 Probable. FT DISULFID 96 119 Probable. FT DISULFID 102 114 Probable. FT DISULFID 108 123 Probable. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 20-FEB-2007, entry version 57. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; DOI=10.1093/nar/12.22.8685; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; DOI=10.1093/nar/10.12.3733; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk protein; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 23-JAN-2007, entry version 56. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR KEGG; rno:114596; -. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR GO; GO:0030414; F:protease inhibitor activity; NAS:RGD. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk protein; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 12-DEC-2006, entry version 55. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR GermOnline; ENSRNOG00000008097; Rattus norvegicus. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GO; GO:0030414; F:protease inhibitor activity; NAS:RGD. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk protein; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 28-NOV-2006, entry version 54. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GO; GO:0030414; F:protease inhibitor activity; NAS:RGD. DR InterPro; IPR008198; Prot_inh_I17. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; Prot_inh_I17; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk protein; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT Reviewed; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 31-OCT-2006, entry version 53. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GO; GO:0030414; F:protease inhibitor activity; NAS:RGD. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk protein; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 17-OCT-2006, entry version 52. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk protein; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 05-SEP-2006, entry version 51. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR ArrayExpress; P01174; -. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 27-JUN-2006, entry version 50. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 18-APR-2006, entry version 49. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR UniGene; Rn.9978; -. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-1989, sequence version 2. DT 07-FEB-2006, entry version 48. DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: Milk-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 07-FEB-2006 (Rel. 49, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted protein. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT /FTId=PRO_0000041353. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1; atypical. FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 10-MAY-2005 (Rel. 47, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -; Genomic_DNA. DR EMBL; X01154; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01155; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; X01156; CAA25600.2; JOINED; Genomic_DNA. DR EMBL; J00802; AAA42347.1; -; mRNA. DR EMBL; J00801; AAA42346.1; -; mRNA. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008198; Prot_inh_antileu. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR Ensembl; ENSRNOG00000008097; Rattus norvegicus. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008198; Prot_inh_antileu. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR RGD; 621851; Wap. DR GO; GO:0030414; F:protease inhibitor activity; NAS. DR InterPro; IPR008198; Prot_inh_antileu. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR RGD; 621851; Wap. DR InterPro; IPR008198; Prot_inh_antileu. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR RGD; 621851; Wap. DR InterPro; IPR008198; Prot_inh_antileu. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Phosphorylation; Protease inhibitor; Repeat; Signal; Whey. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN Name=Wap; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR RGD; 621851; Wap. DR InterPro; IPR008198; Prot_inh_antileu. DR InterPro; IPR008197; WAP. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR RGD; 621851; Wap. DR InterPro; IPR008197; WAP. DR InterPro; IPR008198; WAP_C. DR Pfam; PF00095; WAP; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; P19957; 2REL. DR RGD; 621851; Wap. DR InterPro; IPR008197; WAP. DR InterPro; IPR008198; WAP_C. