ID GU128081; SV 1; linear; viral cRNA; STD; VRL; 15432 BP. XX AC GU128081; XX DT 21-JUN-2010 (Rel. 105, Created) DT 25-JUN-2010 (Rel. 105, Last updated, Version 2) XX DE Tuhoko virus 2, complete genome. XX KW . XX OS Tuhoko virus 2 OC Viruses; Riboviria; Negarnaviricota; Haploviricotina; Monjiviricetes; OC Mononegavirales; Paramyxoviridae; Rubulavirinae; Pararubulavirus; OC Tuhoko pararubulavirus 2. XX RN [1] RP 1-15432 RX DOI; 10.1016/j.virol.2010.03.049. RX PUBMED; 20537670. RA Lau S.K., Woo P.C., Wong B.H., Wong A.Y., Tsoi H.W., Wang M., Lee P., RA Xu H., Poon R.W., Guo R., Li K.S., Chan K.H., Zheng B.J., Yuen K.Y.; RT "Identification and complete genome analysis of three novel RT paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China"; RL Virology 404(1):106-116(2010). XX RN [2] RP 1-15432 RA Lau S.K.P., Woo P.C.Y., Wong B.H.L., Wong A.Y.P., Tsoi H.W., Wang M., RA Lee P., Xu H., Poon R.W.S., Guo R., Li K.S.M., Chan K.H., Zheng B.J., RA Yuen K.Y.; RT ; RL Submitted (22-OCT-2009) to the INSDC. RL Microbiology, The University of Hong Kong, Rm 440, University Pathology RL Building, Queen Mary Hospital, Pokfulam Road, Hong Kong, China XX DR MD5; cf67aa2a3819c0a4f587067fa3dbffc3. DR EuropePMC; PMC3901491; 24447466. DR EuropePMC; PMC4187747; 25078906. DR EuropePMC; PMC5022529; 25919464. DR EuropePMC; PMC6315912; 30487438. XX FH Key Location/Qualifiers FH FT source 1..15432 FT /organism="Tuhoko virus 2" FT /host="fruit bat" FT /mol_type="viral cRNA" FT /country="China" FT /db_xref="taxon:798073" FT misc_feature 1..55 FT /note="leader sequence" FT gene 56..1817 FT /gene="N" FT CDS 165..1736 FT /codon_start=1 FT /gene="N" FT /product="nucleocapsid protein" FT /db_xref="GOA:D8WJ29" FT /db_xref="InterPro:IPR002021" FT /db_xref="UniProtKB/TrEMBL:D8WJ29" FT /protein_id="ADI80716.1" FT /translation="MSSVFQAFEQFTLEQDQQVGGGNLEVPPETLQTTIKVFILNTQNP FT QIRYQMLCFCLRIIASNSARTAQKHGALLTILSLPTAMMQNHIRIADRSPDSVIERIEI FT EGFEPGTYRLRANARTPMTAGEVIALENMAEDLPDTLANQTPFLNPNTEDEICDEMEKF FT LDAVYSVLIQVWVMVCKAMTAFDQPTGSDTRRLAKYQQQGRMDQKYLLQNEVRRLIQLG FT IRESLTIRQFLVFEMQTARRQGPITSKYYAMIGDIARYIENAGMGPFFMTIKFALGTRW FT PPLALAAFSGELVKIKGLMQLYRRLGDRAKYMALLEMSEXMDFAPANYQLLFSYAMGIG FT RVQDPQLQGYNFARPFLNAAFFQLGMETANRQQGSVDREMAEELGLTDADKREMAAQLT FT RLTTGRGGDDQQGIVNVFGRRAQRQQVIQNQDQFRVVEEEESEEEEEEIEEQPVRGAAP FT APIRRPNDEEAAWQARLNELEGMQRRPHPPRHVQLHPLQPVPVGLAAAQIHREPPAQEL FT VADLVE" FT gene 1825..3293 FT /gene="V/P" FT CDS 1938..3141 FT /codon_start=1 FT /exception="RNA editing" FT /gene="V/P" FT /product="phosphoprotein" FT /db_xref="InterPro:IPR004897" FT /db_xref="InterPro:IPR025909" FT /db_xref="UniProtKB/TrEMBL:D8WJ30" FT /protein_id="ADI80717.1" FT /translation="MDPSPSDEEISAWIDKGMDTVQHFISQPVNPQSSLGKNTIKSGNT FT KILIKSAEKKSKATKDNVTQESAPTPPPRDYQSEKKEVVRPKIRKTQGERPRPLPPIPQ FT QEESIYEEVSREVVEEDQPLLQQQQAHVLKGKQKILSTSPVNQEPDLPTGPGGQGFKRG FT GLGLISQQQDSSTYDQGIDESLTSDGMATNLVLESGATLAVPLSDQLQCDIPALVENAL FT QSAPCVKEILRYLRVLENRFNQMESKIDKIISHQNILTQIRNEQLGLKASMAMLEGMIT FT SIKIMDPGVGPGATAAQAKKLFKEVPVVISGNSVGATELTEAAELEIQDLGRPVIPQQT FT PKKRAVVGDSDLASYKLTLKNLAKDCIPNAHIQAEFDKKISSIRSENDFKKIKREILRA FT AT" FT gene 1938..2663 FT /gene="V/P" FT CDS 1938..2663 FT /codon_start=1 FT /gene="V/P" FT /product="V protein" FT /db_xref="GOA:D8WJ31" FT /db_xref="InterPro:IPR024279" FT /db_xref="InterPro:IPR025909" FT /db_xref="UniProtKB/TrEMBL:D8WJ31" FT /protein_id="ADI80718.1" FT /translation="MDPSPSDEEISAWIDKGMDTVQHFISQPVNPQSSLGKNTIKSGNT FT