ID JX005846; SV 1; linear; genomic RNA; STD; VRL; 6368 BP. XX AC JX005846; XX DT 03-SEP-2012 (Rel. 114, Created) DT 03-SEP-2012 (Rel. 114, Last updated, Version 1) XX DE Heartland virus isolate Patient1 segment L, complete sequence. XX KW . XX OS Heartland virus OC Viruses; Riboviria; Negarnaviricota; Polyploviricotina; Ellioviricetes; OC Bunyavirales; Phenuiviridae; Banyangvirus; Heartland banyangvirus. XX RN [1] RP 1-6368 RA McMullan L.K., Folk S.M., Kelly A.J., MacNeil A., Goldsmith C.S., RA Metcalfe M.G., Batten B.C., Albarino C.G., Zaki S.R., Rollin P.E., RA Nicholson W.L., Nichol S.T.; RT "A newly discovered phlebovirus associated with severe febrile illness RT following tick bite in two patients in Missouri"; RL N. Engl. J. Med. 367:834-841(2012). XX RN [2] RP 1-6368 RA McMullan L.K., Folk S.M., Kelly A.J., MacNeil A., Goldsmith C.S., RA Metcalfe M.G., Batten B.C., Albarino C.G., Zaki S.R., Rollin P.E., RA Nicholson W.L., Nichol S.T.; RT ; RL Submitted (01-MAY-2012) to the INSDC. RL Virus Special Pathogens Branch, Centers for Disease Control and Prevention, RL 1600 Clifton Rd MS G14, Atlanta, GA 30333, USA XX DR MD5; cbfd68a8831b82f87ed6ee7972d94c2a. DR EuropePMC; PMC3957954; 24390329. DR EuropePMC; PMC6164824; 30223439. XX FH Key Location/Qualifiers FH FT source 1..6368 FT /organism="Heartland virus" FT /segment="L" FT /host="Homo sapiens" FT /isolate="Patient1" FT /mol_type="genomic RNA" FT /country="USA:Missouri" FT /isolation_source="Human serum" FT /collection_date="19-Jun-2009" FT /db_xref="taxon:1216928" FT CDS 17..6271 FT /codon_start=1 FT /product="polymerase" FT /db_xref="GOA:J3TRD1" FT /db_xref="InterPro:IPR007099" FT /db_xref="InterPro:IPR007322" FT /db_xref="InterPro:IPR022531" FT /db_xref="InterPro:IPR029124" FT /db_xref="UniProtKB/TrEMBL:J3TRD1" FT /protein_id="AFP33395.1" FT /translation="MNLEALCSRVLSERGLSTGEPGVYDQIFERPGLPNLEVTVDSTGV FT VVDVGAIPDSASQLGSSINAGVLTIPLSEAYKINHDFTFSGLTKTTDRKLSEVFPLVHD FT GSDSMTPDVIHTRLDGTVVVIEFTTTRSTNMGGLEAAYRSKLEKYRDPLNRRTDIMPDA FT SIYFGIIVVSASGVLTNMPLTQDEAEELMFRFCVANEIYSQARAMDAEVELQKSEEEYE FT AISRARAFFTLFDYDDGKLSEAFPNSDIEMLRRFLSQPVDTSFVTTTLKEKEQEAYKRM FT CEEHYLKSGMSTKERLEANRSDAIDKTRALMERLHNMSSKELHSNKSTVKLPPWVVKPS FT DRTLDVKTDTGSGELLNHGPYGELWSRCFLEIVLGNVEGVISSPEKELEIAISDDPEAD FT TPKAAKIKYHRFRPELSLESKHEFSLQGIEGKRWKHSARNVLKDEMSHKTMSPFVDVSN FT