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 Phosphoserine (Potential). FT MOD_RES 40 40 Phosphoserine (Potential). FT MOD_RES 50 50 Phosphothreonine (Potential). FT MOD_RES 103 103 Phosphoserine (Potential). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; O46655; 1CJH. DR RGD; 621851; Wap. DR InterPro; IPR008197; WAP. DR InterPro; IPR008198; WAP_C. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; O46655; 1CJH. DR InterPro; IPR008197; WAP. DR InterPro; IPR008198; WAP_C. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (atypical). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; O46655; 1CJH. DR InterPro; IPR008197; WAP. DR InterPro; IPR008198; WAP_C. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 Whey acidic protein. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; O46655; 1CJH. DR InterPro; IPR008197; WAP. DR InterPro; IPR008198; WAP_C. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 By similarity. FT DISULFID 45 65 By similarity. FT DISULFID 48 60 By similarity. FT DISULFID 54 69 By similarity. FT DISULFID 83 115 By similarity. FT DISULFID 96 119 By similarity. FT DISULFID 102 114 By similarity. FT DISULFID 108 123 By similarity. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (in Ref. 3). FT CONFLICT 35 35 S -> P (in Ref. 2 and 3). FT CONFLICT 39 39 F -> S (in Ref. 2 and 3). FT CONFLICT 47 47 N -> K (in Ref. 2). FT CONFLICT 68 68 S -> P (in Ref. 2 and 3). FT CONFLICT 99 99 D -> G (in Ref. 2). FT CONFLICT 116 116 K -> N (in Ref. 2 and 3). FT CONFLICT 127 127 E -> K (in Ref. 2). FT CONFLICT 129 129 K -> E (in Ref. 3). FT CONFLICT 129 129 K -> D (in Ref. 2). FT CONFLICT 134 134 I -> V (in Ref. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; O46655; 1CJH. DR InterPro; IPR008197; WAP. DR InterPro; IPR008198; WAP_C. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: Could be a protease inhibitor. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MilK-specific; major protein component of milk CC whey. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; O46655; 1CJH. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A93920; WYRT. DR HSSP; O46655; 1CJH. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; O46655; 1CJH. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR ProDom; PD001224; WAP_C; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: Contains 2 WAP-type domains. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; O46655; 1CJH. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR ProDom; PD001224; WAP; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; O46655; 1CJH. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR ProDom; PD001224; WAP; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; O46655; 1CJH. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; O46655; 1CJH. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 20-AUG-2001 (Rel. 40, Last annotation update) DE Whey acidic protein precursor (Whey phosphoprotein) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 20-AUG-2001 (Rel. 40, Last annotation update) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; WAP; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: CONTAINS 2 WAP-TYPE DOMAINS. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; -; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 30 73 WAP 1 (ATYPICAL). FT DOMAIN 79 127 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: BELONGS TO THE WAP-TYPE 'FOUR-DISULFIDE CORE' FAMILY. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR InterPro; IPR002221; WAP. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR ProDom; PD001224; -; 1. DR SMART; SM00217; WAP; 1. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: BELONGS TO THE WAP-TYPE 'FOUR-DISULFIDE CORE' FAMILY. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR InterPro; IPR002221; -. DR Pfam; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=85062841; PubMed=6095207; RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE=82274212; PubMed=6896749; RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE=82275050; PubMed=6955785; RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: COULD BE A PROTEASE INHIBITOR. