ID JX857869; SV 1; linear; genomic RNA; STD; VRL; 6518 BP. XX AC JX857869; XX DT 31-OCT-2012 (Rel. 114, Created) DT 17-JAN-2013 (Rel. 115, Last updated, Version 2) XX DE Astrovirus VA4 isolate VA4/human/Nepal/s5363, complete genome. XX KW . XX OS Astrovirus VA4 OC Viruses; Riboviria; Astroviridae; unclassified Astroviridae. XX RN [1] RP 1-6518 RX PUBMED; 23084422. RA Jiang H., Holtz L.R., Bauer I., Franz C.J., Zhao G., Bodhidatta L., RA Shrestha S.K., Kang G., Wang D.; RT "Comparison of novel MLB-clade, VA-clade and classic human astroviruses RT highlights constrained evolution of the classic human astrovirus RT nonstructural genes"; RL Virology 436(1):8-14(2013). XX RN [2] RP 1-6518 RA Jiang H., Holtz L.R., Bauer I., Franz C.J., Zhao G., Bodhidatta L., RA Shrestha S.K., Kang G., Wang D.; RT ; RL Submitted (20-SEP-2012) to the INSDC. RL Molecular Microbiology, Washington University in St. Louis, School of RL Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA XX DR MD5; 7e4604c320f643d61280c506807eabb4. DR EuropePMC; PMC3545029; 23084422. DR EuropePMC; PMC3810933; 23965613. DR EuropePMC; PMC4465002; 25975198. DR EuropePMC; PMC5625321; 28928418. XX FH Key Location/Qualifiers FH FT source 1..6518 FT /organism="Astrovirus VA4" FT /host="Homo sapiens" FT /isolate="VA4/human/Nepal/S5363/2008" FT /mol_type="genomic RNA" FT /country="Nepal" FT /isolation_source="stool" FT /collection_date="2008" FT /db_xref="taxon:1247113" FT 5'UTR 1..40 FT CDS 41..2701 FT /codon_start=1 FT /product="ORF1a" FT /note="putative serine protease" FT /db_xref="GOA:K4P1D4" FT /db_xref="InterPro:IPR009003" FT /db_xref="UniProtKB/TrEMBL:K4P1D4" FT /protein_id="AFV53439.1" FT /translation="MECSYKPKGSQVYDPYDRVLQHGSRSARIKGMQLDKVSKNKLSDI FT FQDGGPLCFGYGELEMAKIVSGSVKPINTLVKTVYVSGVQAGNDYVTFCFKPGVNEWVE FT VEPDIHQPTALVGVLYQEYKKVAASEQELKKDKSQLQLEISLLRHELERARPTTRTLKP FT ISVTRIVMFGLLIGLLLAHATSGFRTGQCLDSDVSETLKPQTCINWKWDGGIAPDTDVP FT FMERLSAWYTGFKQQVREYYTNSAVFEWMLFMTGYLCTWTAVATLIGAYYMFRADNPLY FT MLLTIALATVSKIQLLAIAAVPSMEITSTFSLWSCMVVYYFNQVAAMCASLIITAVCLV FT VCMFMSDVEYIQLIRGHGVVILTIFASHLFHILQVPSWVTIVIMVSYRVAKLTSFIFGE FT KIEARGLDGKIVATIPSQTSWLNKVSRFVQGKFRQGVRTGISSTARVIPNGVVTIETKE FT TVGTGFRVQNYIVTAAHVVGNETQVRVKWGDVSAFAKVCYIHPEKDVAYLTLPSEHQGL FT PTYKFAKNIVDGTVVITSLEECGTLAVAITEGVVVSNNMTYAVNTKNGMSGSPVTNVDG FT RIVGVHQTNTGFTGGAVILYQDDLPPQKKPLREQELEARIKDLEAALDAKMQQRMSDDQ FT IVELVRLAVGRELTILRHELSLNQAKGKNKGKKGGKRGKKKRMWTEEEYKELLEKGFTK FT