ID FJ952385; SV 1; linear; genomic RNA; STD; VRL; 7163 BP. XX AC FJ952385; XX DT 05-JUN-2009 (Rel. 101, Created) DT 29-JUN-2009 (Rel. 101, Last updated, Version 2) XX DE Lujo virus segment L multifunctional matrix-like protein and large DE RNA-dependent RNA polymerase genes, complete cds. XX KW . XX OS Mammarenavirus lujoense OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; OC Ellioviricetes; Bunyavirales; Arenaviridae; Mammarenavirus. XX RN [1] RC Publication Status: Online-Only RP 1-7163 RX DOI; 10.1371/journal.ppat.1000455. RX PUBMED; 19478873. RA Briese T., Paweska J.T., McMullan L.K., Hutchison S.K., Street C., RA Palacios G., Khristova M.L., Weyer J., Swanepoel R., Egholm M., RA Nichol S.T., Lipkin W.I.; RT "Genetic detection and characterization of Lujo virus, a new hemorrhagic RT fever-associated arenavirus from southern Africa"; RL PLoS Pathog. 5(5):E1000455-E1000455(2009). XX RN [2] RP 1-7163 RA Briese T., Lipkin W.I.; RT ; RL Submitted (22-APR-2009) to the INSDC. RL Center for Infection and Immunity, MSPH, Columbia University, 722 West, RL 168th Street, New York, NY 10032, USA XX DR MD5; e670c627039b9f725cc3c1de1ca34c02. DR EuropePMC; PMC2680969; 19478873. DR EuropePMC; PMC3310648; 22000372. DR EuropePMC; PMC3557881; 23171649. DR EuropePMC; PMC3848435; 24011402. XX FH Key Location/Qualifiers FH FT source 1..7163 FT /organism="Mammarenavirus lujoense" FT /segment="L" FT /host="Homo sapiens" FT /mol_type="genomic RNA" FT /country="South Africa:Zambia" FT /collection_date="Oct-2008" FT /db_xref="taxon:3052314" FT CDS 46..333 FT /codon_start=1 FT /product="multifunctional matrix-like protein" FT /note="Z" FT /db_xref="GOA:C5ILC3" FT /db_xref="InterPro:IPR003224" FT /db_xref="InterPro:IPR038485" FT /db_xref="UniProtKB/TrEMBL:C5ILC3" FT /protein_id="ACR56361.1" FT /translation="MGQRHSSGSGQPNPKPSDSDHEARRSELHSDASHLGPLNCKSCWK FT SKKALVKCYDHYLCLNCLSLLMGITPRCPFCYRELPKNLDLAEAPSAPPL" FT variation 375 FT /replace="" FT variation 383 FT /replace="" FT CDS complement(438..7142) FT /codon_start=1 FT /product="large RNA-dependent RNA polymerase" FT /note="L; RdRp" FT /db_xref="GOA:C5ILC4" FT /db_xref="InterPro:IPR007099" FT /db_xref="InterPro:IPR010453" FT /db_xref="InterPro:IPR026382" FT /db_xref="UniProtKB/TrEMBL:C5ILC4" FT /protein_id="ACR56362.1" FT /translation="MDSLKNELLQLISRNFPNDERLAPQKLKVLCQTEPKFIMIEGLKL FT LSTCIEIDICDENGCIHNTEEKSVELILRENGFVVPSLPCVTPDGFKVSGNMLILLECF FT VRLNPLEYEQKYNNDMKKLSSLRGDLEHSGITLVPLVVGRSGYENNSIPDWVVFKFKNL FT IFRLLEYVQENEAMLEESEYIRLSESLKGNGSKLFDLDAFNLLKNNSGEHFENIMRLCV FT EGVRPDIPLSEVNSKIVENFLEFKAKLKKGVIPPLFMMTDKERLLKEFCDLYLDQGVSS FT APESKWELLRDFKEATSFTNFIYFDSKNDEGHPEQDKAEKVGNDRHYHRKSCGMISMLN