Dbfetch
ID X73476; SV 1; linear; genomic RNA; STD; VRL; 15480 BP. XX AC X73476; XX DT 08-JUL-1993 (Rel. 36, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 11) XX DE Beet yellows virus (isolate Ukrainian BYV-U) complete genome XX KW coat protein; heat shock 70-related protein; heat shock 90-related protein; KW methyltransferase; papain-like protease; RNA dependent RNA polymerase; KW RNA helicase. XX OS Beet yellows virus OC Viruses; Riboviria; Closteroviridae; Closterovirus. XX RN [1] RX DOI; 10.1006/viro.1994.1034. RX PUBMED; 8259666. RA Agranovsky A.A., Koonin E.V., Boyko V.P., Maiss E., Froetschl R., RA Lunina N.A., Atabekov J.G.; RT "Beet yellows closterovirus: complete genome structure and identification RT of a leader papain-like thiol protease"; RL Virology 198(1):311-324(1994). XX RN [2] RP 1-15480 RA Agranovsky A.A.; RT ; RL Submitted (18-JUN-1993) to the INSDC. RL A.A. Arganovsky, A.N. Belozersky Institute, Moscow State University, 119899 RL Moscow, Russia XX DR MD5; e74df6cefed9385f82d7867d3cee77e8. DR EuropePMC; PMC2786829; 19793810. DR RFAM; RF01100; PK-BYV. XX CC Related sequence: X53462 XX FH Key Location/Qualifiers FH FT source 1..15480 FT /organism="Beet yellows virus" FT /isolate="Ukrainian (BYV-U)" FT /mol_type="genomic RNA" FT /clone="pBYV p36, x19, R9, R3, 36A, R2, 36, p43, 111-7, FT 112, 115, 1213, 1210, 124, 1313, 1311, 142, 143, 1311, FT 1311, 142, 143, 156, 1510, 154, 1518,1520, 169, 1615, 175" FT /db_xref="taxon:12161" FT 5'UTR 1..107 FT CDS join(108..7983,8045..9393) FT /gene="ORF1a/b" FT /product="fusion protein of papin-like protease, FT methyltransferase, RNA helicase" FT /db_xref="GOA:Q08534" FT /db_xref="InterPro:IPR001788" FT /db_xref="InterPro:IPR002588" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR008749" FT /db_xref="InterPro:IPR027351" FT /db_xref="InterPro:IPR027417" FT /db_xref="InterPro:IPR040910" FT /db_xref="UniProtKB/Swiss-Prot:Q08534" FT /protein_id="CAA51871.1" FT /translation="MAFLNVSAVPSCAFAPAFAPHAGASPIVPDSFPCVPRYSDDISHF FT RLTLSLDFSVPRPLSLNARVHLSASTDNPLPSLPLGFHAETFVLELNGSSAPFSIPSRH FT IDFVVNRPFSVFPTEVLSVSSLRTPSRLFALLCDFFLYCSKPGPCVEIASFSTPPPCLV FT SNCVAQIPTHAEMESIRFPTKTLPAGRFLQFHKRKYTKRPETLIIHESGLALKTSALGV FT TSKPNSRPITVKSASGEKYEAYEISRKDFERSRRRQQTPRVRSHKPRKINKAVEPFFFP FT EEPKKDKRKRASLPTEDEGFITFGTLRFPLSETPKEEPRLPKFREVEIPVVKKHAVPAV FT VSKPVRTFRPVATTGAEYVNARNQCSRRPRNHPILRSASYTFGFKKMPLQRFMKEKKEY FT YVKRSKVVSSCSVTKSPLEALASILKNLPQYSYNSERLKFYDHFIGDDFEIEVHPLRGG FT KLSVLLILPKGEAYCVVTAATPQYHAALTIARGDRPRVGELLQYRPGEGLCYLAHAALC FT CALQKRTFREEDFFVGMYPTKFVFAKRLTEKLGPSALKHPVRGRQVSRSLFHCDVASAF FT SSPFYSLPRFIGGVEEEAPEITSSLKHKAIESVYERVSIHKDNLLARSVEKDLIDFKDE FT IKSLSKEKRSVTVPFYMGEAVQSGLTRAYPQFNLSFTHSVYSDHPAAAGSRLLENETLA FT SMAKSSFSDIGGCPLFHIKRGSTDYHVCRPIYDMKDAQRRVSRELQARGLVENLSREQL FT VEAQARVSVCPHTLGNCNVKSDVLIMVQVYDASLNEIASAMVLKESKVAYLTMVTPGEL FT LDEREAFAIDALGCDVVVDTRRDMVQYKFGSSCYCHKLSNIKSIMLTPAFTFSGNLFSV FT EMYENRMGVNYYKITRSAYSPEIRGVKTLRYRRACTEVVQVKLPRFDKTLKTFLSGYDY FT IYLDAKFVSRVFDYVVSNCSVVNSKTFEWVWSYIKSSKSRVVISGKVIHRDVHIDLKHS FT ECFAAVMLAVGVRSRTTTEFLAKNLNYYTGDASCFETIRFLFREWSRRAYAEINRSFRK FT LMKSILSAGLDYEFLDLDNSLQHLLEYSEVEVRVSIAQNGEVDCNEENRVLTEIIAEAA FT DRKSIAQGLSGALSSVPTQPRGGLRGGSRRSGVSFLYNLVEEVGNLFFSVGDAVRFLVK FT VFKTFSDSPIFRVVRMFLDLAEAASPFVSVVSLCAWLREAVSAFSSWVADRTVSESVKT FT FVNRTVKRFLNFMSAKTLTKKFFRFFLSASALAKTVVRKAKVILEAYWEVWFESILSDS FT GEYSAVEFCSSVVITLLTNSGRLLPGFSPSAIITEVLLDLATKISIEVLLKQISPADST FT ASSALYRRVLSEILSNFRTMGEHGIFTKVFLLCGFLPVFVRKCVALCVPGDMATYARFL