ID JX857870; SV 1; linear; genomic RNA; STD; VRL; 6124 BP. XX AC JX857870; XX DT 31-OCT-2012 (Rel. 114, Created) DT 17-JAN-2013 (Rel. 115, Last updated, Version 2) XX DE Astrovirus MLB3 isolate MLB3/human/Vellore/26564/2004, complete genome. XX KW . XX OS Astrovirus MLB3 OC Viruses; Riboviria; Astroviridae; unclassified Astroviridae. XX RN [1] RP 1-6124 RX PUBMED; 23084422. RA Jiang H., Holtz L.R., Bauer I., Franz C.J., Zhao G., Bodhidatta L., RA Shrestha S.K., Kang G., Wang D.; RT "Comparison of novel MLB-clade, VA-clade and classic human astroviruses RT highlights constrained evolution of the classic human astrovirus RT nonstructural genes"; RL Virology 436(1):8-14(2013). XX RN [2] RP 1-6124 RA Jiang H., Holtz L.R., Bauer I., Franz C.J., Zhao G., Bodhidatta L., RA Shrestha S.K., Kang G., Wang D.; RT ; RL Submitted (20-SEP-2012) to the INSDC. RL Molecular Microbiology, Washington University in St. Louis, School of RL Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA XX DR MD5; fb1f3888b7aa24981dc2dd415d66f104. DR EuropePMC; PMC3545029; 23084422. DR EuropePMC; PMC4465002; 25975198. DR EuropePMC; PMC6081416; 30087387. XX FH Key Location/Qualifiers FH FT source 1..6124 FT /organism="Astrovirus MLB3" FT /host="Homo sapiens" FT /isolate="MLB3/human/Vellore/26564/2004" FT /mol_type="genomic RNA" FT /country="India" FT /isolation_source="stool" FT /collection_date="2004" FT /db_xref="taxon:1247114" FT 5'UTR 1..14 FT CDS 15..2378 FT /codon_start=1 FT /product="ORF1a" FT /note="putative serine protease" FT /db_xref="GOA:K4PES8" FT /db_xref="InterPro:IPR009003" FT /db_xref="UniProtKB/TrEMBL:K4PES8" FT /protein_id="AFV53442.1" FT /translation="MAMPFHIGVADKLMSMGSSRSRMWLNELHPAVQNQLREIFPYEVP FT LNTMIVPLSRYSLGTGVTLAVQGMTELSEYNTYVLHHDSWLEVDEDRVDPACAYIGTLA FT LDRLKLLERNRELQDENSTLIMDNQLLRHEVERLRPPATRPVRFSNFALFVLFFFLFFI FT IGTKAESWQDQTKDYIMDSLQGIKYEFITNLDVYYSFLLGCIRWEVVSCTIALFSFFKL FT KRPCIAIVGLFLATISRYNYSALSIVPYLDVYSTAFLYVLMVVYFLVPHVAVVTSVLCA FT TLFTLVSMICPHHMFITRVRGDWLVVLVTFATYLCDSMGIHTTAIAIMAAVVRIYTCLP FT AASSSVVEIKDSTGKVVQKSTLMPNWLGTMYQSARGMFQRVRSGVASFVRVNPNCLCHI FT KVDGCSGTGFRLGNDIVTAAHVIGNATQVEVVYNNYVAQAKVRHIPDKDIAYLILPEGL FT KSMPVLKLAKTPSYEQVTIIALEGNCMLIPTTEGVCHGETISYACATRDGMSGAPVLDV FT NGNVLGVHQTNTGYTGGATVIRATDAAPYIDENAALKREIEELKKIIKEHALQQRAVQD FT NEVVGIVRAAVQREIGVLRDELNSCYQKKKGKNKKGRGARHRMLRRGQKFLTEEEYQEL FT