ID X03840; SV 1; linear; genomic DNA; STD; FUN; 11220 BP. XX AC X03840; J01333; K00633; M19542; X02991; XX DT 18-NOV-1986 (Rel. 10, Created) DT 23-OCT-2008 (Rel. 97, Last updated, Version 29) XX DE Yeast transposon Ty1-17 and flanking tRNA-Glu 3/Leu 3,LEU2 genes from small DE ring of chromosome III (LEU2 coding for beta-isopropylmalate dehydrogenase) XX KW 3-isopropylmalate dehydrogenase; dehydrogenase; KW isopropylmalate dehydrogenase; transfer RNA-Glu; transfer RNA-Leu; KW transposon; Ty1 transposon. XX OS Saccharomyces cerevisiae (baker's yeast) OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; Saccharomycetaceae; Saccharomyces. XX RN [1] RP 1-11220 RX DOI; 10.1093/nar/14.8.3475. RX PUBMED; 3010239. RA Warmington J.R., Anwar R., Newlon C.S., Waring R.B., Davies R.W., RA Indge K.J., Oliver S.G.; RT "A 'hot-spot' for Ty transposition on the left arm of yeast chromosome RT III"; RL Nucleic Acids Res. 14(8):3475-3485(1986). XX RN [2] RP 9294-9945 RX DOI; 10.1016/0092-8674(82)90125-8. RX PUBMED; 6297759. RA Andreadis A., Hsu Y.P., Kohlhaw G.B., Schimmel P.; RT "Nucleotide sequence of yeast LEU2 shows 5'-noncoding region has sequences RT cognate to leucine"; RL Cell 31(2 Pt 1):319-325(1982). XX RN [3] RP 9911-9954 RX PUBMED; 6313610. RA Erhart E., Hollenberg C.P.; RT "The presence of a defective LEU2 gene on 2 mu DNA recombinant plasmids of RT Saccharomyces cerevisiae is responsible for curing and high copy number"; RL J. Bacteriol. 156(2):625-635(1983). XX RN [4] RP 3427-9388 RX DOI; 10.1093/nar/13.18.6679. RX PUBMED; 2997719. RA Warmington J.R., Waring R.B., Newlon C.S., Indge K.J., Oliver S.G.; RT "Nucleotide sequence characterization of Ty 1-17, a class II transposon RT from yeast"; RL Nucleic Acids Res. 13(18):6679-6693(1985). XX RN [5] RP 3427-4639 RX DOI; 10.1007/BF00365655. RX PUBMED; 2841030. RA Warmington J.R., Oliver S.G.; RT "A downstream activator sequence regulates the expression of the yeast RT transposon"; RL Curr. Genet. 13(5):357-362(1988). XX DR MD5; e51cbaec9365d2a5a720c8e02df0f211. DR EuropePMC; PMC3677243; 23329695. DR RFAM; RF00005; tRNA. XX FH Key Location/Qualifiers FH FT source 1..11220 FT /organism="Saccharomyces cerevisiae" FT /mol_type="genomic DNA" FT /db_xref="taxon:4932" FT tRNA 1428..1499 FT /note="tRNA-Glu" FT misc_feature 1575..1590 FT /note="delta insert" FT misc_feature 1627..1636 FT /note="delta insert" FT repeat_region complement(1680..1818) FT /note="repeat delta sequence" FT repeat_region 1819..1878 FT /note="repeat delta sequence" FT repeat_region 2680..2685 FT /note="direct repeat 1" FT repeat_region 2685..2910 FT /note="repeat delta A sequence" FT repeat_region 2906..2910 FT /note="direct