FT EYGVDDLFFLGRSVNSIKNYLCVVAAGLVDSIVDSVVLKLSGVAKERVLGFKSKIIKNF FT LNVFRKAKVVTRTSSSTDLSEDEYFSCDESKPGLRGGSSRFTLSRLLDIFFNFLKSSKL FT VIENACFSAYERIERNMKLYFFPLNSSEEEARRLIRCAGDFDYLSDSAFDEDEMLRQAF FT EQYYSSDDESVTYDGKPTVLRSYLNVSRRFLETFCNGPKFFVKVSNYFKALYSRLLRVL FT PWVDRNLSDSPGLKGGNEKALLAKFFKTCVITACECVSQICCLRLIRLCWGTPACGLVR FT LFYITYSSTRVLSRVVVAVAVCPLLVRNELDGLSDGLTNMGVSVFRRLFVALRRALSAY FT SNSALRRKIIEFIFGNIHHPFDVAVIETNEVAPEPLSPEVDIDVDCDFGSDSESVSSDE FT VASNPRPGLHGGSRRSSNFLTSLVKVVFKLARRIPRLLFRLRNFVAYFVERRLASKRLK FT TFIGLARLFDNFSLTSVVYLLQEYDSVLNAFIDVELILLNSGSVNVLPLVSWVRGSLTK FT LAEAIVGSGFASFLGRMCCRVSDWCSSSSNAGCNFMSPVRTKGKFVPPSSSGSTASMYE FT RLEALESDIREHVLSTCRVGSDEEEERPKEVTEPGIEHTSEDVVPIRSHSQPLSGGECS FT YSEDREENERANLLPHVSKIVSERRGLETARRNKRTLHGVSEFLNAINTSNEQPRPIIV FT DHSPESRALTNSVREFYYLQELALFELSCKLREYYDQLKVANFNRQECLCDKDEDMFVL FT RAGQGVVSGRNSRLPLKHFKGHEFCFRSGGLVPYDGTSRVDTIFHTQTNFVSANALLSG FT YLSYRTFTFTNLSANVLLYEAPPGGGKTTTLIKVFCETFSKVNSLILTANKSSREEILA FT KVNRIVLDEGDTPLQTRDRILTIDSYLMNNRGLTCKVLYLDECFMVHAGAAVACIEFTK FT CDSAILFGDSRQIRYGRCSELDTAVLSDLNRFVDDESRVYGEVSYRCPWDVCAWLSTFY FT PKTVATTNLVSAGQSSMQVREIESVDDVEYSSEFVYLTMLQSEKKDLLKSFGKRSRSSV FT EKPTVLTVHEAQGETYRKVNLVRTKFQEDDPFRSENHITVALSRHVESLTYSVLSSKRD FT DAIAQAIVKAKQLVDAYRVYPTSFGGSTLDVSVNPSTSDRSKCKASSAPYEVINSFLES FT VVPGTTSVDFGDVSEEMGTQVFESGADNVVIRDSAPVNKSTDHEENLYSYESRNYNFTV FT CERFSGPQEFGQAMAMVMLERSFDLEKVAKVRSDVIAITEKGVRTWMSKREPSQLRALS FT SDLQKPLNLEEEITTFKLMVKRDAKVKLDSSCLVKHPPAQNIMFHRKAVNAIFSPCFDE FT FKNRVITCTNSNIVFFTEMTNSTLASIAKEMLGSEHVYNVGEIDFSKFDKSQDAFIKSF FT ERTLYSAFGFDEDLLDVWMQGEYTSNATTLDGQLSFSVDNQRKSGASNTWIGNSIETLG FT ILSMFYYTNRFKALFVSGDDSLIFSESPIRNSADAMCTELGFETKFLTPSVPYFCSKFF FT VMTGHDVFFVPDPYKLLVKLGASKDEVDDEFLFEVFTSFRDLTKDLVDERVIELLTHLV FT HSKYGYESGDTYAALCAIHCIRSNFSSFKKLYPKVKGWVVHYGKLKFVLRKFANCFREK FT FDTAFGERTFLLTTKLETVL" FT exon 108..7983 FT /number=1 FT regulatory 7983..8045 FT /note="+1 ribosomal frameshift signal" FT /regulatory_class="other" FT intron 7984..8044 FT /number=1 FT exon 8045..9393 FT /number=2 FT CDS 9444..9608 FT /note="putative membrane-binding protein" FT /db_xref="GOA:Q08542" FT /db_xref="InterPro:IPR009591" FT /db_xref="UniProtKB/Swiss-Prot:Q08542" FT /protein_id="CAA51864.1" FT /translation="MDCVLRSYLLLAFGFLICLFLFCLVVFIWFVYKQILFRTTAQSNE FT ARHNHSTVV" FT CDS 9608..11404 FT /product="heat shock 70-related protein" FT /db_xref="GOA:P37092" FT /db_xref="InterPro:IPR013126" FT /db_xref="InterPro:IPR018181" FT /db_xref="InterPro:IPR029047" FT /db_xref="UniProtKB/Swiss-Prot:P37092" FT /protein_id="CAA51865.1" FT /translation="MVVFGLDFGTTFSSVCAYVGEELYLFKQRDSAYIPTYVFLHSDTQ FT EVAFGYDAEVLSNDLSVRGGFYRDLKRWIGCDEENYRDYLEKLKPHYKTELLKVAQSSK FT STVKLDCYSGTVPQNATLPGLIATFVKALISTASEAFKCQCTGVICSVPANYNCLQRSF FT TESCVNLSGYPCVYMVNEPSAAALSACSRIKGATSPVLVYDFGGGTFDVSVISALNNTF FT VVRASGGDMNLGGRDIDKAFVEHLYNKAQLPVNYKIDISFLKESLSKKVSFLNFPVVSE FT QGVRVDVLVNVSELAEVAAPFVERTIKIVKEVYEKYCSSMRLEPNVKAKLLMVGGSSYL FT PGLLSRLSSIPFVDECLVLPDARAAVAGGCALYSACLRNDSPMLLVDCAAHNLSISSKY FT CESIVCVPAGSPIPFTGVRTVNMTGSNASAVYSAALFEGDFVKCRLNKRIFFGDVVLGN FT VGVTGSATRTVPLTLEINVSSVGTISFSLVGPTGVKKLIGGNAAYDFSSYQLGERVVAD FT LHKHNSDKVKLIHALTYQPFQRKKLTDGDKALFLKRLTADYRREARKFSSYDDAVLNSS FT ELLLGRIIPKILRGSRVEKLDV" FT CDS 11310..12971 FT /note="putative heat shock 90-related protein" FT /db_xref="GOA:Q08541" FT /db_xref="InterPro:IPR004909" FT /db_xref="UniProtKB/Swiss-Prot:Q08541" FT /protein_id="CAA51866.1" FT /translation="MTTRFSTPANYYWGELFRRFFGGQEWKNLMSEAASVSRPRYSSDF