KILIKSAEKKSKATKDNVTQESAPTPPPRDYQSEKKEVVRPKIRKTQGERPRPLPPIPQ FT QEESIYEEVSREVVEEDQPLLQQQQAHVLKGKQKILSTSPVNQEPDLPTGPGGQGFKRG FT SRSHISTTGLVHLRPRHRREFDIRWYGNKPCVREWCNPGCSPIRPTPMRYTCTCGECPA FT VCSMCEGDPQILESAGEPI" FT misc_feature 2422..2426 FT /gene="V/P" FT /note="region of RNA editing for phosphoprotein; RNA FT editing introduces 2 G residues causing frame shift" FT gene 3301..4730 FT /gene="M" FT CDS 3336..4466 FT /codon_start=1 FT /gene="M" FT /product="matrix protein" FT /db_xref="GOA:D8WJ32" FT /db_xref="InterPro:IPR000982" FT /db_xref="InterPro:IPR042539" FT /db_xref="InterPro:IPR042540" FT /db_xref="UniProtKB/TrEMBL:D8WJ32" FT /protein_id="ADI80719.1" FT /translation="MAHRQATVSIKVNHESEKNHLRPFPIVQLPPSPGGSRGRLTRQIR FT IKDLTPAGSTEPSLTFINTYGFAKPLRTRTEFFSELHKPDSLPSVTACTLPFGAGPNIE FT HPMRLLDEIEKVHIVMRKSASAREEIVFNVCRLPPILSKHHIATQKLVCISSEKYLKAP FT GKMISGMDYNYHIAFISVVYCPASLKFRVMRPLQLLRSSTMRSIQLEVILVIECSDNSP FT ATRNLIFDDESKTWRASVWFHLCNILKSNKSAEKYDDHYFNEKCKKMDLEVGIADMWGP FT TFLVKAHGKIPKTAQVYFSPKGWSCHPLVDAAPALSKILWSTGARIVNVNAILQPSDLG FT QLVQVSDVIYPKVKINKKLMNTAPSRWNPVKKAVLA" FT gene 4790..6570 FT /gene="F" FT CDS 4857..6476 FT /codon_start=1 FT /gene="F" FT /product="fusion protein" FT /db_xref="GOA:D8WJ33" FT /db_xref="InterPro:IPR000776" FT /db_xref="UniProtKB/TrEMBL:D8WJ33" FT /protein_id="ADI80720.1" FT /translation="MAPCVLFLSSLLLISTISPSHGINQPALRRIGAIVSSVKQLKFYS FT KTKPNYIIVKLLPTINLSKSNCNLTSINRYKESVIEIIKPLADNIDNLNQKLLPKNRRK FT RMAGVAIGLAALGVAAAAQATAAVALVEARKNTQMIQSLADSIQDTNAAVQAVNIGLQN FT SAVAIQAIQNQINNVINPALDRLNCEVLDAQIASILNLYLIKSVTIFQNQLTNPALQQL FT SIQMLSIVMQDTAKILGNFTIGDKFDQHDLLGSGLITGQVVGVNLTNLQLIIAAFIPSI FT APLPQAYIIDLISITISVNDTEAVIQIPERIMEHGSSIYQFGGKQCVYGQFSAYCPFSD FT AVLMTQDLQLCMKGNIEHCIFSSVLGSFPNRFASVDGVFYANCKYMSCACSDPLQVIHQ FT DDSVNLMVIDSSVCRSLTLGHVTFPIIAFSNVSYQMKTNISIEQMIVTSPLDLSTELKQ FT INNSVNIANTFLDSSNRALKTSIFGTSSQIILIVLLIFTCLLILYVIFLTYIIKILIKE FT VKRLRDGNSRTGSKLSFINPDV" FT gene 6590..8548 FT /gene="HN" FT CDS 6644..8410 FT /codon_start=1 FT /gene="HN" FT /product="hemagglutinin-neuraminidase" FT /note="attachment protein" FT /db_xref="GOA:D8WJ34" FT /db_xref="InterPro:IPR000665" FT /db_xref="InterPro:IPR016285" FT /db_xref="InterPro:IPR036278" FT /db_xref="UniProtKB/TrEMBL:D8WJ34" FT /protein_id="ADI80721.1" FT /translation="MPPVPTVSQSIDEGSFTDIPLSPDDIKHPLSKKTCRKLFRIVTLI FT GVGLISILTIISLAQQTGILRKVDSSDFQSYVQESFKQVLNLMKQFSSNLNSLIEITSV FT TLPFRIDQFGTDIKTQVAQLVRQCNAVCRGPIKGPTTQNIVYPALYETSLNKTLETKNV FT RIQEVRQEVDPVPGPGLSNGCTRNPSFSVYHGVWCYTHATSIGNCNGSLGTSQLFRIGN FT VLEGDGGAPYHKSLATHLLTTRNVSRQCSATASYYGCYFICSEPVLTERDDYETPGIEP FT ITIFRLDPDGNWVVFPNINRFTEYSLKALYPGIGSGVLFQGKLIFPMYGGIDKERLSAL FT GLGNIGLIERRMADTCNHTEKELGRSFPGAFSSPYYHDAVMLNFLLICEMIENLPGDCD FT LQILNPTNMSMGSESQLSVLDNELFLYQRSASWWPYTLIYRLNMRYTGKYLKPKSIIPM FT VIKSNTRPGYEGCNHERVCPKVCVTGVFQAPWILSIGRDHKERVSNVTYMVAWSMDKSD FT RTYPAVSVCGSDTCKLTVPLGDSKVHSAYSVTRCYLSRDHMSAYCLVIFELDARPWAEM FT RIQSFLYKLILT" FT gene 8556..15409 FT /gene="L" FT CDS 8564..15367 FT /codon_start=1 FT /gene="L" FT /product="RNA polymerase" FT /db_xref="GOA:D8WJ35" FT /db_xref="InterPro:IPR014023" FT /db_xref="InterPro:IPR016269" FT /db_xref="InterPro:IPR024352" FT /db_xref="InterPro:IPR025786" FT /db_xref="InterPro:IPR026890" FT /db_xref="InterPro:IPR039736" FT /db_xref="UniProtKB/TrEMBL:D8WJ35" FT /protein_id="ADI80722.1" FT /translation="MAAPQQIILPEVHLDSPIVQNKLLYFVRLGGLPLPDLFFEDDFFP FT DVDWDRVRREENRLSSRLETIRSRILAKTQTGSGLNPINKTAPLILLWPSCLTRLHQFT FT FPEALSRFHDANKIMQAACNYLSAGLTTVLTSVSEKLTNKTNLFTHNESQCLHVRSHDR