ID M20562; SV 1; linear; genomic RNA; STD; VRL; 8105 BP. XX AC M20562; XX DT 06-JUL-1989 (Rel. 20, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Theiler murine encephalomyelitis, complete genome. XX KW complete genome; polyprotein. XX OS Theiler's encephalomyelitis virus OC Viruses; Riboviria; Picornavirales; Picornaviridae; Cardiovirus. XX RN [1] RP 1-8105 RX DOI; 10.1016/0042-6822(88)90652-6. RX PUBMED; 2838951. RA Pevear D.C., Borkowski J.A., Calenoff M., Oh C.K., Ostrawski B., RA Lipton H.L.; RT "Insights into Theiler's virus neurovirulence based on a genomic comparison RT of the neurovirulent GDVII and less virulent BeAn strains"; RL Virology 165(1):1-12(1988). XX DR MD5; 552d13872e4b8fa5208f9c441915fa71. DR EuropePMC; PMC1933019; 17460053. DR EuropePMC; PMC2583687; 18815294. DR EuropePMC; PMC2603095; 18760006. DR EuropePMC; PMC2707126; 19004372. DR EuropePMC; PMC2825307; 19728123. DR EuropePMC; PMC3126553; 21543488. DR EuropePMC; PMC3148564; 21708006. DR EuropePMC; PMC3156266; 21445704. DR EuropePMC; PMC5872539; 29587779. DR EuropePMC; PMC6391014; 30807598. DR RFAM; RF00210; IRES_Aptho. DR RFAM; RF00453; Cardiovirus_CRE. DR UniProtKB/Swiss-Prot; P0DOK5; ALT2B_TMEVG. XX CC Draft entry and computer-readable sequence for [1] kindly provided CC by H.L.Lipton, 08-SEP-1988. XX FH Key Location/Qualifiers FH FT source 1..8105 FT /organism="Theiler's encephalomyelitis virus" FT /mol_type="genomic RNA" FT /db_xref="taxon:12124" FT sig_peptide 1069..1296 FT /note="polyprotein signal peptide" FT CDS 1069..7980 FT /codon_start=1 FT /note="viral polyprotein" FT /db_xref="GOA:P08545" FT /db_xref="InterPro:IPR000199" FT /db_xref="InterPro:IPR000605" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR001676" FT /db_xref="InterPro:IPR004004" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR014759" FT /db_xref="InterPro:IPR015031" FT /db_xref="InterPro:IPR029053" FT /db_xref="InterPro:IPR033703" FT /db_xref="InterPro:IPR037080" FT /db_xref="UniProtKB/Swiss-Prot:P08545" FT /protein_id="AAA47929.1" FT /translation="MACKHGYPDVCPICTAVDATPDFEYLLMADGEWFPTDLLCVDLDD FT DVFWPSDTSTQPQTMEWTDVPLVCDTVMEPQGNASSSDKSNSQSSGNEGVIINNFYSNQ FT YQNSIDLSASGGNAGDAPQNNGQLSSILGGAANAFATMAPLLMDQNTEEMENLSDRVAS FT DKAGNSATNTQSTVGRLCGYGKSHHGEHPTSCADAATDKVLAAERYYTIDLASWTTSQE FT AFSHIRIPLPHVLAGEDGGVFGATLRRHYLCKTGWRVQVQCNASQFHAGSLLVFMAPEF FT YTGKGTKSGTMEPSDPFTMDTTWRSPQSAPTGYRYDRQAGFFAMNHQNQWQWTVYPHQI FT LNLRTNTTVDLEVPYVNVAPSSSWTQHANWTLVVAVLSPLQYATGSSPDVQITASLQPV