LDKGLTREQLLDAIEEIVRSRIGFPDWSDPEYSSEEDDAAITYWWEQVKEDNYKDGVPQ FT FEHIVPKYSPNERTFSEQERKDVAKELEMLQSIVDKVNKDEWDEKKKQITDDLNHALYI FT VDKALAQHGYILFEQRMRPKNGKRGPRRRTPNTT" FT CDS <2315..3850 FT /codon_start=1 FT /product="ORF1b" FT /note="putative RNA-dependent RNA polymerase" FT /db_xref="GOA:K4P3P6" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR007094" FT /db_xref="UniProtKB/TrEMBL:K4P3P6" FT /protein_id="AFV53443.1" FT /translation="TKNEAKKREKGSSEEDPKHYLDSWIGMLMPCTRWLVPERYPLYGG FT VPLDRPVFDFKIVNEDLLGLLPPPPNSDFDVFGPTVWDEIAYKKSFEKFEYAEYSDFLN FT MYSDCVAFADSRFLEHFNFLSESGFTHILGTDKNIESTPAYPKMRWWSTEEDYLEEHGW FT EYYVKEFENIASGQNFDVCWYLFLKKEILKQTKIDEGDVRQIVCADPIYSRIGACFEQH FT QNKTMKEYTEKSSGQCGWSPFFGGFEQRMCRLEGKGNSIYVELDWTRFDGTIPPTLLLH FT IKKLRFSLMGDVAHKYENVYKWYCRNLVHRYVILPSGEVTLQNRGNPSGQISTTMDNNM FT INYWLQAFEFKYLGLPEEEWIHFDTIVYGDDRLSTYRTLPDNYVNQVVNMYKDVFGMWV FT KPEKVKVSNTLKGLSFCGFTNTDNGPVPSEPYKLMASLLKPVTKLPDIIALHGKLLCFQ FT LLMANNVEHPFYGYVEQCLHYTHRALSDASLPRRFTRRQLEYIWRGGPNGDYG" FT CDS 3843..6086 FT /codon_start=1 FT /product="putative capsid protein" FT /note="ORF2" FT /db_xref="InterPro:IPR004337" FT /db_xref="InterPro:IPR022027" FT /db_xref="InterPro:IPR029053" FT /db_xref="UniProtKB/TrEMBL:K4P1D9" FT /protein_id="AFV53444.1" FT /translation="MANANKGVTINVGNVKRKQRAPGNQRAKPPGPSPKRTFKLRKRWH FT FPNRNRRRRANLNTTGPKPAVSQTITATLGTVGSNLSDVVETECAVFLNPVVAKDSGAS FT ATFGPLQSLGAQYALWRLKWLEVRLQPLVGSSAVSGTVVRVSLNMTTGPTLNSWSGLGA FT RFHRDVRVGSGLVWKITQRHVSGPCETWWKTDTAEDPSLSLGPALEVHTIGKTMSTYKN FT ETFTAGLFLLEITGHWEFANYAASPALATLTQHKDDSETTKTLAISAEGANEPVEMLIP FT VGKWNMKEQYGGNGTLGEAIYQVVDTSVTVVTDLFPPPFSWLGKASWWFIRKVIGKSKT FT YTISGTNQQITADVYRVYTSASAARDDKPAISSTAHQAKNLTGSVVITQISTDNILNET FT TYTGPRSILPDQPIGPSSYPMTPDSLVLMAGYFRSPEINDNFGMYLPYVFQQSTSVIQF FT GSGNHRVMVVGLWTVERLMWLDKHFNHYTNEPDGVFGEVGNIFINNDNVAKVITMSGSS FT ATSERGATLMLCKTTKPVQNFNLTANVFIPAYRVVDGQGGKDVKIQINLWEENKQLQFP FT AMPSGTYFMVLTMGGGTFTVGRYLVYNERINNDLQLSAFWGKYLSQAMGLSWSSPTYAC FT VTWEPIYSNETIHHRMIDESESDESEDDDDPDEFFDEDPITTLHAIDSERTIRRTIFSA FT LLDGGVDVDRAAEYAARACPTEIQRRRRGLYESLLSDGLSPETSYSEACLLDK" FT 3'UTR 6087..6124 XX SQ Sequence 6124 BP; 1861 A; 1103 C; 1348 G; 1812 T; 0 other; ccaagagtgg taggatggct atgcctttcc atattggtgt tgcagacaag ttaatgtcaa 60 tgggatcttc caggtcacgc atgtggctta atgagttaca tccagctgtt caaaatcagc 120 ttcgggagat atttccctat gaggttccat tgaataccat gattgttcca ctttcacggt 