FT PQDLKQICEQMTNAQWKSQFDLWFLVRHQMRTLINKNNNQSTDKLVIEMDRRVQSIIIT FT PELVALWDREDNFLTYLTFEMVLMVCDLYEGRLNILGVAKMSCYLSPLTSRLNKLFEIV FT DELCTLLGNQVYAIVASLESLVYARLQLLDPVEEVCGDFYSFICKELIDGLTANDVISI FT PEAELIADKLLDCYNNLTPDLIAELLCVMRMWGHPMLTSEKAAAKVRESMCAPKVIDFE FT TTLKTLAFFNEIIINGYRRKHNGIWPKCKLPPYASLSLQELKHDNSEISHQYTLTHWKE FT IAFIEFEKSFDADPGSDLSIFMKDKAISAPKKDWLSVFRKSLIKPLCERLHQPMPSSYN FT RRLLLNFLDDDQFDPVKELEYVTSGAYLDDEDFCASYSLKEKEIKETGRIFAKLTKKMR FT SCQVICESLLANHAGKLFKENGVVVDHLNLTKSLLTMSQIGLISTKSRRAARENITVVS FT HLKSRNNNPTQSIQKQADQPTIDETTEIAAFFLTTDLKKYCLNWRYQSIILFATSLNKL FT YGYPHLFEWIHLRLMRSTLYVGDPFNPPRFLNTLDLDEVQNDGIFIVSPRGGIEGLCQK FT MWTMISIAVITLSATESSTRVMSMVQGDNQAIAMTTKVPRSLNHRQKKEIAYNNSKLFV FT ERLRYNNRGLGHHLKEQETIMSSDFFVYSKRIVFRGRILNQALKNVSKLNLIADVLSEC FT TQTSCSNLTTTIMRLTENGVEKDICYNLSFFFSIKQLVYDLLFPITTIFEDEVTALYLN FT HPILISRLCLLPSQLGGLNFYSISRLFNRNIGDPLTSAIADLKRFLAADLLPKWTIANL FT LGRNPGKGTWSTLAADPYSLNIDYLYPPTTYLKKHTQRVLMEGSVNPMLQGIFTDNAIE FT EENAIAKFLLDRPIVMPRVAHIVLEQTSCGRRKQIQGFLDTTRTIIRHALAKQPPSYKK FT LEKIIDYNRLYLAYNLELISKPNDKKAERKAREDLVNVCSIDLAKLLRRMSWSQLLSGR FT PIDGLETPDPTELIQGYIINGNDNCLACLQGDRKFTWFYIPGNITLDAPPEDNPPIRVP FT YIGSRTDERRVASLGYVKGATQALKSALRLAGVYIWAFGDTDDNWNDALNLASTRVNIT FT LEQLRTLTPMPTSTNLTHRLDDGLTQMKFTPASSYAISSYVHISNDNQNLEIMDKQLDC FT NLIYQQIMLLGLGIIETWLQLPQYQNIDDFSVHLHTEGSCCIRAVDMCVINETSDEVPP FT MSVPYGNKFVYDDSPLDHDQQVKIENLSFQANITGLDIIPTEEKIPLLAHFVGLQFAHS FT LTGLDEATSLVNDAVIETDYANNWISECLNTYMDKVFYYTAWNMLLDLSYQMYYLRVTG FT ITAILDYMTLILDRIPGLALTGIASTISHPKILRRLINLGIVIPSNSPYLATLDYHKMS FT TLSIMWGVQSVLSDISSGLDIELIIPSEDSTELSDRVLNLVARKLSLISLVIGHGSALS FT YVRGLTPDVKCKTLTEKLIVIIETTITDPEQRGKLSTLVTEPKISAFPSNLYYLMRKLL FT NWIRDSDKAQQLIAMFYDSFGYMEFQTSDISPINHSIDTCTSNSLTIHDKVSNILDYDT FT VAEKYAYPKCDPSLQYHMKPVADPPVHHILRPIGLSSTSWYKGLSILNVLSCSKVPTGN FT HLYLAEGSGALMTLIESYIPAQKIYYNSLFSSGQCPPQRNFQPMPTQFTESMVYMNIQN FT GYGNSDLIDQEFIALWSGVERQTDLSKKDCIEFILQQIPSQSLSLISSDIEEGIGSNLT FT QLSKATINSVLLSYVLLKDGGLLIMKINLTPFCKFSQLITLLSSKFKNIKAVRSSYSDP FT STDELYLVATASGDSSVGDFNAARYNSDILDSESFTLVSPQLLLDLHHGITENQKTVYD FT IIEMQISTGQCFENIEDHETLIKLGSSTQRNRLMTSPAAESRSELLERISDIITLYLKE FT TINIIESSQLDRNRLLYNSYNVSSYGKIRTSAKLSAKLVLDIFIRNWINLGVPLRKRIA FT GMIEKGYFCVGETISCKDYLSFCKARKYLLKTIGIDQLAVELEQNLSCEFQRSEQKKLW FT KNIGCIAFIESIEPGDFNSPEQIFQDDEIEERDIGGELL" FT misc_feature 15410..15432 FT /note="trailer sequence" XX SQ Sequence 15432 BP; 4850 A; 3082 C; 3181 G; 4318 T; 1 other; accagaggga aaatatacag aggaatttac cggacgagat caataatgct gatgtgggcc 60 cgaaagtggc atccgtcggg gtcgaagtcg atcccagggt tctgctttcg ggtcttgatt 120 agagttatct tctcactagt aggagtatcc agactctttt caagatgtcg tcagttttcc 180 aagcttttga gcagttcact cttgaacagg atcagcaggt gggaggaggt aatttagaag 240 tgccacctga aactctccag actactatca aggttttcat ccttaatacc caaaaccccc 300 agatacgcta tcagatgctt tgcttttgct tacgaattat cgctagtaat tctgcgagaa 360 ccgctcaaaa acatggagct ctcttgacta ttttgagcct tccaactgca atgatgcaaa 420 atcatatcag aattgccgac agatccccgg actctgtgat tgagagaatt gaaattgaag 480 ggtttgagcc aggcacatac aggctgcgtg ccaatgcaag aacaccaatg acagcgggtg 540 aggttattgc cctggagaac atggctgaag atctgccgga tacactcgct aatcagacac 600 ctttccttaa tcccaatact gaggacgaaa tttgtgatga aatggagaaa tttttggatg 660 cagtgtacag tgtcttgatt caggtttggg taatggtctg taaagcaatg actgcatttg 720 atcagccgac ggggtcggat acaaggaggc tggcgaaata tcagcaacag gggagaatgg 780 accaaaagta cctactacag aatgaagttc gacgattgat acaattgggc attagagaaa 840 gcttaacaat aaggcaattt ctggtatttg aaatgcaaac tgcaagacgt cagggtccaa 900 tcaccagcaa