ID M16560; SV 1; linear; genomic RNA; STD; VRL; 7389 BP. XX AC M16560; XX DT 02-APR-1988 (Rel. 15, Created) DT 17-APR-2005 (Rel. 83, Last updated, Version 5) XX DE Coxsackievirus B1, complete genome. XX KW . XX OS Coxsackievirus B1 OC Viruses; Riboviria; Picornavirales; Picornaviridae; Enterovirus; OC Enterovirus B. XX RN [1] RP 1-7389 RX DOI; 10.1016/0042-6822(87)90436-3. RX PUBMED; 3027969. RA Iizuka N., Kuge S., Nomoto A.; RT "Complete nucleotide sequence of the genome of coxsackievirus B1"; RL Virology 156(1):64-73(1987). XX DR MD5; 72b65582355461c38e66b6ad94333c71. DR EuropePMC; PMC104435; 9971773. DR EuropePMC; PMC111929; 10756027. DR EuropePMC; PMC112895; 10482628. DR EuropePMC; PMC121380; 9457433. DR EuropePMC; PMC1392672; 16455897. DR EuropePMC; PMC1951248; 17537940. DR EuropePMC; PMC225006; 14512548. DR EuropePMC; PMC228507; 12970427. DR EuropePMC; PMC229355; 14557670. DR EuropePMC; PMC2440640; 18378272. DR EuropePMC; PMC2907575; 20367886. DR EuropePMC; PMC3147834; 21543560. DR EuropePMC; PMC3290945; 17176588. DR EuropePMC; PMC3620579; 23521862. DR EuropePMC; PMC368751; 14694117. DR EuropePMC; PMC3828788; 23920231. DR EuropePMC; PMC3931826; 24587020. DR EuropePMC; PMC4110215; 25059857. DR EuropePMC; PMC4460132; 26053872. DR EuropePMC; PMC4766141; 27026855. DR EuropePMC; PMC5015062; 27604323. DR EuropePMC; PMC544264; 15640172. DR EuropePMC; PMC6082906; 30089864. DR EuropePMC; PMC6357135; 30597828. DR RFAM; RF00041; Entero_OriR. DR RFAM; RF00048; Entero_CRE. DR RFAM; RF00229; IRES_Picorna. DR RFAM; RF00386; Entero_5_CRE. XX CC Draft entry and printed copy of sequence in [1] kindly provided CC A.Nomoto (04-AUG-1987). CC The proteolytic processing sites betwween proteins 1D and 2A and CC between 2B and 2C are obscure. XX FH Key Location/Qualifiers FH FT source 1..7389 FT /organism="Coxsackievirus B1" FT /mol_type="genomic RNA" FT /clone="pCV(B1)EE[1,2,3,4]; pCV(B1)KE1; pCV(B1)PP[1,2]" FT /db_xref="taxon:12071" FT misc_RNA 1..7389 FT /note="coxsackievirus genome; origin of viral genome: 68 bp FT upstream of KpnI site" FT mat_peptide 742..948 FT /product="1A(VP4)" FT /note="1A(VP4) mature peptide /pattern" FT CDS 742..7290 FT /codon_start=1 FT /note="coxsackievirus B1 polyprotein" FT /db_xref="GOA:P08291" FT /db_xref="InterPro:IPR000081" FT /db_xref="InterPro:IPR000199" FT /db_xref="InterPro:IPR000605" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR001676" FT /db_xref="InterPro:IPR002527" FT /db_xref="InterPro:IPR003138" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR014759" FT /db_xref="InterPro:IPR014838" FT /db_xref="InterPro:IPR027417" FT /db_xref="InterPro:IPR029053" FT /db_xref="InterPro:IPR033703" FT /db_xref="InterPro:IPR036203" FT /db_xref="InterPro:IPR036988" FT /db_xref="UniProtKB/Swiss-Prot:P08291" FT /protein_id="AAC00531.1" FT /translation="MGAQVSTQKTGAHETGLNASGNSIIHYTNINYYKDAASNSANRQD FT FTQDPGKFTEPVKDIMIKSMPALNSPSAEECGYSDRVRSITLGNSTITTQECANVVVGY FT GVWPEYLKDNEATGEDQPTQPDVATCRFYTLESVQWMKNSAGWWWKLPDALSQMGLFGQ FT NMQYHYLGRTGYTIHVQCNASKFHQGCLLVVCVPEAEMGCSNLNNTPKFAELSGGDNAR FT MFTDTEVGTSNDKKVQTAVWNAGMGVGVGNLTIFPHQWINLRTNNSATIVMPYINSVPM FT DNMYRHNNLTLMIIPFVPLNYSEGSSPYVPITVTIAPMCAEYNGLRLASSQGLPVMTTP FT GSTQFLTSDDFQSPSAMPQFDVTPEMQIPGRVNNLMEIAEVDSVVPVNNTDNNVNGLKA FT YQIPVQSNSDNRRQVFGFPLQPGANNVLNRTLLGEILNYYTHWSGSIKLTFMFCGSAMA FT TGKFLLAYSPPGAGVPKNRRDAMLGTHVIWDVGLQSSCVLCVPWISQTHYRYVVEDEYT FT AAGYVTCWYQTNIIVPADVQSTCDILCFVSACNDFSVRMLKDTPFIRQDNFYQGPVEES FT VERAMVRVADTVSSKPTNSESIPALTAAETGHTSQVVPSDTMQTRHVKNYHSRSESSIE FT NFLCRSACVYYATYNNNSEKGYAEWVINTRQVAQLLRRKLEFTYLRFDLELTFVITSAQ FT EPSTATSVDAPVQTQQIMYVPPGGPVPTKVTDYAWQTSTNPSVFWTEGNAPPRMSIPFI FT SIGNAYSCFYDGWTQFSRNGVYGINTLNNMGTLYMRHVNEAGQGPIKSTVRIYFKPKHV FT KAWVPRPPRLCQYEKQKNVNFNPTGVTTTRSNITTTGAFGQQSGAVYVGNYRVVNRHLA FT TREDWQRCVWEDYNRDLLVSTTTAHGCDIIARCQCTTGVYFCASRNKHYPVSFEGPGLV FT EVQESEYYPKRYQSHVLLAAGFSEPGDCGGILRCEHGVVGIVTMGGEGVVGFADVRDLL FT WLEDDAMEQGVKDYVEQLGNAFGSGFTNQVCEQVNLLKESLVGQDSILEKSLKALVKIV FT SALVIVVRNHDDLITVTATLALIGCTSSPWRWLKQKVSQYYGIPMAERQNSGWLKKFTE FT MTNACKGMEWIAIKIQKFIEWLKVKILPEVKEKHEFLNRLKQLPLLESQIATIEQSAPS FT QSDQEQLFSNVQYFAHYCRKYAPLYAAEAKRVFSLEKKMSNYIQFKSKCRIEPVCLLLH FT GSPGAGKSVATNLIGRSLAEKLNSSVYSLPPDPDHFDGYKQQAVVIMDDLCQNPDGKDV FT SLFCQMVSSVDFVPPMAALEEKGILFTSPFVLASTNAGSINAPTVSDSRALARRFHFDM FT NIEVISMYSQNGKINMPMSVKTCDEECCPVNFKKCCPLVCGKAIQFIDRRTQVRYSLDM FT LVTEMFREYNHRHSVGATLEALFQGPPIYREIKISIAPETPPPPAIADLLKSVDSEAVR FT EYCKEKGWLVPEINSTLQIEKHVSRAFICLQALTTFVSVAGIIYIIYKLFAGFQGAYTG FT MPNQKPKVPTLRQAKVQGPVFEFAVAMMKRNSSTVKTEYGEFTMLGIYDRWAVLPRHAK FT PGPTILMNDQEIGVLDAKELVDKDGTNLELTLLKLNRNEKFRDIRGFLAKEEVEVNEAV FT LAINTSKFPNMYIPVGQVTEYGFLNLGGTPTKRMLMYNFPTRAGQCGGVLMSTGKVLGI FT HVGGNGHQGFSAALLKHYFNDEQGEIEFIESSKEAGFPVINTPSKTKLEPSVFHQVFEG FT NKEPAVLRNGDPRLRANFEEAIFSKYIGNVNTHVDEYMLEAVDHYAGQLATLDISTEPM FT RLEDAVYGTEGLEALDLTTSAGYPYVALGIKKRDILSKKTRDLTKLKECMDKYGLNLPM FT VTYVKDELRSAEKVAKGKSRLIEASSLNDSVAMRQTFGNLYKTFHLNPGIVTGSAVGCD FT PDLFWSKIPVMLDGHLVAFDYSGYDASLSPVWFACLKLLLEKLGYSHKETNYIDYLCNS