repeat 2" FT repeat_region 2911..3243 FT /note="repeat delta B sequence" FT repeat_region 3244..3378 FT /note="repeat delta A sequence" FT repeat_region 3244..3248 FT /note="direct repeat 2" FT repeat_region 3378..3382 FT /note="direct repeat 1" FT mobile_element 3427..9388 FT /mobile_element_type="transposon:Ty 1-17" FT repeat_region 3427..3758 FT /note="direct repeat, delta sequence [4]" FT regulatory 3593..3599 FT /note="put. TATA-box [4]" FT /regulatory_class="TATA_box" FT regulatory 3667..3671 FT /note="put. rRNA binding site [4]" FT /regulatory_class="ribosome_binding_site" FT CDS 3718..5034 FT /note="TYA (aa 1-438) [4]" FT /db_xref="GOA:P25383" FT /db_xref="InterPro:IPR015820" FT /db_xref="UniProtKB/Swiss-Prot:P25383" FT /protein_id="CAA27457.1" FT /translation="MESQQLHQNPRSLHGSAYASVTSKEVPSNQDPLAVSASNLPEFDR FT DSTKVNSQQETTPGTSAVPENHHHVSPQPASVPPPQNGQYQQHGMMTPNKAMASNWAHY FT QQPSMMTCSHYQTSPAYYQPDPHYPLPQYIPPLSTSSPDPIDSQNQHSEVPQAETKVRN FT NVLPPHTLTSDENFSTWVKFYIRFLKNSNLGDIIPNDQGEIKRQMTYEEHAYIYNTFQA FT FAPFHLLPTWVKQILEINYADILTVLCKSVSKMQTNNQELKDWIALANLEYDGSTSADT FT FEITVSTIIQRLKENNINVSDRLACQLILKGLSGDFKYLRNQYRTKTNMKLSQLFAEIQ FT LIYDENKIMNLNKPSQYKQHSEYKNVSRTSPNTTNTKVTTRNYQRTNSSKPRAAKAHNI FT ATSSKFSRVNNDHINESTVSSQYLSDDNELSLRPATERI" FT misc_feature 3759..9056 FT /note="epsilon sequence [4]" FT misc_feature 3759..3782 FT /note="sequence homologous to yeast tRNA-Met [4]" FT repeat_region 3819..3832 FT /note="inverted repeat A [4]" FT misc_feature 4012..4041 FT /note="DAS (homology to SV40 enhancer core) [5]" FT misc_feature 4042..4066 FT /note="DAS (homology to diploid-regulation- site of yeast FT MAT gene) [5]" FT misc_feature 4075..4092 FT /note="put. regulatory region; sequence homologous to FT diploid control site [4]" FT misc_feature 4080..4106 FT /note="DAS (homology to SV40 enhancer core and to FT diploid-regulation-site of yeast MAT gene) [5]" FT regulatory 4215..4229 FT /note="enhancer-like element [4]" FT /regulatory_class="other" FT misc_feature 4234..4262 FT /note="DAS (homology to SV40 enhancer core and to FT diploid-regulation-site of yeast MAT gene) [5]" FT misc_feature 4241..4258 FT /note="put. regulatory region; sequence homologous to FT diploid control site [4]" FT CDS 4991..9034 FT /note="TYB (first ATG pos.) [4]" FT /db_xref="GOA:P25384" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR012337" FT /db_xref="InterPro:IPR013103" FT /db_xref="InterPro:IPR015820" FT /db_xref="InterPro:IPR025724" FT /db_xref="InterPro:IPR036397" FT /db_xref="InterPro:IPR039537" FT /db_xref="UniProtKB/Swiss-Prot:P25384" FT /protein_id="CAA27458.1" FT /translation="MTTNLVLGQQQKESKPTHTIDSNDELPDHLLIDSGRSQTLVRSAH FT YLHHATPNSEINIVDAQKQDIPINAIGNLHFNFQNGTKTSIKALHTPNIAYDLLSLSEL