atactatgca atgattggag acattgctag atatattgag aatgcgggga 960 tggggccatt ctttatgaca atcaaatttg ctcttggcac tcggtggccc ccattggctc 1020 ttgcggcctt ctcaggagaa ctagtaaaga ttaagggatt gatgcaactt tatcgaaggc 1080 ttggagacag agccaagtat atggctctcc ttgaaatgtc tgaaatratg gatttcgccc 1140 cagcaaatta tcagctcctg tttagctatg ctatgggaat tggccgggta caagatcctc 1200 agctgcaggg gtacaatttt gcacggccat tcctcaatgc tgcattcttc cagcttggaa 1260 tggaaacagc aaatcgccaa cagggatcag ttgaccgaga gatggcagag gaactgggac 1320 tcactgacgc cgataaacgg gaaatggctg cccaactgac acgactcaca actggcagag 1380 gtggagatga ccaacagggt atcgtcaatg tgtttgggag gcgtgcacag agacaacagg 1440 ttattcagaa tcaggaccag tttagagtag tggaggaaga ggagagtgag gaggaagagg 1500 aagagattga agaacaacct gttagaggag cggctcccgc accaattcgg cgcccgaatg 1560 atgaagaggc tgcttggcag gcaaggctaa atgaattaga aggaatgcag aggagaccac 1620 accctcccag acatgtccag ttgcacccac tgcagcccgt tccggtagga ctggctgctg 1680 cacagattca cagagagcct cctgctcagg aactggttgc tgatttggtt gaatgaattc 1740 gcagctccag cattgcaggc ttaaatgata gtagactgcg ttagtgctgc tttttgcata 1800 gagtttttaa gaaaaaacaa gggtgggccc gaagagtggt acctctcggg tcctcccctc 1860 ttcgggctct ccttgatctt cgaaggaatc atacaccctg tcactcaaag catagactaa 1920 agatccatag agccaacatg gatcccagcc catcagacga agaaatatcc gcctggattg 1980 acaaaggcat ggacactgtc cagcacttca tatctcaacc cgtaaaccct caaagctctc 2040 ttggcaagaa caccatcaaa tcaggcaata caaaaattct cataaaatct gcagaaaaga 2100 agtccaaggc aaccaaagac aacgtcaccc aagaaagcgc tcccacaccg cccccaagag 2160 actaccaatc agagaagaag gaagtggttc ggccaaaaat tcggaaaact cagggtgagc 2220 ggcctaggcc cctccctcct atacctcaac aggaggaatc aatttatgaa gaagtgtcta 2280 gggaagttgt agaagaggat cagccattac tccaacaaca acaagcccat gttctcaagg 2340 gaaagcagaa gattctgagc acctctccag tgaatcaaga acctgatctt ccaactggcc 2400 ctggtgggca aggttttaag agggggtctc ggtctcatat ctcaacaaca ggactcgtcc 2460 acttacgacc aaggcataga cgagagtttg acatcagatg gtatggcaac aaaccttgtg 2520 ttagagagtg gtgcaaccct ggctgttccc ctatcagacc aactccaatg cgatatacct 2580 gcacttgtgg agaatgccct gcagtctgct ccatgtgtga aggagatcct cagatacttg 2640 agagtgctgg agaaccgatt taatcaaatg gaatccaaga ttgacaaaat cataagccac 2700 cagaatatat tgacccaaat tcggaatgaa caattaggac tcaaagcaag catggcgatg 2760 cttgagggga tgattacatc aataaagata atggatccag gtgttggccc aggagcgact 2820 gctgctcaag ccaaaaaatt gttcaaagaa gttcctgttg tcataagcgg gaacagcgtg 2880 ggagcaactg agttgacaga agcagcagag ctcgagattc aggatcttgg acgccctgtg 2940 atacctcaac agactccgaa aaagagagct gttgttggtg atagtgatct ggcaagttac 3000 aaactcaccc tcaagaatct ggccaaagat tgcatcccaa atgcacatat ccaggctgaa 3060 tttgacaaga agatctcatc tatccgatct gagaatgatt tcaagaagat caagagagag 3120 atcctcaggg cagcaactta ggaacccagc tgctaagagg aagctagcct ctgtttggaa 3180 ttacccgctt tgcttacact gtcattagta ctagcttata atgtccgcat gctaatccct 3240 ctaatcatgc ttgcattaaa gtaggtatta taatagatta gtttaagaaa aaatcaaaat 3300 gggtccgaac ccataggact tcgaccccgg ccaagatggc tcatcggcaa gctactgtgt 3360 cgatcaaggt caatcatgaa agtgagaaaa atcatcttcg tccgttcccc atcgttcaac 3420 tcccaccttc acctgggggg tcaaggggtc ggttaactcg gcagatccga atcaaagatt 3480 taacaccagc cggatcgact gagccgtcac tgaccttcat aaacacttat gggttcgcca 3540 aaccgcttcg cactagaact gagttctttt ctgagctaca caaacctgat tccttaccca 3600 gtgtcactgc ctgtacatta ccctttggtg caggcccgaa catcgagcat ccaatgagat 3660 tgttggatga aattgaaaaa gtacacattg tcatgaggaa aagtgcaagt gctagagagg 3720 agattgtttt taatgtatgc cgccttcccc ctatattaag caaacatcac attgcaactc 3780 aaaaattagt atgtatctca tctgagaaat atctcaaagc tccagggaag atgatctcag 