FT HHLYRDKHYFVRGGMPSGCSGTSIFNSMINNIIIRTLMLKVYKGIDLDQFRMIAYGDDV FT IASYPWPIDASLLAEAGRDCGLIMTPADKGDCFNEVTWANVTFLKRYFRADEQYPFLVH FT PVMPMKDIHESIRWTKDPKNTQDHVRSLCLLAWHNGEHEYEEFIRKIRSVPVGACLTLP FT AFSTLRRKWLDSF" FT mat_peptide 949..1737 FT /product="1B(VP2)" FT /note="1B(VP2) mature peptide /pattern" FT mat_peptide 1738..2451 FT /product="1C(VP3)" FT /note="1C(VP3) mature peptide /pattern" FT mat_peptide 2452..3285 FT /product="1D(VP1)" FT /note="1D(VP1) mature peptide /pattern" FT mat_peptide 3286..3735 FT /product="2A" FT /note="2A mature peptide /pattern" FT mat_peptide 3736..4032 FT /product="2B" FT /note="2B mature peptide /pattern" FT mat_peptide 4033..5019 FT /product="2C" FT /note="2C mature peptide /pattern" FT mat_peptide 5020..5286 FT /product="3A" FT /note="3A mature peptide /pattern" FT mat_peptide 5287..5352 FT /product="3B(VPg)" FT /note="3B(VPg) mature peptide /pattern" FT mat_peptide 5353..5901 FT /product="3C" FT /note="3C mature peptide /pattern" FT mat_peptide 5902..7287 FT /product="3D" FT /note="3D mature peptide /pattern" XX SQ Sequence 7389 BP; 2107 A; 1678 C; 1812 G; 1792 T; 0 other; ttaaaacagc ctgtgggttg ttcccaccca caggcccatt gggcgctagc actctggtat 60 cacggtacct ttgtgcgcct gttttacatc ccctccccaa attgtaattt agaagtttca 120 cacaccgatc attagcaagc gtggcacacc agccatgttt tgatcaagca cttctgttac 180 cccggactga gtatcaatag accgctaacg cggttgaagg agaaaacgtt cgttacccgg 240 ccaactactt cgaaaaacct agtaacacca tggaagttgc ggagtgtttc gctcagcact 300 accccagtgt agatcaggtc gatgagtcac cgcgttcccc acgggcgacc gtggcggtgg 360 ctgcgttggc ggcctgccta cggggaaacc cgtaggacgc tctaatacag acatggtgcg 420 aagagtctat tgagctagtt ggtaatcctc cggcccctga atgcggctaa tcctaactgc 480 ggagcacata ccctcaaacc agggggcagt gtgtcgtaac gggcaactct gcagcggaac 540 cgactacttt gggtgtccgt gtttcatttt attcctatac tggctgctta tggtgacaat 600 tgacaggttg ttaccatata gttattggat tggccatccg gtgactaaca gagcaattat 660 atatctcttt gttgggttta taccacttag cttgaaagag gttaaaacac tacatctcat 720 cattaaacta aatacaacaa aatgggggct caagtatcaa cacaaaagac tggagcacat 780 gagaccgggc tgaatgcaag cgggaattcc atcatccatt acacaaacat aaactactat 840 aaagatgctg catccaactc agccaacaga caggatttca ctcaagaccc aggtaaattt 900 actgagccag tgaaggacat tatgatcaaa tcgatgccag cattgaactc cccctctgcc 960 gaagagtgtg gttatagtga cagggttcga tcaataaccc tcgggaactc cactatcaca 1020 acacaggagt gtgctaatgt tgtggttggg tatggtgtgt ggccagaata tttgaaggac 1080 aatgaagcca caggcgagga ccaaccaaca caacccgacg tggccacatg tcggttctac 1140 