FT NPVFNGLRHETVLAQSPIPVTVREHQGCFYSTNPDTTVPIYGKTISTPSDYMCGEFSDL FT LELCKLPTFLGNPSTDNKRYPYFSATNSVPATSLVDYQVALSCSCTANSMLAAVARNFN FT QYRGSLNFLFVFTGAAMVKGKFRIAYTPPGAGKPTTRDQAMQATYAIWDLGLNSSFNFT FT APFISPTHYRQTSYTSPTITSVDGWVTVWQLTPLTYPSGTPTHSDILTLVSAGDDFTLR FT MPISPTKWVPQGIDNAEKGKVSNDDASVDFVAEPVKLPENQTRVAFFYDRAVPIGMLRP FT GQNMETTFSYQENDFRLNCLLLTPLPSYCPDSSSGPVRTKAPVQWRWVRSGGANGANFP FT LMTKQDYAFLCFSPFTYYKCDLEVTVSAMGAGTVSSVLRWAPTGAPADVTDQLIGYTPS FT LGETRNPHMWIVGSGNSQISFVVPYNSPLSVLPAAWFNGWSDFGNTKDFGVAPTSDFGR FT IWIQGNSSASVRIRYKKMKVFCPRPTLFFPWPTPTTTKINADNPVPILELENPASLYRI FT DLFITFTDELITFDYKVHGRPVLTFRIPGFGLTPAGRMLVCMGAKPAHSPFTSSKSLYH FT VIFTSTCNSFSFTIYKGRYRSWKKPIHDELVDRGYTTFREFFKAVRGYHADYYKQRLIH FT DVEMNPGPVQSVFQPQGAVLTKSLAPQAGIQNILLRLLGIEGDCSEVSKAITVVTDLVA FT AWEKAKTTLVSPEFWSELILKTTKFIAASVLYLHNPDFTTTVCLSLMTGVDLLTNDSVF FT DWLKSKLSSFFRTPPPACPNVMQPQGPLREANEGFTFAKNIEWATKTIQSIVNWLTSWF FT KQEEDHPQSKLDKLLMEFPDHCRNIMDMRNGRKAYCECTASFKYFDDLYNLAVTCKRIP FT LASLCEKFKNRHDHSVTRPEPVVAVLRGAAGQGKSVTSQIIAQSVSKMAFGRQSVYSMP FT PDSEYFDGYENQFSVIMDDLGQNPDGEDFTVFCQMVSSTNFLPNMAHLERKGTPFTSSF FT IVATTNLPKFRPVTVAHYPAVDRRITFDFTVTAGPHCKTPAGMLDIEKAFDEIPGSKPQ FT LACFSADCPLLHKRGVMFTCNRTKTVYNLQQVVKMVNDTITRKTENVKKMNSLVAQSPP FT DWQHFENILTCLRQNNAALQDQVDELQEAFTQARERSDFLSDWLKVSAIIFAGIVSLSA FT VIKLASKFKESIWPTPVRVELSEGEQAAYAGRARAQKQALQVLDIQGGGKVLAQAGNPV FT MDFELFCAKNMVSPITFYYPDKAEVTQSCLLLRAHLFVVNRHVAETEWTAFKLRDVRHE FT RDTVVMRSVNRSGAETDLTFVKVTKGPLFKDNVNKFCSNKDDFPARNDTVTGIMNTGLA FT FVYSGNFLIGNQPVNTTTGACFNHCLHYRAQTRRGWCGSAIICNVNGKKAVYGMHSAGG FT GGLAAATIITRELIEAAEKSMLALEPQGAIVDISTGSVVHVPRKTKLRRTVAHDVFQPK FT FEPAVLSRYDPRTDKDVDVVAFSKHTTNMESLPPIFDIVCGEYANRVFTILGKDNGLLT FT VEQAVLGLSGMDPMEKDTSPGLPYTQQGLRRTDLLDFNTAKMTPQLDYAHSKLVLGVYD FT DVVYQSFLKDEIRPLEKIHEAKTRIVDVPPFAHCIWGRQLLGRFASKFQTKPGFELGSA FT IGTDPDVDWTRYAAELSGFNYVYDVDYSNFDASHSTAMFECLINNFFTEQNGFDRRIAE FT YLRSLAVSRHAYEDRRVLIRGGLPSGCAATSMLNTIMNNVIIRAALYLTYSNFEFDDIK FT VLSYGDDLLIGTNYQIDFNLVKERLAPFGYKITPANKTTTFPLTSHLQDVTFLKRRFVR FT FNSYLFRPQMDAVNLKAMVSYCKPGTLKEKLMSIALLAVHSGPDIYDEIFLPFRNVGIV FT VPTYDSMLYRWLSLFR" FT mat_peptide 1297..1509 FT /note="protein 1A" FT mat_peptide 1510..2310 FT /note="protein 1B" FT mat_peptide 2311..3006 FT /note="protein 1C" FT mat_peptide 3007..3834 FT /note="protein 1D" FT mat_peptide 3835..4260 FT /note="protein 2A" FT mat_peptide 4261..4641 FT /note="protein 2B" FT mat_peptide 4642..5619 FT /note="protein 2C" FT mat_peptide 5620..5883 FT /note="protein 3A" FT