ID   M10051; SV 1; linear; mRNA; STD; HUM; 4723 BP.
XX
AC   M10051;
XX
DT   02-JUL-1986 (Rel. 09, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 7)
XX
DE   Human insulin receptor mRNA, complete cds.
XX
KW   insulin receptor; tyrosine kinase.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-4723
RX   DOI; 10.1016/0092-8674(85)90334-4.
RX   PUBMED; 2859121.
RA   Ebina Y., Ellis L., Jarnagin K., Edery M., Graf L., Clauser E., Ou J.-H.,
RA   Masiarz F., Kan Y.W., Goldfine I.D., Roth R.A., Rutter W.J.;
RT   "The human insulin receptor cDNA: the structural basis for
RT   hormone-activated transmembrane signalling";
RL   Cell 40(4):747-758(1985).
XX
DR   MD5; e4e6ebf2e723a500c1dd62385c279351.
DR   Ensembl-Gn; ENSG00000171105; homo_sapiens.
DR   Ensembl-Tr; ENST00000302850; homo_sapiens.
DR   Ensembl-Tr; ENST00000341500; homo_sapiens.
DR   EuropePMC; PMC2739203; 19682364.
DR   EuropePMC; PMC3164640; 21909271.
DR   EuropePMC; PMC452597; 15146055.
XX
CC   [1] suggests that the insulin receptor may be the cellular homolog
CC   of the v-ros transforming (oncogene) protein.  [1] notes
CC   similarities between the insulin receptor and several growth factor
CC   receptors and oncogenes.  Insulin receptor is a heterodimer
CC   consisting of 2 alpha and 2 beta subunits.  Beta-prime may be a
CC   cleavage product produced upon binding of insulin.  [1] suggests
CC   that translation may begin at the 'atg' start codon at positions
CC   79-81 with protein cleavage occurring after position 120 to yield
CC   the signal peptide.  [1] gives illustrations of the various domains
CC   present in the protein.  A draft entry and sequence for [1] in
CC   computer-readable form were kindly provided by K. Jarnagin
CC   (30-JUL-1985).
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..4723
FT                   /organism="Homo sapiens"
FT                   /map="19p13.3-p13.2"
FT                   /mol_type="mRNA"
FT                   /db_xref="taxon:9606"
FT   sig_peptide     137..219
FT                   /note="insulin receptor signal peptide"
FT   CDS             139..4287
FT                   /codon_start=1
FT                   /gene="INSR"
FT                   /note="insulin receptor precursor"
FT                   /db_xref="GOA:P06213"
FT                   /db_xref="H-InvDB:HIT000194074.15"
FT                   /db_xref="HGNC:HGNC:6091"
FT                   /db_xref="InterPro:IPR000494"
FT                   /db_xref="InterPro:IPR000719"
FT                   /db_xref="InterPro:IPR001245"
FT                   /db_xref="InterPro:IPR002011"
FT                   /db_xref="InterPro:IPR003961"
FT                   /db_xref="InterPro:IPR006211"
FT                   /db_xref="InterPro:IPR006212"
FT                   /db_xref="InterPro:IPR008266"
FT                   /db_xref="InterPro:IPR009030"
FT                   /db_xref="InterPro:IPR011009"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR016246"
FT                   /db_xref="InterPro:IPR017441"
FT                   /db_xref="InterPro:IPR020635"
FT                   /db_xref="InterPro:IPR036116"
FT                   /db_xref="InterPro:IPR036941"
FT                   /db_xref="InterPro:IPR040969"
FT                   /db_xref="PDB:1GAG"
FT                   /db_xref="PDB:1I44"
FT                   /db_xref="PDB:1IR3"
FT                   /db_xref="PDB:1IRK"
FT                   /db_xref="PDB:1P14"
FT                   /db_xref="PDB:1RQQ"
FT                   /db_xref="PDB:2AUH"
FT                   /db_xref="PDB:2B4S"
FT                   /db_xref="PDB:2HR7"
FT                   /db_xref="PDB:2MFR"
FT                   /db_xref="PDB:2Z8C"
FT                   /db_xref="PDB:3BU3"
FT                   /db_xref="PDB:3BU5"
FT                   /db_xref="PDB:3BU6"
FT                   /db_xref="PDB:3EKK"
FT                   /db_xref="PDB:3EKN"
FT                   /db_xref="PDB:3ETA"
FT                   /db_xref="PDB:3W11"
FT                   /db_xref="PDB:3W12"
FT                   /db_xref="PDB:3W13"
FT                   /db_xref="PDB:4IBM"
FT                   /db_xref="PDB:4OGA"
FT                   /db_xref="PDB:4XLV"
FT                   /db_xref="PDB:4XSS"
FT                   /db_xref="PDB:4XST"
FT                   /db_xref="PDB:4ZXB"
FT                   /db_xref="PDB:5E1S"
FT                   /db_xref="PDB:5HHW"
FT                   /db_xref="PDB:5J3H"
FT                   /db_xref="PDB:5KQV"
FT                   /db_xref="PDB:5U1M"
FT                   /db_xref="PDB:6HN4"
FT                   /db_xref="PDB:6HN5"
FT                   /db_xref="UniProtKB/Swiss-Prot:P06213"
FT                   /protein_id="AAA59174.1"
FT                   /translation="MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLT
FT                   RLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFP
FT                   NLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI
FT                   LDSVEDNHIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTI
FT                   CKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCV
FT                   NFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCH
FT                   LLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRR
FT                   SYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTTTQGKLFFHYN
FT                   PKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDKASCENELLKFSYIRTSFDKILLRWE
FT                   PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHP
FT                   GWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
FT                   SQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDS
FT                   QKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAE
FT                   DPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGL
FT                   RHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMW
FT                   QEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSL
FT                   AGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLG
FT                   PLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKG
FT                   EAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMA
FT                   HGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCM
FT                   VAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVV
FT                   LWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
FT                   EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGR
FT                   DGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS"
FT   mat_peptide     220..2424
FT                   /gene="INSR"
FT                   /note="insulin receptor alpha subunit"
FT   mat_peptide     2425..4284
FT                   /gene="INSR"
FT                   /note="insulin receptor beta subunit"
FT   mat_peptide     2425..2469
FT                   /partial
FT                   /gene="INSR"
FT                   /note="insulin receptor beta-prime subunit"
XX
SQ   Sequence 4723 BP; 1068 A; 1298 C; 1311 G; 1046 T; 0 other;