FT RFSDGVILSRKTFGESTGESFVREFSLLLTFPKTYEVCKLCGVAMELALNGMNRLSDYN FT VSEFNIVDVKTVGCKFNIQSVTEFVKKINGNVAEPSLVEHCWSLSNSCGELINPKDTKR FT FVSLIFKGKDLAESTDEAIVSSSYLDYLSHCLNLYETCNLSSNSGKKSLYDEFLKHVID FT YLENSDLEYRSPSDNPLVAGILYDMCFEYNTLKSTYLKNIESFDCFLSLYLPLLSEVFS FT MNWERPAPDVRLLFELDAAELLLKVPTINMHDSTFLYKNKLRYLESYFEDDSNELIKVK FT VDSLLTRDNPELKLAQRWVGFHCYYGVFRTAQTRKVKRDAEYKLPPALGEFVINMSGVE FT EFFEELQKKMPSISVRRRFCGSLSHEAFSVFKRFGVGFPPITRLNVPVKYSYLNVDYYR FT HVKRVGLTQDELTILSNIEFDVAEMCCEREVALQARRAQRGEKPFQGWKGTKNEISPHA FT RSSIRVKKNNDSLLNILWKDVGARSQRRLNPLHRKH" FT CDS 12919..13569 FT /product="coat protein homolog" FT /db_xref="GOA:Q08538" FT /db_xref="InterPro:IPR002679" FT /db_xref="UniProtKB/Swiss-Prot:Q08538" FT /protein_id="CAA51867.1" FT /translation="MLAPEARGDLIHFTENTRDAMETFFNSYDLAEYSEVNPNKLNRKE FT TDELLGVIRERFKSELVITDEDFVKHLAFALIRAANITTSVKVNYVGAYEYTIGGKKFL FT VKDAWVFPLIKECMKKFNKPNPVRTFCATFEDAYIVIARSLPKLFLNRTIGKRGIPSGY FT EFLGADFLTATSVCLNDHEKAIVLQASRAAIDRAVSSSVDGKIVSLFDLGRLS" FT CDS 13640..14254 FT /product="coat protein" FT /db_xref="GOA:Q08531" FT /db_xref="InterPro:IPR002679" FT /db_xref="UniProtKB/Swiss-Prot:Q08531" FT /protein_id="CAA51868.1" FT /translation="MGSAEPISAIATFENVSLADQTCLHGEDCDKLRKNFEECLKLKGV FT PEDNLGIALGLCLYSCATIGTSNKVNVQPTSTFIKASFGGGKELYLTHGELNSFLGSQK FT LLEGKPNKLRCFCRTFQKDYISLRKEYRGKLPPIARANRHGLPAEDHYLAADFISTSTE FT LTDLQQSRLLLARENATHTEFSSESPVTSLKQLGRGLGTGR" FT CDS 14251..14793 FT /note="orf7" FT /db_xref="GOA:Q08544" FT /db_xref="UniProtKB/Swiss-Prot:Q08544" FT /protein_id="CAA51869.1" FT /translation="MTSSVELAQTKPLFRVLLLKGFVFYVVAFETEEESSEAELPLVYL FT HDFELNINKRGKIEASYVDFMSCMTRLKPSSVSYTRVSSEKSSEDFSLPGSGKTFGSKV FT LNRKVTFTFENGVQLVFGMYGLEQRCVSSDYLWFENVFVGAHCGTLTYCLNCELDKSGG FT ELEILTFSKNEVLLKRW" FT CDS 14768..15301 FT /note="orf8" FT /db_xref="GOA:Q08545" FT /db_xref="InterPro:IPR021575" FT /db_xref="InterPro:IPR021742" FT /db_xref="PDB:2CWO" FT /db_xref="UniProtKB/Swiss-Prot:Q08545" FT /protein_id="CAA51870.1" FT /translation="MKFFLKDGETSRALSRSESLLRRVKELGTNSQQSEISECVDEFNE FT LASFNHLLVTVEHREWMEQHPNQSSKLRVPSRIGEMLKEIRAFLKVRVVTPMHKETASD FT TLNAFLEEYCRITGLAREDALREKMRKVKSVVLFHHSELLKFEVTENMFSYTELLKLNL FT SLRVISSQILGMAI" FT 3'UTR 15299..15480 XX SQ Sequence 15480 BP; 3891 A; 3446 C; 3680 G; 4463 T; 0 other; gtttttaacc atccttctac tagacgtaca ctcgtacatc ctctagtatt tcctttattt 60 atcttcccat aagcccctgc ctttaacgtt taactctcgc tatcgacatg gcattcttga 120 acgtttctgc tgtccccagc tgtgctttcg cacctgcttt cgcaccccac gccggtgcaa 180 gccccattgt gcccgacagt ttcccttgcg taccccgtta ttcggacgac atatcccatt 240 tccgtttaac gttgtcgctt gacttctctg tcccacgccc gctctctttg aacgcgcgtg 300 tgcacttgag tgcttctacc gacaacccct taccatcgct tccccttggt ttccacgctg 360 aaacctttgt tttggaattg aacggcagtt cggctccctt ctctataccg tcccgccaca 420 ttgacttcgt tgtgaaccgg cctttctccg tgttccctac tgaagtcctc tccgtcagtt 480 cccttcgaac accttctagg ttgttcgctc ttttatgcga ctttttcctt tactgttcca 540 aaccaggtcc ttgcgttgaa attgcttctt tttcaactcc accaccctgt ttagtttcga 600 actgcgttgc acaaattccc acgcacgccg aaatggaaag tattcgtttt ccaacgaaga 660 ctcttccagc tggtcggttc ttacagttcc acaaacgaaa atacacgaaa cgacctgaaa 720 ctctaatcat acacgagagc ggcttggctc tcaaaaccag cgcgttaggt gttacatcga 780 aacctaattc gcgccctatc accgtgaaat ctgcttccgg tgaaaaatat gaagcttacg 840 agatctctcg taaagacttc gaacgctccc gcaggaggca acaaactcct cgcgttcgtt 900 ctcacaagcc ccggaagata aataaagctg tcgaaccttt cttctttcca gaagaaccaa 960 agaaagacaa acggaagaga gcttctcttc cgactgaaga tgaaggtttc attacttttg 1020 