ID M14008; SV 1; linear; genomic RNA; STD; VRL; 2630 BP. XX AC M14008; XX DT 19-SEP-1987 (Rel. 13, Created) DT 01-MAR-2018 (Rel. 136, Last updated, Version 4) XX DE Avian carcinoma Mill Hill virus 2 strain MH2E21, complete genome. XX KW c-myc proto-oncogene; complete genome; long terminal repeat (LTR); KW myc gene. XX OS Avian carcinoma Mill Hill virus 2 OC Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus. XX RN [1] RP 1-2630 RX PUBMED; 3016301. RA Patschinsky T., Jansen H.W., Blocker H., Frank R., Bister K.; RT "Structure and transforming function of transduced mutant alleles of the RT chicken c-myc gene"; RL J. Virol. 59(2):341-353(1986). XX DR MD5; 4f91901a83bb27be358411b00cfb269e. DR EuropePMC; PMC111557; 10590135. DR EuropePMC; PMC291877; 14654682. DR RFAM; RF00214; Retro_dr1. DR RFAM; RF00467; RSV_PBS. XX CC Computer-readable sequence kindly provided by K.Bister CC (26-JAN-1987). CC The sequence presented below represents the complete proviral CC genome including two complete LTRs derived from figure 3 in [1]. CC The terminal inverted repeats 5' 'aatg' and 'catt' 3' (positions CC 1-4 and 2627-2630 respectively) may not be completely present in CC the integrated proviral DNA. CC The MH2E21 myc protein differs from chicken c-myc and MH2 virus CC v-myc. [1] constucted various mutants of MH2E21 that expressed CC variant myc proteins. CC [1] describes the construction and isolation of the MH2E21 CC retrovirus. The MH2E21 virus appears to be a recombinant between CC ring-necked pheasant virus and a deletion mutant of MH2 that was CC constructed in vitro. CC The MH2E21 virus lacks gag, pol and env genes, and thus needs a CC helper virus to reproduce. XX FH Key Location/Qualifiers FH FT source 1..2630 FT /organism="Avian carcinoma Mill Hill virus 2" FT /strain="MH2E21" FT /mol_type="genomic RNA" FT /db_xref="taxon:11870" FT repeat_region 1..357 FT /rpt_type=LONG_TERMINAL_REPEAT FT /note="5' LTR" FT repeat_region 257..277 FT /note="5' R region" FT CDS 655..1926 FT /codon_start=1 FT /product="v-myc (59/61 kDa) protein" FT /db_xref="GOA:P0C0N8" FT /db_xref="InterPro:IPR002418" FT /db_xref="InterPro:IPR003327" FT /db_xref="InterPro:IPR011598" FT /db_xref="InterPro:IPR012682" FT /db_xref="InterPro:IPR036638" FT /db_xref="UniProtKB/Swiss-Prot:P0C0N8" FT /protein_id="AAA42389.1" FT /translation="MEAVIKAAAAAMPLSVSLPSKNYDYDYDSVQPYFYFEEEEENFYL FT AAQQRSSELQPPAPSEDIWKKFELLPAPPLSPSCRSNLAAASCFPSTADQLEMVTELLG FT GDMVNQSSICDPDDESFVKSIIIRDCMWSGFSAAAKLEKVVSEKLATYKASRREGGPAA FT ASRPGPPPSGPPPPPAGPAASAGLYLHDLGAAAAGCIGSSVVFPCPLGRRGPPGAGPAA FT LLGVDAPPTAGGGSEEEQEEDEEIDVVTLAEANESESSTESSTEASEEHCKPHHSPLVL FT ERCHVNIHQHNYAAPPSTKVEYPAAKRLKLDSGRVLKQVSNNRKCSSPRTSDSEVNDKR FT RTHNVLERQRRNELKLSFFALRDQIPEVANNEKAPKVVILKRATEYVLSIQSDEHRLIA FT EKEQLRRRREQLKHKLEQLRNSRA" FT repeat_region 2274..2630 FT /rpt_type=LONG_TERMINAL_REPEAT FT /note="3' LTR" FT repeat_region 2530..2550 FT /note="3' R region" XX SQ Sequence 2630 BP; 628 A; 718 C; 765 G; 519 T; 0 other; aatgtagtct tatgcaatac tcttgtagtc ttgcaacatg cttatgtaac