IEEFLIMNNLLNDTSFNREGLQETINLLLEKATEMHQNGLSTALNDSFKRNFNTNVVQW FT SMWVSCLAQELASALKQHCKPGEFIIKKLMHWPIFVIIKPTKSSSHIFYSLAIKKANIK FT RRLIGDVFTDTIDAGEWEFSEFKSLKTCKLTNLINLPCTMLNSIAFWREKMGVAPWISR FT KACSELREQVAITFLMSLEDKSTTEELVTLTRYSQMEGFVSPPLLPKPQKMVEKLEVPL FT RTKLQVFLFRRHLDAIVRVAASPFPIVARDGRVEWTGTFNAITGRSTGLENMVNNWYIG FT YYKNKEESTELNALGEMYKKIVEIEAEKPTSSEYLGWGDTSSPKRHEFSRSFLKSACIS FT LEKEIEMRHGKSWKQSLEERVLKELGSKNLLDLATMKATSNFSKEWEAFSEVRTKEYHR FT SKLLEKMAELIEHGLMWYVDAAGHAWKAVLDDKCMRICLFKKNQHGGLREIYVTNANAR FT LVQFGVETMARCVCELSPHETIANPRLKSSIIENHGLKSARQLGQGTINVNSSNDAKKW FT SQGHYTTKLAMVLCWFMPAKFHRFIWAGISMFRCKKMMMDLRFLEKLSTKANQKTDDDF FT RKDLAGAFHGNVEVPWMTQGATYLQTETGMMQGILHFTSSLLHSCVQSFYKAYFLSRLK FT EGIAGRTIKAAIDVLEGSDDSAIMISLKPASDNEEAMARFLTANLLYSVRVINPLFGIY FT SSEKSTVNTLFCVEYNSEFHFHKHLVRPTIRWVAASHQISESEALASRQEDYANLLTQC FT LEGGSSFSLTYLIQCAQLVHHYMLLGLCLHPLFGTFVGMLIEDPDPALGFFIMDNPAFA FT GGAGFRFNLWRSCKFTNLGKKYAFFFNEIQGKTKGDADYRALDATTGGTLSHSVMTYWG FT DRRKYQHLLDRMGLPKDWVERIDENPSILYRRPENKQELILRLAEKVHSPGVTSSFSKG FT HVVPRVVAAGVYLLSRHCFRYTASIHGRGASQKASLIKLLVMSSTSAERNQGRLNPNQE FT RMLFPQVQEYERVLTLLDEVTALTGKFVVRERNIVKSRVELFQEPVDLRCKAENLIAEM FT WFGLKRTKLGPRLLKEEWDKLRASFSWLSTDHKETLDVGPFLSHVQFRNFIAHVDAKSR FT SVRLLGAPVKKSGGVTTVSQVVKSNFFPGFILDSSESLDDQERVEGVSILKHILFMTLN FT GPYTDEQKKAMVLETFQYFALPHAAEVVKRSRSLTLCLMKNFIEQRGGSILDQIEKAQS FT GTVGGFSKPQKPYRKQSGGIGYKGKGVWSGIMENTNVQILIDGDGSSNWIEEIRLSSES FT RLFDVIESVRRLCDDINVNNRVTSSFRGHCMVRLSNFKVKPASRVEGCPVRLMPSSFRI FT KELQNPDEVFLRVRGDILNLSILLQEDRVMNLLSYRARDTDISESAASYLWMNRTDFSF FT GKKEPSCSWMCLKTLDSWAWNQAARVLERNIKTPGIDNTAMGNIFKDCLESSLRKQGLL FT RSRIAEMVERHVIPLTSQELVDILEEDVDFSEMMQSDIMEGDLDIDILMEGSPMLWAAE FT VEEMGEAMVILSQSGKYYHLKLMDQAATTLSTILGKDGCRLLLGRPTGRSNLREQVKPY FT LTLLQIREGDVNWVSEYKDDTRGLDEDSAEMWG" XX SQ Sequence 6368 BP; 1932 A; 1261 C; 1613 G; 1562 T; 0 other; acacaaagac gtccagatga atttagaagc tctttgctct agagtgcttt cagagagagg 60 gctatcaact ggtgagcctg gggtatatga ccagattttt gaaaggcctg gcctcccaaa 120 ccttgaagtc acagtggact ccactggggt agttgtcgat gttggggcca ttcctgactc 180 agcatcacag ctagggtcct cgataaatgc aggcgtgctc accatacctc tctcagaagc 240 atataagata aatcatgact tcactttctc tggactgact aagacaacag ataggaagtt 300 gtctgaagta ttccctttgg ttcatgatgg ctcagactca atgacccccg atgtgatcca 360 cacaagacta gatggaacag tagttgtaat tgaattcaca acaaccagaa gcacaaacat 420 gggaggactt gaggctgcct atcggagcaa gcttgaaaaa