ggaccttgcg ctttccgctt tcggaaaccc ctaaggaaga acctcgtctt cctaaatttc 1080 gggaagttga aattcctgta gtcaagaaac atgctgtacc agcagtagtt tctaaaccag 1140 ttcgaacgtt tagaccagtc gctaccactg gcgctgagta tgtcaacgct cggaaccagt 1200 gttcgcgccg tccaagaaat catccgattt tacgcagtgc ttcttatact ttcggtttta 1260 agaaaatgcc gctccagcgt ttcatgaaag aaaagaaaga atactacgtg aagcgctcta 1320 aggtcgtgag tagttgtagt gtaactaaaa gtcctttgga agctttggcc agcatactaa 1380 agaacttacc acagtattcc tacaactcag aacggttaaa attttacgat cattttatcg 1440 gcgacgactt tgaaattgaa gtgcatccgc tgcgaggcgg caaattaagt gtgcttctta 1500 ttttgcctaa gggcgaagct tactgcgtag tcactgcggc cacgccgcag taccacgctg 1560 ctttaactat tgcgcgtggc gatcgtcctc gcgttggtga acttttgcag taccgacccg 1620 gcgaagggtt atgttacctc gcccacgctg ctctttgttg cgctcttcag aagcgcacct 1680 ttcgcgaaga agacttcttc gttggtatgt acccgacgaa gtttgtcttc gctaaacgac 1740 tcactgaaaa gttgggtcct agtgctctca aacatcctgt gcgcggaaga caagtctctc 1800 gttcactctt ccactgtgat gtggcttctg ctttttcgag ccccttttac agtttgccgc 1860 gtttcatcgg cggcgtggaa gaagaagctc ctgagatcac gtcgtctctt aagcacaagg 1920 cgatcgaatc ggtctacgaa cgtgtcagca ttcacaaaga caacttgttg gctcgtagcg 1980 tggaaaagga tttgatcgac tttaaagacg aaatcaagtc gctgtcgaag gaaaaacgtt 2040 ccgttaccgt ccccttctat atgggggagg ccgtacagag tggtttgacg cgcgcgtacc 2100 ctcagtttaa tttgagtttc actcacagtg tctattcgga ccaccctgcg gcggccggtt 2160 cccgtctgtt ggaaaacgaa actttagcct cgatggctaa atcttccttt tctgatatag 2220 ggggctgccc gctttttcac ataaagaggg ggagcacaga ttaccacgtg tgcagaccga 2280 tttacgacat gaaggacgct caacgaagag tttcgaggga actccaagcg agagggctgg 2340 tggaaaacct ttcccgcgaa caacttgttg aagctcaggc gcgcgtttcg gtgtgccctc 2400 acactctcgg caattgtaac gtgaaaagcg acgtgctaat catggtgcag gtttacgacg 2460 catctttgaa cgaaattgcg tcggcgatgg tcctaaagga atcgaaagtc gcttacctca 2520 ccatggtgac tccgggtgaa cttctagatg aacgcgaagc cttcgctatc gacgctttgg 2580 ggtgcgacgt cgtcgtggac acccgccgag acatggtgca gtacaaattc ggatcatctt 2640 gttactgcca caaactgtcg aatataaaga gtataatgtt gactcccgca ttcactttca 2700 gcgggaatct tttttcggtc gagatgtacg aaaaccgaat gggcgtcaac tactacaaaa 2760 tcactcgttc agcgtattct cctgagatac gcggcgttaa gacgctgcgg taccgccgag 2820 cctgcaccga ggtcgtgcaa gttaaactgc cacgcttcga taaaactcta aagacgtttc 2880 tctccgggta tgattacata tatttggatg cgaaattcgt ctctcgagtc ttcgattacg 2940 tggttagcaa ctgtagcgtt gttaacagta aaaccttcga gtgggtgtgg agttacataa 3000 aatcaagtaa atcgcgcgtt gtcataagtg ggaaagtgat acatcgagat gtgcatatcg 3060 acctcaaaca ctctgaatgt tttgcggctg tgatgctcgc ggttggggtg cgttctcgca 3120 caactactga atttttagcg aagaacctca attattacac tggcgatgct tcgtgctttg 3180 agactatccg tttcctcttt cgggagtgga gccggagggc ttacgcggaa ataaatcgca 3240 gttttcgaaa gcttatgaag agcattcttt ccgctgggtt agattacgaa tttctcgatc 3300 ttgacaactc gctccaacac ttgcttgaat actcagaggt tgaagtgcgc gtttcaatcg 3360 ctcagaatgg tgaggtggat tgcaacgaag agaaccgtgt tttgacggag ataatagccg 3420 aagcagcgga caggaaatct atcgctcaag gtctcagcgg agcgttgagc tccgttccaa 3480 cgcaaccgag aggcggtctg agagggggta gtcgccgaag tggagtttct ttcctttata 3540 acttggtaga ggaagtcgga aatcttttct tttccgtcgg tgatgccgtg cggtttcttg 3600 ttaaggtttt taaaactttt tccgactctc ccatctttcg ggtcgttcgg atgttcctgg 3660 acttggcgga agcagcttca ccgttcgttt cggttgtttc tttgtgcgcg tggttgcgcg 3720 aagctgtaag cgctttctca agctgggttg ccgacagaac ggtgtcggaa agtgtaaaaa 3780 cctttgtaaa ccgtacggta aaaaggtttc taaactttat gtctgcaaaa accctgacga 3840 aaaaattttt taggtttttc ttatccgctt ccgccttagc taaaaccgtt gtgaggaagg 3900 cgaaggtgat tttggaagct tactgggaag