actttagagt ccgtgcagtg gatgaagaat tcagcaggtt ggtggtggaa gttaccagat 1200 gcactttcac aaatggggtt gtttggacaa aatatgcagt accactactt agggagaaca 1260 ggctacacca tccacgtgca gtgcaacgca tctaagtttc atcagggctg tctactagtg 1320 gtgtgtgtgc cggaagcgga aatgggatgc tcaaatctaa acaacacccc aaagtttgct 1380 gaactttccg gaggagataa tgctagaatg ttcactgaca ccgaagtggg gacatccaac 1440 gataagaaag tacaaacagc agtgtggaat gcaggtatgg gtgttggtgt tggcaacctg 1500 actatattcc cacaccagtg gatcaacctg aggacaaaca atagtgctac cattgtaatg 1560 ccttacatca acagcgttcc catggacaac atgtatagac acaacaactt gacactgatg 1620 ataatcccat tcgtcccgct caactatagt gagggatcat caccttacgt accaatcaca 1680 gtcacaattg cgccaatgtg cgcagaatac aatggcctta gactggctag tagccagggt 1740 ttgcccgtca tgacgacacc gggtagcacg caatttctga cttctgatga tttccaatcg 1800 ccatcagcaa tgccacaatt cgacgtcaca ccagagatgc agatcccggg tcgtgtcaac 1860 aatctgatgg aaatagctga ggtggactct gtggtcccag tgaacaacac tgacaacaac 1920 gtgaatggtc ttaaagccta ccaaatcccc gtgcaatcca atagcgacaa tagaaggcaa 1980 gtgttcgggt ttcccttaca acctggggcc aacaatgttc tcaacaggac tttgttaggt 2040 gagattttga actactacac ccactggagt ggtagtataa agctcacgtt catgttttgt 2100 ggatcggcga tggccactgg gaagtttttg ttagcatact caccaccagg cgcaggggtt 2160 ccaaaaaaca gaagagacgc aatgttgggt acacatgtca tctgggacgt gggtttgcaa 2220 tcaagttgtg tactttgtgt accctggatc agccagacac actataggta tgtggtggag 2280 gatgagtata cagcggcagg gtatgttaca tgctggtacc aaacaaatat cattgttcca 2340 gcggacgttc aaagcacatg cgacatcttg tgcttcgtat cggcatgcaa tgatttctct 2400 gtgcgtatgt taaaggatac cccttttata agacaagaca atttttacca gggcccagtg 2460 gaagaatcgg tggaacgcgc catggtgcgc gtggctgata cggtcagctc aaagcctacg 2520 aattcagaat ccatccccgc cctcactgct gcggagactg gtcatacctc tcaagtcgta 2580 cccagtgaca ccatgcaaac tagacacgtg aagaattacc actcaaggtc ggaatcttcc 2640 attgaaaatt tcttgtgccg atctgcttgt gtgtattacg ccacctacaa taataattct 2700 gagaagggct acgcagagtg ggttatcaac accaggcagg ttgcgcagtt gctgaggagg 2760 aaactagagt tcacttactt aaggttcgat ctggaattga catttgtgat aacaagtgcc 2820 caggagccca gtaccgctac cagtgtagac gcacctgtac aaacccaaca gataatgtat 2880 gtgcctccag gcgggccggt acctaccaag gttacagact acgcctggca aacatccaca 2940 aaccccagcg tcttttggac agaggggaat gccccaccga ggatgtctat tcccttcatc 3000 agtattggaa atgcttatag ctgcttttat gatggatgga cacagttctc taggaatggg 3060 gtttacggca ttaataccct gaacaacatg ggtacgctgt acatgcggca cgtaaatgag 3120 gcaggccaag gcccgatcaa aagtacagtt agaatatatt ttaaacccaa acatgtgaag 3180 gcgtgggtgc ccagaccgcc gaggctatgt caatatgaga agcaaaagaa