QQLRDMAEALREAEYSDEDSDEYEAGYPQWSDPEDDDELEAEWFGPKKKILDEVEEGWS FT KTDFWEQCQKVWKELEPMSEEAVNTLPSHLNDKYGITCYVITKADMEALAKDLQKYQMA FT VEDKIKANVIRGQWMEGVDPKTVINELDELWLGINHIMWENGLVPFTQRKKINRRKQAK FT NLKGGPRMGPQQKTN" FT CDS <2644..4224 FT /codon_start=1 FT /product="ORF1b" FT /note="putative RNA-dependent RNA polymerase" FT /db_xref="GOA:K4P3T2" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR007094" FT /db_xref="UniProtKB/TrEMBL:K4P3T2" FT /protein_id="AFV53440.1" FT /translation="AGKKLEGGPQDGAPTEDQLRLDYWERLLEPGDYFLTPSTYPLIGV FT LPIDRPISDYDEPIDDLLNLLPNYDDEIAYGPTVWGPEAYRKSFQKFTYKEPQENIELN FT YPREWKFAMRVLRREYDFLVDTQLTDITATSKNSDSTASYPKCLWWKTESEYLKDRGYK FT DYIQQFDSILNGERPKVLWYLFLKKEIQKLSKIEESDIRQIVCSDPIFARIGCVFEEHQ FT NQLMKNRTKTRMGQCGWSPFSGGFHSRISRLVDKGNRHFVEFDWTRYDGTIPNEVLIAI FT KKFRYSCLSDHCKSAKLLDAYKWYCHNIMHRYVMLPSGEVTIQNRGNPSGQISTTMDNN FT MCNVFFQAFEYAFIHPNKTVEELCDMWDKVDSLIYGDDRLSTYPELPDNYKDIVISMYA FT DIFGMWVKPDKVKVSNTIEGLTFCGFTVVKDKNMYVPVPTETEKLIAGLVKPTKKLPDV FT LSLYGKLLCYRILSHNLPDDHKFKNYILVALEVVARHIRAAGGEEPFHITDTMLDRLWR FT GGPKRGDGW" FT CDS 4214..6403 FT /codon_start=1 FT /product="putative capsid protein" FT /note="ORF2" FT /db_xref="InterPro:IPR004337" FT /db_xref="InterPro:IPR029053" FT /db_xref="UniProtKB/TrEMBL:K4P1L5" FT /protein_id="AFV53441.1" FT /translation="MAGKQPQHAATKAAIKAVAKEVVKEENKQQQRKQKWQPRKKQGKT FT KWFNKNQVKHEVKTELKRKGLEGPRTKFTVKVSATIGKIGPNVNAGPELQISTFMHPAL FT MKEPNDGTNFGPLQAAAAQWGLWRLSDLKIQFTPLVGASALTGSMYRASLNLTQSPGST FT SWGGLGARKHLDIPVGVSRVWHLRKGDLAGPRETWWLTDTNEEGGQSCGPMLEIHGLGK FT TTSTYRDAPWQGDLFVVEVTGVWQFTNYNAKPALGTLNRVVEETNASIEVGADGVMKMT FT IPSTSRLARHMSEQCERTSSAASQIGETIWQVVDQGAGLVASVAPEPFGWLIKGGWWFV FT KKILGRANTGDEVYYVYASLADAQNNKPVEANQFNKQSHNTTLAVTQINAPNTGPNNAP FT AVVTSRLFPIPQAGIPDGWFWISGHFESLHMVGLNGTNGSTLPCGIITTFPQWEFKLKK FT GATEWGCAMQGVASSPDNVTCWSVDSDYQLKGWYDVAGIPSTGIVVDWVTGSNQTVHLD FT WADVLAWRSDEWGTLRLTYWLCRTRREVTASDFDTTQKNPSPYITNAEAQKYKADVREV FT WIPTVVTNEQRTNSRVQYISRVRAGTIVVLWCLGSHTFESGTGKGTIVSKDNYGAYGQL FT PTKMSTTGLWHRALSTVGPSTDWLTVAFDAHAAVTSDDIVTKLLAEIENKYDLEPRRQR FT SRDHNRDLTRLKLYEALRDADWEHLPAEGMSSVLQ" FT 3'UTR 6404..6518 XX SQ Sequence 6518 BP; 1966 A; 1202 C; 1602 G; 1748 T; 0 other; caaatgaggg ttggtgcctt ttggcatctg gggggtagcc atggagtgct catacaagcc 60 caaagggtct caagtttatg acccttatga tcgggtttta caacatggga gcagaagtgc 120 aagaattaag gggatgcaat tggacaaggt ttcaaagaac aagctctcgg acatatttca 180 agacggtggg ccattgtgtt ttggttatgg cgagctagaa atggcaaaaa ttgtttctgg 240 ctcagtcaaa ccaataaata ctttggtgaa aactgtctat gtatcaggtg