ID   K00650; SV 1; linear; genomic DNA; STD; HUM; 6210 BP.
XX
AC   K00650; M16287;
XX
DT   26-JUL-1991 (Rel. 28, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 4)
XX
DE   Human fos proto-oncogene (c-fos), complete cds.
XX
KW   c-myc proto-oncogene; fos oncogene; proto-oncogene.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-4165
RX   DOI; 10.1073/pnas.80.11.3183.
RX   PUBMED; 6574479.
RA   van Straaten F., Muller R., Curran T., Van Beveren C., Verma I.M.;
RT   "Complete nucleotide sequence of a human c-onc gene: deduced amino acid
RT   sequence of the human c-fos protein";
RL   Proc. Natl. Acad. Sci. U.S.A. 80(11):3183-3187(1983).
XX
RN   [2]
RX   DOI; 10.1016/0092-8674(85)90285-5.
RX   PUBMED; 2414012.
RA   Treisman R.;
RT   "Transient accumulation of c-fos RNA following serum stimulation requires a
RT   conserved 5' element and c-fos 3' sequences";
RL   Cell 42(3):889-902(1985).
XX
RN   [3]
RP   4166-6210
RX   PUBMED; 3555978.
RA   Verma I.M., Deschamps J., Van Beveren C., Sassone-Corsi P.;
RT   "Human fos gene";
RL   Cold Spring Harb. Symp. Quant. Biol. 51:0(0).
XX
DR   MD5; 2cdb1f2aa6c13c384c8522058c958a7c.
DR   EPD; EP11145; HS_FOS.
DR   Ensembl-Gn; ENSG00000170345; homo_sapiens.
DR   Ensembl-Tr; ENST00000303562; homo_sapiens.
DR   Ensembl-Tr; ENST00000535987; homo_sapiens.
DR   Ensembl-Tr; ENST00000555686; homo_sapiens.
DR   EuropePMC; PMC116128; 11711622.
DR   EuropePMC; PMC19553; 9012824.
DR   EuropePMC; PMC3220474; 21937452.
DR   EuropePMC; PMC3750569; 23919306.
DR   EuropePMC; PMC4786693; 26786102.
XX
CC   [2]  sites; promoter region.
CC   C-fos is the human cellular homolog of the v-fos oncogene of
CC   Finkel-Biskis-Jinkins murine osteosarcoma virus (FBJ-MuSV).  [2] It
CC   was found that both human and murine c-fos genes contained an
CC   enhancer-like element in their 5' noncoding regions that was
CC   necessary for increased transcription following serum activation.
CC   The FBJ-MuSV v-fos oncogene contains a deletion relative to murine
CC   and human c-fos proto-oncogenes that causes complete divergence of
CC   the COOH terminal protein sequences encoded.  That deletion
CC   corresponds to positions 3182-3285 inclusive of this sequence.  The
CC   FBJ-MuSV v-fos sequence is more closely related to murine than
CC   human c-fos sequences.  The FBJ-MuSV v-fos coding sequence ends at
CC   a 'tag' stop codon coresponding to positions 3434-2436 of this
CC   sequence [1].  [1] notes two alu repeats beginning aproximately 500
CC   and 1700 nucleotides downstream of the last base in this sequence.
CC   A TATA box is located at positions 701-707.  Two potential
CC   polyadenylation signals are present in the 3' untranslated region.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..6210
FT                   /organism="Homo sapiens"
FT                   /map="14q24.3"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:9606"
FT   misc_feature    402..453
FT                   /note="transcriptional activator region [2]"
FT   prim_transcript 734..>3329
FT                   /note="c-fos mRNA [1]"
FT   gene            889..1029
FT                   /gene="FOS"
FT   CDS             join(889..1029,1783..2034,2466..2573,2688..3329)
FT                   /codon_start=1
FT                   /note="c-fos protein"
FT                   /db_xref="GOA:P01100"
FT                   /db_xref="HGNC:HGNC:3796"
FT                   /db_xref="InterPro:IPR000837"
FT                   /db_xref="InterPro:IPR004827"
FT                   /db_xref="InterPro:IPR029816"
FT                   /db_xref="PDB:1A02"
FT                   /db_xref="PDB:1FOS"
FT                   /db_xref="PDB:1S9K"
FT                   /db_xref="UniProtKB/Swiss-Prot:P01100"
FT                   /protein_id="AAA52471.1"
FT                   /translation="MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVN
FT                   AQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAG
FT                   AYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTD
FT                   TLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLD
FT                   LTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPS
FT                   GSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSS
FT                   FVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL"
FT   exon            <889..1029
FT                   /gene="FOS"
FT                   /number=1
FT                   /note="c-fos protein; G00-119-917"
FT   intron          1030..1782
FT                   /note="c-fos intron A"
FT   exon            1783..2034
FT                   /number=2
FT   intron          2035..2465
FT                   /note="c-fos intron B"
FT   exon            2466..2573
FT                   /number=3
FT   intron          2574..2687
FT                   /note="c-fos intron C"
FT   exon            2688..>3329
FT                   /number=4
FT                   /note="c-fos protein"
XX
SQ   Sequence 6210 BP; 1497 A; 1571 C; 1619 G; 1523 T; 0 other;