tgtggttcga atcgattctt tcggatagtg 3960 gagagtacag tgctgttgaa ttttgtagca gcgttgtgat cacactgtta acgaattccg 4020 gtcggctgct acctgggttt agtccatccg ctatcattac tgaagtactg cttgacctag 4080 ccacgaaaat atccattgaa gttcttctaa aacaaatttc tcctgccgac tcgacagctt 4140 cttcggcctt atatcgccgc gtcctaagcg agattctgtc gaattttcgc acaatgggcg 4200 aacacgggat cttcactaaa gtctttttac tctgcgggtt tctacccgtg tttgttagga 4260 agtgcgtcgc tctgtgcgtt cctggtgaca tggcgacgta cgcccggttt ctcgaatacg 4320 gggtcgacga tctcttcttt ttgggaaggt ccgtgaactc gattaagaac tacctatgtg 4380 tggtcgctgc cgggttggtg gactccattg tcgattccgt tgttttgaaa ctttccggtg 4440 tcgccaaaga gcgagtgctt ggttttaaat caaaaatcat aaagaatttt ttaaacgtct 4500 ttaggaaggc gaaagtcgtt acacgtactt cttccagcac ggacttgtcg gaagacgaat 4560 atttttcgtg cgacgaaagc aaacccggct tgagaggcgg ttcctctagg ttcacgcttt 4620 cgcgattgct tgacatcttt ttcaatttcc tgaaaagttc aaagctcgtc atagagaatg 4680 cgtgcttttc tgcttacgaa aggattgaaa ggaacatgaa actatacttt tttcctttaa 4740 attcttcgga agaagaagct cgccgcttaa ttcggtgcgc gggagacttc gactacttaa 4800 gcgatagcgc tttcgacgaa gatgaaatgt tacggcaagc tttcgaacaa tactattcca 4860 gtgacgacga gagtgtaact tacgatggaa aacccacagt tctccgtagt tacttgaacg 4920 tgagtagaag gttcttggaa acgttctgta acggcccgaa gtttttcgtc aaagtttcga 4980 attactttaa agcgctgtat agtcgtttgc tccgtgttct accgtgggta gacagaaatc 5040 tttctgactc gccaggactt aaaggaggta acgagaaagc tcttcttgcg aagttcttta 5100 aaacctgcgt cataaccgct tgcgaatgtg tgtcgcagat atgctgcctg cgtcttattc 5160 gcttatgttg ggggacacca gcgtgtggtt tagttaggtt attttacata acttattcca 5220 gtactcgcgt gttgtcgcgt gttgtggtcg cggtggctgt atgccctctt ttggtcagaa 5280 acgaactgga tggcttgagt gatggattaa ccaacatggg cgtttcggtt tttcgtcgct 5340 tgttcgtcgc ccttcggcgc gcgctttcgg cgtactctaa ttccgcccta cgacggaaga 5400 ttatcgaatt cattttcgga aacattcacc acccttttga tgtcgcagta atcgaaacaa 5460 acgaagttgc gccggaacct ctttcaccgg aagtagacat tgatgtcgac tgcgactttg 5520 gttccgattc agaatcggtt tcttcagatg aagtcgcgtc gaatccccgt ccaggcttac 5580 acggtgggag taggcgctct tccaactttc taacctctct cgtgaaggtt gtttttaaat 5640 tggctaggcg cattccgcgt ttgcttttcc gtttgcgcaa ttttgtggcg tactttgttg 5700 aacgacggct ggcttcaaaa aggttgaaga cattcatcgg tctggccagg ctgtttgata 5760 atttctcact cacttcggtg gtttaccttc tccaagagta cgattcagtg ctgaacgcat 5820 ttatagacgt cgagctaatc ctacttaact cgggtagcgt gaatgtgcta cctttagttt 5880 cttgggtcag gggatctcta acgaagttag cggaagcgat cgttggttca ggcttcgctt 5940 cgtttctagg aaggatgtgc tgtcgtgtgt ctgactggtg ctcctcgtct tcgaacgccg 6000 gttgtaactt tatgagtccg gttcgtacga aagggaagtt cgttccccct tcgtcttccg 6060 gttcaaccgc ttcgatgtat gaacgtctcg aagctctcga gagcgatatc cgcgaacacg 6120 tgctttccac gtgtcgtgta ggaagcgacg aagaagaaga aaggccgaaa gaagtgacag 6180 aaccaggaat tgaacatact tctgaagatg ttgttcctat tcgttcacac tcgcaaccct 6240 tatctggagg tgaatgttcg tattctgaag atcgtgaaga gaatgaacga gcgaacctgt 6300 taccgcacgt tagcaaaatc gtcagtgaac gaaggggttt ggagaccgcc cgtcgaaaca 6360 aacgtactct acatggtgta agcgagtttc tcaacgctat taatactagc aatgagcaac 6420 ctaggccgat aatcgttgac cactctcccg aatctcgcgc gttgaccaac tccgtgaggg 6480 aattctatta cctccaggaa ctcgctcttt ttgagttgag ttgcaaactt cgtgagtatt 6540 acgatcaatt gaaggttgcg aattttaaca gacaagagtg tttgtgcgac aaagacgaag 6600 acatgtttgt tctacgagcc ggacaaggtg tagtttccgg cagaaactcg aggttgcctc 6660 ttaagcattt caagggtcac gaattttgtt ttcgatctgg agggttggtc ccttacgacg 6720 gtaccagcag agtggacacc atttttcaca cgcaaacgaa tttcgtttcc gcgaacgcgc 6780 ttctttcggg ctatctctcc tatagaactt tcactttcac taatttgagc gctaacgtac 