180 attcccttgg gacaggtgtt acacttgctg tccaagggat gactgaactt agtgaataca 240 acacctacgt gttgcaccat gattcatggc ttgaggttga tgaagatcga gtggatcctg 300 catgtgccta tattggcaca ttggcactag atagactcaa gctacttgaa cgtaaccgtg 360 aattgcaaga tgaaaattca acattaatta tggacaatca attactgcga cacgaagtgg 420 agaggctgag accacctgct actcgaccgg tgcgatttag taatttcgca ctttttgttc 480 tctttttctt ccttttcttt ataattggaa caaaggcaga aagttggcag gatcagacta 540 aagattatat aatggattca ttacaaggca taaagtatga atttattaca aatttggatg 600 tttattattc cttcctattg ggatgtatta ggtgggaagt tgtgtcatgc actatagctc 660 ttttctcttt ctttaaatta aagaggccct gtatagcaat tgtaggttta tttttagcaa 720 ctatatcaag gtacaattac tcagctttgt ccattgttcc ataccttgat gtttatagta 780 ctgcattttt gtatgtgtta atggttgtct atttccttgt gcctcatgta gcagttgtga 840 catctgtttt atgtgctaca ctttttacac ttgttagtat gatatgccca catcacatgt 900 ttataacacg tgtacgtggt gattggcttg tggtgttagt tacttttgca acatatttgt 960 gtgactccat gggcatacat actacagcca ttgctattat ggctgctgtg gtacgtattt 1020 atacgtgtct accagctgct tcttcatctg ttgttgagat aaaagacagt acaggtaagg 1080 ttgtacaaaa atccactctt atgccaaact ggttgggcac aatgtaccag agtgctcgtg 1140 gcatgttcca acgagttcgc tctggtgtag cgtcctttgt aagagttaac ccaaactgtc 1200 tatgtcatat aaaagttgat ggctgtagtg gcacaggttt tagacttggc aatgatattg 1260 tcacagctgc acatgtcata ggcaacgcaa cgcaagttga ggttgtctac aacaattatg 1320 ttgcccaagc aaaggttaga cacataccag ataaagatat agcatatctt attcttccag 1380 aaggattgaa atcaatgcca gtacttaaac tagcaaaaac accttcatat gaacaggtta 1440 ccattattgc acttgaaggg aactgtatgt taatacctac tacagagggt gtttgccatg 1500 gtgaaacaat ttcatacgct tgtgccacac gagatggcat gagtggtgcc ccagtcttgg 1560 atgttaatgg taatgttcta ggtgtccatc agacaaatac tggctataca ggtggtgcaa 1620 cagttataag agctacagac gcagcaccat atattgatga gaatgctgcg cttaaaagag 1680 aaattgaaga gttgaagaag atcataaaag aacatgcttt gcaacagcgt gctgttcagg 1740 ataatgaagt cgttggcata gtacgtgcag cagtccaacg tgaaattggt gttctccggg 1800 atgagttaaa ttcatgttat cagaaaaaga aaggaaagaa taaaaaagga cgtggcgctc 1860 gtcatagaat gttgcgccgt ggccaaaaat tcttaactga agaagagtat caggaacttt 1920 tagataaggg tcttactagg gaacaactat tggatgctat agaggaaata gttagatcta 1980 gaattggttt tcctgattgg tcagaccctg aatactcatc tgaggaggat gatgctgcaa 2040 tcacttactg gtgggaacag gtgaaagaag acaattataa agatggtgtc ccccagtttg 2100 aacacattgt accaaaatat tcacctaatg aaagaacttt ttctgaacag gagcgcaaag 2160 atgttgcaaa