ID M25381; SV 1; linear; genomic RNA; STD; VRL; 9474 BP. XX AC M25381; M25729; XX DT 20-DEC-1990 (Rel. 26, Created) DT 14-NOV-2006 (Rel. 89, Last updated, Version 8) XX DE Feline immunodeficiency virus complete genome. XX KW complete genome; env protein; gag protein; long terminal repeat; KW pol protein. XX OS Feline immunodeficiency virus OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus. XX RN [1] RP 1-355 RX DOI; 10.1073/pnas.86.7.2448. RX PUBMED; 2928341. RA Olmstead R.A., Barnes A.K., Yamamoto J.K., Hirsch V.M., Purcell R.H., RA Johnson P.R.; RT "Molecular cloning of feline immunodeficiency virus"; RL Proc. Natl. Acad. Sci. U.S.A. 86(7):2448-2452(1989). XX RN [2] RP 1-9472 RX DOI; 10.1073/pnas.86.15.5743. RX PUBMED; 2762293. RA Talbott R.L., Sparger E.E., Lovelace K.M., Fitch W.M., Pedersen N.C., RA Luciw P.A., Elder J.H.; RT "Nucleotide sequence and genomic organization of feline immunodeficiency RT virus"; RL Proc. Natl. Acad. Sci. U.S.A. 86(15):5743-5747(1989). XX RN [3] RP 1-9474 RX DOI; 10.1073/pnas.86.20.8088. RX PUBMED; 2813380. RA Olmsted R.A., Hirsch V.M., Purcell R.H., Johnson P.R.; RT "Nucleotide sequence analysis of feline immunodeficiency virus: genome RT organization and relationship to other lentiviruses"; RL Proc. Natl. Acad. Sci. U.S.A. 86(20):8088-8092(1989). XX RN [4] RP 7175-7182 RA Elder J.H.; RT ; RL Unpublished. XX DR MD5; 4e85fd5fba1de36d375617d692fddeb7. DR EuropePMC; PMC104329; 10438892. DR EuropePMC; PMC109955; 9696827. DR EuropePMC; PMC1143723; 15956574. DR EuropePMC; PMC114918; 11333894. DR EuropePMC; PMC1262595; 16227303. DR EuropePMC; PMC136364; 12097574. DR EuropePMC; PMC149757; 12584357. DR EuropePMC; PMC1622752; 17038183. DR EuropePMC; PMC1642619; 16971429. DR EuropePMC; PMC1847453; 17376229. DR EuropePMC; PMC1866009; 17192306. DR EuropePMC; PMC2045550; 17670835. DR EuropePMC; PMC2244644; 17971219. DR EuropePMC; PMC2270836; 18251995. DR EuropePMC; PMC2397500; 18315870. DR EuropePMC; PMC2453118; 18559113. DR EuropePMC; PMC2519550; 18550661. DR EuropePMC; PMC2603253; 19075221. DR EuropePMC; PMC2789563; 18279991. DR EuropePMC; PMC2821968; 19896220. DR EuropePMC; PMC2898260; 20444897. DR EuropePMC; PMC2987497; 20732330. DR EuropePMC; PMC3169092; 18689668. DR EuropePMC; PMC3347033; 22590677. DR EuropePMC; PMC3439265; 22632459. DR EuropePMC; PMC369484; 14747582. DR EuropePMC; PMC3706335; 23800358. DR EuropePMC; PMC371036; 15016897. DR EuropePMC; PMC3721975; 20210778. DR EuropePMC; PMC3812036; 24204263. DR EuropePMC; PMC3835772; 24298557. DR EuropePMC; PMC3999937; 24642186. DR EuropePMC; PMC4176367; 25147212. DR EuropePMC; PMC4180853; 25699660. DR EuropePMC; PMC4304674; 23800540. DR EuropePMC; PMC4327927; 25613718. DR EuropePMC; PMC4361796; 25535323. DR EuropePMC; PMC4373062; 25808580. DR EuropePMC; PMC4702554; 26491161. DR EuropePMC; PMC4908968; 26887496. DR EuropePMC; PMC5074269; 26935128. DR EuropePMC; PMC5110171; 27630243. DR EuropePMC; PMC5249086; 28107367. DR EuropePMC; PMC5432859; 28331087. DR EuropePMC; PMC545975; 15510684. DR EuropePMC; PMC5754089; 29300759. DR EuropePMC; PMC5827384; 29263270. DR EuropePMC; PMC5894237; 29636069. DR EuropePMC; PMC5899207; 29467316. DR EuropePMC; PMC5977254; 29772651. DR GOA; P20885. DR InterPro; IPR018582; Envelope_glycop_lentivirus. DR RFAM; RF01834; fiv_FSE. DR