taccgtgacc cactaaacag 480 aagaacagac ataatgcctg atgcatcaat ttactttgga atcattgttg ttagtgcatc 540 tggtgttctc acaaatatgc ctctgaccca agatgaagct gaagaattga tgttcaggtt 600 ctgtgtggca aatgagattt attcccaggc aagagcaatg gatgctgagg ttgaacttca 660 aaagtcagag gaggaatatg aggccatatc cagagcaaga gctttcttca cgctttttga 720 ctatgacgat ggtaagctct ctgaggcatt ccctaactct gacattgaga tgctcagaag 780 atttctgagt cagcctgtag acacaagttt tgtgaccaca accctcaaag aaaaagagca 840 agaggcttat aagagaatgt gtgaggagca ctatctaaag agtggcatga gcacaaaaga 900 gaggcttgag gcgaatcgca gtgatgcaat agacaaaact agagctctca tggagagact 960 ccacaacatg agcagcaagg agctacactc gaataagagc acagtgaagt tgcctccctg 1020 ggtagtgaag ccttctgata ggacgttaga tgtcaaaacg gacacgggat caggggagct 1080 actcaaccat ggcccatatg gggagttgtg gtcaagatgc ttcctggaga ttgtccttgg 1140 gaatgtggag ggggtcatca gcagccctga aaaggagctg gagatcgcca tcagtgatga 1200 ccctgaggct gacaccccta aggctgcaaa gattaaatac cataggttcc ggcctgagct 1260 cagtttagag agcaagcatg aattttcatt acaaggcatc gagggcaaaa gatggaagca 1320 ttcagctagg aatgtcctta aagatgaaat gtcccacaag acaatgagcc catttgttga 1380 tgtctcgaac attgaggagt ttctgattat gaacaacctg ttaaatgaca catcttttaa 1440 tcgggaagga ctgcaagaaa caatcaacct gttgttggag aaggctactg aaatgcacca 1500 aaatggctta tcaacagctt tgaatgattc cttcaagaga aacttcaaca caaacgttgt 1560 gcagtggagc atgtgggtct catgcttagc tcaggaattg gcaagtgctt tgaagcaaca 1620 ttgcaagcct ggtgagttta tcatcaaaaa attaatgcac tggccaatat tcgtcataat 1680 taagcccact aagtcatcaa gtcacatatt ctacagcttg gcaataaaaa aagccaacat 1740 taagaggagg ctgattggtg atgtattcac agacacaatt gatgcggggg agtgggagtt 1800 ttcagaattc aaaagcctca agacgtgcaa gctgacaaat ctcattaacc tgccgtgcac 1860 catgctcaac tcaatagcgt tctggagaga gaagatggga gtagccccct ggatttctag 1920 aaaggcctgc tcagagctca gggaacaagt ggcaatcact ttccttatga gtctggaaga 1980 caaatcaaca acagaagagc ttgttactct cacgaggtat tcacaaatgg agggatttgt 2040 gtctccaccc ctgctcccta aaccccagaa gatggtggaa aagttagaag ttcctttgcg 2100 aacaaagctt caagtgtttt tgtttaggag gcatcttgat gctattgtta gagttgctgc 2160 atccccattc cccattgtgg caagagatgg tcgagtggaa tggacaggga cattcaatgc 2220 aatcactggc cgaagcactg ggctggaaaa catggtaaac aactggtata ttggctacta 2280 taaaaacaaa gaagagtcga ccgagctaaa tgccttgggc gagatgtaca agaagattgt 2340 tgagattgag gctgagaagc caacatcttc tgagtaccta ggatggggag acactagcag 2400 ccctaagagg catgagttca gtagaagctt