ID JX857868; SV 1; linear; genomic RNA; STD; VRL; 6581 BP. XX AC JX857868; XX DT 31-OCT-2012 (Rel. 114, Created) DT 17-JAN-2013 (Rel. 115, Last updated, Version 2) XX DE Astrovirus VA3 isolate VA3/human/Vellore/28054/2005, complete genome. XX KW . XX OS Astrovirus VA3 OC Viruses; Riboviria; Astroviridae; unclassified Astroviridae. XX RN [1] RP 1-6581 RX PUBMED; 23084422. RA Jiang H., Holtz L.R., Bauer I., Franz C.J., Zhao G., Bodhidatta L., RA Shrestha S.K., Kang G., Wang D.; RT "Comparison of novel MLB-clade, VA-clade and classic human astroviruses RT highlights constrained evolution of the classic human astrovirus RT nonstructural genes"; RL Virology 436(1):8-14(2013). XX RN [2] RP 1-6581 RA Jiang H., Holtz L.R., Bauer I., Franz C.J., Zhao G., Bodhidatta L., RA Shrestha S.K., Kang G., Wang D.; RT ; RL Submitted (20-SEP-2012) to the INSDC. RL Molecular Microbiology, Washington University in St. Louis, School of RL Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA XX DR MD5; 7dee4242e88882a227a8ecdf25300498. DR EuropePMC; PMC3545029; 23084422. DR EuropePMC; PMC4465002; 25975198. DR EuropePMC; PMC5625321; 28928418. XX FH Key Location/Qualifiers FH FT source 1..6581 FT /organism="Astrovirus VA3" FT /host="Homo sapiens" FT /isolate="VA3/human/Vellore/28054/2005" FT /mol_type="genomic RNA" FT /country="India" FT /isolation_source="stool" FT /collection_date="2005" FT /db_xref="taxon:683174" FT 5'UTR 1..36 FT CDS 37..2706 FT /codon_start=1 FT /product="ORF1a" FT /note="putative serine protease" FT /db_xref="GOA:K4P1L2" FT /db_xref="InterPro:IPR009003" FT /db_xref="UniProtKB/TrEMBL:K4P1L2" FT /protein_id="AFV53436.1" FT /translation="MERTYRPSGLGHMDPYDRILQHGSLKARIQGIQLNKVAKTKLEDI FT FESGGPLCFGYGDVETTHVKNGVVEPHPIIVKTVYVSGVREGNEYVTYLFKPGVNDWVE FT TEVNIHQPTAIVGVLYQEFRRLTVENQTLKSERSTLQLELSLVRHELERVRPAEKVLKP FT MKISSIIFYGLLIGLIFAHITTAFRTGVCLDSDVSETLKPQTCINWKWDGGIDPDDTVP FT YYDRLIAWYSGVSQQIKSIYNDQLFNWLLYISTLTYTWTAVALAIGTYYMIRAENPIYM FT LITLIMATISKMQLFAVSAIPNMEMTSMFSLWCCMALYVLNQAAAMAASLMIAMLCSVI FT CLFMGDAEYIQVIRGHGVVIITIVLSHVFHVLQIPNWVTVLVIVALRVIRLMSAVIGEK FT IEIRNIDGKVVNVIPTTTSWLNRVSGFVQSRFRQKVRTGIVSTARVIPNGVVVVESKET FT SGTGFRVQNYIVTAAHVVGNETQLKVKWGDVVVYSKVVYIHPNKDVAYITLPAEFQALP FT TYKFAKTVEDGTIVITSLEDCGVLAVAVSEGVVVKDNMTYAIQTKNGMSGSPVTNVDGR FT IIGVHQSNTGFTGGAVIIRPEDLPPQKKPQRELELEAKIKELEETLKSQMNQGLNENQI FT VDLIRLAVGRELEILRHEMNLNQAKGKNKHRGKHGARRRRKVRVWTEEEYKDLLEKGFS FT RQQLRDMADVLREAEYTDDDSEDFAEEEGYPQWSDPEDYEEIEREWFGPKKKILDEVED FT