UniProtKB/Swiss-Prot; P20885; REV_FIVPE. XX CC [4] revision. [2] sequence kindly provided in computer-readable CC form by John Elder, Scripps Institute, La Jolla, CA. [3] sequence CC kindly provided in computer-readable form by Robert Olmstead, CC NIAID, NIH, Bethesda, MD. [1] contains the LTR sequence from the CC complete genome in [3]. The sequence from [3] is shown (with CC differences from [2]); the substantive difference from [2] is at CC position 6123 where the latter possesses an early stop codon in CC orf2, which is thought to encode the transactivator protein. Clone CC 34TF10 is, nevertheless, biologically active as described in [2]. A CC difference earlier reported at 7175-7182 turns out to have been a CC typo [2,4]. Orf1 is weakly homologous (PLSEARCH) with the Q orf of CC visna and has no detectable similarity to the vif protein of HIV CC and SIV. This is consistent with the clustering of FIV with the CC ungulate lentiviruses [2],[3]. Several 'urfs' are identified by [2] CC and [3] of which only orf3, possibly analogous to the L orf of CC visna, is annotated below; a small, possibly associated, orf is CC found at 8955-9170. For a fuller discussion of the reading frames, CC see [2] and [3]. NCBI gi: 323933 XX FH Key Location/Qualifiers FH FT source 1..9474 FT /organism="Feline immunodeficiency virus" FT /strain="Petaluma" FT /mol_type="genomic RNA" FT /clone="34TF10" FT /clone="FIV-14" FT /db_xref="taxon:11673" FT repeat_region 1..355 FT /standard_name="5' LTR" FT /rpt_type=LONG_TERMINAL_REPEAT FT variation 12 FT /replace="t" FT /citation=[3] FT variation 12 FT /replace="c" FT /citation=[2] FT variation 122 FT /replace="t" FT /citation=[2] FT variation 122 FT /replace="c" FT /citation=[3] FT variation 146 FT /replace="t" FT /citation=[2] FT variation 146 FT /replace="g" FT /citation=[3] FT repeat_region 217..281 FT /note="R repeat 5' copy" FT misc_binding 357..377 FT /bound_moiety="unspecified" FT /note="primer binding site" FT variation 373..374 FT /note="replace (373,'ag')" FT /citation=[3] FT variation 373..374 FT /note="replace (373,'a')" FT /citation=[2] FT variation 498..501 FT /note="ggac in [3]; agca in [2]" FT CDS 628..1980 FT /codon_start=1 FT /gene="gag" FT /product="gag protein" FT /db_xref="GOA:P16087" FT /db_xref="InterPro:IPR000721" FT /db_xref="InterPro:IPR001878" FT /db_xref="InterPro:IPR008916" FT /db_xref="InterPro:IPR008919" FT /db_xref="InterPro:IPR012344" FT /db_xref="InterPro:IPR036875" FT /db_xref="PDB:2N1R" FT /db_xref="PDB:4IC9" FT /db_xref="PDB:4ICA" FT /db_xref="PDB:5DCK" FT /db_xref="PDB:5NA2" FT /db_xref="PDB:5XMF" FT /db_xref="PDB:5XMM" FT /db_xref="UniProtKB/Swiss-Prot:P16087" FT /protein_id="AAB59936.1" FT /translation="MGNGQGRDWKMAIKRCSNVAVGVGGKSKKFGEGNFRWAIRMANVS FT TGREPGDIPETLDQLRLVICDLQERREKFGSSKEIDMAIVTLKVFAVAGLLNMTVSTAA FT AAENMYSQMGLDTRPSMKEAGGKEEGPPQAYPIQTVNGVPQYVALDPKMVSIFMEKARE FT GLGGEEVQLWFTAFSANLTPTDMATLIMAAPGCAADKEILDESLKQLTAEYDRTHPPDA FT PRPLPYFTAAEIMGIGLTQEQQAEARFAPARMQCRAWYLEALGKLAAIKAKSPRAVQLR FT QGAKEDYSSFIDRLFAQIDQEQNTAEVKLYLKQSLSIANANADCKKAMSHLKPESTLEE FT KLRACQEIGSPGYKMQLLAEALTKVQVVQSKGSGPVCFNCKKPGHLARQCREVKKCNKC FT GKPGHVAAKCWQGNRKNSGNWKAGRAAAPVNQMQQAVMPSAPPMEEKLLDL" FT variation 1575 FT /gene="gag" FT /note="g in [3]; a in [2]" FT variation 1840 FT /gene="gag" FT /note="g in [3]; c in [2]" FT variation 1977 FT /gene="gag" FT /note="a in [3]; g in [2]" FT variation 2028 FT /note="g in [3]; a in [2]" FT variation 2033 FT /note="c in [3]; t in [2]" FT CDS 2251..5243 FT /partial FT /codon_start=3 FT /gene="pol" FT /product="pol polyprotein" FT /db_xref="GOA:P16088" FT /db_xref="InterPro:IPR000477" FT /db_xref="InterPro:IPR001037" FT /db_xref="InterPro:IPR001584" FT /db_xref="InterPro:IPR001969" FT /db_xref="InterPro:IPR001995" FT /db_xref="InterPro:IPR002156" FT /db_xref="InterPro:IPR003308" FT /db_xref="InterPro:IPR008181" FT /db_xref="InterPro:IPR010659" FT /db_xref="InterPro:IPR010661" FT /db_xref="InterPro:IPR012337" FT /db_xref="InterPro:IPR017856" FT /db_xref="InterPro:IPR018061" FT /db_xref="InterPro:IPR021109" FT /db_xref="InterPro:IPR029054" FT /db_xref="InterPro:IPR033704" FT /db_xref="InterPro:IPR034170" FT /db_xref="InterPro:IPR036157" FT /db_xref="InterPro:IPR036397" FT /db_xref="InterPro:IPR036862" FT /db_xref="PDB:1B11" FT /db_xref="PDB:1DUT" FT /db_xref="PDB:1F7D" FT /db_xref="PDB:1F7K" FT /db_xref="PDB:1F7N" FT /db_xref="PDB:1F7O" FT /db_xref="PDB:1F7P" FT /db_xref="PDB:1F7Q" FT /db_xref="PDB:1F7R" FT /db_xref="PDB:1FIV" FT /db_xref="PDB:2FIV" FT /db_xref="PDB:2HAH" FT /db_xref="PDB:3FIV" FT /db_xref="PDB:3OGP" FT /db_xref="PDB:3OGQ" FT /db_xref="PDB:4FIV" FT /db_xref="PDB:4MQ3" FT /db_xref="PDB:4PA1" FT /db_xref="PDB:5FIV" FT /db_xref="PDB:6FIV" FT /db_xref="UniProtKB/Swiss-Prot:P16088" FT /protein_id="AAB59937.1" FT /translation="VLEDNSLIQPLLGRDNMIKFNIRLVMAQISDKIPVVKVKMKDPNK FT GPQIKQWPLTNEKIEALTEIVERLEREGKVKRADPNNPWNTPVFAIKKKSGKWRMLIDF FT RELNKLTEKGAEVQLGLPHPAGLQIKKQVTVLDIGDAYFTIPLDPDYAPYTAFTLPRKN FT NAGPGRRFVWCSLPQGWILSPLIYQSTLDNIIQPFIRQNPQLDIYQYMDDIYIGSNLSK FT KEHKEKVEELRKLLLWWGFETPEDKLQEEPPYTWMGYELHPLTWTIQQKQLDIPEQPTL FT NELQKLAGKINWASQAIPDLSIKALTNMMRGNQNLNSTRQWTKEARLEVQKAKKAIEEQ FT VQLGYYDPSKELYAKLSLVGPHQISYQVYQKDPEKILWYGKMSRQKKKAENTCDIALRA FT CYKIREESIIRIGKEPRYEIPTSREAWESNLINSPYLKAPPPEVEYIHAALNIKRALSM FT IKDAPIPGAETWYIDGGRKLGKAAKAAYWTDTGKWQVMELEGSNQKAEIQALLLALKAG FT SEEMNIITDSQYVINIILQQPDMMEGIWQEVLEELEKKTAIFIDWVPGHKGIPGNEEVD FT KLCQTMMIIEGDGILDKRSEDAGYDLLAAKEIHLLPGEVKVIPTGVKLMLPKGYWGLII FT GKSSIGSKGLDVLGGVIDEGYRGEIGVIMINVSRKSITLMERQKIAQLIILPCKHEVLE FT QGKVVMDSERGDNGYGSTGVFSSWVDRIEEAEINHEKFHSDPQYLRTEFNLPKMVAEEI FT RRKCPVCRIRGEQVGGQLKIGPGIWQMDCTHFDGKIILVGIHVESGYIWAQIISQETAD FT CTVKAVLQLLSAHNVTELQTDNGPNFKNQKMEGVLNYMGVKHKFGIPGNPQSQALVENV FT NHTLKVWIRKFLPETTSLDNALSLAVHSLNFKRRGRIGGMAPYELLAQQESLRIQDYFS FT AIPQKLQAQWIYYKDQKDKKWKGPMRVEYWGQGSVLLKDEEKGYFLIPRRHIRRVPEPC FT ALPEGDE" FT variation 2288 FT /gene="pol" FT /note="a in [3]; g in [2]" FT variation 2464 FT /gene="pol" FT /note="g in [3]; a in [2]" FT variation 2490 FT /gene="pol" FT /note="c in [3]; t in [2]" FT variation 2580 FT /gene="pol" FT /note="c in [3]; t in [2]" FT variation 2631 FT /gene="pol" FT /note="t in [3]; c in [2]" FT variation 2735 FT /gene="pol" FT /note="a in [3]; g in [2]" FT variation 3733 FT /gene="pol" FT /note="a in [3]; g in [2]" FT variation 3743 FT /gene="pol" FT /note="a in [3]; t in [2]" FT variation 3812 FT /gene="pol" FT /note="g in [3]; a in [2]" FT variation 4202 FT /gene="pol" FT /note="g in [3]; a in [2]" FT variation 4211 FT /gene="pol" FT /note="c in [3]; t in [2]" FT variation 4271 FT /gene="pol" FT /note="c in [3]; t in [2]" FT variation 4493 FT /gene="pol" FT /note="a in [3]; g in [2]" FT variation 4540 FT /gene="pol" FT /note="g in [3]; t in [2]" FT variation 4706 FT /gene="pol" FT /note="c in [3]; t in [2]" FT variation 4891 FT /gene="pol" FT /note="g in [3]; a in [2]" FT CDS 5236..5991 FT /codon_start=1 FT /note="ORF 1; NCBI gi: 323936" FT /db_xref="GOA:P16089" FT /db_xref="InterPro:IPR008668" FT /db_xref="UniProtKB/Swiss-Prot:P16089" FT /protein_id="AAB59938.1" FT /translation="MSEEDWQVSRRLFAVLQGGVNSAMLYISRLPPDEREKYKKDFKKR FT LFDTETGFIKRLRKAEGIKWSFHTRDYYIGYVREMVAGSTTSLSLRMYIYISNPLWHSQ FT YRPGLKNFNKEWPFVNMWIKTGFMWDDIEKQNICIGGEVSPGWGPGMVGIAIKAFSCGE FT RKIEATPVMIIRGEIDPKKWCGDCWNLMCLRNSPPKTLQRLAMLACGVPAKKWRGCCNQ FT RFVSPYRTPADLEVIQSKPSWNLLWSGEL" FT variation 5332 FT /note="g in [3]; a in [2]" FT variation 5497 FT /note="t in [3]; c in [2]" FT variation 5559 FT /note="t in [3]; c in [2]" FT variation 5986 FT /note="t in [3]; c in [2]" FT CDS 5992..6228 FT /codon_start=1 FT /note="ORF 2; NCBI gi: 323937" FT /db_xref="GOA:Q66013" FT /db_xref="UniProtKB/Swiss-Prot:Q66013" FT /protein_id="AAB59939.1" FT /translation="MEDIIVLFNRVTEKLEKELAIRIFVLAHQLERDKAIRLLQGLFWR FT YRFKKPRVDYCLCWWCCKFYYWQLQSTLSITTA" FT variation 6000 FT /note="c in [3]; a in [2]" FT variation 6123 FT /note="g in [3]; a in [2]" FT variation 6149 FT /note="t in [3]; c in [2]" FT variation 6179 FT /note="a in [3]; g in [2]" FT variation 6238 FT /note="g in [3]; t in [2]" FT variation 6245..6248 FT /note="attt in [3]; ttt in [2]" FT CDS 6266..8836 FT /codon_start=1 FT /gene="env" FT /product="envelope polyprotein" FT /db_xref="GOA:P16090" FT /db_xref="InterPro:IPR000328" FT /db_xref="InterPro:IPR018582" FT /db_xref="UniProtKB/Swiss-Prot:P16090" FT /protein_id="AAB59940.1" FT /translation="MAEGFAANRQWIGLEEAEELLDFDIATQMSEEGPLNPGVNPFRVP FT GITEKEKQNYCNILQPKLQDLRNEIQEVKLEEGNAGKFRRARFLRYSDESVLSLVHAFI FT GYCIYLGNRNKLGSLRHDIDIEAPQEECYNNREKGTTDNIKYGRRCCLGTVTLYLILFI FT GIIIYSQTTNAQVVWRLPPLVVPVEESEIIFWDCWAPEEPACQDFLGAMIHLKAKTNIS FT IREGPTLGNWAREIWATLFKKATRQCRRGRIWKRWNETITGPSGCANNTCYNVSVIVPD FT YQCYLDRVDTWLQGKINISLCLTGGKMLYNKVTKQLSYCTDPLQIPLINYTFGPNQTCM FT WNTSQIQDPEIPKCGWWNQMAYYNSCKWEEAKVKFHCQRTQSQPGSWFRAISSWKQRNR FT WEWRPDFESKKVKISLQCNSTKNLTFAMRSSGDYGEVTGAWIEFGCHRNKSKLHAEARF FT RIRCRWNVGSNTSLIDTCGNTQKVSGANPVDCTMYSNKMYNCSLQNGFTMKVDDLIMHF FT NMKKAVEMYNIAGNWSCTSDLPSSWGYMNCNCTNSSSSYSGTKMACPSNRGILRNWYNP FT VAGLRQSLEQYQVVKQPDYLVVPEEVMEYKPRRKRAAIHVMLALAAVLSIAGAGTGATA FT IGMVTQYHQVLATHQEAVEKVTEALKINNLRLVTLEHQVLVIGLKVEAMEKFLYTAFAM FT QELGCNQNQFFCKIPPELWTRYNMTINQTIWNHGNITLGEWYNQTKDLQQKFYEIIMDI FT EQNNVQGKKGIQQLQKWEDWVGWIGNIPQYLKGLLGGILGIGLGVLLLILCLPTLVDCI FT RNCIHKILGYTVIAMPEVEGEEIQPQMELRRNGRQCGMSEKEEE" FT variation 6306 FT /gene="env" FT /note="t in [3]; c in [2]" FT variation 6430 FT /gene="env" FT /note="c in [3]; t in [2]" FT variation 6548 FT /gene="env" FT /note="a in [3]; c in [2]" FT CDS 6712..6918 FT /codon_start=1 FT /gene="env" FT /note="ORF 3; NCBI gi: 323939" FT /db_xref="InterPro:IPR009588" FT /db_xref="UniProtKB/TrEMBL:Q66014" FT /protein_id="AAB59941.1" FT /translation="MLPRNGDFVPDFIYRNNNIFTDNQRSGSMETSTISSPSRRIRNNF FT LGLLGTRRTRLSGLSWGNDTSKS" FT variation 6739 FT /gene="env" FT /note="c in [3]; t in [2]" FT variation 6753 FT /gene="env" FT /note="t in [3]; c in [2]" FT