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- TISSUE SPECIFICITY: MILK-SPECIFIC; MAJOR PROTEIN COMPONENT OF MILK CC WHEY. CC -!- SIMILARITY: BELONGS TO THE WAP-TYPE 'FOUR-DISULFIDE CORE' FAMILY. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR INTERPRO; IPR002221; -. DR PFAM; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT DISULFID 34 61 BY SIMILARITY. FT DISULFID 45 65 BY SIMILARITY. FT DISULFID 48 60 BY SIMILARITY. FT DISULFID 54 69 BY SIMILARITY. FT DISULFID 83 115 BY SIMILARITY. FT DISULFID 96 119 BY SIMILARITY. FT DISULFID 102 114 BY SIMILARITY. FT DISULFID 108 123 BY SIMILARITY. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 30-MAY-2000 (Rel. 39, Last annotation update) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 85062841. RA Campbell S.M., Rosen J.M., Hennighausen L.G., Strech-Jurk U., RA Sippel A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 82274212. RA Hennighausen L.G., Sippel A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 82275050. RA Dandekar A.M., Robinson E.A., Appella E., Qasba P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- PTM: EIGHT DISULFIDE BONDS ARE PRESENT. CC -!- SIMILARITY: BELONGS TO THE WAP-TYPE 'FOUR-DISULFIDE CORE' FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.2; -. DR EMBL; X01154; CAA25600.2; JOINED. DR EMBL; X01155; CAA25600.2; JOINED. DR EMBL; X01156; CAA25600.2; JOINED. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR INTERPRO; IPR002221; -. DR PFAM; PF00095; wap; 2. DR PRINTS; PR00003; 4DISULPHCORE. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 1C2E8ADA9FD97949 CRC64; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (Rel. 01, Created) DT 01-OCT-1989 (Rel. 12, Last sequence update) DT 15-DEC-1998 (Rel. 37, Last annotation update) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 85062841. RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL Nucleic Acids Res. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 82274212. RA HENNIGHAUSEN L.G., SIPPEL A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL Nucleic Acids Res. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 82275050. RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL Proc. Natl. Acad. Sci. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -!- PTM: EIGHT DISULFIDE BONDS ARE PRESENT. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; CAA25600.1; -. DR EMBL; X01154; CAA25601.1; ALT_SEQ. DR EMBL; X01155; E10797; -. DR EMBL; X01156; CAA25603.1; ALT_INIT. DR EMBL; J00802; AAA42347.1; -. DR EMBL; J00801; AAA42346.1; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR HSSP; P19957; 1FLE. DR PFAM; PF00095; wap; 2. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW Milk; Whey; Protease inhibitor; Repeat; Phosphorylation; Signal. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 7A0CA78C CRC32; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 15-DEC-1998 (REL. 37, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA; OC RODENTIA; SCIUROGNATHI; MURIDAE; MURINAE; RATTUS. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 85062841. RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RT "Comparison of the whey acidic protein genes of the rat and mouse."; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 82274212. RA HENNIGHAUSEN L.G., SIPPEL A.E.; RT "Comparative sequence analysis of the mRNAs coding for mouse and rat RT whey protein."; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 82275050. RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RT "Complete sequence analysis of cDNA clones encoding rat whey RT phosphoprotein: homology to a protease inhibitor."; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- PTM: EIGHT DISULFIDE BONDS ARE PRESENT. CC -!- SUBCELLULAR LOCATION: SECRETED. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; G758268; -. DR EMBL; X01154; E10796; ALT_SEQ. DR EMBL; X01155; E10797; -. DR EMBL; X01156; E10798; ALT_INIT. DR EMBL; J00802; G207683; -. DR EMBL; J00801; G207681; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. DR PFAM; PF00095; wap; 2. DR HSSP; P19957; 1FLE. KW MILK; WHEY; PROTEASE INHIBITOR; REPEAT; PHOSPHORYLATION; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 7A0CA78C CRC32; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-NOV-1997 (REL. 35, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). GN WAP. OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 85062841. RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 82274212. RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 82275050. RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- PTM: EIGHT DISULFIDE BONDS ARE PRESENT. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; G758268; -. DR EMBL; X01154; E10796; ALT_SEQ. DR EMBL; X01155; E10797; -. DR EMBL; X01156; E10798; ALT_INIT. DR EMBL; J00802; G207683; -. DR EMBL; J00801; G207681; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE; 2. KW MILK; WHEY; PROTEASE INHIBITOR; REPEAT; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 7A0CA78C CRC32; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 85062841. RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 82274212. RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 82275050. RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- PTM: EIGHT DISULFIDE BONDS ARE PRESENT. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; G758268; -. DR EMBL; X01154; E10796; ALT_SEQ. DR EMBL; X01155; E10797; -. DR EMBL; X01156; E10798; ALT_INIT. DR EMBL; J00802; G207683; -. DR EMBL; J00801; G207681; -. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; REPEAT; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 2). FT CONFLICT 116 116 K -> N (IN REF. 2 AND 3). FT CONFLICT 127 127 E -> K (IN REF. 2). FT CONFLICT 129 129 K -> E (IN REF. 3). FT CONFLICT 129 129 K -> D (IN REF. 2). FT CONFLICT 134 134 I -> V (IN REF. 3). SQ SEQUENCE 137 AA; 14827 MW; 7A0CA78C CRC32; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 85062841. RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RX MEDLINE; 82274212. RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RX MEDLINE; 82275050. RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- PTM: EIGHT DISULFIDE BONDS ARE PRESENT. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; X01153. DR EMBL; X01154; X01154. DR EMBL; X01155; X01155. DR EMBL; X01156; X01156. DR EMBL; J00802; J00802. DR EMBL; J00801; J00801. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; REPEAT; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-OCT-1994 (REL. 30, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RM 85062841 RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RM 82274212 RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RM 82275050 RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- PTM: EIGHT DISULFIDE BONDS ARE PRESENT. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; RNWAP1. DR EMBL; X01154; RNWAP2. DR EMBL; X01155; RNWAP3. DR EMBL; X01156; RNWAP4. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; REPEAT; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT DOMAIN 20 72 WAP 1. FT DOMAIN 73 137 WAP 2. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP_RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RM 85062841 RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RM 82274212 RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RM 82275050 RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; RNWAP1. DR EMBL; X01154; RNWAP2. DR EMBL; X01155; RNWAP3. DR EMBL; X01156; RNWAP4. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 38 38 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 40 40 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 50 50 PHOSPHORYLATION (POTENTIAL). FT MOD_RES 103 103 PHOSPHORYLATION (POTENTIAL). FT REPEAT 20 72 FT REPEAT 73 137 FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP$RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC MEDLINE=85062841; RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] RP SEQUENCE FROM N.A. RC MEDLINE=82274212; RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] RP SEQUENCE FROM N.A. RC MEDLINE=82275050; RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; RNWAP1. DR EMBL; X01154; RNWAP2. DR EMBL; X01155; RNWAP3. DR EMBL; X01156; RNWAP4. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 38 38 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 40 40 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 50 50 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 103 103 PHOSPHORYLATION (PUTATIVE). FT REPEAT 20 72 FT REPEAT 73 137 FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP$RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RATTUS NORVEGICUS (RAT). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] (SEQUENCE FROM N.A.) RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] (SEQUENCE FROM N.A.) RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] (SEQUENCE FROM N.A.) RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; RNWAP1. DR EMBL; X01154; RNWAP2. DR EMBL; X01155; RNWAP3. DR EMBL; X01156; RNWAP4. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 38 38 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 40 40 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 50 50 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 103 103 PHOSPHORYLATION (PUTATIVE). FT REPEAT 20 72 FT REPEAT 73 137 FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP$RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RAT (RATTUS NORVEGICUS). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] (SEQUENCE FROM N.A.) RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] (SEQUENCE FROM N.A.) RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] (SEQUENCE FROM N.A.) RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; X01153; RNWAP1. DR EMBL; X01154; RNWAP2. DR EMBL; X01155; RNWAP3. DR EMBL; X01156; RNWAP4. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. DR PIR; A01228; WYRT. DR PIR; A23879; A23879. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 38 38 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 40 40 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 50 50 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 103 103 PHOSPHORYLATION (PUTATIVE). FT REPEAT 20 72 FT REPEAT 73 137 FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP$RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-APR-1990 (REL. 14, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RAT (RATTUS NORVEGICUS). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] (SEQUENCE FROM N.A.) RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] (SEQUENCE FROM N.A.) RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] (SEQUENCE FROM N.A.) RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PIR; A01228; WYRT. DR EMBL; X01153; RNWAP1. DR EMBL; X01154; RNWAP2. DR EMBL; X01155; RNWAP3. DR EMBL; X01156; RNWAP4. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. DR PROSITE; PS00317; 4_DISULFIDE_CORE. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 38 38 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 40 40 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 50 50 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 103 103 PHOSPHORYLATION (PUTATIVE). FT REPEAT 20 72 FT REPEAT 73 137 FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP$RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 01-OCT-1989 (REL. 12, LAST SEQUENCE UPDATE) DT 01-OCT-1989 (REL. 12, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RAT (RATTUS NORVEGICUS). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] (SEQUENCE FROM N.A.) RA CAMPBELL S.M., ROSEN J.M., HENNIGHAUSEN L.G., STRECH-JURK U., RA SIPPEL A.E.; RL NUCLEIC ACIDS RES. 12:8685-8697(1984). RN [2] (SEQUENCE FROM N.A.) RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). RN [3] (SEQUENCE FROM N.A.) RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). CC -!- FUNCTION: THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE CC MILK WHEY; ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES CC WITH KNOWN PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, CC AS YET UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PIR; A01228; WYRT. DR EMBL; X01153; RNWAP1. DR EMBL; X01154; RNWAP2. DR EMBL; X01155; RNWAP3. DR EMBL; X01156; RNWAP4. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 39 39 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 40 40 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 50 50 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 103 103 PHOSPHORYLATION (PUTATIVE). FT SIMILAR 102 131 WITH THE 2ND DOMAIN OF BASIC PROTEASE FT INHIBITOR FROM RED SEA TURTLE; 14 OF 31 FT POSITIONS ARE IDENTICAL. FT REPEAT 20 72 FT REPEAT 73 137 FT CONFLICT 4 4 S -> F (IN REF. 3). FT CONFLICT 35 35 S -> P (IN REF. 2 AND 3). FT CONFLICT 39 39 F -> S (IN REF. 2 AND 3). FT CONFLICT 47 47 N -> K (IN REF. 2). FT CONFLICT 68 68 S -> P (IN REF. 2 AND 3). FT CONFLICT 99 99 D -> G (IN REF. 3). FT CONFLICT 127 127 E -> K (IN REF. 3). FT CONFLICT 129 129 K -> E (IN REF. 2). FT CONFLICT 129 129 K -> D (IN REF. 3). FT CONFLICT 134 134 I -> V (IN REF. 2). SQ SEQUENCE 137 AA; 14827 MW; 93803 CN; ID WAP$RAT STANDARD; PRT; 137 AA. AC P01174; DT 21-JUL-1986 (REL. 01, CREATED) DT 21-JUL-1986 (REL. 01, LAST SEQUENCE UPDATE) DT 13-AUG-1987 (REL. 05, LAST ANNOTATION UPDATE) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RAT (RATTUS NORVEGICUS). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] (SEQUENCE FROM N.A.) RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. U.S.A. 79:3987-3991(1982). RN [2] (SEQUENCE FROM N.A.) RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCLEIC ACIDS RES. 10:3733-3744(1982). CC -!- WHEY ACIDIC PROTEIN AND THE NEUROPHYSINS CLOSELY RESEMBLE EACH CC OTHER IN THE NUMBER AND PATTERN OF DISTRIBUTION OF THE CYS CC RESIDUES, INCLUDING THE EXISTENCE OF TWO DOMAINS (DUPLICATED CC REGION), BUT OTHERWISE THERE IS LITTLE DETECTABLE SIMILARITY CC BETWEEN THESE PROTEINS. CC -!- THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE MILK WHEY; CC ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES WITH KNOWN CC PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, AS YET CC UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC -!- THE SEQUENCE DIFFERENCES BETWEEN THE TWO REFERENCES MAY BE DUE CC AN ALLELIC VARIANT. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PIR; A01228; WYRT. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 39 39 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 40 40 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 50 50 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 103 103 PHOSPHORYLATION (PUTATIVE). FT SIMILAR 102 131 WITH THE 2ND DOMAIN OF BASIC PROTEASE FT INHIBITOR FROM RED SEA TURTLE; 14 OF 31 FT POSITIONS ARE IDENTICAL. FT REPEAT 20 72 FT REPEAT 73 137 FT VARIANT 4 4 F -> S (IN REF. 2). FT VARIANT 47 47 N -> K (IN REF. 2). FT VARIANT 99 99 D -> G (IN REF. 2). FT VARIANT 127 127 E -> K (IN REF. 2). FT VARIANT 129 129 E -> D (IN REF. 2). FT VARIANT 134 134 V -> I (IN REF. 2). SQ SEQUENCE 137 AA; 14820 MW; 93421 CN; ID WAP$RAT STANDARD; PRT; 137 AA. AC P01174; DT 13-AUG-1987 (ANNOTATIONS EDITED) DT 28-OCT-1986 (ANNOTATIONS EDITED) DT 21-JUL-1986 (ADAPTED FROM A PIR ENTRY) DE WHEY ACIDIC PROTEIN PRECURSOR (WHEY PHOSPHOPROTEIN) (WAP). OS RAT (RATTUS NORVEGICUS). OC EUKARYOTA. RN [1] (SEQUENCE FROM N.A.) RA DANDEKAR A.M., ROBINSON E.A., APPELLA E., QASBA P.K.; RL PROC. NATL. ACAD. SCI. USA 79:3987-3991(1982). RN [2] (SEQUENCE FROM N.A.) RA HENNIGHAUSEN L.G., SIPPEL A.E.; RL NUCL. ACIDS RES. 10:3733-3744(1982). CC -!- WHEY ACIDIC PROTEIN AND THE NEUROPHYSINS CLOSELY RESEMBLE EACH CC OTHER IN THE NUMBER AND PATTERN OF DISTRIBUTION OF THE CYS CC RESIDUES, INCLUDING THE EXISTENCE OF TWO DOMAINS (DUPLICATED CC REGION), BUT OTHERWISE THERE IS LITTLE DETECTABLE SIMILARITY CC BETWEEN THESE PROTEINS. CC -!- THIS IS ONE OF THE MAJOR PROTEIN COMPONENTS IN THE MILK WHEY; CC ALTHOUGH ITS FUNCTION IS UNKNOWN, SEQUENCE HOMOLOGIES WITH KNOWN CC PROTEINASE INHIBITORS SUGGESTS THAT IT MAY HAVE AN, AS YET CC UNDESCRIBED, INHIBITORY FUNCTION. CC -!- EIGHT DISULFIDE BONDS ARE PRESENT IN THE SECRETED PROTEIN. THE CC ARRANGEMENT OF CYS RESIDUES IN THE REGION OF RESIDUES 48-72 IS CC DUPLICATED IN THE REGION OF RESIDUES 102-131. CC -!- THE SEQUENCE DIFFERENCES BETWEEN THE TWO REFERENCES MAY BE DUE CC AN ALLELIC VARIANT. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR PIR; A01228; WYRT. DR EMBL; J00802; RNWAP52. DR EMBL; J00801; RNWAP. KW MILK; WHEY; PROTEASE INHIBITOR; DUPLICATION; ACIDIC PROTEIN; SIGNAL. FT SIGNAL 1 19 FT CHAIN 20 137 WHEY ACIDIC PROTEIN. FT MOD_RES 39 39 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 40 40 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 50 50 PHOSPHORYLATION (PUTATIVE). FT MOD_RES 103 103 PHOSPHORYLATION (PUTATIVE). FT SIMILAR 102 131 WITH THE 2ND DOMAIN OF BASIC PROTEASE FT INHIBITOR FROM RED SEA TURTLE; 14 OF 31 FT POSITIONS ARE IDENTICAL. FT REPEAT 20 72 FT REPEAT 73 137 FT VARIANT 4 4 F -> S (IN REF. 2). FT VARIANT 47 47 N -> K (IN REF. 2). FT VARIANT 99 99 D -> G (IN REF. 2). FT VARIANT 127 127 E -> K (IN REF. 2). FT VARIANT 129 129 E -> D (IN REF. 2). FT VARIANT 134 134 V -> I (IN REF. 2). SQ SEQUENCE 137 AA; 14820 MW; 93421 CN;