tccaggcagg 300 taatgattat gtaacctttt gcttcaagcc aggcgtaaac gaatgggttg aagttgagcc 360 tgatattcat cagcctacag cacttgttgg cgttttgtat caggagtaca agaaggttgc 420 tgccagtgaa caagagctta agaaagacaa gtcacaattg cagttggaaa tatccctact 480 aaggcacgag ctggagagag caagacccac cactaggacc ctcaaaccaa tcagtgttac 540 tcgaattgtt atgttcgggc tgctgattgg attattgttg gcacatgcaa ctagcggctt 600 cagaactggt caatgcttag acagtgatgt tagtgaaaca ctcaagccac aaacctgcat 660 taactggaaa tgggatggtg ggattgctcc agatacggat gtcccattta tggaaaggtt 720 gagtgcatgg tatacaggat ttaaacaaca agtgagagag tactacacaa atagtgctgt 780 ttttgagtgg atgctgttca tgaccggtta tctttgtacg tggacagctg ttgcaacact 840 tattggagca tattacatgt ttagggcaga taatccactg tacatgctat taactatagc 900 tttagctaca gtctctaaaa tacagctatt ggctatagca gcagtcccaa gcatggaaat 960 cacttcaaca ttttctctgt ggtcctgtat ggttgtctat tatttcaatc aggtggcagc 1020 tatgtgcgca tcactaataa taacggcagt ttgtttagtt gtgtgcatgt ttatgtcaga 1080 tgttgaatat attcagctaa taaggggcca tggagttgtg attttgacaa tctttgcatc 1140 tcatttgttc catattttac aagtacctag ctgggtgacc attgtaatta tggtgtctta 1200 tagagtcgcc aaattaacaa gctttatatt tggcgagaaa atagaagcta gaggacttga 1260 tggtaagatt gttgcaacga tacctagtca gacatcctgg ttaaacaagg tgtcaaggtt 1320 tgttcaaggc aaattcaggc agggggtcag aacaggaata tcatcaacgg cgcgtgtgat 1380 tccaaatggc gttgttacta ttgaaactaa ggaaacagtg ggaactggct ttagagttca 1440 gaattacata gtgacagctg cacatgttgt tggcaatgag acacaagttc gtgtgaagtg 1500 gggcgatgtc tctgcttttg ctaaggtttg ctatatacac cctgaaaagg atgttgcata 1560 cctaacattg ccatcagaac atcaaggttt gccaacatac aaattcgcca aaaacattgt 1620 tgatggtact gttgtgatca catcacttga ggaatgcggc acactcgccg ttgccataac 1680 agagggtgtt gtggtgtcta acaacatgac atatgccgtc aatacaaaaa atggcatgag 1740 tggttcacct gtgacaaatg tggatggaag gatagttgga gtacatcaaa ccaatactgg 1800 gttcacaggt ggagccgtaa tattatatca agatgatttg ccaccccaga agaaacctct 1860 acgggaacaa gaacttgaag ccaggataaa agatctagaa gcagctcttg atgccaaaat 1920 gcagcagcgg atgagtgatg atcagatcgt tgaacttgtc cggttagctg ttgggagaga 1980 actcacgatc ctgagacatg aactaagctt aaaccaggcc aaaggtaaga acaaaggtaa 2040 gaaaggtgga aagcgtggga aaaagaaacg catgtggact gaggaagagt acaaagaact 2100 cttagaaaaa ggctttacta aacaacaatt gagagatatg gctgaggcat tgcgtgaagc 2160 tgagtactct gatgaagaca gtgacgagta tgaagctgga tacccccaat ggtcagatcc 2220 tgaggatgat gacgagttgg aggctgagtg gtttggacca aagaagaaga tcctcgatga 2280 ggttgaagag ggttggtcca aaacagattt ctgggaacaa tgccaaaaag tttggaagga 2340 actagagcca atgagtgaag aagccgtcaa