GWSKTDFWEQCQKIWKETEPMPEESVNTLPSHLHDKYGLTCYVVTKADMQALAKDLQEY FT QQKVEDKIKTNVVRGQWVSGIDPKVVITELDELWLKLNHLMWSHGLVPFIQRKKINRRK FT QQKNLKGAPKSGPQNQTN" FT CDS <2568..4229 FT /codon_start=1 FT /product="ORF1b" FT /note="putative RNA-dependent RNA polymerase" FT /db_xref="GOA:K4PES4" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR007094" FT /db_xref="UniProtKB/TrEMBL:K4PES4" FT /protein_id="AFV53437.1" FT /translation="TLAQVEPPYVVTWFGSIYTKKEDQQAQATKKLEGGPEVGAPKPDQ FT LRLDSWKQMLEPGEYFLTPVNCPLIGVLPIDRPISDYDEPVDDLLNLLPKCDEDPPYAP FT STWGPEAYRKSFQKFFYKEPVKNIKEKYKREWKFAMSALRREFDFLNDSVMIDITATSK FT NADSTPAYPKTLWWKTETDYLKERGYQDYITELDRIMNGDRPDVLWYLFLRKEILKISK FT IEDEDIRQIVCSDPIFARIGCVFEENQNQLMKGRTLTRMGQCGWSPFMGGFHRRVKRLV FT DKGNHHFIEFDWTRYDGTIPTEVFSAIKDFRFSCLRKEFRTEKNKSVYDWYCKNIFRRY FT VMLPSGEVTVQERGNPSGQISTTMDNNLCNVFFQAFEFAHLNPDKTIDELREGWEKVDS FT LIYGDDRLSTVPYVCSNYVEKVIDMYENIFGMWVKPNKVKLSDSVIGLTFCGFTITMSD FT NVYVPVPTDTDKLLAGLVTPVKKLPDILSLYGKLLCYRILGHNLPDDHKFKNYILVALE FT VLARHIRNGGGEEPYHITDEMLDRLWRGGPKLGYGW" FT CDS 4219..6486 FT /codon_start=1 FT /product="putative capsid protein" FT /note="ORF2" FT /db_xref="InterPro:IPR004337" FT /db_xref="InterPro:IPR029053" FT /db_xref="UniProtKB/TrEMBL:K4P3P2" FT /protein_id="AFV53438.1" FT /translation="MAGKQPQQAMPKATVKQLAKEVVKQERQVKQNQPKKKYFPVKNKK FT YIKREVRKDLKKQGFEGPKPRFSVSVSATIGKVGPNKAQGPELQISTFMHPSLMKEPND FT GTNFGPLQSAAAQWGLWRLKNLSVTFTPLVGPSAVTGSVFRISLNMAQSPGATSWGGLG FT ARKHRDVAVGKQFTWKLQRGDLTGPRETWWLTDTNEEGAQSCGPLLEIHGLGATTSTYK FT DAAWNGDLFIVEVKGRWEFANYNSKPALGMLERITESTSASIEVTDGNMIMTVPRSSQL FT ARHMGERYEKSGNASTVGETIWQIVDEGAGLVANVAPPPFTWLIKGGWWFVKKLLGRSA FT NTDAQYLVYASLADAQNNRPVEAQTFPKTTHTTVLSSTQINAPNTGPNTTTGSISNDIS FT VWPIIPSGSPVVDFYVSGRMKSLHMGGQAGTQATTLVGGLIYRPELPPSATPPVSKWEF FT TVHEGNNIVGAGMSCVMFRANDVVSWSQDGQDLVGWYRLDNIKTTQLTVSWRQQNRVVY FT GWGNVVAWNSEEWHTNSETPHQPILRLTYWLVKVNVTADPADFDILQKMPLGYLDPYNT FT SESTAAIQKINFQTVQKPSGGNTLRVQYSSTPQQGDFVVIWQIGRHDFDMSTGKGTAVD FT TVSDYIFPQAKDAAGGLWYRALTMVGPRTDRMVLHFYYPTATDDLVEQIITQIQSRYKL FT APLPADSDSDTSSSDSEMDCYDGFEKLQVYENVRQAGLNHAVSENLALAVVKKKLRRGH FT AE" FT 3'UTR 6487..6581 XX SQ Sequence 6581 BP; 2068 A; 1198 C; 1552 G; 1763 T; 0 other; ccaatgtttg gttctgtgcc gattggcacc tgtgggatgg agcggacata ccgacctagt 60 ggcttaggcc acatggatcc atatgatagg atccttcagc atggcagctt gaaagcacgc 120 atacaaggca tccaacttaa taaagttgct aagaccaaat tagaagacat atttgagtca 180 ggaggtcctt tgtgctttgg atatggtgat gtggaaacaa cacatgtaaa gaatggcgtt 240 gttgaaccac atcccataat agtcaagact gtctatgtgt caggagtccg tgaaggtaat 