ID FJ436234; SV 1; circular; genomic RNA; STD; VRL; 16486 BP. XX AC FJ436234; XX DT 16-DEC-2008 (Rel. 98, Created) DT 27-FEB-2009 (Rel. 100, Last updated, Version 2) XX DE Grapevine leafroll-associated virus 2 isolate OR1, complete genome. XX KW . XX OS Grapevine leafroll-associated virus 2 OC Viruses; Riboviria; Closteroviridae; Closterovirus. XX RN [1] RP 1-16486 RX DOI; 10.1016/j.virol.2008.09.035. RX PUBMED; 19007962. RA Liu Y.P., Peremyslov V.V., Medina V., Dolja V.V.; RT "Tandem leader proteases of Grapevine leafroll-associated virus-2: RT host-specific functions in the infection cycle"; RL Virology 383(2):291-299(2009). XX RN [2] RP 1-16486 RA Liu Y.-P., Peremyslov V., Medina V., Dolja V.; RT ; RL Submitted (03-NOV-2008) to the INSDC. RL Botany and Plant Pathology, Oregon State University, 2082 Cordley Hall, RL Corvallis, OR 97331, USA XX DR MD5; 6f8ade2ce09cc6ca4280d041510ceb6d. DR EuropePMC; PMC3828392; 24171725. XX FH Key Location/Qualifiers FH FT source 1..16486 FT /organism="Grapevine leafroll-associated virus 2" FT /host="Vitis vinifera (common grapevine)" FT /lab_host="Nicotiana benthamiana" FT /isolate="OR1" FT /mol_type="genomic RNA" FT /country="USA" FT /db_xref="taxon:64003" FT gene 106..8916 FT /gene="ORF1a" FT CDS 106..8916 FT /codon_start=1 FT /gene="ORF1a" FT /product="polyprotein" FT /note="contains 2 papain-like proteases, methyltransferase FT and helicase" FT /db_xref="GOA:B7U5T5" FT /db_xref="InterPro:IPR002588" FT /db_xref="InterPro:IPR008749" FT /db_xref="InterPro:IPR022054" FT /db_xref="InterPro:IPR027351" FT /db_xref="InterPro:IPR027417" FT /db_xref="UniProtKB/TrEMBL:B7U5T5" FT /protein_id="ACJ54663.1" FT /translation="MSSLAISALPCSVAQLSVGQPVATVARSFLMTSLPSLQTYPSSSE FT LTSFLFCFGAFQKIKMFLSFLRSVHVFAPFSEISTIGSCYEFIRLGGGAYPLFFCSFQC FT GPLSVSLGFVNGVFAVLNMSFPFLSNASLLTGVGKNVVQEKIKISKFEKKQKKRVFSIA FT RATARHVPSRRNPKEKRVVHVQHLPSGSLRFSQNKNKTELLILKEEVGIVARVKCSASV FT VRRRVCGGVVKCKPLIAVSPSGVKFRCFAPSCSTSACLKLKIMRRVAVGDCRGEKIIAA FT RRAALQKQAFNSRTPKKVRENPISVSGVNLGRSAAAQVIYFGSFTQPFALYPRQESAIV FT KTQPPPVSVVKVECVAAEVAPDRGVVDKKPTSVGVPPQRGVLSFPTVVRNRGDVIITGV FT