variation 6758 FT /gene="env" FT /note="a in [3]; g in [2]" FT variation 6764 FT /gene="env" FT /note="a in [3]; g in [2]" FT variation 6779 FT /gene="env" FT /note="a in [3]; g in [2]" FT variation 6782..6783 FT /gene="env" FT /note="aa in [3]; gg in [2]" FT variation 7175..7182 FT /gene="env" FT /note="acaggagg in [3]; caggagga in [2]" FT variation 7381 FT /gene="env" FT /note="a in [3]; g in [2]" FT variation 7484 FT /gene="env" FT /note="g in [3]; a in [2]" FT variation 7512..7513 FT /gene="env" FT /note="ag in [3]; ca in [2]" FT variation 7618 FT /gene="env" FT /note="a in [3]; c in [2]" FT variation 7625 FT /gene="env" FT /note="g in [3]; a in [2]" FT variation 7670 FT /gene="env" FT /note="a in [3]; g in [2]" FT variation 7704..7708 FT /gene="env" FT /note="aaaaa in [3]; caaat in [2]" FT variation 7750 FT /gene="env" FT /note="t in [3]; c in [2]" FT variation 7808..7810 FT /gene="env" FT /note="atg in [3]; gta in [2]" FT variation 7824..7828 FT /gene="env" FT /note="aaaag in [3]; caaaa in [2]" FT variation 7996 FT /gene="env" FT /note="g in [3]; a in [2]" FT variation 8054 FT /gene="env" FT /note="g in [3]; c in [2]" FT variation 8129 FT /gene="env" FT /note="g in [3]; a in [2]" FT variation 8222 FT /gene="env" FT /note="g in [3]; a in [2]" FT variation 8238 FT /gene="env" FT /note="a in [3]; g in [2]" FT variation 8329 FT /gene="env" FT /note="g in [3]; a in [2]" FT variation 8377 FT /gene="env" FT /note="t in [3]; c in [2]" FT variation 8394 FT /gene="env" FT /note="c in [3]; t in [2]" FT variation 8548..8550 FT /gene="env" FT /note="gaa in [3]; aac in [2]" FT variation 8588 FT /gene="env" FT /note="g in [3]; a in [2]" FT repeat_region 9120..9474 FT /rpt_type=LONG_TERMINAL_REPEAT FT /note="3' LTR" FT variation 9131 FT /note="t in [3]; c in [2]" FT variation 9241 FT /note="c in [3]; t in [2]" FT variation 9265 FT /note="g in [3]; t in [2]" FT repeat_region 9336..9400 FT /note="R repeat 3' copy" XX SQ Sequence 9474 BP; 3571 A; 1370 C; 2119 G; 2414 T; 0 other; tgggatgagt attggaaccc tgaagaaata gaaagaatgc ttatggacta gggactgttt 60 acgaacaaat gataaaagga aatagctgag catgactcat agttaaagcg ctagcagctg 120 cctaaccgca aaaccacatc ctatggaaag cttgctaatg acgtataagt tgttccattg 180 taagagtata taaccagtgc tttgtgaaac ttcgaggagt ctctttgttg aggacttttg 240 agttctccct tgaggctccc acagatacaa taaatatttg agattgaacc ctgtcgagta 300 tctgtgtaat cttttttacc tgtgaggtct cggaatccgg gccgagaact tcgcagttgg 360 cgcccgaaca gggacttgat tgagagtgat tgaggaagtg aagctagagc aatagaaagc 420 tgttaagcag aactcctgct gacctaaata gggaagcagt agcagacgct gctaacagtg 480 agtatctcta gtgaagcgga ctcgagctca taatcaagtc attgtttaaa ggcccagata 540 aattacatct ggtgactctt cgcggacctt caagccagga gattcgccga gggacagtca 600 acaaggtagg agagattcta cagcaacatg gggaatggac aggggcgaga ttggaaaatg 660 gccattaaga gatgtagtaa tgttgctgta ggagtagggg ggaagagtaa aaaatttgga 720 gaagggaatt tcagatgggc cattagaatg gctaatgtat ctacaggacg agaacctggt 780 gatataccag agactttaga tcaactaagg ttggttattt gcgatttaca agaaagaaga 840 gaaaaatttg gatctagcaa agaaattgat atggcaattg tgacattaaa agtctttgcg 900 gtagcaggac ttttaaatat gacggtgtct actgctgctg cagctgaaaa tatgtattct 960 caaatgggat tagacactag gccatctatg aaagaagcag gtggaaaaga ggaaggccct 1020 ccacaggcat atcctattca aacagtaaat ggagtaccac aatatgtagc acttgaccca 1080 aaaatggtgt ccatttttat ggaaaaggca agagaaggac