6840 tgctgtacga agctcctcca ggtggtggaa agaccacgac tttgataaag gttttttgtg 6900 aaactttttc aaaagttaat tcgctgattt taacggcgaa taagagttcg cgagaagaaa 6960 tacttgcgaa ggtgaatcgc atcgtacttg acgaaggcga tacgcctctt cagacgcgtg 7020 acaggatttt aactatcgat tcttatctaa tgaacaacag aggtttgacg tgtaaggttt 7080 tgtacctcga tgagtgtttc atggttcacg ctggagctgc tgtagcttgc atcgaattca 7140 ccaaatgcga ttcagccatc ttatttggag acagcaggca aattcgttac ggtcgatgta 7200 gtgaattgga tactgctgtt ctttcagatt tgaaccgttt tgtcgatgac gaatcgagag 7260 tatatggtga agtctcatac aggtgtcctt gggacgtttg tgcttggttg tcaactttct 7320 acccgaaaac tgtggccact accaacttgg tttcagccgg tcaatcttcg atgcaagtac 7380 gcgagattga aagcgtagac gacgtcgaat attccagtga attcgtctac ttgactatgt 7440 tacagtcaga gaagaaagat ctgctgaaat ctttcggcaa gaggtctcgt tcgagcgttg 7500 agaaacccac ggtcttaaca gtccatgaag ctcagggtga aacctaccgc aaagttaacc 7560 tcgtcagaac gaaatttcaa gaggacgatc cttttcggag cgagaaccac atcacagtgg 7620 ccttgtctag gcatgtcgag agtctgacct attcggtcct gagtagtaaa cgtgacgacg 7680 caatagccca agctatagtg aaggcgaaac aacttgtgga tgcctatcgc gtttacccca 7740 cgtcatttgg tgggagtact cttgatgtta gtgttaaccc ttctacttct gacaggagca 7800 aatgtaaagc ttcctctgcc ccttacgaag ttataaacag cttcttggag agcgtggttc 7860 cgggcactac ttcagtagac tttggggacg tttccgaaga gatgggtact caggtttttg 7920 agtccggtgc tgataacgtt gttattcgtg attccgcacc tgttaacaag tcgacggatc 7980 acgacccgca gcgggtttag ctcgattcgc tcgcaggcga ttcctaagag gaaaccgtcg 8040 ctgcaagaga atttatactc ttatgagtcg cgtaattaca actttaccgt ttgtgaacgt 8100 ttttccggac cgcaggagtt cggacaggcg atggcgatgg ttatgttgga acgaagcttt 8160 gacttagaga aagttgctaa agttagaagc gatgtgatcg ccataacaga aaaaggggtg 8220 cgaacatgga tgtcaaaacg tgaaccttct cagcttaggg ctcttagtag tgacttacaa 8280 aagcctctaa acttggaaga ggaaataacg acttttaagt tgatggttaa gcgggacgcg 8340 aaagtcaaac tcgattcgtc gtgtttggtg aaacacccac cagcgcagaa tataatgttc 8400 catcgcaagg cggtgaacgc gattttctcg ccgtgtttcg acgagtttaa aaatagagtc 8460 attacctgta cgaattcaaa tattgttttc tttaccgaaa tgactaactc tactctcgcg 8520 tcgatagcga aagagatgct ggggagcgaa cacgtttaca acgttgggga aatagacttt 8580 tcgaaattcg acaaatccca agacgctttc attaagtcgt ttgaacgaac cttgtattca 8640 gcgtttggtt tcgacgaaga cctgcttgac gtgtggatgc aaggtgaata caccagcaac 8700 gctacaactc tggacggtca actttctttt tccgtcgaca accagaggaa atcgggcgct 8760 tctaatacgt ggattggtaa ttccatcgag actcttggta ttttgagcat gttctattac 8820 accaatcgat ttaaggctct tttcgtgtcc ggggacgact ctttgatttt ctccgaatct 8880 cctatcagaa attcagccga tgcgatgtgc acagaactcg gttttgagac taagtttctc 8940 actccgagcg tcccgtattt ctgctcaaag tttttcgtta tgaccggtca cgacgttttc 9000 ttcgtgcccg acccttataa acttttagtg aaattaggag cttctaagga tgaagtagac 9060 gatgagtttc tgtttgaagt gttcacctct tttcgcgatt taacgaaaga tttagtcgat 9120 gaaagagtga tcgaactctt gacgcatttg gttcacagta agtacgggta cgaaagtggt 9180 gatacgtacg ccgccctgtg tgctattcat tgtattcgtt caaacttttc atcgttcaag 9240 aaattgtacc ctaaagttaa gggttgggtc gttcactacg gtaaactgaa gtttgtgctg 9300 cgcaaattcg cgaactgttt tcgcgagaag tttgacactg ctttcggcga acgtactttc 9360 ttacttacga cgaagcttga aacggtgttg tgactcagtt gctgttttgt ttatttgtgt 9420 gtctgtagtc ctactttgcg gttatggact gtgtactccg ctcgtattta ttactcgcat 9480 tcggtttttt gatttgcttg ttccttttct gcttggtggt cttcatttgg ttcgtgtata 9540 aacagatact ttttcgaact accgcgcagt cgaacgaagc gcgtcacaac cattctacgg 9600 tcgtgtgatg gttgttttcg gtttagactt cggcaccact ttttcaagtg tgtgtgccta 9660 tgttggagaa gaactgtatc tgttcaagca gagagatagt gcttacatac ctacttacgt 9720 atttttacat tctgatactc aagaagtggc