300 gaatatgtta cctatctttt caagccaggt gttaatgatt gggttgaaac cgaagtcaat 360 atacaccaac ccacagccat agttggcgtc ctgtatcagg aatttaggag gctgactgtg 420 gagaaccaaa cattgaaatc agaaagatca actttacagc tagagttgtc cctggttagg 480 catgaacttg agagagttag accagcagaa aaagtgttga agcctatgaa aatcagtagt 540 attatctttt atggcttgct gattggatta atttttgccc acatcactac agcttttaga 600 acaggagtat gcctagatag tgatgttagt gagacactta aaccacaaac ctgcattaac 660 tggaaatggg atggtggaat tgatcccgat gacaccgttc cctattatga cagacttatc 720 gcgtggtata gtggtgtctc acagcaaatt aaaagtatat ataacgacca gttgtttaac 780 tggttgttgt atatttccac tcttacatac acatggacag ctgtggcatt ggcaataggc 840 acttattaca tgattagagc tgaaaacccc atatatatgc tgataacttt gataatggcc 900 accatttcaa aaatgcaact ttttgccgta tcagctatac ccaatatgga aatgacttca 960 atgttttcat tgtggtgttg catggcactt tatgtgttaa accaagcagc agcaatggca 1020 gcgtccctta tgatagctat gctatgttca gtgatttgcc tttttatggg tgatgctgaa 1080 tatatacagg ttattagagg gcatggtgtt gttatcatca ccattgtgct gtcacatgtt 1140 ttccatgttt tacaaatacc aaattgggtt actgttttgg tgatagttgc actaagggtt 1200 atcaggttga tgagtgcagt cattggagaa aaaattgaaa ttaggaacat agatggaaaa 1260 gttgtcaatg taattcctac aacaacatca tggcttaaca gagtttctgg gtttgtacag 1320 tccaggttta ggcaaaaagt taggaccggt atagtttcaa cagctagagt aattccaaat 1380 ggtgtcgtag ttgttgagtc aaaggagaca tcaggtaccg gttttagagt ccaaaattat 1440 attgtaacag cagcacatgt tgttggtaat gaaacacagc ttaaagttaa atggggagat 1500 gtggtggtgt attcaaaagt tgtatatatc catccaaata aagatgtagc ttacatcaca 1560 ttaccagctg agtttcaggc tcttccaaca tataaatttg ccaaaactgt tgaggatggc 1620 accatagtca taacatcact tgaagattgt ggtgttttgg cagtggccgt gtcagagggt 1680 gttgttgtca aagataacat gacctatgct attcaaacca aaaatgggat gagtggttct 1740 ccagtgacaa atgttgacgg tcgtattatt ggggtacatc aaagtaacac aggctttaca 1800 ggaggtgctg tcataatacg gccggaggac ttgccaccac aaaagaaacc ccagcgggag 1860 ttggaattgg aagcaaaaat taaggaactg gaggaaactc tcaagagtca aatgaatcag 1920 gggctgaatg aaaatcaaat agttgatctt attaggttag ctgttggtag ggaacttgaa 1980 attctccgcc atgaaatgaa tttaaatcaa gcaaaaggta agaacaagca ccgaggtaaa 2040 catggtgccc gcagacgtag aaaagtgcgt gtgtggacag aggaagaata taaggatttg 2100 cttgagaaag gattttcaag acaacaatta cgtgacatgg ctgacgtgtt acgtgaggct 2160 gaatatactg atgatgacag tgaagacttt gctgaagagg aaggatatcc tcagtggtct 2220 gatcctgaag actatgaaga aattgagagg gagtggtttg gccccaagaa gaaaatccta 2280 gatgaagtgg aggatggatg gtcaaaaacc gatttctggg agcagtgtca aaaaatttgg 2340 aaagaaacgg aaccaatgcc agaagaatct gtcaatacac taccatcaca tttacatgat 2400 