FT ANQNITACFTRNTLERSDGTVLAPIVKHGDFYWLSKKYLIPSHISKLTINNVNKSKSVN FT KYPYPLIHRMLGHANFRSIQKSLKKNAVTYLKESDIEWSNACTYQCPDCLIGKSTKHRH FT VKGSRLKYQESYEPFQYLHTDIFGPVHHLPKSAPSYFISFTDEKTRFQWVYPLHDRREE FT SILNVFTSILAFIKNQFNARVLVIQMDRGSEYTNKTLHKFFTNRGITACYTTTADSRAH FT GVAERLNRTLLNDCRTLLHCSGLPNHLWFSAVEFSTIIRNSLVSPKNDKSAARQHAGLA FT GLDITTILPFGQPVIVNNHNPDSKIHPRGIPGYALHPSRNSYGYIIYLPSLKKTVDTTN FT YVILQDKQSKLDQFNYDTLTFDDDLNRLTAHNQSFIEQNETEQSYDQNTESDHDYQSEI FT EINSDPLVNDFSSQSINPLQLDKEPVQKVRAPKEVDADISEYNILPSPVRSRTPHIINK FT ESTEMGGTVESDTTSPRHSSTFTARNQKRPGSPNDMIDLTSQDRVNYGLENIKTTRLGG FT TEEPYIQRNSDTNIKYRTTNSTPSIDDRSSNSESTTPIISIETKAVCDNTPSIDTDPPE FT YRSSDHATPNIMPDKSSKNVTADSILDDLPLPDLTHQSPTDTSDVSKDIPHIHSRQTNS FT SLGGMDDSNVLTTTKSKKRSLEDNETEIEVSRDTWNNKNMRSLEPPRSKKRINLIAAIK FT GVKSIKPVRTTLRYDEAITYNKDNKEKDRYVEAYHKEISQLLKMNTWDTNKYYDRNDID FT PKKVINSMFIFNKKRDGTHKARFVARGDIQHPDTYDSDMQSNTVHHYALMTSLSIALDN FT DYYITQLDISSAYLYADIKEELYIRPPPHLGLNDKLLRLRKSLYGLKQSGANWYETIKS FT YLINCCDMQEVRGWSCVFKNSQVTICLFVDDMILFSKDLNANKKIITTLKKQYDTKIIN FT LGESDNEIQYDILGLEIKYQRSKYMKLGMEKSLTEKLPKLNVPLNPKGKKLRAPGQPGH FT YIDQDELEIDEDEYKEKVHEMQKLIGLASYVGYKFRFDLLYYINTLLNHILFPSRQVLD FT MTYELIQFMWDTRDKQLIWHKNKPTKPDNKLVAISDASYGNQPYYKSQIGNIFLLNGKV FT IGGKSTKASLTCTSTTEAEIHAVSEAIPLLNNLSHLVQELNKKPIIKGLLTDSRSTISI FT IKSTNEEKFRNRFFGTKAMRLRDEVSGNNLYVYYIETKKNIADVMTKPLPIKTFKLLTN FT KWIH" FT repeat_region 9057..9388 FT /note="direct repeat, delta sequence [4]" FT repeat_region 9170..9183 FT /note="inverted repeat A' [4]" FT regulatory 9309..9312 FT /note="5' end of put. transcript termination signal [4]" FT /regulatory_class="other" FT misc_difference 9318 FT /replace="c" FT /note="conflict" FT /citation=[2] FT /citation=[3] FT misc_feature 9357..9362 FT /note="transcription termination region [4]" FT tRNA 9478..9594 FT /note="tRNA-Leu-3" FT misc_difference 9917..9918 FT /replace="" FT /note="conflict" FT /citation=[2] FT /citation=[3] FT CDS 9943..11037 FT /gene="LEU 2" FT /product="beta-isopropylmalate dehydrogenase" FT /db_xref="GOA:P04173" FT /db_xref="InterPro:IPR004429" FT /db_xref="InterPro:IPR019818" FT /db_xref="InterPro:IPR024084" FT /db_xref="SGD:S000000523" FT /db_xref="UniProtKB/Swiss-Prot:P04173" FT /protein_id="CAA27459.1" FT /translation="MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHL FT IGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYA FT NLRPCNFASDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYT FT VPEVQRITRMAAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQ FT LIDSAAMILVKNPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAF FT GLYEPCHGSAPDLPKNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTG FT DLGGSNSTTEVGDAVAEEVKKILA" FT