FT KSKSIKLMNTRRKLLLGLDVVRLSHLISLKNEFPRGDDDESVWCGQSFTTVSDRLVSVM FT STQRDLKKHLFRLSRMPKNKSKGKTKALNEIFLDYRRLILNKVFNSLNAHGLTAHSYGL FT EASDFENWPSLEDFMSFKKSGSIPVMNYERDNFRPQMHLDETSFSEDITDLRMISSLSL FT SLVNSMKTSSVSKIRQNASGKNRYGRVSCEECFFQEIKSPKGTFTLIYQKTGESSKCYS FT INRDGEHICSFYADPKRYFLPIMSSEVIKGVIDTMVQWLSDVKELEGCIDEIKILLKII FT FMSVLLNPSKRSQKFLQNLRYFIMAFFGLAHHVDLMEKVKEDLITKSEYLIYRCVRKVM FT ILVLGDSVETMLTSRFKFLLNLSYICHFITKETPDRVTDQIKCFEKFLEPKLKFKSVFV FT NPKNDVTKEESSLLLESGSRFLNKDEFDVKAPGVSKQMLSLMLSFVNSTSGFTPDELAK FT IKTNPLKDARCSTALDLSSNKSVVIPKTDDKGNSVDYDYDKLVGVSLCDIVEKFHNKTK FT FCLSPEQLEYKILKSISHTMAEENRKEKKKKTTTRDSQTSVSESIDLEESEDSVPLEEL FT LPSESLSKIRCSIDKIFSKYQHKQNPKKVQDTEGISVSEALRDLVANHRDRNLILSEVS FT YHLVEDFEESLFPDSFYEDFCERVGNSPKYSKLVMTETVLESCPIEMFTKNITRKFYEE FT GDWFKCFKTILLQLNVNHYSGRFKHNSRLRLNYKFDYKKLYEDARISERESNSEAMCKL FT LSFTKCITSTLKNLCFYSDESPTSYNGAGPDTGRLQFSLSYKEQVGGNRELYIGDMKTK FT MYTRFVEDFFESLTGQLNGSCLNDEAQFEEAISEMKQCIREGNLSYNMDHSKWGPTMCP FT LLFLTVLKNIKYIKDFDKPIEHISTLLSWHVHKYVEVPFNVINAITKSFVKRQLGIQQG FT VINTKTEEFIFSHLDHGIVPSHISSILDMGQGILHNASDYYGLITEKFINYTLKLLFRG FT ELKSFTSSDDQISLFDKELSATLRDDTEELLCFLNYHYYLSSQLNKFVSPKSSLCEFVA FT EFKSRFFVWGEEVPLLTKFVAASLHNVKCKTPHQLSETVDTIVDQCAANGVPINICNLL FT QKRCINLLRYCRFPINPFLLNVNTDIKDWIDGTRGYRIQRQLENLFPDSTGTVRKLVRR FT LYNSLKNDEVREDFLAELFSRDPFTVLKSLFKHYDLDEPQLRDCWLNLEAHHPIRMVLR FT QKVLFPSALQIESVNLPTVIRVLQNKLSHSFTKSTQKLLSDSVNKSAFQSSVASGFIGL FT AKTIGSKCVRDADRNCHYIVEILSKLESLPGLKVIMKDDILIVELESEDGSIQSDWPPE FT CEWLRPMIRPILIDYLCIVLSNCLELGTWVLGDPEPPQRGPFLGRSSHDYVAVFPVKSA FT VLEDKVGYNHILQSVRRLYPSLFETHLLPFLDDNSLRKSSWAPKIRFLDLCVSLDITCE FT AISLISHVVKWKRSEQYTVLTLDLSNSHNRKFTTMIDSKVISTSDTCINFLKQLFFESL FT IRPVLLSSRTLGSFTWFPHASMMPKGEGAPSLGPFENFVLKTIHKGQERPMYRDDLSSG FT FSWIDLKDFKAYISSAHQRISRVSSADAGRDCFNLDERVVITITHNFIKRNRNGACDSK FT FSIIHRIHGSVSDASEGFLMVEVLGVECGFSGAVRDEFVRTNILAIARSLSFSKEDMTV FT FVQRQMIDQHEEPSNQDTIMVELIPGESFSVDDPLAYTRLGPDWVPVGLVLIDGDVKEL FT KETVAQLKVSLDTKDVMIFLAELYPEHMALIKKGIETMLKKSQKHEVDLSRVDLIKCFK FT DVGLTEHDLVDCFSGVIGWVKLSSYTLAYSKHLKDLVIAHPGGGMRLGGVCCRLLREGT FT STIEIE" XX SQ Sequence 7163 BP; 2030 A; 1622 C; 1316 G; 2195 T; 0 other; gttaattgga ctacttttct agtacctcac ttcagtgaga gtgacatggg tcagagacat 60 tcctctggct ccggccaacc caaccccaag ccgagtgaca gcgatcatga agcgagaagg 120 tcagagcttc actcggacgc ctcccatctc ggacctctga actgcaaatc ttgctggaag 180 tcaaagaagg cactggtgaa gtgctatgat cactacctct gtctaaactg cttaagcctt 240 ctaatgggca tcaccccaag atgtcccttc tgttacagag agctacccaa aaatctggac 300 cttgcagagg caccaagcgc accacccctc tgaagacccg cagcgaaacc caaccaaggg 360 gcgcccccct ctcgcggggg gggcgcagct ccgccgtcgc gcgctccaca gaccacacca 420 atcatcgatg cagaagatca ttcaatctca atagtggatg