3840 ggatggatta taattatcat attgcattca tttccgtggt ctactgtcct gccagtctga 3900 agttccgtgt aatgcgccca ttgcagcttt taagatctag tacgatgagg agcatacagc 3960 tagaagtgat cttggtcatt gaatgctcag acaattcccc tgcaactcgc aacctcatct 4020 ttgatgatga aagtaagaca tggagagcat cagtgtggtt ccatttgtgc aacattctca 4080 agagtaataa gagtgctgag aaatatgatg accattattt taatgagaag tgcaagaaga 4140 tggatcttga agttggaatc gcagatatgt gggggcccac atttctggtg aaagcacacg 4200 ggaagatacc gaagactgca caggtatact ttagccctaa aggttggtct tgtcacccat 4260 tagtagatgc tgcccctgct ttgagcaaaa tattatggtc cactggtgca cggattgtaa 4320 atgttaatgc aatcttacag ccatcagatc ttgggcaatt agtccaagtc tctgatgtga 4380 tctatccaaa agtcaagatc aacaagaaac tgatgaatac cgctccatct cgttggaatc 4440 cagttaagaa ggcagtcctg gcataatgtt gatgatgatt aaccgctatg gccttactct 4500 ttcctcagac agacttagat agggaggaaa tacttattgc ttatcatgat gaacattttg 4560 ttttttagaa aagcttcaat ggcactggga gcccaattgc aaggcagaac gaccgctaag 4620 tacaacaaga acacaagttc ataatctctt gctactgtcg catgcttctt tcattgtctt 4680 atttcatgcc ctatcatttt ctgctcatgc acgtatagtt taagaaaaaa ctaatattat 4740 taccttcgga aacggattac acccatatcg tatagagtcc aggaacattg ggcccgaacc 4800 cagaagccca accgccctgc ccgaatccga actgtacagc gagtgctcac ctcacaatgg 4860 ctccatgcgt attattccta tcatccctct tgttgatttc aaccatcagt ccttctcatg 4920 ggatcaatca acctgcactg agacggattg gtgcaatagt atcgtccgtt aagcaactta 4980 aattttattc aaagacaaaa ccgaattata taattgttaa gctactgcct acaattaacc 5040 tgtcaaaaag taattgtaat ctcactagta tcaacagata taaagaatct gtgatagaaa 5100 ttatcaaacc actggctgac aatattgaca acttgaatca gaaattactt ccaaaaaata 5160 gaaggaaaag gatggcaggt gtagctattg gtcttgctgc cttaggtgtg gctgcggctg 5220 cacaagcaac ggcagcagtt gcacttgttg aagctaggaa gaatactcaa atgatacagt 5280 ctttggctga ttcgattcaa gatactaatg cggcagtgca agctgtcaac attgggttac 5340 aaaatagtgc cgttgcaatc caggccatcc aaaatcaaat caataatgta attaatccgg 5400 ctctagatcg tcttaactgt gaggtccttg atgctcagat cgcaagcata cttaacctct 5460 acttgatcaa atcagtgact attttccaga accagttgac taatcctgct ttacagcaat 5520 tatcaattca aatgttgtct atagttatgc aagatacagc aaaaattctt ggcaatttca 5580 ccatcggaga caagtttgac caacatgatc ttttaggttc tggattaatt acaggacaag 5640 tagtaggagt taatcttact aatcttcaat taataatcgc agcttttatc ccatcaatag 5700 caccactacc acaggcatac attattgatt taatatctat aactattagt gtaaatgaca 5760 ctgaagcagt aattcaaata cctgaaagaa ttatggagca tgggtcgagt atttatcaat 5820 ttggtgggaa gcaatgtgta tacggtcaat tttctgctta ttgcccgttt agtgatgcag 5880 ttctgatgac tcaagatctt caactatgca tgaaaggcaa catagagcat tgcattttta 5940 gttctgtttt aggctctttc ccgaatcgtt ttgcatcagt tgatggagta ttctatgcta 6000 attgtaagta tatgtcatgc gcatgctcag atcctttgca ggttatccat caggatgata 6060 gtgtgaattt aatggtaatt gactcttccg tgtgcagatc tctcacactt ggtcatgtga 6120 cattcccaat tatagcattt tcgaatgtga gttatcaaat gaagactaat atatctatag 6180 aacaaatgat tgttacaagt cctttagatc tatccacgga gttaaaacaa ataaacaatt 6240 cagttaacat tgcaaatact tttctagatt caagcaatag ggcattgaaa actagtattt 6300 ttgggacaag ttcgcaaata atactgattg tgttactcat attcacatgc ttattgattt 6360 tatatgtaat attccttaca tatataatca aaatattgat caaagaagtc aagagactaa 6420 gagatggtaa cagcaggact ggcagtaagt tatcatttat taatccggat gtgtaaacgc 6480 ctagtgattg tatgctaaat ttagtaaaca ggccgtttaa ttgatctctg acaattacga 6540 ttctattagt attttagttt taataaaaaa cctagtggac tggaagcctg ggcccgaccc 6600 catcaagtcc agaagccccc cacaacacca gttcgactca accatgccac cggtaccaac 6660 tgtctcacaa tcaattgatg agggaagttt cactgacatc ccactgtcac ccgatgacat 6720 caaacatcca ttgtctaaaa agacgtgccg gaaattgttt