agaattggaa atgctgcaat ccattgttga taaagtgaat aaagatgaat 2220 gggatgagaa aaagaaacaa atcactgatg atttaaatca tgcattgtat attgttgata 2280 aagcattggc acaacatggg tatatcctgt ttgaacaaag aatgaggcca aaaaacggga 2340 aaaggggtcc tcggaggagg accccaaaca ctacctagat tcatggattg gtatgctaat 2400 gccttgcact cggtggctgg tccccgagcg ctatccattg tatggtggtg tacctttaga 2460 taggcctgtt tttgatttta aaatagttaa tgaagattta ttaggtttat tacccccacc 2520 tcccaatagt gattttgatg tttttggtcc tactgtttgg gatgagatag catataaaaa 2580 atcttttgaa aagtttgaat atgcagaata tagtgatttt ttaaatatgt atagtgattg 2640 tgttgccttt gctgatagta gatttttaga gcattttaat tttctatctg agtctggatt 2700 tacacatata ttaggtactg acaaaaatat agagtctaca cctgcatatc caaaaatgag 2760 atggtggtca actgaagaag attatcttga agaacatggt tgggaatatt atgttaaaga 2820 atttgaaaat attgcgtctg gccaaaattt tgatgtgtgt tggtatcttt ttcttaaaaa 2880 agaaattctt aaacaaacaa aaattgatga gggtgatgtc agacaaattg tttgtgcaga 2940 tccaatatat tcacgcatag gtgcgtgttt tgaacaacat caaaataaaa ctatgaaaga 3000 atacactgaa aagtcatctg gacaatgtgg ttggtcaccg ttttttggag gttttgaaca 3060 aaggatgtgt agacttgaag ggaaagggaa ttccatttat gtagaattgg attggaccag 3120 atttgatggt actataccac caacattatt gttgcacatc aaaaaactgc ggttttcctt 3180 aatgggtgat gttgcacata aatatgagaa tgtgtataag tggtattgta gaaacctggt 3240 ccataggtat gtcatacttc cctctggcga agtaaccctc caaaatcgtg gcaatccatc 3300 tggtcaaata tccacaacaa tggacaataa tatgattaat tattggctcc aagcatttga 3360 gtttaaatat ttaggcttac ctgaagagga gtggattcat tttgacacaa tagtgtacgg 3420 tgatgaccga ttgtccactt atagaacatt gccagacaat tatgttaatc aagttgttaa 3480 catgtacaaa gatgtctttg gaatgtgggt taaacctgaa aaagtcaaag tttcaaatac 3540 cctcaaagga ctctcatttt gtggttttac aaacacagat aatggcccag ttcctagtga 3600 accatataaa ttgatggctt ctcttttaaa accagttaca aagctgccag atataatagc 3660 cctacatggg aaacttttgt gcttccagtt gttgatggcg aacaacgtag aacatccatt 3720 ttatggatac gttgagcaat gcctacatta tacacaccga gctcttagtg atgctagctt 3780 gccaaggcgc ttcactcgga gacaattgga gtacatttgg aggggtggac caaatggaga 3840 ttatggctaa tgccaataag ggtgtgacta ttaatgtagg aaatgtcaaa cgcaagcaac 3900 gtgctccagg taaccagcga gctaaacctc ctggacctag tcctaagcga acattcaaac 3960 ttaggaaacg ttggcatttt cctaatagga atcgccgtcg tagggcgaat cttaatacaa 4020 ctgggcctaa acctgcggtg tcgcaaacaa tcactgcaac actcggcacc gttggatcaa 4080 atttaagtga tgttgttgaa acagaatgtg cagttttctt aaatccagtg gtagctaaag 4140 actcaggtgc