cacgttacct tcccacctta atgacaagta 2400 tggtattact tgttatgtta ttaccaaagc tgatatggaa gccctagcta aagatttgca 2460 aaaataccag atggctgttg aagataagat caaggcaaat gttattaggg ggcaatggat 2520 ggaaggtgtt gatcctaaaa cggtcatcaa tgagcttgat gaattgtggt tgggaattaa 2580 tcatatcatg tgggagaatg gtttggttcc atttacacag aggaagaaaa taaacaggcg 2640 taagcaggca aaaaacttga aggggggccc caggatgggg ccccaacaga agaccaatta 2700 aggttggact attgggaacg cctacttgaa cctggagatt atttcctaac accttccaca 2760 tatccattga ttggagtttt gccaattgat cgtccaatta gtgattatga tgaaccaata 2820 gatgatttat taaatttgtt gccaaattat gatgatgaga ttgcttatgg tccaacagtg 2880 tggggtccag aggcttatag aaaatctttt caaaaattta catataagga accacaggaa 2940 aatattgaat taaattatcc tagagagtgg aagtttgcaa tgagggttct tagaagagaa 3000 tatgattttc ttgtagacac acaactgact gatatcactg caacatcaaa gaactctgac 3060 tcaaccgcat catacccaaa atgcttgtgg tggaaaacgg agtcagagta tctaaaagat 3120 cgtggttata aagattatat ccaacaattt gactctattt tgaatggtga aagacctaaa 3180 gttttgtggt atcttttctt gaagaaagag atacaaaaat tgagcaagat agaggaaagt 3240 gatatcaggc aaatagtttg ttcagacccg atttttgcca gaattggttg tgttttcgaa 3300 gaacatcaaa atcagctgat gaaaaatcga acaaagacaa gaatgggcca atgtggatgg 3360 tcgccctttt caggcggctt ccactcaagg atatcccgct tggttgacaa aggcaacagg 3420 cactttgtcg aatttgattg gacgagatat gatggcacaa tacctaatga ggtgttaatt 3480 gctatcaaaa agtttagata ttcttgcctt tcagatcatt gcaaaagtgc taaattgctg 3540 gatgcctaca agtggtattg ccacaacatc atgcatagat atgtcatgtt accatctggt 3600 gaagtaacaa tacaaaatcg gggaaatccc tctggccaga tttccacaac tatggacaac 3660 aacatgtgca atgtgttctt ccaggcattt gagtatgcat tcatacatcc aaacaaaaca 3720 gttgaagagc tttgtgacat gtgggataaa gtcgattcac taatttatgg tgatgacagg 3780 ctttccactt atcctgagtt acctgataac tataaggata ttgtcattag tatgtatgca 3840 gacatatttg gtatgtgggt caaacctgac aaagttaaag tttctaacac aattgaaggt 3900 ctcactttct gtggttttac tgttgttaaa gataagaaca tgtatgtccc tgttccaact 3960 gaaacagaaa agctgattgc tggattggtc aagccaacaa agaaattacc tgatgttctt 4020 tcgctgtatg ggaaactcct ttgctatcgc atacttagcc acaatttgcc agatgaccac 4080 aaatttaaga actatatttt ggtggcgcta gaggtagtgg ctaggcatat tcgtgctgcg 4140 ggaggcgaag agccctttca catcacggac accatgctgg atcggctttg gaggggcgga 4200 ccaaagcgtg gagatggctg gtaagcagcc ccagcatgcc gctacgaagg ctgccattaa 4260 ggcagtggct aaggaggttg ttaaggagga gaacaaacaa cagcaaagaa aacaaaaatg 4320 gcaaccccgt aagaaacagg gtaagactaa atggtttaat aagaatcagg ttaagcatga 4380 ggttaagact gagcttaaga ggaagggcct tgaaggccca agaaccaaat tcacagtaaa 4440 agtttcagct