taggaggtga ggaagttcaa 1140 ctatggttta ctgccttctc tgcaaattta acacctactg acatggccac attaataatg 1200 gccgcaccag ggtgcgctgc agataaagaa atattggatg aaagcttaaa gcaactgaca 1260 gcagaatatg atcgcacaca tccccctgat gctcccagac cattacccta ttttactgca 1320 gcagaaatta tgggtatagg attaactcaa gaacaacaag cagaagcaag atttgcacca 1380 gctaggatgc agtgtagagc atggtatctc gaggcattag gaaaattggc tgccataaaa 1440 gctaagtctc ctcgagctgt gcagttaaga caaggagcta aggaagatta ttcatccttt 1500 atagacagat tgtttgccca aatagatcaa gaacaaaata cagctgaagt taagttatat 1560 ttaaaacagt cattgagcat agctaatgct aatgcagact gtaaaaaggc aatgagccac 1620 cttaagccag aaagtaccct agaagaaaag ttgagagctt gtcaagaaat aggctcacca 1680 ggatataaaa tgcaactctt ggcagaagct cttacaaaag ttcaagtagt gcaatcaaaa 1740 ggatcaggac cagtgtgttt taattgtaaa aaaccaggac atctagcaag acaatgtaga 1800 gaagtgaaaa aatgtaataa atgtggaaaa cctggtcatg tagctgccaa atgttggcaa 1860 ggaaatagaa agaattcggg aaactggaag gcggggcgag ctgcagcccc agtgaatcaa 1920 atgcagcaag cagtaatgcc atctgcacct ccaatggagg agaaactatt ggatttataa 1980 attataataa agtaggtact actacaacat tagaaaagag gccagaaata ctcatatttg 2040 taaatggata tcctataaaa tttttattag acacaggagc agatataaca attttaaata 2100 ggagagattt tcaagtaaaa aattctatag aaaatggaag gcaaaatatg attggagtag 2160 gaggaggaaa gagaggaaca aattatatta atgtacattt agagattaga gatgaaaatt 2220 ataagacaca atgtatattt ggtaatgttt gtgtcttaga agataactca ttaatacaac 2280 cattattagg gagagataat atgattaaat tcaatattag gttagtaatg gctcaaattt 2340 ctgataagat tccagtagta aaagtaaaaa tgaaggatcc taataaagga cctcaaataa 2400 aacaatggcc attaacaaat gaaaaaattg aagccttaac agaaatagta gaaagactag 2460 aaagagaagg gaaagtaaaa agagcagatc caaataatcc atggaataca ccagtatttg 2520 ctataaaaaa gaaaagtgga aaatggagaa tgctcataga ttttagagaa ttaaacaaac 2580 taactgagaa aggagcagag gtccagttgg gactacctca tcctgctggt ttacaaataa 2640 aaaaacaagt aacagtatta gatatagggg atgcatattt caccattcct cttgatccag 2700 attatgctcc ttatacagca tttactttac ctagaaaaaa taatgcggga ccaggaagga 2760 gatttgtgtg gtgtagtcta ccacaaggct ggattttaag tccattgata tatcaaagta 2820 cattagataa tataatacaa ccttttatta gacaaaatcc tcaattagat atttaccaat 2880 atatggatga catttatata ggatcaaatt taagtaaaaa ggagcataaa gaaaaggtag 2940 aagaattaag aaaattacta ttatggtggg gatttgaaac tccagaagat aaattacagg 3000 aagaaccccc atatacatgg atgggttatg aattacatcc attaacatgg acaatacaac 3060 agaaacagtt agacattcca gaacagccca ctctaaatga gttgcaaaaa ttagcaggaa 3120 aaattaattg ggctagccaa gctattccag acttgagtat aaaagcatta actaacatga 3180 tgagaggaaa tcaaaaccta aattcaacaa gacaatggac taaagaagct cgactggaag 3240 tacaaaaggc aaaaaaggct atagaagaac aagtacaact aggatactat gaccccagta 3300 aggagttata tgctaaatta agtttggtgg gaccacatca aataagttat caagtatatc 3360 agaaggatcc agaaaagata ctatggtatg gaaaaatgag tagacaaaag aaaaaggcag 3420 aaaatacatg tgatatagcc ttaagagcat gctataagat aagagaagag tctattataa 3480 gaataggaaa agaaccaaga tatgaaatac ctacttctag agaagcctgg gaatcaaatt 3540 taattaattc accatatctt aaggccccac ctcctgaggt agaatatatc catgctgctt 3600 tgaatataaa gagagcgtta agtatgataa aagatgctcc aataccagga gcagaaacat 3660 ggtatataga tggaggtaga aagctaggaa aagcagcaaa agcagcctat tggacagata 3720 caggaaagtg gcaagtgatg gaattagaag gcagtaatca gaaggcagaa atacaagcat 3780 tattattggc attaaaagca ggatcagagg agatgaatat tataacagat tcacaatatg 3840 ttataaatat tattcttcaa caaccagata tgatggaggg aatctggcaa gaagttttag 3900 