cctcaagtca gcatgcatat ctcttgagaa 2460 ggagatagag atgaggcatg gaaagagctg gaagcaaagc ttggaggaga gagtccttaa 2520 agagctgggc tcaaagaact tgctggactt agcaacaatg aaggcaacaa gcaactttag 2580 caaggaatgg gaagctttct cagaagtcag aacaaaagaa taccataggt ccaaactcct 2640 agaaaagatg gctgaactaa tagagcatgg gttaatgtgg tatgttgatg ctgcaggtca 2700 tgcatggaag gctgtccttg atgacaagtg tatgagaata tgcttgttta agaaaaatca 2760 gcatggaggc ctgagggaaa tttatgtaac gaatgcaaat gcaaggcttg ttcaatttgg 2820 agtagagaca atggcacggt gtgtgtgtga gctaagccca catgaaacaa tagctaaccc 2880 tagactcaag tcaagcatca tagagaatca tggtctcaag agtgctcgac aattagggca 2940 ggggaccatt aatgtcaact cttcaaatga cgcaaaaaaa tggagtcagg gccattatac 3000 aaccaaattg gctatggtat tatgctggtt catgccagct aagttccata ggttcatatg 3060 ggcaggcatc tcaatgttta ggtgcaagaa gatgatgatg gacctcaggt ttttagaaaa 3120 attgagcaca aaggctaatc agaaaactga tgatgacttc aggaaagact tagctggggc 3180 cttccatggc aatgttgagg ttccttggat gactcaagga gctacatatc tccagactga 3240 gacagggatg atgcaaggga tcctgcattt tacatcaagc ctactgcatt catgcgtcca 3300 aagtttttac aaggcatatt ttttatctcg gcttaaagaa gggatcgcag gcagaaccat 3360 caaggcagct atagatgttt tagaaggctc tgatgactca gctatcatga taagcttgaa 3420 gccagcctca gacaatgagg aagcgatggc tcggttttta acagccaact tgctatactc 3480 agtcagagtc ataaacccgc tctttggcat ttatagctct gagaagtcaa cagtaaatac 3540 cttattttgt gtggaataca actcagagtt ccacttccac aagcatttag tcaggcctac 3600 aatcagatgg gttgcagcat cccaccaaat ctctgagtca gaagccctgg caagcaggca 3660 ggaagattat gcgaaccttc tcactcaatg tcttgaaggg ggttcatcat tctctctaac 3720 atatttgatc cagtgtgccc agctcgtcca tcattatatg ctgctcgggc tctgcttgca 3780 cccgctgttt gggacatttg tagggatgct gattgaggat ccagatccag ccctaggctt 3840 cttcataatg gacaatccag cttttgcagg gggagctgga tttagattca acctttggag 3900 atcttgcaag ttcacaaacc ttggcaaaaa gtatgcattc tttttcaatg agattcaagg 3960 aaaaaccaag ggggatgcag attacagagc actggatgca acaactggtg gaacattaag 4020 ccactctgta atgacctact ggggggacag gagaaagtac caacatctcc tagacaggat 4080 ggggcttccc aaggactggg ttgagaggat agatgaaaac ccaagcatct tatataggag 4140 gcctgagaac aagcaggaac ttatcttgag gctggcagaa aaagtgcatt ctccaggtgt 4200 cacttccagc ttcagcaaag ggcatgttgt acctagggtg gtggcagctg gagtctactt 4260 gctgtcaaga cattgcttca ggtacactgc atcaatccac ggtagggggg catctcagaa 4320 ggcgagtctg attaagctgc ttgtcatgtc ttcaacatca gctgagagga atcaaggaag 4380 gctgaaccca aatcaagaaa