acaattggga agattggacc aaatgttaat gctggtcctg aattacaaat 4500 atcaactttt atgcatccag cattaatgaa agagcccaat gatggcacca attttggacc 4560 tttacaagct gcagccgcac aatggggttt gtggcggctt tcagatctaa aaattcagtt 4620 cactcctcta gtaggagctt ctgcattaac tggatccatg tatcgtgcat cgttaaacct 4680 tacacagtcc ccgggatcaa catcttgggg gggccttggc gccaggaagc atctagatat 4740 acctgttggt gtgtctcgag tctggcattt gaggaaaggt gaccttgctg gcccgcgtga 4800 aacatggtgg ttgactgaca ccaatgagga aggtggtcag agttgtggtc ccatgcttga 4860 gattcatggt ttgggtaaga ctacatccac ttaccgtgat gcaccatggc aaggtgatct 4920 ctttgttgtt gaggttactg gtgtttggca gtttaccaac tacaatgcaa aacccgctct 4980 tggtacactg aatcgtgtgg ttgaagaaac caatgcatca attgaggttg gtgccgatgg 5040 tgtcatgaag atgacaattc cttcaactag ccgtcttgct aggcacatgt ctgagcaatg 5100 cgaaagaaca tcaagtgctg ctagccagat tggcgaaacc atctggcagg tagttgacca 5160 aggtgctggg ttggttgcaa gtgttgcccc tgaacctttt ggctggctca ttaaaggtgg 5220 gtggtggttt gtcaagaaaa ttcttggcag agcaaacact ggtgatgagg tgtattatgt 5280 ttacgcctct cttgcagatg cacaaaataa taagccagtt gaagcaaatc aatttaataa 5340 gcagtctcat aatacaacat tggctgtgac ccaaattaat gctccaaata ctgggccaaa 5400 caatgcgcca gcagtagtta catccaggct gtttcccata ccacaagctg ggataccaga 5460 tggctggttt tggattagtg gacactttga atcactacac atggttggct taaatggtac 5520 aaatggatca acattaccct gtggcatcat aactactttc ccccagtggg aatttaaatt 5580 gaaaaaggga gctaccgaat ggggctgtgc aatgcagggt gtggcatcaa gcccagataa 5640 tgtaacatgc tggtccgttg actcggacta tcagttgaaa gggtggtacg acgttgctgg 5700 tataccatca accggcatag tcgttgattg ggtcactggt tccaatcaaa ctgtccacct 5760 agactgggct gatgtcttgg cttggagatc cgatgagtgg ggaacgcttc gtctaacata 5820 ctggttgtgt aggactaggc gtgaggtcac tgcttcggat tttgatacaa ctcagaagaa 5880 tcctagccca tacattacaa atgcagaggc ccaaaaatac aaagctgatg tgcgggaggt 5940 ttggatacca accgttgtca ctaatgagca acgcaccaat agcagagtcc agtacatttc 6000 tagagttcgt gctgggacaa tagttgtgct ttggtgctta ggtagccaca cttttgagag 6060 tggaactggc aaaggtacca tagtttctaa ggataactat ggtgcttatg gccagttacc 6120 cactaagatg tctactacag ggctatggca cagagctctg tcaacagtgg ggccatccac 6180 tgattggctt actgttgctt ttgatgcaca tgccgccgtg acaagtgatg atattgtcac 6240 taagctgctg gctgaaattg agaataagta tgatctggaa ccccgaagac agagatcacg 6300 ggatcataat agagatttaa ccagattaaa attatatgaa gcactacgtg atgctgattg 6360 ggaacatctc cctgcagagg gaatgagctc agtgcttcag taaatccccg aggccacgcc 6420 gagtaggatc gagggtacag ggatacacta attgtcttgt ggtttgaatc attcattata 6480 tgtgattatt caatgaatta gtgtgaattg attttccc 6518 //