aagtatggct taacatgtta tgtggtaaca aaagctgata tgcaggcttt agctaaagat 2460 ttgcaagaat accagcaaaa agttgaggac aagattaaga caaatgttgt ccgtggccaa 2520 tgggtcagtg gaatcgaccc aaaggttgta attacagaat tggatgaact ctggctcaag 2580 ttgaaccacc ttatgtggtc acatggtttg gttccattta tacaaagaaa gaagatcaac 2640 aggcgcaagc aacaaaaaaa cttgaagggg gccccgaagt cggggcccca aaaccagacc 2700 aattaagatt ggactcttgg aaacagatgc ttgagcctgg tgaatatttt cttactccag 2760 taaattgccc tttaataggt gtcctaccaa tagatagacc aattagtgat tatgatgaac 2820 cagttgatga tttgttgaat ttattaccca aatgtgatga agatccacca tatgccccgt 2880 caacgtgggg cccagaagct tatcgcaaat cattccaaaa attcttttat aaagaacctg 2940 ttaaaaatat aaaagaaaag tataagcgtg agtggaagtt tgccatgtca gcgctacgca 3000 gagaatttga tttcttgaat gatagcgtca tgattgacat aacagcaaca tctaaaaatg 3060 cagactccac accagcttat cccaaaactt tatggtggaa aactgagaca gattacctta 3120 aagagagagg ttatcaagat tacatcactg aattggatag gataatgaat ggtgaccgcc 3180 ctgatgtact ttggtatctc tttttgagaa aagagattct aaagataagc aaaatagaag 3240 atgaggacat acgacaaata gtttgttctg atcctatatt tgctagaata ggctgtgttt 3300 ttgaggagaa tcaaaatcag ttgatgaagg gcagaacgct gaccagaatg ggtcagtgtg 3360 gttggtcacc attcatgggt ggtttccacc gtagggtcaa aagattagtg gacaaaggta 3420 atcaccattt tatagagttt gattggaccc gatatgatgg caccatccca acagaagttt 3480 tcagtgcaat taaagatttt agattttcat gtctcaggaa ggaatttaga acagagaaga 3540 acaaaagtgt ctatgactgg tactgtaaaa atatttttag aaggtatgtt atgttgccat 3600 ctggagaagt cacagttcaa gagcgtggaa atccttcagg ccagatatca actaccatgg 3660 ataataatct atgtaatgta tttttccagg catttgagtt tgctcatttg aatccggata 3720 aaacaattga tgaactgaga gaaggatggg agaaagttga ttcacttatc tacggtgatg 3780 acaggctttc tacagttcca tatgtttgct ctaactatgt tgaaaaagta atagacatgt 3840 atgaaaacat ctttggtatg tgggtaaaac ccaataaagt gaaattgtca gatagtgtga 3900 ttggcctaac gttttgtggt tttaccatca caatgtcaga taatgtctat gtaccagtcc 3960 caacagacac agacaaattg ttagctggac ttgttacacc agtcaagaaa ttgccagata 4020 tattatctct ctatgggaag ctcctttgct atcgcatcct tggccataac ttgccagacg 4080 accataagtt caagaactat attttggtcg ctttagaggt attggctaga cacatccgca 4140 atggtggtgg tgaagaaccc tatcatatta cggatgagat gctggataga ctttggaggg 4200 gaggaccaaa gttaggatat ggctggtaaa cagccccagc aggccatgcc taaggccact 4260 gtcaagcagt tggccaagga ggtggttaag caggagcgac aagtaaaaca gaaccaacca 4320 aagaagaagt atttcccagt gaaaaataaa aaatatatta agagggaggt taggaaggat 4380 ttaaagaaac aaggctttga aggtccaaaa cctagattct ctgtttcagt ctcagcaaca 4440 attggaaaag ttgggccgaa caaggcacag gggcccgagt tgcaaatttc aacttttatg 