gaatgctctt tcctcaagtc caagagtatg aaagagtatt 4440 gaccttgtta gatgaggtta ctgcgctcac agggaagttt gttgtgagag aaaggaacat 4500 agtcaaaagc agagtagagc ttttccagga gcctgtggac ttaaggtgca aagctgaaaa 4560 cctcattgca gaaatgtggt ttggacttaa aagaacaaag ttgggcccaa ggctgctaaa 4620 ggaagaatgg gacaaactcc gcgcctcctt ctcatggtta agcactgatc ataaagaaac 4680 actggatgtg ggtccatttc ttagtcatgt tcaattcagg aatttcattg cacatgtgga 4740 tgcgaagtct aggagtgttc gacttttggg ggcccctgtc aagaagtctg gaggagtgac 4800 tacagtgtcc caggtggtga aatctaattt ctttccaggt ttcattttgg actccagtga 4860 gagcttagat gaccaagaga gggttgaggg ggtgtcaatc ttaaaacaca ttctatttat 4920 gaccttgaat ggcccttaca ctgatgagca aaagaaagcc atggttctgg agaccttcca 4980 atattttgca ctgccacatg ctgctgaagt tgtgaagaga tcacgatcac taaccctatg 5040 cttgatgaag aattttattg agcagagagg agggtcaata cttgaccaaa ttgaaaaggc 5100 tcagtcaggt acagtgggtg gattcagtaa gccccagaag ccttaccgca aacagtcagg 5160 aggcattggc tacaagggga aaggtgtttg gtcaggcata atggaaaaca caaatgtaca 5220 gatcctgata gatggtgatg gttcatcaaa ctggatagaa gaaatcaggc tgagtagtga 5280 gtccaggcta tttgatgtca tagaatctgt caggaggctg tgtgatgaca ttaatgtcaa 5340 taatagagtt acatcaagct ttcggggtca ttgcatggtg aggcttagca actttaaggt 5400 caagccagct tcaagggtag aaggttgccc agtgcgactc atgccctctt cattccggat 5460 aaaggagctc caaaacccag atgaggtctt cttaagggtg aggggagaca ttctaaacct 5520 gtccatcctc cttcaagagg accgagtcat gaatctgctt agctacagag ctcgtgacac 5580 tgacatctca gagtctgcag catcctacct atggatgaat agaacagact tctcatttgg 5640 aaagaaggag ccatcttgca gctggatgtg cttgaaaaca ttggactcat gggcttggaa 5700 tcaagcagca agagttcttg aaagaaacat caaaacccct ggaattgata acaccgccat 5760 ggggaacatt ttcaaggatt gcttagaaag ctcactcaga aagcaggggt tgcttagatc 5820 tagaattgct gagatggtgg aacgtcatgt tatcccacta acaagtcagg agctggtgga 5880 tatcctggag gaagatgtcg acttttcaga aatgatgcaa tctgatataa tggaagggga 5940 cctagacatt gatatcctga tggaagggtc accaatgctc tgggcagcag aagtggagga 6000 gatgggagaa gctatggtga tactcagtca gtcaggaaag tattatcatc taaaattaat 6060 ggatcaagca gcaacaaccc tttcaacaat ccttgggaaa gatggttgca ggcttctact 6120 ggggagacct actgggagat caaatctcag ggagcaggtg aagccctact tgacattatt 6180 gcaaataaga gagggagatg tcaactgggt ttctgagtac aaagatgaca cacgtggtct 6240 tgatgaagac tctgcagaaa tgtggggtta aaccaaccag gactggggct cgggttgagg 6300 tgaagtgact ctgctgtctc acttgagcta tcagtaccta aaggttgata tctggacggt 6360 ctttgtgt 6368 //