tgttaatttc 3240 aacccaacag gagtcaccac aacgcgctca aacattacca caaccggcgc ttttggacaa 3300 cagtcagggg ctgtctacgt aggcaactac agagtggtga atagacacct cgccacccgc 3360 gaggactggc agcggtgcgt gtgggaagat tacaacagag atcttcttgt gagtacaacc 3420 acggcacatg gatgcgatat catagccagg tgtcagtgca caaccggggt ttatttctgt 3480 gcgtcaagga ataagcacta tccagtttcc tttgaggggc cgggtcttgt ggaggttcaa 3540 gagagtgagt actatccaaa gaggtaccaa tcccacgtgc ttttagcggc aggcttttcc 3600 gaaccagggg attgtggtgg aatcctaagg tgcgaacatg gtgtcgtggg cattgtaact 3660 atgggagggg agggtgttgt tggctttgcc gacgtacgcg acctgctgtg gttagaagat 3720 gatgcaatgg agcagggggt caaagattac gtagagcaac ttggaaacgc ctttgggtca 3780 ggattcacta accaagtctg tgaacaggtt aaccttttga aagagtccct agtgggccaa 3840 gactccatct tagaaaaatc tctgaaagcc ctagtaaaaa ttgtgtcagc cttggtgata 3900 gtcgtgagga accacgacga tttaataaca gtgactgcaa cacttgccct cattggctgc 3960 acctcctcac catggagatg gcttaagcaa aaggtgtccc agtactatgg cattccaatg 4020 gctgagcgcc agaacagtgg ttggctcaag aagttcactg aaatgaccaa cgcctgcaag 4080 ggaatggagt ggatagctat taaaatccag aaatttatag aatggctcaa agttaaaatc 4140 ctaccagaag ttaaagaaaa acatgagttc ttaaacagac ttaaacaact tccgttactg 4200 gagagtcaga ttgccaccat tgagcaaagt gcaccttctc agagtgatca agagcaattg 4260 ttttctaatg ttcagtactt tgcacattac tgcaggaaat acgcacccct gtatgcggcc 4320 gaagcaaaaa gggtgttctc ccttgagaag aaaatgagta actacataca gttcaagtcc 4380 aaatgccgta ttgaacctgt atgcttgctc ttgcacggga gtcctggtgc agggaagtca 4440 gttgccacta acctgattgg gcgctcactc gcggagaagc ttaatagctc tgtgtactct 4500 ctaccaccag acccagacca ttttgacggt tacaaacaac aggccgttgt gatcatggat 4560 gatttatgcc agaacccaga tggtaaggat gtttctttgt tttgtcaaat ggtctccagt 4620 gtggactttg taccgccaat ggcagcgcta gaagagaaag gcattttgtt cacctctccc 4680 tttgtcctgg cttcaaccaa cgccggctct attaatgctc caacagtttc agacagtagg 4740 gcactggcta ggaggtttca ctttgatatg aacatcgagg tcatttccat gtacagccag 4800 aatgggaaga taaacatgcc tatgtcggtg aagacgtgtg atgaagagtg ttgcccagtc 4860 aactttaaga aatgctgccc cttagtgtgt ggaaaggcta tccagtttat agatagaagg 4920 acacaagtca gatactccct tgacatgctg gtaactgaga tgttcagaga atataaccat 4980 agacatagtg ttggggccac ccttgaggcg ctatttcagg gcccgccaat atatagagag 5040 attaagatca gtattgcgcc agagacgcca ccaccacctg ccattgcaga tctactcaaa 5100 tcagtagaca gtgaggctgt gagggagtac tgcaaagaaa aaggatggct ggttccagag 5160 atcaactcca ccctgcagat tgaaaagcac gtcagtaggg cctttatctg tttgcaagca 5220 ttgactactt ttgtctcagt agcaggaatc atctacataa tatataaact cttcgcaggc 5280 tttcaaggag catacacggg aatgcccaat