tcccctctct caatagtcta 480 cagcatactc caccaagtct cattccacca ccaggatgag caatcaccag atccttgaga 540 tgcttgctgt acgctaatgt gtaggaactg agcttgaccc atccgattac ccctgagaaa 600 cagtccacca aatcatgctc cgttaggccc acatctttga aacacttgat taggtccacc 660 ctagacaaat caacctcatg tttttgagac tttttcagca ttgtctctat ccctttcttt 720 attaaagcca tgtgctctgg gtatagctca gccaagaata tcataacatc tttagtatca 780 agactgactt ttagctgtgc aactgtctct ttcagctctt tcacatcacc atcaattaag 840 acaaggccta ccggaaccca gtctggccca aggcgtgtat aagcaagtgg gtcatcaaca 900 gagaaggact ccccaggaat cagttcaacc atgatggtat cctggtttga tggctcttca 960 tgctgatcaa tcatctgtct ctggacaaac actgtcatgt cttctttgct aaatgagagg 1020 ctcctagcaa tggccaagat attggtcctc acaaactcgt ccctcacagc tccagaaaat 1080 ccacactcaa cacccaggac ctccaccatc aggaagccct cagacgcatc gctgacactg 1140 ccgtgaattc tgtgaatgat actaaatttg ctgtcacagg ctccgtttct atttctttta 1200 ataaaattgt gagtgattgt tatgacgact ctctcatcaa gattaaaaca gtctctccct 1260 gcatcagcag aagacactct agatattctt tgatgagccg aagagatgta cgccttaaaa 1320 tccttaaggt caatccagct aaatccacta cttagatcat ccctgtacat tggcctctcc 1380 tggcctttgt ggattgtttt cagaacaaaa ttctcgaatg ggcccaaaga aggtgcaccc 1440 tcaccctttg gcatcatgga ggcatgtggg aaccatgtga atgaacctaa tgttctgctg 1500 gacagcaaca ctggcctaat cagagactcg aagaacaatt gctttaagaa attgatacat 1560 gtatcagatg tactgatcac ttttgaatca atcatagtcg tgaattttct attatgacta 1620 ttcgagaggt ctaaagtgag aactgtgtac tgctcagacc tcttccattt aacgacatga 1680 ctgataagac tgatagcttc acaagtgatg tcaagtgaga cacatagatc tagaaatctg 1740 atcttaggag cccaagaaga ctttctcaat gagttgtcgt ccagaaacgg aaggaggtga 1800 gtttcaaaaa gcgatggata taatcgtctt acactctgta aaatatgatt gtaacccact 1860 ttgtcttcca agacagcact tttgacaggg aacacagcaa catagtcatg gctagatctg 1920 cctaaaaatg ggcccctttg tggaggttca gggtccccta gtacccatgt ccccaactct 1980 agacaattgg acaatacaat gcatagataa tctatcaaaa ttggtcttat cattggtctt 2040 aaccattcgc actctggagg ccagtcagac tgaattgagc cgtcctctga ctccaattcc 2100 actatgagaa tgtcatcctt catgatgact tttaaaccag gcagtgattc cagttttgat 2160 aagatctcta ctatgtaatg acagttcctg tcagcatctc tcacacactt acttcctatc 2220 gtctttgcta gcccaataaa ccctgaagca acactgcttt ggaatgcact tttgttcact 2280 gaatctgata acagcttttg ggtgcttttt gtgaagctat ggcttaattt gttttgcagc 2340 accctgatca cagttggtag gttgactgat tctatctgaa gtgcagaagg aaagagaact 2400 ttctgacgaa gaaccattct gatggggtga tgtgcttcaa ggttcaacca gcagtctctc 2460 aattggggct catcaaggtc ataatgtttg aatagggact ttaggacagt gaatgggtct 2520 cttgagaaca actcagccaa aaagtcttcc ctcacctcat cattttttaa ggagttatac 2580 aatctcctta ctaactttcg aacagtccca gtgctatctg gaaataagtt ttctaactgt 2640 ctttgaatcc tgtaacctct ggttccatca atccaatctt tgatgtctgt attcacattg 