aagaattgga gaagaaaaca gcaatattta tagattgggt cccaggacat aaaggtattc 3960 caggaaatga ggaagtagat aagctttgtc aaacaatgat gataatagaa ggggatggga 4020 tattagataa aaggtcagaa gatgcaggat atgatttatt agctgcaaaa gaaatacatt 4080 tattgccagg agaggtaaaa gtaataccaa caggggtaaa gctaatgttg cctaaaggat 4140 attggggatt aataatagga aaaagctcga tagggagtaa aggattggat gtattaggag 4200 gggtaataga cgaaggatat cgaggtgaaa ttggagtaat aatgattaat gtatcaagaa 4260 aatcaatcac cttaatggaa cgacaaaaga tagcacaatt aataatattg ccttgtaaac 4320 atgaagtatt agaacaagga aaagtagtaa tggattcaga gagaggagac aatggttatg 4380 ggtcaacagg agtattctcc tcttgggttg acagaattga ggaagcagaa ataaatcatg 4440 aaaaatttca ctcagatcca cagtacttaa ggactgaatt taatttacct aaaatggtag 4500 cagaagagat aagacgaaaa tgcccagtat gcagaatcag aggagaacaa gtgggaggac 4560 aattgaaaat agggcctggt atctggcaaa tggattgcac acactttgat ggcaaaataa 4620 ttcttgtggg tatacatgtg gaatcaggat atatatgggc acaaataatt tctcaagaaa 4680 ctgctgactg tacagttaaa gctgtcttac aattgttgag tgctcataat gttactgaat 4740 tacaaacaga taatggacca aattttaaaa atcaaaagat ggaaggagta ctcaattaca 4800 tgggtgtgaa acataagttt ggtatcccag ggaacccaca gtcacaagca ttagttgaaa 4860 atgtaaatca tacattaaaa gtttggattc ggaaattttt gcctgaaaca acctccttgg 4920 ataatgcctt atctctcgct gtacatagtc tcaattttaa aagaagaggt aggataggag 4980 ggatggcccc ttatgaatta ttagcacaac aagaatcctt aagaatacaa gattattttt 5040 ctgcaatacc acaaaaattg caagcacagt ggatttatta taaagatcaa aaagataaga 5100 aatggaaagg accaatgaga gtagaatact ggggacaggg atcagtatta ttaaaggatg 5160 aagagaaggg atattttctt atacctagga gacacataag gagagttcca gaaccctgcg 5220 ctcttcctga aggggatgag tgaagaagat tggcaggtaa gtagaagact ctttgcagtg 5280 ctccaaggag gagtaaatag cgctatgcta tacatatcta ggctacctcc ggatgaaaga 5340 gaaaagtata aaaaagactt caagaaaaga ctttttgaca cagaaacagg atttataaag 5400 agactacgga aagctgaagg aataaaatgg agctttcata ctagagatta ttacatagga 5460 tatgtcagag aaatggtggc aggatccact acatcattaa gtctaaggat gtatatatat 5520 ataagtaacc cactatggca ttctcagtat cgtccaggtt tgaaaaattt caataaggaa 5580 tggccttttg taaatatgtg gataaaaaca ggatttatgt gggatgatat tgaaaaacaa 5640 aatatttgta taggaggaga agtttcacca ggatggggac cagggatggt aggtatagca 5700 ataaaagctt ttagttgtgg cgaaagaaag attgaggcta ctcctgtaat gattataaga 5760 ggagaaatag atccaaaaaa atggtgcgga gattgttgga atttaatgtg tcttagaaac 5820 tcacctccaa agactttaca aagactcgct atgttggcgt gtggcgtgcc ggctaagaag 5880 tggcgaggat gctgtaatca acgctttgtt tctccttaca gaacgcctgc tgatttagag 5940 gtcattcaat ccaagcccag ctggaacctg ttatggtcgg gagaattatg aatggaagac 6000 ataatagtat tattcaatag ggtcactgag aaactagaaa aagaattagc tatcagaata 6060 tttgtattag cacatcaatt agaaagggac aaagctatta gattactaca aggattattt 6120 tggagatata gatttaagaa accccgagta gattattgtt tatgttggtg gtgttgcaaa 6180 ttctattatt ggcagttgca atctacatta tcaataacta ctgcttagaa atatttagat 6240 taatatttca tttgcaacaa taagaatggc agaaggattt gcagccaata gacaatggat 6300 aggactagaa gaagctgaag agttattaga ttttgatata gcaacacaaa tgagtgaaga 6360 aggaccacta aatccaggag taaacccatt tagggtacct ggaataacag aaaaagaaaa 6420 gcaaaactac tgtaacatat tacaacctaa gttacaagat ctaaggaacg aaattcaaga 6480 ggtaaaactg gaagaaggaa atgcaggtaa gtttagaaga gcaagatttt taaggtattc 6540 tgatgaaagt gtattgtccc tggttcatgc gttcatagga tattgtatat atttaggtaa 6600 tcgaaataag ttaggatctt taagacatga cattgatata gaagcacccc aagaagagtg 6660 ttataataat agagagaagg gtacaactga