misc_difference 9950 FT /replace="g" FT /note="conflict" FT /citation=[3] XX SQ Sequence 11220 BP; 3998 A; 2177 C; 1933 G; 3112 T; 0 other; ggatcccgga ttaacgcctg ttactgagac acttcctaac aacctaaaag aaaaaacagc 60 tctgctgcag gatactgaaa agaaaataat agaaacgata cgcagatcca aatttttagg 120 atcgctacta aatgttagag ggggactatc gccagggaaa agtgaactgg cacctatcga 180 agagtctccc atagtttcaa ccacaccact aatatataat gatcgaatgg aacctcgtag 240 gatatccgat gtggaagtcc cacatttcac gaggaaatca aaacacttta ctactgctaa 300 taatcggcgc tcagtcttat ctttgtatgc gaaggattca atcaaagact taaacgaatt 360 tttaataaag gaagatcctg atttgcctcc acaaggaagc actgataacg aaagtaggag 420 cgaagatccc gaaatagccg agagtatcac tgattcaagg aatatacaat atgatgagga 480 tgatagtaag gatggtgata atgtgaataa tgataatata ttgagcgact ttccctcaag 540 gcgttggcat atcacaggaa tacgacatga aggataaaaa tccaaaccaa tctccaatat 600 caaaaagcgc agagcccaca ctggtagtga aacttccgtc tttgagttct ttccaaggaa 660 aaaacgccag tgggttgggc ctataccaaa gagagccttc taaggtaacc ttaccgagcc 720 ttacaagtaa taacagcagc gtcggagaaa acactagagg atggggcgga aaaagggact 780 gagagtgaga aaatcgctgc ttccctgtca gacgatgact tgaaggaaga taatgacaag 840 aaagataacg acacagtgaa tgccctacta cagtaaaaaa gccacctaac agcgtactct 900 tgaaaaaatt ctcaaaaggt aaaatcttag aacttgaaat acatgccaaa atacctgaaa 960 agagactata cgagggccta cataaactac tagaaggctg gaagcaatac gggttgaaaa 1020 acctggtgtt taacatcact aatatgatca taacaggaaa attggtgaat gacagtattt 1080 tatttttacg atctacgctt tttgaaataa tggttttacc aaatggagac ggtagaagtt 1140 taattaaatt caataagaaa acaggatcta ctaaaacgct gaccaagctt gctacagaaa 1200 tccaaattat tttacaaaaa gaaggtgttt tggacaaata aaaaaaaggg agggataatc 1260 tatccccaaa tggacaatac gatgtaacac cgttatataa ttaataaatg tatatatgta 1320 actatttttt gaaaaaaata aaatggtaat ttattaaata tttggaccgg tcaacaatct 1380 cagatatagt tgaaaaaatc tttaattgta atagcagaaa aaaaaaactc cgatacgggg 1440 agtcgaaccc cggtctccac ggtgaaagcg tgatgtgata gccgttacac tatatcggat 1500 aacaaattat taaaattatt taataaaaag atgaactaat ggtgtataaa aacatcataa 1560 aaactcaact caactgttcc aataaaatct gcaatttaaa ttaattattc tgaaaaaaca 1620 cgtaaattgt tggaatggaa ccctaaaata tttcctcttt agtactattc atgttacttg 1680 agaaatgggt gaattttgag atagttgttg ggattccatt gttgataaag gctaataata 1740 ttaggtatac agaatatgct agaggttctc ctcgagcata taggaatcct caaaatggaa 1800 ttagcatttc tacataataa cctcaattcc cttttgtgga ttcacatatt ctcgatcgga 1860 actcctagca tagtgcagac aacactcaca tagctctccc atttatcaag ttggaattca 1920 ctccaagaaa ttttcttgct tctctctttc ccacagaaat gaaaaggaac agtttggcgg 1980 ctattgtttt agcccttact ttttggaccc tttgaaaaaa tgccaagaat gcgtgacggt 2040 ttccctccat gctcgagaac cacaaaaacc ctatgtggta ttcgattatg cgactcacgg 2100 caaatatttg acttgtcaaa gttattcggg atttccttga atccctgaga agtgaaatgg 2160 aaagaattta