2700 agcaagaatg gattaatagg gaatctacaa tacctcaata agttaataca tctcttttgc 2760 agaaggttgc atatgttaat tggcacccca tttgcagcgc attgatccac aatggtgtcc 2820 acagtttctg acagttgatg cggtgttttg cattttacat tgtgtaatga agctgctacg 2880 aactttgtta acaaagggac ctcttcaccc caaacaaaga atcttgactt aaattctgca 2940 acgaactcac agagcgagct tttgggactg acaaacttat taagctgact agataaataa 3000 tagtggtagt tcaaaaagca taggagctct tcagtgtcat cccttagtgt ggctgataat 3060 tctttgtcaa acaatgatat ttgatcatcg ctagaagtga aactcttcag ctcacctctg 3120 aacaaaagct tcagtgtgta gtttatgaac ttctcagtta ttaaaccata ataatcagat 3180 gcgttatgca atataccctg acccatgtct aagatgctgc taatgtgaga cggaacaata 3240 ccatgatcta aatgagaaaa gatgaactct tctgtttttg tgttaatgac accctgttgt 3300 atacctaact gacgttttac aaaggatttg gtaatggcat tgatgacgtt gaagggaacc 3360 tcaacatatt tatgaacatg ccaggacagt aatgttgaga tatgctcaat tggcttatca 3420 aaatctttaa tgtacttgat attttttaaa actgtcaaga agagaagcgg acacatagtt 3480 gggccccact tgctgtgatc catgttgtag ctaagattcc cttctctaat gcactgcttc 3540 atctctgaga ttgcctcctc aaactgtgct tcatcgttta agcagctccc atttagctga 3600 ccagtgagag actcaaaaaa gtcttccaca aaccttgtgt acatcttagt cttcatgtca 3660 ccgatgtaca attctctatt cccaccaacc tgttccttgt atgataaaga gaactggagc 3720 ctacccgtgt ctggaccagc accattgtag gaggtgggtg actcatctga atagaaacac 3780 aagtttttca gagtggacgt aatgcattta gtgaaagaca gcagtttaca catagcctca 3840 gaattactct ctctttcact tatcctggca tcttcgtaga gttttttgta atcaaactta 3900 taattaagtc ttagtctgga attgtgcttg aatctaccag agtagtgatt cacatttagt 3960 tgcaataaga tggtcttaaa gcatttgaac caatctccct cttcataaaa ctttcttgtg 4020 atgttttttg tgaacatctc tatgggacag gattctaaca ctgtctctgt catgactaat 4080 tttgagtatt ttggtgagtt tccaactcgc tcacagaaat cttcatagaa tgaatccgga 4140 aagagtgact cttcaaaatc ttcaactaaa tgataagaaa cctctgagag tatgagattt 4200 ctatctctgt gattggccac taaatctctc aaagcttcag aaacacttat accctcagtg 4260 tcttgaacct tttttgggtt ttgtttgtgt tgatactttg agaaaatctt gtctatagaa 4320 catctgatct tactcagaga ttcagatggc aagagttctt caagtggtac tgaatcttcg 4380 ctctcctcga gatctattga ttctgacaca ctagtctgac tatcccttgt tgttgttttt 4440 ttcttctttt cttttctatt ttcttcagcc attgtgtgtg aaattgattt caggattttg 4500 tattccagtt gttcaggact taagcaaaac ttagttttat tgtggaactt ctcaacaata 4560 tcacacaggg aaactccgac caacttatca taatcatagt ccacagaatt ccccttatca 4620 tcagtctttg ggattacaac actcttattg ctagacagat caagtgcagt cgaacaacgt 4680 gcatctttca atgggtttgt tttaatctta gcaagctcat caggggtgaa gccactggtt 4740 gaattaacga aagataacat cagcgatagc atctgttttg aaacaccagg tgccttgaca 4800 tcaaattcat ctttgttcag aaaccttgag ccactctcta gtaacagtga cgactcttct 4860 ttcgtaacgt cgttcttggg gttgacaaaa acgcttttaa atttcaactt tggttccaag 4920 aatttttcaa