ID   AAA59452; SV 1; linear; genomic DNA; STD; HUM; 4149 BP.
XX
PA   AH002851.2
XX
DT   13-JUN-2016 (Rel. 129, Created)
DT   13-JUN-2016 (Rel. 129, Last updated, Version 1)
XX
DE   Homo sapiens (human) insulin receptor
XX
KW   .
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RX   DOI; 10.1073/pnas.86.1.114.
RX   PUBMED; 2911561.
RA   Seino S., Seino M., Nishi S., Bell G.I.;
RT   "Structure of the human insulin receptor gene and characterization of its
RT   promoter";
RL   Proc. Natl. Acad. Sci. U.S.A. 86(1):114-118(1989).
XX
RN   [2]
RX   PUBMED; 2210055.
RA   Seino S., Seino M., Bell G.I.;
RT   "Human insulin-receptor gene. Partial sequence and amplification of exons
RT   by polymerase chain reaction";
RL   Diabetes 39(1):123-128(1990).
XX
DR   MD5; 4c7ab6fae5c07f3becb459d31ae2d7fc.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..4149
FT                   /organism="Homo sapiens"
FT                   /map="19p13.3-p13.2"
FT                   /mol_type="genomic DNA"
FT                   /dev_stage="foetus"
FT                   /tissue_type="liver"
FT                   /db_xref="taxon:9606"
FT   CDS             join(AH002851.2:1824..1923,AH002851.2:2359..2910,
FT                   AH002851.2:3327..3648,AH002851.2:4270..4418,
FT                   AH002851.2:4903..5047,AH002851.2:5414..5628,
FT                   AH002851.2:6156..6282,AH002851.2:6695..6945,
FT                   AH002851.2:7178..7345,AH002851.2:7779..7980,
FT                   AH002851.2:8332..8367,AH002851.2:8813..9087,
FT                   AH002851.2:9564..9703,AH002851.2:10095..10254,
FT                   AH002851.2:10588..10690,AH002851.2:11286..11353,
FT                   AH002851.2:11741..11985,AH002851.2:12307..12417,
FT                   AH002851.2:12622..12781,AH002851.2:13114..13243,
FT                   AH002851.2:13488..13622,AH002851.2:13977..14331)
FT                   /codon_start=1
FT                   /gene="INSR"
FT                   /product="insulin receptor"
FT                   /note="precursor"
FT                   /protein_id="AAA59452.1"
FT                   /translation="MGTGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLT
FT                   RLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFP
FT                   NLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI
FT                   LDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTI
FT                   CKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCV
FT                   NFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCH
FT                   LLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRR
FT                   SYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYN
FT                   PKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWE
FT                   PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHP
FT                   GWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSS
FT                   SQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDS
FT                   QKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAE
FT                   DPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGL
FT                   RHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMW
FT                   QEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSL
FT                   AGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLG
FT                   PLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKG
FT                   EAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMA
FT                   HGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCM
FT                   VAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVV
FT                   LWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
FT                   EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGR
FT                   DGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS"
XX
SQ   Sequence 4149 BP; 952 A; 1145 C; 1159 G; 893 T; 0 other;