mat_peptide 5884..5943 FT /note="protein 3B" FT mat_peptide 5944..6594 FT /note="protein 3C" FT mat_peptide 6595..7977 FT /note="protein 3D" XX SQ Sequence 8105 BP; 1944 A; 2226 C; 1758 G; 2177 T; 0 other; ttgaaagggg gcccggggga tctcccccgc ggtaactggt cacagttgcc gcggacggag 60 atcatccccc ggttaccccc tttcgacgcg ggtactgcga tagtgccacc ccagtccttc 120 ctactcccga ctcccgaccc caacccaggt tccttggaac aggaacacca atttattcat 180 cccttggatg ctgactaatc agaggaacgt cagcattttc cggcccaggc taagagaagt 240 agataagtta gaatctaaat tatttatcat ccccttgacg aattcgcgtt ggaaaagcac 300 ctctcacttg ccgctcttca cacccatcat tctaattcgg cccctgtgtt gagccccttg 360 ttgaagtgtt tccctccatc gcgacgtggt tggagatcta agttaaccga ctccgacgaa 420 actaccatca tgcctccccg attatgtgat gctttctgcc ctgctgggtg gagcatcctc 480 gggttgagaa atctttcttc cttttacctt ggactccggt cccccggtct aagccgcttg 540 gaataagaca gggttatctt cactcctctt cttttctact tcacagtgtt ctatgctgtg 600 aaagggtatg tgtcgcccct tccttcttcg gagaacacgc gtggcggttt tttccgtctc 660 tcgacaagcg cgtgtgcgac atgcagagtc tcgcgaagaa agcagttctc ggtctagctt 720 tagtgcccac aagaaaacag ctgtagcgac cacacaaagg cagcggaacc cccctcctgg 780 taacaggagc ctctgcggcc aaaagccacg tggataagat ccacctttgt gtgcggtgca 840 accccagcac cctgttttct tggtgacact ctagtgaacc cctgaatggc gatcttaagc 900 gcctctgtag ggaagccagg aatgtccagg aggtacccct tccgctcgga agggatctga 960 cctggagaca catcacatgt gctttacacc tgtgcttgtg tttaaaaaat tgtcgcagct 1020 tccccaaacc aagtggtctt ggttttctct ttttattata ttgtcaatat ggcttgcaaa 1080 cacggatacc cagacgtgtg ccctatttgc acagccgttg acgctactcc cgactttgaa 1140 tatttgctca tggcagacgg agaatggttc cctacggacc ttctttgtgt ggacttggac 1200 gatgacgtct tctggccttc ggacacgagc actcaacctc aaacaatgga atggactgat 1260 gtaccgctcg tatgcgatac tgtcatggaa ccccagggaa atgcctcgtc atctgataag 1320 agtaactccc agtcctcagg aaatgagggg gttatcatta ataacttcta ttccaatcaa 1380 taccagaact caattgattt gtctgccagt ggtggcaacg ctggcgatgc tccccagaac 1440 aatggacaac tgtccagcat tctgggtgga gctgcaaatg cttttgctac tatggcacct 1500 ctcctcatgg accagaacac agaggagatg gaaaacctct ctgacagagt agcttctgac 1560 aaagcaggga attcggccac aaacacacag tctactgttg gccggctctg tggctatgga 1620 aagtcccacc acggagaaca cccaacctct tgtgccgatg ccgcgactga caaggtcctc 1680 gcggctgaac gttactacac tatcgatctg gctagttgga ccacttccca agaagctttc 1740 tctcacatca ggattcctct ccctcacgtc cttgctggcg aggacggagg ggtttttgga 1800 gctaccttaa ggagacacta cctctgcaag actggatggc gcgtacaagt ccaatgcaac 1860 gcctcccagt ttcatgctgg ctcccttctt gtcttcatgg ctccagaatt