VHEALKKIKDGLLRFRVGGDMRFSRFFSSNYGCRFVASVRTNTTVWLNCTKASGEKFSL FT AAACTADYVAMLRYVCGGKFPLVLMSRVIYPDGRCYLAHMRYLCAFYCRPFRESDYALG FT MWPTVARLRACVEKNFGVEACGIALRGYYTSRNVYHCDYDSAYVKYFRNLSGRIGGGSF FT DPTSLTSVITVKISGLPGGLPKNIAFGAFLCDIRYVEPVDSGGIQSSVKTKREDAHRTV FT EERAAGGSVEQPRQKRIDEKGCGRVPSGGFSHLLVGSLNEVRRKVAAGLLRFRVGGDMD FT FHRSFSTQAGHRLLVWRRSSRSVCLELYSPSKNFLRYDVLPCSGDYAAMFSFAAGGRFP FT LVLMTRIRYPNGFCYLAHCRYACAFLLRGFDPKRFDIGAFPTAAKLRNRMVSELGERSL FT GLNLYGAYTSRGVFHCDYDAKFIKDLRLMSAVIAGKDGVEEVVPSDITPAMKQKTIEAV FT YDRLYGGTDSLLKLSIEKDLIDFKNDVQSLKKDRPIVKVPFYMSEATQNSLTRFYPQFE FT LKFSHSSHSDHPAAAASRLLENETLVRLCGNSVSDIGGCPLFHLHSKTQRRVHVCRPVL FT DGKDAQRRVVRDLQYSNVRWGDDDKILEGPRNIDICHYPLGACDHESSAMMMVQVYDAS FT LYEICGAMIKKKSRITYLTMVTPGEFLDGRECVYMESLDCEIEVDVHADVVMYKFGSSC FT YSHKLSIIKDIMTTPYLTLGGFLFSVEMYEVRMGVNYFKITKSEVSPSISCTKLLRYRR FT ANSDVVKVKLPRFDKKRRMCLPGYDTIYLDSKFVSRVFDYVVCNCSAVNSKTFEWVWSF FT IKSSKSRVIISGKIIHKDVNLDLKYVESFAAVMLASGVRSRLASEYLAKNLSHFSGDCS FT FIEATSFVLREKIRNMTLNFNERLLQLVKRVAFATLDVSFLDLDSTLESITDFAECKVA FT IELDELGCLRAEAENEKIRNLAGDSIAAKLASEIVVDIDSKPSPKQVGNSSSENADKRE FT VQRPGLRGGSRNGVVGEFLHFVVDSALRLFKYATDQQRIKSYVRFLDSAVSFLDYNYDN FT LSFILRVLSEGYSCMFAFLANRGDLSSRVRSAVRAVKEVATSCANASVSKAKVMITFAA FT AVCAMMFNSCGFSGDGREYKSYIHRYTQVLFDTIFFEDSSYLPIEVLSSAICGAIVTLF FT SSGSSISLNAFLLQITKGFSLEVVVRNVVRVTHGLSTTATDGVIRGVFSQIVSHLLVGN FT TGNVAYQSAFIAGVVPLLVKKCVSLIFILREDTYSGFIKHGISEFSFLSSILKFLKGKL FT VDELKSIIQGVFDSNKHVFKEATQEAIRTTVMQVPVAVVDALKSAAGKIYNNFTSRRTF FT GKDEGSSSDGACEEYFSCDEGEGPGLKGGSSYGFSILAFFSRIMWGARRLIVKVKHECF FT GKLFEFLSLKLHEFRTRVFGMNRTDVGVYDFLPTDIVETLSSIEECDQIEELLGDDLKG FT DKDASLTDMNYFEFSEDFLASVEEPPFAGLRGGSKNVAILAILEYAHNLFRIVASKCSK FT RPLFLAFAELSSALIEKFKEVFPRKSQLVAIVREYTQRFLRSRMRALGLNNEFVVKSFA FT DLLPALMKRKVSGSFLASVYRPLRGFSYMCVSAERREKFFALVCLIGLSLPFFVRIVGA FT KACEELVSSARRFYERIKIFLRQKYVSLSNFFCHLFSSDVDDSSASAGLKGGASRMTLF FT HLLVRLASALLSLGWEGLKLLLSHHNLLFLCFALVDDVNVLIKVLGGLSFFVQPVFSLF FT AAMLLQPDRFVGYSEKLVTAFEFFLKCSPRAPALLKGFFECVANSTVSKTVRRLLRYFV FT RMLKLRKGRGLRADGRGLHRQKAVPVIPSNRVVTDGVERLSVKMQGVEALRTELRILED FT LDSAVIEKLNRRRNRDTNDDEFTRPAHEQMQEVTTFCSKANSAGLALERAVLVEDAIKS FT EKLSKTVNEMVRKGSTTSEEVAVALSDDEAVEEISVADERDDSPKTVRISEYLNRLNSS FT