agggcataaa tacctttcaa gcacccagaa gaacagtaaa ataaagcaag 2220 gtacgtgaaa ttaatatttt taaatggttc taaccgatgc cgaagaactg cgcgatccgg 2280 ttataacgtc tgacatgtcc ttttttgatt tggaatccaa ccactcagtg actctgtcat 2340 tacttgcgaa attattccac aaattccatc gaaagtgaat cgcaaaccac cttcagactg 2400 gcaccgacaa agcaaagatt atacagacag agtactttat acgtaccgtt aagtctcaag 2460 caaagggttt tcttatttac tgaacgggta aagagtatct gggccggctt gccaagatgc 2520 aaaccgaata agtatttcaa agttgcattt gccttagccg tcctgacacc attggctatt 2580 tggatatttt atattgactt tcgtgtacat tgatcacatc gactgttcta ttggcaaatg 2640 aaccacgggc attgactatt tttcaggtta ctactatata ttattgttgg aataaaaatc 2700 aactatcatc tactaactag tatttacgtt actagtatat tatcatatac ggtgttagaa 2760 gatgacgcaa atgatgagaa atagtcatct aaattagtgg aagctgaaac acaaggattg 2820 ataatgtaat aggatcaatg aatattaaca tataaaatga tgataataat atttatagaa 2880 ttgtgtagaa ttgcagattc ccttttatgg tgttggaata aaaatcaact atcatctact 2940 aactagtatt tacgttacct agtatattat catatacggt gttagaagat gacgcaaatg 3000 atgagaaata gtcatctaaa ttagtggaag ctgaaacgca aggattgata atgtaatagg 3060 atcaatgaat attaacatat aaaatgatga taataatatt tatagaattg tgtagaattg 3120 cagattccct tttatggatt cctaaatcct cgaggagaac ttctagtata tctacatacc 3180 taatattatt gccttataaa aaatggaatc ccaacaatta catcaaaatc cacgttcttt 3240 tcatatggat tcctaaatcc tcgaggagaa tttataatat agtctgtata cataatatta 3300 tagcttctaa cgacaatgga attctaacaa ttatcaaatt gccgccagtt cctcaaaaag 3360 atccatgtat aatcttcatt attacagccc tcttgacctc taatcatgaa tgttctcaaa 3420 taaatctgtt ggaataaaaa tcaactatca tctactaact agtatttacg ttactagtat 3480 attatcatat acggtgttag aagatgacgc aaatgatgag aaatagtcat ctaaattagt 3540 ggaagctgaa acgcaaggat tgataatgta ataggatcaa tgaatattaa catataaaat 3600 gatgataata atatttatag aattgtgtag aattgcagat tcccttttat ggattcctaa 3660 atcctcgagg agaacttcta gtatatctac atacctaata ttattgcctt ataaaaaatg 3720 gaatcccaac aattacatca aaatccacgt tctcttcatg gtagcgccta tgcttcggtt 3780 acttctaagg aagtcccatc aaatcaagat ccgttagccg tttcagcttc caatttaccg 3840 gaatttgata gagattccac taaggttaat tctcaacaag agacaacacc tgggacatca 3900 gctgttccag agaaccatca tcatgtctct cctcaacctg cttcagtacc acctccacag 3960 aatggacagt accaacagca cggcatgatg accccaaaca aagctatggc ctctaactgg 4020 gcacattacc aacaaccgtc tatgatgacg tgttcacatt atcaaacgtc acctgcgtat 4080 tatcaaccgg acccacacta tccgttgcca cagtatatcc caccactgag tacttcctca 4140 cctgatccaa tcgattcaca gaatcaacac tctgaagtac ctcaagctga gacaaaggtg 4200 agaaataacg tcttaccacc acacacttta acatcagatg aaaacttttc tacatgggtt 4260 aaattttaca tcagattttt gaagaactct aatctcggtg acatcattcc aaatgaccag 4320 ggtgaaatca aaagacaaat gacttatgaa gaacatgcgt atatatacaa taccttccaa 4380 gcatttgccc catttcattt attgccaaca tgggtaaaac aaattttaga aattaattat 