ctatactggt 1920 aaaggaacaa aatcaggcac tatggagcct tcagacccat ttaccatgga caccacctgg 1980 cgcagcccgc aaagtgcgcc cacaggctac cgctatgaca gacaagccgg ctttttcgcc 2040 atgaaccacc agaaccaatg gcaatggact gtctaccctc accagatttt gaatttgcgc 2100 acaaacacca ccgttgactt ggaagttccc tatgtcaatg tggcaccctc cagctcttgg 2160 actcaacatg caaactggac tctcgttgtt gctgtgctca gccctcttca gtacgccacc 2220 ggttcttcac cggacgttca aatcacagcc tccctgcaac ctgttaatcc cgtgtttaat 2280 ggtttgagac acgaaactgt gcttgcgcaa agtcctattc cagtcacggt gcgtgagcac 2340 cagggctgtt tctactccac taaccctgac accactgttc ccatctatgg gaaaaccatt 2400 tccaccccga gtgactacat gtgtggtgag ttttctgatc ttcttgaatt gtgcaagctc 2460 cccacattcc ttggcaaccc cagcaccgac aacaagcgtt acccttattt ctctgccacc 2520 aactccgtgc cagccacatc cctggttgac taccaagttg ctctctcatg ctcttgtacg 2580 gccaactcaa tgcttgctgc tgttgctcgt aactttaatc agtaccgtgg ttcactgaat 2640 tttcttttcg ttttcactgg tgctgcaatg gttaagggca agtttcgcat agcctacacc 2700 ccgcctggtg cgggaaagcc caccacccgg gaccaagcta tgcaggctac ctacgccatt 2760 tgggacttgg gcttgaattc cagcttcaac ttcactgcgc cttttatatc tccaactcat 2820 taccgtcaga ctagctatac tagccccacc atcacatctg ttgacggttg ggtcactgtt 2880 tggcagctga cccccctgac ctacccttct ggaaccccca cccattctga tattctcacc 2940 cttgtctccg ccggcgatga cttcacgctc aggatgccaa tttcacccac caaatgggtt 3000 ccacagggaa ttgacaatgc tgagaaggga aaggtctcca acgatgacgc ttcggtcgat 3060 ttcgttgccg agccagtcaa gctacccgag aaccaaaccc gggtggcctt cttttacgac 3120 agagctgtcc ccataggaat gttgagaccc ggccaaaata tggaaaccac ctttagctac 3180 caagagaatg atttccgcct caattgtctt ctgttgaccc ctcttccttc ttattgtccc 3240 gacagttcct ccggtcctgt cagaacgaag gctcccgtcc agtggcgatg ggtgcggtct 3300 ggtggcgcca atggtgccaa cttcccactc atgaccaaac aggactacgc cttcctctgc 3360 ttttcccctt tcacctacta caagtgtgac cttgaagtta ccgttagtgc tatgggagca 3420 ggcaccgttt cttctgttct gcgctgggca cccaccgggg cgcccgcgga tgtcactgac 3480 cagctgatcg gctatactcc tagtcttggt gaaacacgta acccccacat gtggatcgtt 3540 ggctctggaa attctcaaat ttcttttgtc gtaccttaca attcccctct gtccgtctta 3600 cccgctgctt ggttcaatgg atggtccgac tttggaaaca ccaaggattt tggagttgct 3660 cctacgtcgg attttgggcg catttggata cagggtaaca gctctgcctc agttcgaatc 3720 aggtacaaga agatgaaggt cttctgcccc cgcccgaccc tctttttccc ctggccaacg 3780 cccaccacca ccaagatcaa tgctgacaat ccagtcccca ttcttgagct tgagaatccc 3840 gcttctctct accgcattga tcttttcatc acctttactg atgagctcat aacttttgac 3900 tacaaggtcc acggacgtcc tgtgctcacc ttccggattc caggcttcgg tctgacaccg 3960 gcaggcagaa tgctcgtgtg