cgaattgtca ctctgattgg 6780 agtagggtta ataagtattt taacaattat ctcacttgca caacaaaccg gaattctcag 6840 aaaggttgac agttcagatt tccaaagtta tgtacaggag tctttcaagc aggtattaaa 6900 tctaatgaag caattcagca gcaacttaaa ttctcttatt gaaattacat ctgttacatt 6960 accgtttcgt attgatcaat tcggaacaga tattaaaact caggttgcac aacttgtgcg 7020 gcaatgtaat gcagtctgcc gtggtcctat aaagggcccg acaacccaaa atattgtata 7080 cccagcattg tatgagacaa gcctcaataa aacattagag actaagaatg tcagaataca 7140 agaggtcaga caggaggtag acccagtgcc aggtccgggt ttatctaatg ggtgtactcg 7200 taacccttca tttagtgtgt accatggagt atggtgttat acgcatgcta cttccattgg 7260 taattgtaat ggctcattgg ggacttctca gctattcagg attgggaatg ttctagaagg 7320 tgatggtgga gcaccttacc ataaatctct agcaacacac ttattaacaa ctagaaatgt 7380 gtcacgacag tgctccgcaa ctgcctctta ttatggttgt tatttcatct gtagtgagcc 7440 cgtcctgacc gaaagagatg attatgagac accagggatc gaacctatta caatattcag 7500 gcttgatcct gacggaaatt gggttgtgtt ccctaatata aatagattca ctgagtactc 7560 acttaaggca ctttaccctg gtataggtag tggggtatta tttcaaggga agctaatttt 7620 ccctatgtat ggtggcattg ataaagaacg gctgagtgca ttaggccttg ggaatatagg 7680 attgatagaa cggcgtatgg cagatacctg taatcataca gaaaaagaac tgggtagatc 7740 attcccgggt gctttctcaa gcccatatta tcatgatgca gttatgctta atttcttatt 7800 gatatgtgag atgattgaga atcttccagg ggattgtgac ctgcagatat tgaacccaac 7860 aaatatgtct atgggatcag aatcccagtt gtccgtttta gacaatgaac tattcctgta 7920 tcagagaagt gcttcatggt ggccatatac tttaatttat agattgaaca tgaggtacac 7980 agggaagtac ttaaaaccaa aatctattat cccaatggtc attaagtcaa acacacgacc 8040 tggttatgag ggatgcaatc atgaacgagt ctgcccgaaa gtatgtgtca caggtgtttt 8100 ccaggcaccc tggattttgt caattggaag agatcacaag gaaagagtat ctaatgtaac 8160 ttatatggtt gcttggagta tggataaatc tgacaggaca tatcctgcag tatctgtgtg 8220 cggctctgat acatgtaaat tgactgttcc attaggggac tcaaaagtac attcagctta 8280 ctcagtaaca agatgttacc tatcaaggga tcacatgtca gcatactgcc ttgttatatt 8340 tgaacttgat gctagaccat gggctgagat gcgcatacaa tctttcttat acaaactaat 8400 actcacttag gattttccag ggtctatcaa attatctctc taattatcta taacatatta 8460 cgttaattgt catctctgtg attactaatg tctgagatta taatagatat tatattgaat 8520 ataaatgaat aacatcttta agaaaaaact gaattgggcc agaatggctg cccctcagca 8580 gatcattctg cccgaggtcc atctggactc tcccattgtt cagaacaaat tactgtactt 8640 tgtgagacta ggtggccttc cattgcctga ccttttcttt gaagacgatt tcttccccga 8700 tgttgattgg gatcgtgttc gaagggaaga gaatagactt tcatccagac tagaaactat 8760 tagaagtaga attcttgcaa aaactcaaac tggctctggc ttaaatccta tcaataaaac 8820 tgctcctctc atccttctct ggcctagctg tttaactcga ttacatcaat tcacattccc 8880 tgaagcttta tcaagatttc atgatgctaa caaaatcatg caggcagctt gtaattatct 8940 ctctgctggg ctgactactg tcctcacatc agtcagtgaa aagctaacta ataaaaccaa 9000 tttgtttaca cacaatgaat ctcagtgttt gcatgtccga tctcatgatc gccctcaaga 9060 ccttaaacaa atatgtgaac agatgacaaa tgcgcagtgg aaaagtcaat ttgacttatg 9120 gttcctagtc agacaccaaa tgaggacatt gatcaataag aataacaacc aatcaactga 9180 caaattagtg atagaaatgg acaggagagt acaatcaata attatcacgc cagaattagt 9240 ggctctttgg gacagagaag ataacttttt gacttacctg acattcgaga tggttctcat 9300 ggtatgtgac ctgtacgaag gccggctaaa cattttggga gtagcaaaaa tgagctgtta 9360 tctttcaccc ctgacttctc gccttaacaa gctttttgaa attgttgatg agctttgcac 9420 actgttaggt aatcaggtct atgccattgt agcgtcactt gaaagccttg tgtatgcccg 9480 actgcagcta ttagatcctg tagaagaagt ttgcggtgat ttttattcat tcatctgcaa 9540 agaactgatt gatggcctca ctgcaaatga tgtcattagc attccagaag ctgagcttat 9600 tgctgacaaa ctgctagact gctataataa tttgactcct gatcttattg ctgagctttt 9660 atgcgttatg agaatgtggg