4500 catccaagtc ttatgaagga gcctaatgat ggcacaaatt ttggcccatt gcagtcggct 4560 gcagcccagt ggggactgtg gagactcaaa aatcttagtg tcacttttac accattagtt 4620 ggcccatcag cggtcactgg ctcagttttc agaatctcac tgaacatggc acaatctcca 4680 ggtgccacat cttggggagg attgggtgct agaaaacatc gagatgttgc tgttggaaaa 4740 cagttcacgt ggaaactcca acgtggagat ctcactggac ccagagaaac ttggtggctg 4800 acagacacaa atgaagaggg agcccaaagc tgtgggccct tgcttgaaat acatggtctt 4860 ggagcaacta cttcaaccta caaggatgca gcatggaacg gtgacctttt tatagttgag 4920 gtaaaaggta ggtgggagtt tgccaactat aatagcaaac cagcattggg aatgctagag 4980 aggatcaccg agagtactag tgcatctata gaagttactg atggtaacat gattatgact 5040 gttcctagaa gttctcaact agctcgccac atgggtgaac gctatgagaa gtctgggaat 5100 gcatcaacag taggtgagac aatttggcaa atagttgatg agggtgcagg ccttgtggcg 5160 aatgtcgccc caccgccatt cacttggttg ataaagggcg gttggtggtt tgtcaagaaa 5220 ttgcttggta ggtcagcaaa tactgatgct cagtaccttg tctatgcgtc cttggctgac 5280 gcacagaata atcggccagt tgaggcacag acattcccta agacaacaca cacaacagta 5340 ctctcttcaa cacaaataaa tgctccaaac actgggccta acaccacaac tggatccata 5400 tcgaatgata tcagtgtttg gccaataatt ccatcaggta gcccagttgt tgacttctat 5460 gtgagtggaa ggatgaagtc attgcacatg ggtggacaag cagggaccca agccacaaca 5520 ctagtgggtg gtctcattta caggccagaa ctaccgccct cagcaacccc gccagtctcg 5580 aagtgggaat ttactgtaca tgaaggtaat aacatagttg gagctggcat gagctgtgtt 5640 atgtttcgtg ccaacgatgt agtgtcttgg tcgcaggacg gtcaggacct tgttggttgg 5700 tatcgtttag acaacataaa aacaacacaa ctcactgtct cttggagaca acagaacagg 5760 gttgtctatg gatggggcaa tgtagtcgcc tggaattcag aagagtggca taccaattca 5820 gaaacaccac atcaacccat attaaggctt acatattggt tggttaaagt aaatgtgaca 5880 gcagacccag ctgattttga catattacag aaaatgcccc ttgggtattt ggatccctat 5940 aatacttctg agtcaacagc agcaatccaa aaaatcaatt ttcagacagt tcaaaaacca 6000 tcaggtggca atacacttag ggtgcagtac tcatcaacac cgcagcaagg tgattttgtc 6060 gtgatctggc aaattggaag gcatgatttt gacatgtcta ctggaaaggg tactgctgtg 6120 gatactgttt cagattacat atttccacaa gcaaaagatg ccgccggtgg cctttggtat 6180 cgggcactta caatggttgg tcccaggact gacaggatgg tcttgcattt ttattatcca 6240 actgcaactg atgaccttgt tgaacagata ataacacaaa ttcaaagcag gtataagctg 6300 gcccctttac cagctgactc tgattcagat acctctagct ctgattcaga gatggattgt 6360 tatgatggct ttgaaaagct tcaggtctat gaaaatgtga gacaagctgg cttgaaccat 6420 gcagtgtccg agaatttagc actagctgtt gtgaagaaaa aattgcgccg aggccacgcc 6480 gagtaggatc gagggtacag cgcttagttg attgtctaga gggttgttta atgaaataat 6540 ttcagtaatc aattaatcaa cttaaaattg aaaagcacat c 6581 //