catgggcgcg aagcccgcac acagtccgtt cacctcgtct 4020 aaatctctat accatgttat cttcacttcc acttgcaatt ccttcagctt taccatctat 4080 aaaggacgct accgctcctg gaagaagccc atccacgatg agcttgtgga tcgtggttac 4140 accactttcc gcgagttctt caaggctgtg cgcggatacc atgctgacta ctacaaacag 4200 agactcatac atgatgtaga aatgaaccca ggccctgtgc agtcggtttt tcagccacaa 4260 ggtgcggtgc taactaaatc cctagcaccc caggcaggaa ttcaaaacat ccttctacgc 4320 ctccttggca tagaaggtga ctgttcagaa gttagtaaag caatcacagt tgtcactgac 4380 ttggttgctg catgggaaaa agcaaaaacc actctggtct ctcctgaatt ttggtcagaa 4440 cttatattaa aaactaccaa gttcattgct gcttccgtgc tctaccttca caaccctgac 4500 ttcactacca ctgtttgtct ctcattgatg actggtgtag acctcctcac caatgattct 4560 gtttttgatt ggcttaagag caaattgtcc tccttctttc gtactcctcc cccagcttgc 4620 cccaatgtca tgcaacctca ggggcctcta cgcgaggcca atgagggttt tacctttgcc 4680 aagaatattg aatgggccac gaaaaccatc cagtccattg tcaattggct tactagctgg 4740 ttcaagcagg aagaggacca cccccaatca aaattagaca aattgcttat ggaattccct 4800 gatcattgta ggaacattat ggatatgagg aacggtcgaa aggcctattg tgaatgcact 4860 gcttccttta agtattttga tgatctttac aatcttgctg ttacttgcaa aagaattcca 4920 ttagcctccc tttgtgagaa atttaagaat agacacgacc actctgtcac cagacccgag 4980 ccggtggttg ctgtcctgcg cggcgccgct gggcaaggca aatctgtgac cagccaaatc 5040 attgcccaat ctgtttctaa gatggccttt ggccgtcagt ctgtttattc tatgcccccc 5100 gattcggaat attttgatgg ctatgaaaat caattttctg tgattatgga tgatctagga 5160 caaaatcccg atggtgaaga tttcaccgtc ttttgtcaaa tggtttctag cacaaatttt 5220 ctcccgaata tggctcacct ggaaagaaaa ggcacccctt tcacctctag ctttattgtt 5280 gccacaacaa atttgcccaa attccgcccc gttacggtag cccattaccc tgctgttgat 5340 aggcgaatca cctttgactt caccgttact gctggacccc actgtaaaac acccgctgga 5400 atgttggaca ttgagaaggc ttttgatgaa atacctggct ccaaacctca gcttgcctgc 5460 tttagtgctg attgtcccct cctacacaag agaggagtta tgttcacctg caatcgcacc 5520 aaaactgtct acaaccttca acaggttgtg aaaatggtca acgacactat cactcgcaag 5580 actgaaaacg ttaagaaaat gaacagcttg gttgcccagt ccccaccaga ctggcaacac 5640 tttgagaata tcctcacttg cctccgtcag aataatgctg ctcttcagga tcaagttgat 5700 gaattgcaag aagcgttcac ccaagcccgc gagcgttctg attttctttc tgattggttg 5760 aaggtttctg ctatcatttt tgctggtatt gtctcacttt ctgctgtcat aaaactagcc 5820 tccaaattta aagaatcaat ttggcccacg cccgtgagag ttgagctctc tgagggcgaa 5880 caggccgcgt atgctggtcg tgcgcgcgct caaaaacaag cccttcaggt cctagatatt 5940 caaggaggcg ggaaggttct agcccaggcc ggtaaccccg tcatggactt tgagcttttc 6000 tgtgccaaaa acatggtttc cccgattacc ttctactacc ctgacaaggc