FEFPKPIVVDDNKDTGGLTNAVREFYYMQELALFEIHSKLCAYYDQLRIVNFDRSVAPC FT SEDAQLYVRKSGSTIVQGKEVRLHIKDFHDHDFLFDGKISINKRRRGGNVLYHDNLAFL FT ASNLFLAGYPFSRSFVFTNSSVDILLYEAPPGGGKTTTLIDSFLKVFKKGEVSTMILTA FT NKSSQVEILKKVEKEVSNIECQKRKDKRSPKKSIYTIDAYLMHHRGCDADVLFIDECFM FT VHAGSVLACIEFTRCHKVMIFGDSRQIHYIERNELDKCLYGDLDRFVDLQCRVYGNISY FT RCPWDVCAWLSTVYGNLIATVKGESEGKSSMRINEINSVDDLVPDVGSTFLCMLQSEKL FT EISKHFIRKGLPKLNVLTVHEAQGETYARVNLVRLKFQEDEPFKSIRHITVALSRHTDS FT LTYNVLAARRGDATCDAIQKAAELVNKFRVFPTSFGGSVINLNVKKDVEDNSRCKASSA FT PLSVINDFLNEVNPGTAVIDFGDLSADFSTGPFECGASGIVVRDNISSSNITDHDKQRV FT " FT gene <8915..10924 FT /gene="ORF1b" FT CDS <8915..10294 FT /codon_start=1 FT /gene="ORF1b" FT /product="RNA-dependent RNA polymerase" FT /note="putatively translated through a +1 frameshift FT mechanism" FT /db_xref="GOA:B7U5T6" FT /db_xref="InterPro:IPR001788" FT /db_xref="InterPro:IPR007094" FT /db_xref="UniProtKB/TrEMBL:B7U5T6" FT /protein_id="ACJ54664.1" FT /translation="SVVRSQAIPRRKPSLQENLYSFEARNYNFSTCDRYTSASMFGEAM FT AMNCLRRCFDLDAFSSLRNDVISITRSGIEQWLEKRTPSQIKALMKDVESPLEIDDEIC FT RFKLMVKRDAKVKLDSSCLTKHSAAQNIMFHRKSINAIFSPIFNEVKNRIMCCLKPNIK FT FFTEMTNRDFASVVSNMLGDDDVYHIGEVDFSKYDKSQDAFVKAFEEVMYKELGVDEEL FT LAIWMCGERLSIANTLDGQLSFTIENQRKSGASNTWIGNSLVTLGILSLYYDVRNFEAL FT YISGDDSLIFSRSEISNYADDICTDMGFETKFMSPSVPYFCSKFVVMCGHKTFFVPDPY FT KLFVKLGAVKEDVSMDFLFETFTSFKDLTSDFNDERLIQKLAELVALKYEVQTGNTTLA FT LSVIHCLRSNFLSFSKLYPRVKGWQVFYTSVKKALLKSGCSLFDSFMTPFGQAVMVWDD FT E" FT gene 10358..10528 FT /gene="ORF2" FT CDS 10358..10528 FT /codon_start=1 FT /gene="ORF2" FT /product="6 kDa small hydrophobic protein" FT /db_xref="GOA:O39853" FT /db_xref="UniProtKB/TrEMBL:O39853" FT /protein_id="ACJ54665.1" FT /translation="MNQVLQFECLFLLNLAVFAVTFIFILLVFRVIKSFRQKGHEAPVP FT VVRGGGFSTVV" FT gene 10544..12343 FT /gene="ORF3" FT CDS 10544..12343 FT /codon_start=1 FT /gene="ORF3" FT /product="HSP70h" FT /note="member of the HSP70 family of heat shock proteins" FT /db_xref="GOA:B7U5T8" FT /db_xref="InterPro:IPR013126" FT /db_xref="InterPro:IPR018181" FT /db_xref="InterPro:IPR029047" FT /db_xref="UniProtKB/TrEMBL:B7U5T8" FT /protein_id="ACJ54666.1" FT /translation="MVVFGLDFGTTFSTVCVYKDGRVFSFKQNNSAYIPTYLYLFSDSN FT HMTFGYEAESLMSNLKVKGSFYRDLKRWVGCDSSNLDAYLDRLKPHYSVRLVKIGSGLN FT ETVSIGNFGGTVKSEAHLPGLIALFIKAVISCAEGAFACTCTGVICSVPANYDSVQRNF FT TDQCVSLSGYQCVYMINEPSAAALSACNSVGKKSANLAVYDFGGGTFDVSIISYRNNTF FT VVRASGGDLNLGGRDVDRAFLTHLFSLTSLEPDLTLDISNLKESLSKTDAEIVYTLRGV FT DGRKEDVRVNKNILTSVMLPYVNRTLKILESTLKTYAKSMNESARVKCDLVLIGGSSYL FT PGLADVLTKHQSVDRILRVSDPRAAVAVGCALYSSCLSGSGGLLLIDCAAHTVAIADRS FT CQQIICAPAGAPIPFSGSMPLYLARVNKNSQREIAVFEGEYVKCPKNRKICGANIRFFD FT IGVTGDSYAPVTFYMDFSISSVGAVSFVVRGPEGKQVSLTGTPAYNFSSVALGSRSVRE FT LHISLNNKVFLGLLLHRKADRRILFTKDEAIRYADSIDIADVLKEYKSYAASALPPDED FT VELLLGKSVQKVLRGSRLEEIPL" FT gene 12270..13925 FT /gene="ORF4" FT CDS 12270..13925 FT /codon_start=1 FT /gene="ORF4" FT /product="63 kDa protein" FT /db_xref="InterPro:IPR004909" FT /db_xref="UniProtKB/TrEMBL:B7U5T9" FT /protein_id="ACJ54667.1" FT /translation="MSNYSWESLFKKFYGEADWKKYLSRSIAAHSSEIKTLPDIRLYGG FT RVVKKSDFESALPNSFEQELGLFILSEREVGWSKLCGITVEEAAYDLTNPKAYKFTAET FT CSPDVKGEGQKYSMEDVMNFMRLSNLDVNDKMLAEQCWSLSNSCGELINPDDKGRFVAL FT TFKDRDTADDTGAANVECRVGDYLVYAMSLFEQRTQKSQSGNISLYEKYCEYIRTYLGS FT TDLFFTAPDRIPLLTGILYDFCKEYNIFYSSYKRNVDNFRFFLANYMPLISDVFVFQWV FT KPAPDVRLLFELSAAELTLEVPTLSLIDSQVVVGHILRYVESYTSDPAIDALEDKLEAI FT LKSSNPRLSTAQLWVGFFCYYGEFRTAQSRVVQRPGVYKTPDSVGGFEINMKDVEKFFD FT KLQRELPNVSLRRQFNGARAHEAFKIFKNGNISFKPISRLNVPREFWYLNIDYFRHANR FT SGLTEEEILILNNISVDVRKLCAERACNTLPSAKRFSKNHKSNIQSSRQERRIKDPLVV FT LKDTLYEFQRKRAGWGSRSTRDLGSRADHAKGSG" FT gene 13837..14508 FT /gene="CPm" FT CDS 13837..14508 FT /codon_start=1 FT /gene="CPm" FT /product="minor capsid protein" FT /note="ORF5" FT /db_xref="GOA:B7U5U0" FT /db_xref="InterPro:IPR002679" FT /db_xref="UniProtKB/TrEMBL:B7U5U0" FT /protein_id="ACJ54668.1" FT /translation="MSSNASVPVGGLEALETSGVVLTTRKEAVDKFFNELKNENYSSVD FT SSRLSDSEVKEVLEKSKESFKSELASTDEHFVYHIIFFLIRCAKISTSEKVKYVGSHTY FT VVDGKTYTVLDAWVFNMMKSLTKKYKRVNGLRAFCCACEDLYLTVAPIMSERFKTKAVG FT MKGLPVGKEYLGADFLSGTSKLMSDHDRAVSIVAAKNAVDRSAFTGGERKIVSLYDLGR FT Y" FT gene 14577..15173 FT /gene="CP" FT CDS 14577..15173 FT /codon_start=1 FT /gene="CP" FT /product="major capsid protein" FT /note="ORF6" FT /db_xref="GOA:O39857" FT /db_xref="InterPro:IPR002679" FT /db_xref="UniProtKB/TrEMBL:O39857" FT /protein_id="ACJ54669.1" FT /translation="MELMSDSNLSNLVITDASSLNGVDKKLLSAEVVKMLVQKGAPNEG FT IEVVFGLLLYALAARTTSPKVQRADSDVIFSNSFGERNVVVTEGDLKKVLDGCAPLTRF FT TNKLRTFGRTFTEAYVDFCIAYKHKLPQLNAAAELGIPAEDSYLAADFLGTCPKLSELQ FT QSRKMFASMYALKTEGGVVNTPVSNLRQLGRREVM" FT gene 15173..15658 FT /gene="ORF7" FT CDS 15173..15658 FT /codon_start=1 FT /gene="ORF7" FT /product="19 kDa protein" FT /db_xref="UniProtKB/TrEMBL:B7U5U2" FT /protein_id="ACJ54670.1" FT /translation="MEDYEEKSESLILLRTNLNTMLLVVKSDASVELPKLLICGYLRVS FT GRGEVTCCNREELTRDFEGNHHTVIRSRIIQYDSESAFEEFNNSDCVVKFFLETGSVFW FT FFLRSETKGRAVRHLRTFFEANNFFFGSHCGTMEYCLKQVLSETESIIDSFCEERNR" FT gene 15660..16277 FT /gene="ORF8" FT CDS 15660..16277 FT /codon_start=1 FT /gene="ORF8" FT /product="24 kDa protein" FT /db_xref="InterPro:IPR021575" FT /db_xref="InterPro:IPR021742" FT /db_xref="UniProtKB/TrEMBL:B7U5U3" FT /protein_id="ACJ54671.1" FT /translation="MRVIVSPYEAEDILKRSTDMLRNIDSGVLSTKECIKAFSTITRDL FT HCAKASYQWGVDTGLYQRNCAEKHLIDTVESNIRLAQPLVREKVAVHFCKDEPKELVAF FT ITRKYVELTGVGVREAVKREMRSLTKTVLNKMSLEMAFYMSPRAWKNAEWLELKFSPVK FT IFRDLLLDVETLNELCAEDDVHVDKVNENGDENHDLELQDEC" XX SQ Sequence 16486 BP; 4174 A; 3422 C; 4193 G; 4697 T; 0 other; atattctgtt ggctttcatc tgtgcttgtg cttcggttca atcacactct gaaagtttca 60 gttccccgga atttcggttt tcttcataag ccttattcct acaggatgtc tagccttgct 120 atctctgccc ttccctgttc agtcgctcaa ctgagcgttg gtcagcctgt tgccacggtt 180 gccaggtcat ttttgatgac ttcccttccg tcccttcaga cttacccatc ttcgtctgag 240 ttgacttcct ttttattttg ttttggtgct ttccaaaaaa taaaaatgtt tttatctttc 300 ctacgttcgg tgcacgtctt tgcgcctttt tctgaaattt ccacgattgg ttcatgctat 360 gaattcattc ggttgggagg tggtgcttac cctctctttt tctgttcctt ccaatgcgga 420 cctttgtccg tttctttggg ttttgttaac ggcgtttttg ctgttttaaa catgtcattt 480 cctttcttaa gcaacgcatc tcttttgacg ggcgtcggaa aaaatgttgt tcaagagaaa 540 ataaaaattt ccaaatttga gaagaaacag aagaagcgcg ttttttcgat agctcgcgct 600 accgcgcgtc atgtgccttc ccgtcgcaat cctaaggaga agcgtgttgt ccatgtacag 660 catctcccta gtggttcttt acgcttttcc caaaacaaaa acaaaacaga actgctcatc 720 ttaaaagagg