tttcggatac gacgccgagg ttctttctaa 9780 cgatctttca gttcgtggag gtttctatcg cgacttaaaa cgctggatag gatgcgacga 9840 agaaaactat agagactacc tggaaaaact taagccgcac tacaagacag agctgcttaa 9900 ggttgctcaa agttcgaagt ccactgtgaa attggactgt tactctggta ccgtgccaca 9960 gaatgccact ttaccaggtt tgatagcgac tttcgtcaaa gctctgattt ccacagccag 10020 cgaagctttc aaatgtcagt gcaccggtgt tatctgttca gtccctgcca actacaattg 10080 tttgcaaagg tcttttaccg aaagttgtgt caatctgagt ggctacccct gtgtttacat 10140 ggttaacgag ccgtcggctg cggcgctttc tgcttgttct agaatcaaag gcgccacttc 10200 acccgttctc gtgtacgatt tcggaggtgg aacgtttgac gtttccgtga tttcagcgct 10260 caacaacact tttgtggtgc gcgcttcggg aggtgacatg aacttgggtg gtcgcgacat 10320 cgacaaggct tttgttgaac acttgtacaa caaagctcaa ctgcccgtga actacaaaat 10380 tgatatttcc ttcttgaaag agtcgctttc aaagaaggtt tctttcctga acttcccggt 10440 ggtcagtgaa cagggcgtaa gagttgacgt tttagttaac gtcagcgagt tagctgaagt 10500 ggcggccccg ttcgtggaga gaacgataaa aatagttaaa gaagtttacg aaaagtactg 10560 tagcagtatg cgattggaac caaacgttaa agctaaattg cttatggtgg gtgggtcttc 10620 ttacttgccc ggtctgctgt cacgtctttc ctctataccg ttcgtggacg aatgcctcgt 10680 gctgcccgac gctcgagcgg cggtcgccgg ggggtgcgct ttgtactcag cttgtcttcg 10740 aaacgattct ccgatgttgt tggttgactg cgcagctcac aatctcagca ttagtagcaa 10800 atattgtgaa tccatcgtat gtgttcctgc tggttcacct atcccgttta cgggagttag 10860 aacggttaac atgaccggtt ctaacgcttc cgctgtctat agtgcggcgc tttttgaagg 10920 ggacttcgtt aagtgtcgtc taaacaagag gattttcttt ggcgatgtcg ttttaggaaa 10980 cgtcggggtg actggttccg ctactaggac agtcccgcta acactcgaaa ttaacgtttc 11040 gagcgtcgga acgatctctt tttctctcgt cggaccgacg ggtgttaaga aactaatagg 11100 tggaaacgct gcttacgatt tctcgagtta tcagctcggg gagcgcgtcg tcgctgactt 11160 gcacaaacat aattctgata aagtgaaact cattcatgct ctgacatatc aaccttttca 11220 aaggaagaaa ttgactgacg gcgacaaagc tctgttctta aagagactga ctgctgatta 11280 ccgacgtgaa gcaaggaagt ttagttcgta tgacgacgcg gttctcaact ccagcgaatt 11340 actactgggg agaattattc cgaagattct tcgggggtca agagtggaaa aacttgatgt 11400 ctgaagctgc ttcggttagt cgacctaggt acagtagcga ctttcgtttt tcagacggtg 11460 ttatattaag tcgcaagacg tttggcgaat caaccggcga gtcattcgta cgcgagtttt 11520 ccttgttgct gacgttccca aagacttacg aagtttgcaa attatgcggt gtggccatgg 11580 aactagctct gaatggtatg aatcgtctgt ccgattataa tgtttcggag ttcaacattg 11640 tcgatgtgaa aaccgtgggt tgcaagttta atatacagtc cgtcactgaa ttcgtgaaaa 11700 agatcaacgg gaatgtggcc gaaccttctc tcgtcgagca ctgctggtct ctgtctaatt 11760 cttgcggtga attgatcaat ccgaaagata cgaagcgatt cgtctctctt atctttaaag 11820 ggaaagacct cgccgaaagt accgacgaag ctatagtttc ctcttcttac ttagattacc 11880 tttcccattg tttgaactta tatgaaacgt gtaatctttc atctaactcg gggaagaaat 11940 ctttgtacga tgaatttcta aagcacgtga tcgattacct tgaaaacagc gacttagaat 12000 atcgttcacc ttctgacaac cctttggttg ccggcattct ttacgatatg tgttttgagt 12060 acaacacgct taagtcgaca tacttgaaga acatagagtc tttcgattgt tttctaagtc 12120 tgtatttgcc gttgcttagt gaagtctttt cgatgaactg ggaacgacca gcgcctgatg 12180 tcaggttgct tttcgaactc gacgctgctg aacttctttt aaaagttccg acgattaaca 12240 tgcacgactc aactttccta tacaagaata agttgaggta tttggagtcc tactttgaag 12300 acgactctaa cgaacttata aaggtgaaag ttgactcact cttaacccga gacaatcctg 12360 aactaaaact agcccagagg tgggtgggtt tccattgtta ctacggggtc ttcaggaccg 12420 cccagactag gaaagtgaag agagacgcgg aatacaaact tcctccggct ctcggtgaat 12480 tcgtaataaa tatgagtggg gttgaagagt tctttgagga gctacagaag aaaatgcctt 12540 ccatttccgt tcgccgcagg ttttgtggca gtttatctca cgaagctttt tctgttttca 12600 aaagattcgg ggtgggtttc