4440 gctgacatcc ttacagtcct ttgtaaaagt gtgtccaaaa tgcaaactaa caatcaagaa 4500 ttaaaggatt ggatagctct tgccaacctt gagtacgacg gaagtacatc tgctgataca 4560 tttgaaatta cagtcagtac gatcattcag aggctaaaag aaaacaatat caatgttagc 4620 gacagattgg cctgtcaact aatacttaaa ggtctatccg gtgacttcaa atacctacgt 4680 aatcaatatc gtaccaaaac gaacatgaaa ctttcccaat tattcgctga aattcagtta 4740 atatatgacg aaaataaaat catgaatcta aataaaccgt cccaatacaa acaacacagc 4800 gaatacaaaa atgtttctcg cacatctcca aacacgacta acacaaaggt tacaactcgt 4860 aattatcaga gaacaaatag ttcaaaacca agagcagcaa aagctcacaa tattgctaca 4920 tctagtaaat tctcaagggt gaacaatgat cacattaatg aatcaaccgt ttcatcacaa 4980 tacttaagcg atgacaacga acttagtctt aggccagcaa cagaaagaat ctaagccaac 5040 acacacaata gactcgaatg acgaactacc tgatcacctt cttattgatt caggacgttc 5100 gcaaacgctt gtcagatcag cccattattt acaccatgca acacccaatt ctgaaataaa 5160 catagtcgat gctcaaaaac aagacattcc tataaatgcc attggtaatc ttcacttcaa 5220 ctttcagaac ggcaccaaaa catcaataaa agcactacac acaccaaaca tagcctatga 5280 tctattaagt ttgagtgagc tggctaatca aaatattaca gcctgcttta ccagaaacac 5340 tttagaaaga tcggatggta cagtcctagc tcccatagtc aaacatggag acttttactg 5400 gttatctaaa aaatacctaa ttccttcgca catttcaaag ctaacaataa acaacgtcaa 5460 caaaagcaaa agcgtaaata aatatccata tccgttaata catcgaatgc ttggacatgc 5520 taacttccga agtattcaga agtctcttaa gaagaatgca gttacatatt tgaaggaatc 5580 ggatattgaa tggtctaacg catgcacata tcaatgtcct gactgtctaa tcggcaaaag 5640 cacgaaacat agacatgtca aaggatcacg actaaagtac caagaatcat atgagccttt 5700 tcagtacttg cataccgata tatttggtcc tgtacatcac ttaccgaaaa gtgcaccttc 5760 ttactttata tcgtttacag atgagaaaac cagattccaa tgggtgtacc cattacacga 5820 ccgtcgtgaa gaatctatcc tcaatgtttt tacatcgata ttagcattta ttaagaacca 5880 attcaatgct cgcgttctag ttatccagat ggatcgtggc tccgagtaca ctaacaaaac 5940 tcttcataag ttctttacga acagaggtat tactgcatgc tatacaacca cggcagattc 6000 tagagcacac ggtgtcgctg aacgattaaa tcgtacttta ttaaacgatt gtcgcacact 6060 gcttcattgc agtggtctac caaatcatct atggttctca gcagtcgaat tttctactat 6120 aatcagaaat tcattagtct caccaaaaaa cgataaatcc gccgcaagac aacatgcagg 6180 tttagctgga ctggacatta ctactatact acctttcggt caaccggtta tagttaacaa 6240 ccataatccc gactcgaaaa tacatcctcg tggcattcca ggttacgcct tacatccgtc 6300 acgaaactct tatggctata ttatctatct tccatcatta aaaaagacag tagatactac 6360 caattacgtt atattacaag acaagcaatc caaattggac caattcaatt atgatacact 6420 cacctttgat gatgatctca atcgtttaac agcccataac caatctttta ttgaacaaaa 6480 tgaaacggag cagtcatatg atcaaaatac agaatctgat catgactatc aatcggagat 6540 tgaaataaac tctgatcctc tagtgaacga cttctcgtcc caatcaataa accctttaca 6600 attagacaag gaaccagtcc aaaaagtacg tgcaccaaaa gaagttgatg ccgacatatc 6660 tgaatacaat attcttccat ctcctgtacg atctcgtaca ccccatatca