cagaagccca aggtacccac tctccgtcaa 5340 gcaaaagtac aaggacctgt atttgagttt gccgtagcca tgatgaagag gaattcgagc 5400 acagtgaaaa ctgaatacgg tgagttcact atgctgggta tctatgatag gtgggctgtt 5460 ttgccacgtc atgccaaacc tgggccaacc atcttaatga atgatcaaga aattggtgtg 5520 ctagacgcca aggagttagt ggacaaggac ggtacaaact tggaactgac actacttaag 5580 ctgaaccgaa atgaaaagtt cagagatatt aggggcttct tagccaagga agaggtggag 5640 gttaatgagg ctgtgctagc aattaacacc agcaagttcc ctaacatgta tatcccagtg 5700 ggacaagtta cagagtatgg cttcctgaat ctgggtggta cacccaccaa gagaatgctt 5760 atgtacaact tccccacgag ggcaggtcag tgtggcggag tgctcatgtc cactggcaaa 5820 gttttgggga tccatgttgg cgggaatggt catcaaggct tctcagcggc acttcttaaa 5880 cactacttca atgatgaaca aggagaaatc gagttcattg aaagctcaaa ggaagcaggg 5940 ttcccagtca tcaacacgcc tagcaaaact aaattggagc caagtgtctt ccaccaggtt 6000 tttgaaggca ataaagagcc agcagtcctc aggaatggcg atccacgcct cagagccaac 6060 tttgaggagg ccatattttc caaatacatc ggaaatgtta acacacacgt ggatgaatac 6120 atgctggaag ctgttgacca ttatgctggt caattggcaa ccttagacat cagcaccgag 6180 ccaatgagat tggaagatgc tgtatatggt actgaaggcc ttgaggctct tgatttaaca 6240 acgagtgcgg gctacccgta tgtcgctctg ggcattaaaa agagggacat cctctcaaag 6300 aagaccagag acctgaccaa gctgaaggag tgcatggaca agtatggcct aaacctacca 6360 atggtaacct atgtgaaaga tgaactcaga tctgcagaga aggtggcgaa agggaaatct 6420 aggctaattg aggcatccag tttgaatgac tccgtggcaa tgagacaaac atttggcaac 6480 ctatacaaaa cttttcacct aaacccaggg attgtaactg gcagtgccgt cgggtgtgat 6540 ccagatctct tttggagcaa gataccagtg atgttggatg gccatctcgt agcttttgat 6600 tattctggat atgacgctag cttgagtccc gtatggtttg cctgtctaaa gctactgctt 6660 gagaaacttg gttactcgca caaggagacc aattacattg actacctgtg caactcccat 6720 cacctgtaca gggataaaca ttactttgtg cggggtggca tgccatcagg atgctctggc 6780 acaagcatct tcaactcaat gataaataac atcataatca ggacactaat gttgaaggtg 6840 tacaaaggga tcgacttgga tcaattcaga atgattgctt atggtgatga cgtgatcgca 6900 tcatatccgt ggcccataga tgcgtccctg cttgctgaag ctggtaggga ttgtgggttg 6960 atcatgacac cagcagacaa aggggattgc ttcaatgaag tcacctgggc taatgtcaca 7020 tttctaaaga ggtattttag agcagatgaa cagtacccct ttttagtgca ccccgtcatg 7080 cctatgaaag acatacatga atcaatcaga tggaccaagg acccaaagaa cacccaagat 7140 catgtgcgct cgttgtgctt attggcctgg cacaacgggg agcacgaata tgaggagttc 7200 atccgcaaaa ttagaagcgt cccagttgga gcttgcttga ctctacctgc gttttcaact 7260 ctacgcagga agtggttgga ctctttttaa attagagaca atttgaacta attttaattg 7320 gcttaaccct accgcactaa ccgaactaga taacggtgca gtgggggtaa attctccgca 7380 ttcggtgcg 7389 //