agcattttat ctgatctgtt accctgtccg gcgtctcttt agttatgaaa 4980 tggcaaatgt aggacaggtt gagaagaaat ttgaaccgac tagtgagcat agtttcaaca 5040 ctgtcaccca atacaagaat catcactttt cttacacatc tatagattag atactcactc 5100 tttgtgatta aatcttcctt caccttttcc atcaaatcaa catgatgtgc aaggccaaag 5160 aaagccatga tgaagtatct aaggttttgt aagaactttt ggctcctttt gctaggattc 5220 aaaagtactg acatgaaaat tatcttcaat agaattttaa tttcatcaat gcagccttcc 5280 agctccttta catcagaaag ccactgcacc attgtatcga tgacaccctt gatcacctcc 5340 gaggacatta ttggcaaaaa gtatctcttg gggtcagcat aaaaagaaca gatgtgctca 5400 ccatccctat ttatagaata gcattttgaa gactcaccag ttttctggta aatgagagta 5460 aatgtacctt tgggagactt tatttcttgg aaaaaacact cttcacaact cactcttcca 5520 tatctgttct ttccactagc attttgtctt atcttagata ctgatgatgt cttcattgag 5580 tttaccaaac tcaaagataa cgaagaaatc atgcggaggt cagttatgtc ctcactaaaa 5640 ctggtttcat ccaagtgcat ttggggtctg aagttatctc tctcataatt cataactggg 5700 atgcttcctg actttttaaa agacataaaa tcttcaagag acggccaatt ctcgaaatca 5760 gaggcctcaa gtccataact gtgagcggta agcccatgag catttagact attgaagact 5820 ttgttaagaa tcaaccttct atagtctaga aagatttcat taagcgcttt ggtcttaccc 5880 ttacttttgt tttttggcat tctactaagt ctgaataaat gctttttaag atctctctga 5940 gttgacatca ctgacacaag tctatctgag actgtggtga atgactgccc gcaccagaca 6000 gactcatcat catcccctct aggaaactca ttctttaatg aaattagatg acttaaccta 6060 acaacatcaa gacctaggag cagtttcctt cttgtgttca ttagtttgat actctttgat 6120 ttattcaaca tgctaatcat tccacatgat tttctatgat aatgacggtc gttcccaacc 6180 ttttcggcct tatcctgttc ggggtgtcct tcatcattct tagagtcaaa ataaatgaaa 6240 ttggtgaatg atgttgcttc tttgaaatct cgcagcaact cccacttgga ttctggtgct 6300 gatgaaactc cctgatctaa gtacaagtca cagaattctt tcagcaacct ttctttgtct 6360 gtcatcatga ataagggtgg gatgactccc ttcttcaact tcgctttgaa ttctaagaag 6420 ttctccacta tcttggaatt aacctctgac aagggaatgt ctgggcgcac accttcaaca 6480 cacagcctca ttatattctc gaaatgctca cctgaattat tcttaagcag attgaatgcg 6540 tctaaatcaa agagcttgct accattgcct ttgagtgatt ctgacagcct aatatactct 6600 gactcttcca acatcgcctc attctcttgc acatactcta atagtctgaa gattaaattc 6660 ttaaatttga acaccaccca atcaggaatg gagttgtttt catacccact cctgcccacc 6720 accagtggca caagagtgat ccctgagtgt tcaagatcac ccctcagtga tgatagcttc 6780 ttcatgtcat tgttgtattt ctgctcatac tctaggggat tcagtctcac aaaacattct 6840 agtagaatca acatgtttcc tgacaccttg aatccgtctg gagtgacaca tggaagagaa 6900 gggacaacaa atccattttc tcttaagata agttccactg acttctcttc agtgttgtgg 6960 atgcaaccat tctcatcgca gatgtcaatc tcaatacacg tggataatag cttgagaccc 7020 tcaatcataa tgaacttggg ctctgtttgg caaaggactt ttagcttttg gggagctagt 7080 ctctcatcat taggaaagtt tcttgagata agctgcagga gttcattctt taatgagtcc 7140 attgtgaatt ttgtcccata aaa 7163 //