ttaataaaga 6720 gagtaccgaa atgggtggta ccgttgaatc agatactact tcacctagac actcgtctac 6780 cttcactgca cgaaaccaaa agcgacctgg tagtcccaat gatatgattg atttgacctc 6840 acaggataga gttaattatg gacttgaaaa catcaaaact acacgtttgg gtggtacgga 6900 ggaaccatat attcaacgaa atagtgatac aaatatcaaa tacaggacta caaatagtac 6960 gccctcaata gatgaccgtt cgtccaacag tgaatccact actcccatca tctccataga 7020 aacaaaggct gtatgtgata atacaccctc cattgatacg gatccgccag aatatcgatc 7080 ttctgaccat gcgactccta atataatgcc tgacaaatcc tcaaaaaatg ttacggctga 7140 ttctattctt gacgacctcc cacttcctga cttaacccat caatctccta cggacacttc 7200 tgatgtttca aaagatattc cacacataca ctctcgtcag actaattcca gtttgggtgg 7260 tatggatgat tctaatgttc tgactactac caaaagtaag aaaagatcat tagaagataa 7320 tgaaactgaa attgaggtat cccgagacac atggaataat aagaatatga gaagtctgga 7380 accaccaaga tcgaagaaac gcataaattt aattgcagca ataaaaggag tgaaatcgat 7440 caaaccagtt cgaacgacct taagatatga tgaagcaatt acttataata aagacaacaa 7500 agaaaaagac agatatgttg aagcttatca taaagaaatt agccaactat tgaaaatgaa 7560 cacttgggat acaaacaaat attatgatag aaatgacata gatcctaaaa aagtaataaa 7620 ctcaatgttt atatttaaca agaaacgtga tggtacacac aaagctagat ttgttgcaag 7680 aggcgacatt caacaccccg atacatatga ttctgatatg caatccaata ccgtacatca 7740 ctatgcactg atgacgtcac tgtcaatcgc attagacaac gactattata tcacacagct 7800 ggacatatcc tctgcttact tatatgctga tatcaaagaa gaattataca taagacctcc 7860 accacattta ggtttgaatg ataaattact acgtttgaga aaatcactct atggtttgaa 7920 acaaagtggt gcaaactggt atgaaaccat taaatcatat ttaataaatt gttgcgacat 7980 gcaagaagtt cgcggatggt catgcgtatt taagaatagt caagtaacaa tttgcttatt 8040 cgttgatgat atgatattat tcagcaaaga cttaaatgca aataagaaaa tcataacaac 8100 actcaagaaa caatacgata caaagataat aaatctgggt gaaagtgata acgaaattca 8160 gtacgacata cttggattag agatcaaata tcaaagaagc aagtacatga aattaggtat 8220 ggaaaaatcc ttgacagaaa aattacccaa actaaacgta cctttgaacc caaaaggaaa 8280 gaaacttaga gctccaggtc aaccaggtca ttatatagac caggatgaac tagaaataga 8340 tgaagatgaa tacaaagaga aagtacatga aatgcaaaag ttgattggtc tagcttcata 8400 tgttggatat aaatttagat ttgacttact atactacatc aacacattgc tcaaccatat 8460 actattcccc tctaggcaag ttttagacat gacatatgag ttaatacaat tcatgtggga 8520 cactagagat aaacaattaa tatggcacaa aaacaaacct accaagccag ataataaact 8580 agtcgcaata agcgatgctt catatggtaa ccaaccatat tacaagtcac aaattggtaa 8640 cattttccta ctcaacggaa aagtgattgg aggaaagtcg acaaaggctt cgttaacatg 8700 cacttcaact acagaagcag aaatacacgc ggtcagtgaa gctattccgc tattgaataa 8760 cctcagtcac cttgtgcaag aacttaacaa gaaaccaatt attaaaggct tacttactga 8820 tagtagatca acgatcagta taattaagtc tacaaatgaa gagaaattta gaaacagatt 8880 ttttggcaca aaggcaatga gacttagaga tgaagtatca ggtaataatt tatacgtata 8940 ctacatcgag accaagaaga acattgctga