tgaagtgacc 6060 cagagctgct tgctgctccg tgcccacctc ttcgtggtca accgccacgt cgctgaaacg 6120 gaatggacag ctttcaagct tagggatgtg aggcacgaac gtgacactgt tgtcatgcgt 6180 tccgttaacc gctcaggagc tgaaacggac cttacattcg tgaaggttac taaaggacca 6240 ctcttcaagg acaatgtgaa caagttttgc tcaaacaagg acgattttcc tgctaggaat 6300 gacactgtta ccgggataat gaacactgga ttggccttcg tgtattccgg taactttctg 6360 attggcaatc aacctgtgaa cacaacaact ggagcctgct tcaaccactg cctccactat 6420 cgagctcaaa ctcgacgtgg ttggtgtggt tctgccatca tctgcaatgt taacggcaaa 6480 aaagctgttt acggaatgca ctctgctgga ggcggaggcc ttgccgccgc taccatcatc 6540 accagagagt tgattgaagc agctgagaag tctatgttgg cgctggaacc gcaaggtgcc 6600 atcgtggaca tttccacagg atctgtcgta catgtcccca gaaagaccaa actgaggaga 6660 acagtcgctc atgacgtttt ccaacccaaa ttcgaacctg cagttctgtc ccgttatgac 6720 cctcggaccg acaaggatgt agatgttgta gccttctcca aacacactac taacatggaa 6780 agcttgcctc caatctttga cattgtctgc ggtgaatacg ctaaccgtgt tttcaccatc 6840 cttggtaaag acaacggtct cttaaccgtt gaacaggctg tgcttggctt gtcgggcatg 6900 gaccccatgg agaaggacac ctcccctgga ttgccctaca ctcaacaagg actcagacga 6960 actgaccttc tggatttcaa cactgccaaa atgacacccc aattggacta tgcccattcc 7020 aaactggtac tcggcgttta tgacgacgtt gtctaccaat catttttgaa agatgaaatt 7080 cggcccttgg agaagatcca cgaagcaaaa acccggattg ttgatgtgcc cccgtttgcc 7140 cactgcattt ggggaagaca gcttttggga cgcttcgctt ccaaatttca aactaaacct 7200 ggatttgaac ttggatctgc aattggaact gacccggatg ttgattggac gcgctatgcc 7260 gccgagctga gcgggttcaa ctacgtctat gatgtagatt actccaactt tgatgcttcc 7320 cattctactg caatgtttga atgtttgatt aacaatttct ttacagagca aaatggattt 7380 gacagacgca ttgccgagta ccttagatct ctggctgtgt cgcgacatgc ttatgaggac 7440 cgccgtgtcc tcatacgtgg gggcctgcct tcgggctgtg ctgctaccag catgttaaac 7500 accatcatga acaatgtcat aattcgtgct gccctgtacc ttacttattc aaattttgaa 7560 tttgatgata ttaaggtcct ttcctacgga gacgaccttt taattggaac taattaccaa 7620 attgatttta atcttgttaa agaaagatta gcccccttcg gttataagat tactcctgcc 7680 aacaagacca ctacttttcc tctgacctcc catttgcaag atgttacctt tctaaagaga 7740 agatttgtga gatttaattc ttacctgttc agacctcaaa tggatgctgt caatttgaaa 7800 gcaatggtta gctactgtaa accaggaaca cttaaggaga aactaatgtc cattgctctt 7860 ctggccgttc attctggacc agatatttat gatgagattt tccttccttt taggaatgtt 7920 ggaatagttg tccccaccta tgattctatg ctttacagat ggcttagctt atttagatga 7980 acatcctctc gatcggatcg caacgcttta ccctagaagc cactagggtg tacgcggccg 8040 ttctgacgtt ggaattcttt taggcaaaag ttgtgtagat gcttataatt ggaaatgaga 8100 acaac 8105 //