aagtcggaat tgtcgcgcgc gttaagtgtt cggcaagcgt cgtgcgccgt 780 cgcgtttgtg gcggtgtggt taagtgcaaa cccctaatag ccgtttctcc ctctggcgtg 840 aaattccgtt gtttcgcgcc gtcttgcagc acgtccgctt gtttaaagct caaaatcatg 900 cgccgtgttg ccgtcggtga ctgccgaggt gagaagataa tcgcggcacg acgtgcggcg 960 ctgcagaagc aggctttcaa cagccgcaca ccgaagaaag tgcgagagaa ccccattagc 1020 gtctccgggg tgaacttggg aaggtctgcc gccgctcagg ttatttattt cggcagtttc 1080 acgcagccct tcgcgttgta tccgcgccaa gagagcgcga tcgtaaaaac gcaacctcca 1140 ccggtcagtg tagtgaaggt ggagtgcgta gctgcggagg tagctcccga caggggcgtg 1200 gtcgacaaga aacctacgtc tgttggcgtt cccccgcagc gcggtgtgct ttcttttccg 1260 acggtggttc ggaaccgcgg cgacgtgata atcacagggg tggtgcatga agccctgaag 1320 aaaattaaag acgggctctt acgcttccgc gtaggcggtg acatgcgttt ttcgagattt 1380 ttctcatcga actacggctg cagattcgtc gcgagcgtgc gtacgaacac tacagtttgg 1440 ctaaattgca cgaaagcgag tggtgagaaa ttctcactcg ccgccgcgtg cacggcggat 1500 tacgtggcga tgctgcgtta tgtgtgtggc gggaaatttc ctctcgtcct catgagtaga 1560 gttatttacc cggatgggcg ctgttacttg gcccatatga ggtatttgtg cgccttttac 1620 tgtcgcccgt ttagagagtc ggattatgcc ctcggaatgt ggcctacggt ggcgcgtctc 1680 agggcatgcg ttgagaagaa cttcggtgtc gaagcttgtg gcatagctct tcgtggctat 1740 tacacctctc gcaatgttta tcactgtgat tatgactctg cttatgtaaa atattttaga 1800 aacctttccg gccgcattgg cggtggttcg ttcgatccga catctttaac ctccgtaata 1860 acggtgaaga ttagcggtct tccaggtggt cttcctaaaa atatagcgtt tggtgccttc 1920 ctgtgcgata tacgttacgt cgaaccggta gactcgggcg gcattcaatc gagcgttaag 1980 acgaaacgtg aagatgcgca ccgaaccgta gaggaacggg cggccggcgg atccgtcgag 2040 caaccgcgac aaaagaggat agatgagaaa ggttgcggca gagttcctag tggaggtttt 2100 tcgcatctcc tggtcggcag ccttaacgaa gttaggagga aggtagctgc cggacttcta 2160 cgctttcgcg ttggcggtga tatggatttt catcgctcgt tctccaccca agcgggccac 2220 cgcttgctgg tgtggcgccg ctcgagccgg agcgtgtgcc ttgaacttta ctcaccatct 2280 aaaaactttt tgcgttacga tgtcttgcct tgttctggag actatgcagc gatgttttct 2340 ttcgcggcgg gcggccgttt ccctttagtt ttgatgacta gaattagata cccgaacggg 2400 ttttgttact tggctcactg ccggtacgcg tgcgcgtttc tcttaagggg ttttgatccg 2460 aagcgtttcg acatcggtgc tttccccacc gcagccaagc tcagaaaccg tatggtttcg 2520 gagcttggtg