cctccgatca ctaggttaaa tgttccagtg aagtactcct 12660 atctaaacgt tgattattac agacatgtaa agagggtagg tttgacgcag gacgagttga 12720 ctattcttag taacatcgaa ttcgatgtcg ctgaaatgtg ttgcgagagg gaagtggctt 12780 tacaagcccg tcgcgctcag cgcggcgaaa aaccatttca gggttggaaa ggtacaaaaa 12840 acgaaatttc tccgcacgcg cgttcttcaa ttcgagtgaa aaagaacaac gactctttac 12900 taaacatttt gtggaaagat gttggcgccc gaagccagag gagacttaat ccacttcacc 12960 gaaaacacta gagatgctat ggaaactttc ttcaacagct acgatctagc tgaatattcc 13020 gaagtgaatc ctaacaaact taatcggaag gaaaccgacg aactattggg cgttattcga 13080 gagaggttca aatccgaact ggtgatcaca gatgaagatt ttgtgaagca cttagctttc 13140 gcgttgatcc gcgccgctaa tatcacaact agtgtgaaag ttaactacgt cggagcatac 13200 gaatatacga taggaggaaa gaagttcctg gtcaaggatg cttgggtttt tcctctaata 13260 aaagagtgta tgaaaaagtt taataaacct aatcctgtga ggacgttttg cgccactttc 13320 gaagacgctt acattgtgat agctcgttcg ttacccaaac tgttcctgaa tagaaccatt 13380 ggcaaacgcg ggatcccgtc ggggtacgaa ttcctcgggg cagattttct gaccgcaacc 13440 agtgtgtgtt tgaacgatca cgaaaaagct atcgtattac aagcctcaag agctgccatt 13500 gacagagctg tttcttcgtc ggtcgacggg aagatagtca gtcttttcga cctcggtcgt 13560 cttagttaac acagttacta aggttccatt ttattacagt attgtttttg ttttagcgta 13620 atcgtacttg agtttcgtta tgggatcagc tgaacctatt agtgcaatcg cgacttttga 13680 aaacgtaagt ctcgcagacc aaacctgttt gcacggagaa gactgcgata aacttaggaa 13740 gaacttcgaa gagtgtttga aattaaaagg ggttccggaa gataacctcg gaatcgcgtt 13800 aggactttgt ttgtattcct gtgctacgat aggcacttcc aacaaagtta acgtccaacc 13860 gacgtctacc ttcatcaaag cttcgtttgg tggtgggaag gaactgtacc tcactcacgg 13920 tgaattgaat tcctttctgg ggtctcaaaa acttttggag ggaaaaccta acaaattgcg 13980 gtgtttctgc cgtacttttc agaaggacta catatccttg cgcaaggaat accgagggaa 14040 attacctccg attgccagag ctaaccgtca cggtctaccc gctgaagatc actacttagc 14100 cgctgacttc atatcgacgt cgacggaact cactgaccta caacaaagtc gtctgctgtt 14160 agcgcgcgaa aacgccactc acacggaatt ctcgtctgaa tcaccggtaa ccagtttgaa 14220 acaactaggt cgtggtctag gcaccgggag atgactagtt ctgtcgaact agctcagaca 14280 aaaccccttt ttagagtatt gctattaaag ggctttgttt tttatgttgt tgcgttcgaa 14340 accgaagagg aatcatcgga agctgaactt cctttggtat acctccacga tttcgaatta 14400 aacattaaca agagagggaa aattgaagct tcatacgtcg actttatgtc ttgtatgact 14460 aggttaaaac ctagttcggt ttcttatact cgagtgagtt cagaaaaatc ttccgaagac 14520 ttttctttac caggctcggg aaagactttc ggttctaaag ttcttaatcg taaagtgacg 14580 tttacgttcg aaaacggagt ccaactagtg ttcgggatgt atggactcga acaacggtgc 14640 gtttcttccg actacttgtg gtttgaaaac gttttcgttg gcgcgcactg cggcacctta 14700 acctattgtc tgaattgcga attagacaaa agtggtggtg aattagagat tttgaccttt 14760 tcgaaaaatg aagttcttct taaaagatgg tgaaacttct cgagccttgt ctaggtctga 14820 atcgctccta cgtcgtgtga aggaactcgg aacgaattcg caacaaagcg agatttccga 14880 atgcgtcgac gaattcaacg aactggcgag ttttaatcac ttgttagtta cagttgaaca 14940 cagggaatgg atggaacagc atccgaacca gtcgtcaaaa ctccgcgttc catcacgaat 15000 tggtgaaatg cttaaagaga tacgcgcgtt ccttaaagta cgcgtggtaa ctcctatgca 15060 caaggaaacc gccagcgata ctctgaatgc gtttctagaa gagtactgcc gaattactgg 15120 actcgctcgt gaagacgctt tacgagaaaa gatgagaaaa gtgaagagtg tggtactatt 15180 tcatcattcg gaacttttga agttcgaagt gactgaaaac atgttcagct atactgaact 15240 actaaaactg aatctaagct tgagggtaat ttcttctcaa atcctcggaa tggctatata 15300 gagaagtgac ggaggcgacc tacctaccgt gtaatttaag tcgtcacaga gtgacaacgg 15360 caccaagtgg tgcttagtgc gtatgtaaat tacgaagtgc aaaaaatttt tctttttata 15420 ttaagaaaat ttttgcacac tcctagcgaa gtcccgctag gaagaaaaaa taaggggccc 15480 //