gacatccgat gctcacatca gaaaaagcag cagccaaagt 9720 cagggaatct atgtgcgctc caaaagtgat tgattttgaa acaacactca agacacttgc 9780 attctttaat gaaatcataa ttaatggata ccgtcgaaaa cataacggaa tttggcccaa 9840 atgcaaatta ccaccatatg catcattgag tcttcaggaa cttaagcatg acaattctga 9900 aatttcacac caatacactc taacacattg gaaggaaatc gcgtttatag aatttgagaa 9960 aagttttgat gcagatccag gttcagattt gagtattttc atgaaagaca aagctataag 10020 tgctcccaaa aaagattggt tgagtgtatt taggaagagc ttaattaaac cgctctgtga 10080 aagacttcat caacccatgc cttcatctta caacaggagg ttactgttga actttcttga 10140 tgatgatcag tttgatccag ttaaggaatt ggaatatgtg acctcaggag catatcttga 10200 tgatgaggat ttctgtgcat cttactccct caaagaaaag gagatcaaag aaaccgggag 10260 aatttttgct aaacttacta agaagatgag atcctgtcaa gtaatttgtg agtccctgct 10320 tgccaatcat gcaggaaaat tgttcaaaga gaatggagta gttgtcgatc acttaaattt 10380 aaccaaatca ttattaacaa tgtctcagat tggactgata tctactaaat ccaggcgtgc 10440 tgcaagagaa aatatcactg tagtctcaca tcttaaatca agaaacaata atccgacaca 10500 gagtatacag aaacaggctg atcaacccac aattgatgaa actacagaaa ttgcagcctt 10560 cttcctcaca accgacctaa aaaaatactg tctcaattgg agataccaat caattatcct 10620 gtttgcaaca tcattgaata aattgtatgg ctacccacac ctatttgagt ggatccatct 10680 gaggcttatg aggagtactc tgtatgtggg tgatcctttc aatcctccca gattcctaaa 10740 cacactggat ttggacgaag tgcaaaatga tggaatattc atagtatcac caagaggtgg 10800 gatagaaggt ctatgccaga aaatgtggac aatgatttca attgcagtta ttacactctc 10860 tgcaaccgaa tctagcacta gagttatgag tatggtgcag ggtgacaatc aagcaatcgc 10920 aatgacaact aaagtaccaa gatcacttaa ccacagacag aaaaaggaga tagcttacaa 10980 taacagcaaa ttgtttgttg agaggcttcg atacaataac aggggcctgg gtcaccatct 11040 aaaagaacaa gaaaccatca tgagttcaga tttctttgta tacagtaaga ggattgtttt 11100 ccggggaaga attttaaacc aagcattaaa gaatgtgagc aaacttaatt tgatagctga 11160 tgtgcttagt gaatgcacac aaacatcttg ttccaatttg actaccacca ttatgagatt 11220 gactgaaaat ggagtagaga aagatatctg ctataatctg agcttctttt tctcgatcaa 11280 gcaactagtc tatgatcttt tgtttccaat tacgacaatc tttgaggatg aggttactgc 11340 cttatatctt aatcatccca tcttgatttc taggttatgt cttttaccat ctcaattagg 11400 aggccttaat ttttattcaa ttagtagatt gttcaacaga aacatagggg atcccctcac 11460 atcagcaatt gcagacctta aacgtttcct ggctgctgat ctattgccaa agtggactat 11520 tgcaaatttg ttagggagaa atccgggaaa agggacatgg agtactctcg ctgctgatcc 11580 gtactcgctc aatatagact atctttaccc tccaacaaca tatctcaaaa aacataccca 11640 gagagtcttg atggaaggaa gtgtgaatcc catgctccag gggatattta cagacaatgc 11700 aatagaggaa gaaaatgcaa ttgcgaagtt cttattagac agacctattg ttatgccaag 11760 agtagcacat attgttttag agcagacatc atgtggaaga agaaaacaaa tacaaggatt 11820 ccttgacaca actcggacca taattcggca tgctcttgca aagcaaccac caagttacaa 11880 aaagttggag aaaattatcg actataatcg gttatatctg gcatacaatc ttgaactgat 11940 atccaagcct aatgacaaaa aggcggaaag aaaagctaga gaggacctgg tcaatgtttg 12000 cagcatagat ttggctaagt tactaagacg gatgtcctgg tcgcaattgc tttctggaag 12060 gcctattgat ggtcttgaaa cccctgaccc aactgagttg attcaaggat acattatcaa 12120 tggaaatgat aactgtttgg catgcttaca aggagatagg aaatttacat ggttttatat 12180 tccaggaaac ataacccttg atgctcctcc tgaagacaat ccacccataa gagttcctta 12240 catagggtcg agaactgatg aaagaagggt agcatcatta ggatatgtta agggagctac 12300 acaggctttg aaatctgcat taaggttggc aggagtctat atttgggcat ttggcgacac 12360 agatgacaat tggaatgatg cgctcaatct tgctagcacc cgggtaaaca taaccttaga 12420 acaactgagg actctgacac caatgccaac cagtaccaac ttaacccaca ggcttgatga 12480 tggattaaca cagatgaagt ttacaccagc cagttcttat gcaatttcaa gctatgttca 12540 tatctcaaat gataatcaga