tgtgatgaca aaacctcttc cgataaaaac 9000 atttaaacta ttaactaaca aatggattca ttagatctat tacattatgg gtggtatgtt 9060 ggaataaaaa tcaactatca tctactaact agtatttacg ttactagtat attatcatat 9120 acggtgttag aagatgacgc aaatgatgag aaatagtcat ctaaattagt ggaagctgaa 9180 acgcaaggat tgataatgta ataggatcaa tgaatattaa catataaaat gatgataata 9240 atatttatag aattgtgtag aattgcagat tcccttttat ggattcctaa atcctcgagg 9300 agaacttcta gtatatctac atacctaata ttattgcctt attaaaaatg gaatcccaac 9360 aattacatca aaatccacat tctcttcaaa atcaattgtc ctgtacttcc ttgttcatgt 9420 gtgttcaaaa acgttatatt tataggataa ttatactcta tttctcaaca agtaattggt 9480 tgtttggccg agcggtctaa ggcgcctgat tcaagaaata tcttgaccgc agttaactgt 9540 gggaatactc aggtatcgta agatgcaaga gttcgaatct cttagcaacc attatttttt 9600 tcctcaacat aacgagaaca cacaggggcg ctatcgcaca gaatcaaatt cgatgactgg 9660 aaattttttg ttaatttcag aggtcgcctg acgcatatac ctttttcaac tgaaaaattg 9720 ggagaaaaag gaaaggtgag agccgcggaa ccggcttttc atatagaata gagaagcgtt 9780 catgactaaa tgcttgcatc acaatacttg aagttgacaa tattatttaa ggacctattg 9840 ttttttccaa taggtggtta gcaatcgtct tactttctaa cttttcttac cttttacatt 9900 tcagcaatat atatatatat atttcaagga tataccattc taatgtctgc ccctaagaag 9960 atcgtcgttt tgccaggtga ccacgttggt caagaaatca cagccgaagc cattaaggtt 10020 cttaaagcta tttctgatgt tcgttccaat gtcaagttcg atttcgaaaa tcatttaatt 10080 ggtggtgctg ctatcgatgc tacaggtgtc ccacttccag atgaggcgct ggaagcctcc 10140 aagaaggttg atgccgtttt gttaggtgct gtgggtggtc ctaaatgggg taccggtagt 10200 gttagacctg aacaaggttt actaaaaatc cgtaaagaac ttcaattgta cgccaactta 10260 agaccatgta actttgcatc cgactctctt ttagacttat ctccaatcaa gccacaattt 10320 gctaaaggta ctgacttcgt tgttgtcaga gaattagtgg gaggtattta ctttggtaag 10380 agaaaggaag acgatggtga tggtgtcgct tgggatagtg aacaatacac cgttccagaa 10440 gtgcaaagaa tcacaagaat ggccgctttc atggccctac aacatgagcc accattgcct 10500 atttggtcct tggataaagc taatgttttg gcctcttcaa gattatggag aaaaactgtg 10560 gaggaaacca tcaagaacga attccctaca ttgaaggttc aacatcaatt gattgattct 10620 gccgccatga tcctagttaa gaacccaacc cacctaaatg gtattataat caccagcaac 10680 atgtttggtg atatcatctc cgatgaagcc tccgttatcc caggttcctt gggtttgttg 10740 ccatctgcgt ccttggcctc tttgccagac aagaacaccg catttggttt gtacgaacca 10800 tgccacggtt ctgctccaga tttgccaaag aataaggtca accctatcgc cactatcttg 10860 tctgctgcaa tgatgttgaa attgtcattg aacttgcctg aagaaggtaa ggccattgaa 10920 gatgcagtta aaaaggtttt ggatgcaggt atcagaactg gtgatttagg tggttccaac 10980 agtaccacgg aagtcggtga tgctgtcgcc gaagaagtta agaaaatcct tgcttaaaaa 11040 gattctcttt ttttatgata tttgtacata aactttataa atgaaattca taatagaaac 11100 gacacgaaat tacaaaatgg aatatgttca tagggtagac gaaactatat acgcaatcta 11160 catacattta tcaagaagga gaaaaaggag gatgtaaagg aatacaggta agcaaattga 11220 //