gatgagttag 60 caacatgcct tataaggaaa gaaaaagcac cgtgcatgcc gattggtgga agtaaggtgg 120 tatgatcgtg gtatgatcgt ggtatgatcg tgccttatta ggaaggcaac agacgggtct 180 aacacggatt ggacgaacca ctgaattccg cattgcagag atattgtatt taagtgccta 240 gctcgataca ataaacgcca tttgaccatt caccacattg gtgtgcacct gggttgatgg 300 ccggaccgtt gattccctga cgactacgag cacatgcatg aagcagaagg cttcatttgg 360 tgaccccgac gtgatcgtta gggaatagtg gtcggccaca ggcggcgtgg cgatcctgtc 420 ctcatccgtc tcgcttattc ggggagcgga cgatgaccct agtagagggg gctgcggctt 480 aggagggcag aagctgagtg acgtcggagg gagctccacg gccgggggcc aagataccct 540 accgagaact cagagagtcg ttggaagacg ggaagaaagc ccgacgactg agcggtccac 600 cccaggcgtg attccggttg ctctgcgtga ttccggtcgc ccggtgaatc aagcatggaa 660 gccgtcataa aggcagcagc cgccgcgatg ccgctcagcg tcagcctccc cagcaagaac 720 tacgattacg actacgactc ggtgcagccc tacttctact tcgaggagga ggaggagaac 780 ttctacctgg cggcgcagca gcggagcagc gagctgcagc ctccagcccc gtccgaggac 840 atctggaaga agtttgagct cctgcccgcg ccgcccctct cgcccagctg ccgctccaac 900 ctggccgccg cctcctgctt cccttccacc gccgaccagc tggagatggt gacggagctg 960 ctcggggggg acatggtcaa ccagagctcc atctgcgacc cggacgacga atccttcgtc 1020 aaatccatca tcatccggga ctgcatgtgg agcggcttct ccgccgccgc caagctggag 1080 aaggtggtgt cggagaagct cgccacctac aaagcctccc gccgggaggg gggccccgcc 1140 gccgcctccc gacccggccc gccgccctcg gggccgccgc ctcctcccgc cggccccgcc 1200 gcctcggccg gcctctacct gcacgacctg ggagccgcgg ccgccggctg catcggctcc 1260 tcggtggtct tcccctgccc gctcggcagg cgcggcccgc ccggcgccgg ccccgcggct 1320 ctgctggggg tcgacgcgcc gcccacggcc ggcggcggct cggaggaaga acaagaagaa 1380 gatgaggaaa tcgatgtcgt tacattagct gaagcgaacg agtctgaatc cagcacagag 1440 tccagcacag aagcatcaga ggagcactgt aagccccacc acagtccgct ggtcctcgag 1500 cggtgtcacg tcaacatcca ccaacacaac tacgctgctc ctccctccac caaggtggaa 1560 tacccagccg ccaagaggct aaagttggac agtggcaggg tcctcaaaca ggtcagcaac 1620 aaccgaaaat gctccagtcc ccgcacgtca gactcagagg tgaacgacaa gaggcgaacg 1680 cacaacgtct tggagcgcca gcgaaggaat gagctgaagc tgagcttctt tgccctgcgg 1740 gaccagatac ccgaggtggc caacaacgag aaggcgccca aggttgtcat cctgaaaaga 1800 gccacggagt acgttctgtc tatccaatcg gacgagcaca gactgatcgc agagaaagag 1860 cagttgaggc ggaggagaga acagttgaaa cacaaacttg agcagctaag gaactctcgt 1920 gcataggaac tcttggacat cacttagaat accccaaact agactccgtg tgatagctgg 1980 ttggatcgtt aatcggacgg ctggcacacg gaatgtagga ggtcgctgag taagtacgaa 2040 caaaatttac gttgtaataa ggtgaggctt gacctacaat tgttcaaata atgcttctgt 2100 agaaatgttt agcattaggc atcttgcgct gctccgcgat gtacgggtca ggtataatgt 2160 gcagtttgac tgaggggacc atgatatgta taggcgaaag gcggggcttc ggttgtacgc 2220 ggttaggagt cccctcagga tatagtagtt tcgcttttgc atagggaggg ggaaatgtag 2280 tcttatgcaa tactcttgta gtcttgcaac atgcttatgt aacgatgagt tagcaacatg 2340 ccttataagg aaagaaaaag caccgtgcat gccgattggt ggaagtaagg tggtatgatc 2400 gtggtatgat cgtggtatga tcgtgcctta ttaggaaggc aacagacggg tctaacacgg 2460 attggacgaa ccactgaatt ccgcattgca gagatattgt atttaagtgc ctagctcgat 2520 acaataaacg ccatttgacc attcaccaca ttggtgtgca cctgggttga tggccggacc 2580 gttgattccc tgacgactac gagcacatgc atgaagcaga aggcttcatt 2630 //