accttgaaat tatggataag caattggatt gcaatcttat 12600 ctaccaacaa attatgctgt taggattggg aattatagaa acttggttgc aattgcctca 12660 gtaccagaat atagatgatt tttctgtcca tctacatact gaggggtctt gctgcataag 12720 agctgtagac atgtgtgtta tcaatgagac ttctgatgaa gtgcctccaa tgagtgtccc 12780 ttatggtaat aaatttgttt atgatgattc accattggat catgatcaac aggttaaaat 12840 tgagaactta agctttcagg ctaatatcac tggcttagat ataataccaa ctgaagaaaa 12900 gatccctctc cttgcacatt ttgtaggact gcaatttgct catagcctta ctggtttaga 12960 tgaggctact tccttggtta acgatgcagt tatagagact gattatgcta acaattggat 13020 cagtgaatgt ctcaatacat acatggataa ggtgttctat tatactgcat ggaacatgct 13080 gcttgatttg tcataccaaa tgtattacct tagggttact ggaataactg caattttgga 13140 ctatatgaca ttgattcttg atagaatacc gggtcttgca ctaactggga ttgcctcaac 13200 aatcagtcac cccaaaatat taaggaggtt aatcaacctc ggaattgtaa ttcctagtaa 13260 ttctccatat ttagcaacac ttgattatca taaaatgtcc actttatcta tcatgtgggg 13320 agttcagagt gttctcagtg acatcagctc agggttagat attgaactta tcattccctc 13380 tgaagatagt acagagttat ctgacagagt tttgaatctt gttgcaagaa agctgtcttt 13440 aatctcactt gtgattggac acgggagtgc tctgtcgtat gttagaggac tgacccctga 13500 tgtcaagtgc aaaacattga cagagaaatt aattgttatc attgaaacaa caatcaccga 13560 tcctgagcaa agaggcaaac tctcaacatt agttactgaa ccaaaaatat cagcatttcc 13620 aagtaatttg tattatctta tgcgaaagtt actcaattgg attagggatt cagataaagc 13680 tcagcaatta attgcaatgt tttatgatag ttttggatat atggaatttc aaacctcaga 13740 tatctctccc attaatcata gcatcgatac atgtacatcc aattcgttaa caattcacga 13800 taaagtgagt aacatactgg attatgatac tgttgcagaa aagtatgcct acccaaaatg 13860 tgatccatca ctacagtacc acatgaaacc tgttgcagat cctcctgtac atcatatatt 13920 aagacccata ggattgtctt caacttcttg gtataaaggc ttgtccattc tgaatgttct 13980 atcttgctct aaagttccta cagggaatca tctctatctt gctgagggga gtggcgccct 14040 gatgactctc atagaatctt atatacctgc acagaagata tattacaaca gcctgttttc 14100 aagcggtcag tgccctccac aacggaattt ccagccaatg ccaactcagt ttacagaaag 14160 catggtgtac atgaacatcc aaaatggcta tgggaatagt gatttgattg atcaagaatt 14220 tattgctttg tggagtggag tggagagaca gacagactta agcaagaaag attgtattga 14280 attcatactc cagcagattc catcacaatc attgtcatta atatcctcag atattgaaga 14340 gggaataggt agtaatctta ctcaactgtc aaaggctaca ataaattctg tcttactatc 14400 atatgtactt ttgaaagatg gcgggttatt aataatgaag attaatttga ctcctttttg 14460 caaattctca caattgataa cactcttaag ctcaaaattt aagaacataa aagctgtaag 14520 gtcatcatac tctgacccaa gtacagacga attatatctg gttgcaacag catcaggaga 14580 ttcctcagtt ggggatttca atgcagcaag atacaattcg gatattcttg atagtgagtc 14640 atttacacta gtttcacctc aattgctcct agatctacat catgggatta ctgagaatca 14700 gaaaacagta tatgatataa tagaaatgca aatttcaact ggtcagtgtt ttgagaatat 14760 tgaagatcat gagactttaa tcaaactagg tagtagcact caaagaaata gactaatgac 14820 atccccagcc gctgagtcaa gatcagaatt gctagaacgg atatctgata ttatcactct 14880 ctacctgaag gagacaataa atataattga gtcatcacag ctagatagga atcgattgtt 14940 atacaactca tacaatgtct ctagttatgg gaaaattagg acttctgcca aattgagtgc 15000 aaagttggta cttgacatct tcataagaaa ttggattaat ttgggagtac ctctgagaaa 15060 aagaattgca ggtatgatag aaaaggggta tttttgtgtt ggtgaaacca tttcatgtaa 15120 ggattatttg tcattctgta aagcaagaaa atacttgtta aagactattg ggatcgatca 15180 gctagcagta gaattggaac aaaatctttc ttgtgaattt caaagatccg agcaaaagaa 15240 actctggaag aacataggat gcattgcatt cattgaatcc attgaacccg gtgatttcaa 15300 ttcaccagag cagattttcc aggatgatga aattgaggag cgcgacatcg gaggcgaatt 15360 gctgtaacca gggaaaccat aaagttttaa ctgcagtttt aagaaaaaac ccatttagat 15420 tttccccttg gt 15432 //