tagtgccact tttggccctc tgcagtcatt aggtgcacag tatgcactgt 4200 ggaggttgaa atggctagaa gttagacttc agccattagt gggtagttct gcagttagtg 4260 gcacagttgt tagggtcagc ttaaacatga ctactggacc aactttgaac tcatggtctg 4320 gtctcggagc tcggtttcac cgagatgttc gagttggctc tgggcttgtc tggaagataa 4380 cccagaggca tgtttctggc ccgtgtgaaa catggtggaa aacagataca gcagaggacc 4440 catcattatc actgggacct gcacttgagg tccacaccat tggtaaaacc atgagtacat 4500 ataaaaatga gacttttaca gctggtctgt ttctgttaga aataacagga cattgggaat 4560 ttgcaaatta cgcagcatca ccagcattgg caaccttgac acaacataaa gatgacagtg 4620 aaacaaccaa aaccctcgcc attagcgctg agggtgcaaa tgagccagta gagatgctta 4680 tcccagtagg aaaatggaac atgaaagaac aatatggtgg taatggaaca cttggggaag 4740 caatatatca agttgttgat actagtgtaa ctgtagttac agacttgttc cccccaccgt 4800 tctcatggtt gggtaaagct tcatggtggt ttatcagaaa ggttatagga aaaagcaaga 4860 catatactat atcaggaacc aaccaacaaa ttactgcaga tgtgtatcgt gtttacactt 4920 cagcatctgc cgctagagat gacaaacccg ccatttctag cactgctcac caggccaaaa 4980 atttgactgg ctcagttgtt atcactcaaa tttcaacaga caatatttta aatgagacta 5040 catatacagg accaaggtca attctacccg accaacctat tggcccatct tcttacccaa 5100 tgacaccaga ttcacttgtt cttatggctg gatatttcag gtctccagaa ataaatgaca 5160 attttggtat gtacttgccc tatgttttcc aacaaagtac cagtgtgata cagtttggta 5220 gtggcaacca tcgtgtcatg gttgttggtt tatggacagt agaaagattg atgtggctag 5280 acaaacattt taaccactat accaatgagc cggatggcgt gtttggtgag gttggcaata 5340 tatttatcaa caatgataat gttgccaaag taatcaccat gagtggttca tcagctacat 5400 ctgagagagg tgcaaccctc atgttatgca aaactaccaa accagttcaa aatttcaatc 5460 tcactgctaa tgtttttata ccagcctata gggtagttga tggccaagga ggcaaagatg 5520 ttaaaataca gattaatctg tgggaggaaa ataaacagct acaatttcct gccatgccca 5580 gtggcactta ctttatggtt ctaaccatgg ggggtggtac attcacagtt ggtaggtatc 5640 ttgtatataa tgagagaatc aataatgacc tccaactatc agctttctgg ggaaaatact 5700 tgtctcaagc tatgggtctg agttggagtt ctccaactta tgcttgtgtc acctgggagc 5760 cgatctatag taatgagact attcatcatc gtatgattga tgaaagtgaa tcagatgaaa 5820 gtgaagatga tgatgaccca gatgaattct ttgatgaaga tcccatcaca actctccatg 5880 caattgattc agaaagaacc atacgccgca cgatttttag tgcactactt gatggtggtg 5940 ttgatgttga tcgtgcggcc gagtatgctg ccagagcatg tcctacagaa atacaaagaa 6000 gaaggagagg actttatgaa agcctgctgt ccgatggact ttcccctgag acatcgtaca 6060 gtgaggcatg tcttttagac aaataaatca attctttttt tttctaatca ggtagattta 6120 gagg 6124 //