caatataaaa tatggtagac gatgttgcct 6720 aggaacggtg actttgtacc tgattttatt tataggaata ataatatatt cacagacaac 6780 caacgctcag gtagtatgga gacttccacc attagtagtc ccagtagaag aatcagaaat 6840 aattttttgg gattgttggg caccagaaga acccgcctgt caggactttc ttggggcaat 6900 gatacatcta aaagctaaga caaatataag tatacgagag ggacctacct tggggaattg 6960 ggctagagaa atatgggcaa cattattcaa aaaggctact agacaatgta gaagaggcag 7020 aatatggaaa agatggaatg agactataac aggaccatca ggatgtgcta ataacacatg 7080 ttataatgtt tcagtaatag tacctgatta tcagtgttat ttagatagag tagatacttg 7140 gttacaaggg aaaataaata tatcattatg tctaacagga ggaaaaatgt tgtacaataa 7200 agttacaaaa caattaagct attgtacaga cccattacaa atcccactga tcaattatac 7260 atttggacct aatcaaacat gtatgtggaa tacttcacaa attcaggacc ctgaaatacc 7320 aaaatgtgga tggtggaatc aaatggccta ttataacagt tgtaaatggg aagaggcaaa 7380 agtaaagttt cattgtcaaa gaacacagag tcagcctgga tcatggttta gagcaatctc 7440 gtcatggaaa caaagaaata gatgggagtg gagaccagat tttgaaagta aaaaggtgaa 7500 aatatctcta cagtgcaata gcacaaaaaa cctaaccttt gcaatgagaa gttcaggaga 7560 ttatggagaa gtaacgggag cttggataga gtttggatgt catagaaata aatcaaaact 7620 tcatgctgaa gcaaggttta gaattagatg tagatggaat gtagggagta atacctcgct 7680 cattgataca tgtggaaaca ctcaaaaagt ttcaggtgcg aatcctgtag attgtaccat 7740 gtattcaaat aaaatgtaca attgttcttt acaaaacggg tttactatga aggtagatga 7800 ccttattatg catttcaata tgaaaaaggc tgtagaaatg tataatattg ctggaaattg 7860 gtcttgtaca tctgacttgc catcgtcatg ggggtatatg aattgtaatt gtacaaatag 7920 tagtagtagt tatagtggta ctaaaatggc atgtcctagc aatcgaggca tcttaaggaa 7980 ttggtataac ccagtggcag gattacgaca atccttagaa cagtatcaag ttgtaaaaca 8040 accagattac ttagtggtcc cagaggaagt catggaatat aaacctagaa ggaaaagggc 8100 agctattcat gttatgttgg ctcttgcagc agtattatct attgccggtg cagggacggg 8160 ggctactgct atagggatgg taacacaata ccaccaagtt ctggcaaccc atcaagaagc 8220 tgtagaaaag gtgactgaag ccttaaagat aaacaactta agattagtta cattagagca 8280 tcaagtacta gtaataggat taaaagtaga agctatggaa aaatttttgt atacagcttt 8340 cgctatgcaa gaattaggat gtaatcaaaa tcaatttttc tgcaaaatcc ctcctgagtt 8400 gtggacaagg tataatatga ctataaatca aacaatatgg aatcatggaa atataacttt 8460 gggggaatgg tataaccaaa caaaagattt acaacaaaag ttttatgaaa taataatgga 8520 catagaacaa aataatgtac aagggaagaa agggatacaa caattacaaa agtgggaaga 8580 ttgggtagga tggataggaa atattccaca atatttaaag ggactattgg gaggtatctt 8640 gggaatagga ttaggagtgt tattattgat tttatgttta cctacattgg ttgattgtat 8700 aagaaattgt atccacaaga tactaggata cacagtaatt gcaatgcctg aagtagaagg 8760 agaagaaata caaccacaaa tggaattgag gagaaatggt aggcaatgtg gcatgtctga 8820 aaaagaggag gaatgatgaa gtatctcaga cttattttat aagggagata ctgtgctgag 8880 ttcttccctt tgaggaaggt atgtcatatg aatccatttc gaatcaaatc aaactaataa 8940 agtatgtatt gtaaggtaaa aggaaaagac aaagaagaag aagaaagaag aaagccttca 9000 agaggatgat gacagagtta gaagatcgct tcaggaagct atttggcacg acttctacaa 9060 cgggagacag cacagtagat tctgaagatg aacctcctaa aaaagaaaaa agggtggact 9120 gggatgagta ttggaaccct gaagaaatag aaagaatgct tatggactag ggactgttta 9180 cgaacaaatg ataaaaggaa atagctgagc atgactcata gttaaagcgc tagcagctgc 9240 ctaaccgcaa aaccacatcc tatggaaagc ttgctaatga cgtataagtt gttccattgt 9300 aagagtatat aaccagtgct ttgtgaaact tcgaggagtc tctttgttga ggacttttga 9360 gttctccctt gaggctccca cagatacaat aaatatttga gattgaaccc tgtcgagtat 9420 ctgtgtaatc ttttttacct gtgaggtctc ggaatccggg ccgagaactt cgca 9474 //