aaagaagttt aggtttgaac ttgtacggcg catatacgtc acgcggcgtc 2580 tttcactgcg attatgacgc taagtttata aaggatttgc gtcttatgtc agcagttata 2640 gctggaaagg acggagtgga agaggtggta ccttctgaca taactcctgc catgaagcag 2700 aaaacgatcg aagccgtgta tgatagatta tatggcggca ctgactcgtt gctgaaactg 2760 agcatcgaga aagacttaat cgatttcaaa aatgacgtgc agagtttgaa gaaagatcgg 2820 ccgattgtca aagtgccctt ttatatgtcg gaagcaacac agaattcgct gacgcgtttc 2880 taccctcagt tcgaacttaa gttttcgcac tcctcgcatt cagatcatcc cgccgccgcc 2940 gcttctagac tgctggaaaa tgaaacgtta gtgcgcttat gtggtaatag cgtttcagat 3000 attggaggtt gtcctctttt ccatttgcat tccaagacgc aaagacgggt tcacgtatgt 3060 aggcctgtgt tggatggcaa ggatgcgcag cgtcgcgtgg tgcgtgattt gcagtattcc 3120 aacgtgcgtt ggggagacga tgataaaatt ttggaagggc cacgcaatat cgacatttgc 3180 cactatcctc tgggcgcgtg tgaccacgaa agtagtgcta tgatgatggt gcaggtgtat 3240 gacgcgtccc tttatgagat atgtggcgcc atgatcaaga agaaaagccg cataacgtac 3300 ttaaccatgg tcacgcccgg cgagtttctt gacggacgcg aatgcgtcta tatggagtcg 3360 ttagactgtg agattgaggt tgatgtgcac gcggacgtcg taatgtacaa attcggtagt 3420 tcttgctatt cgcacaagct ttcaatcatc aaggacatca tgaccactcc gtacttgaca 3480 ctaggtggtt ttctattcag cgtggagatg tatgaggtgc gtatgggcgt gaattacttc 3540 aagattacga agtccgaagt atcgcctagc attagctgca ccaagctcct gagataccga 3600 agagctaata gtgacgtggt taaagttaaa cttccacgtt tcgataagaa acgtcgcatg 3660 tgtctgcctg ggtatgacac catataccta gattcgaagt ttgtgagtcg cgttttcgat 3720 tatgtcgtgt gtaattgctc tgccgtgaac tcaaaaactt tcgagtgggt gtggagtttc 3780 attaagtcta gtaagtcgag ggtgattatt agcggtaaaa taattcacaa ggatgtgaat 3840 ttggacctta agtacgtcga gagtttcgcc gcggttatgt tggcctctgg cgtgcgcagc 3900 agactagcgt ccgagtacct tgctaagaac cttagtcatt tttcgggaga ttgctccttt 3960 attgaagcca cgtctttcgt gttgcgtgag aaaatcagaa acatgactct gaattttaac 4020 gaaagacttt tacagttagt gaagcgcgtt gcctttgcga ccttggacgt gagttttcta 4080 gatttagatt caactcttga atcaataact gattttgccg agtgtaaggt agcgattgaa 4140 ctcgacgagt tgggttgctt gagagcggag gccgagaatg aaaaaatcag gaatctggcg 4200 ggagattcga ttgcggctaa actcgcgagc gagatagtgg tcgatattga ctctaagcct 4260 tcaccgaagc aggtgggtaa ttcgtcatcc gaaaacgccg ataagcggga agttcagagg 4320 cccggtttgc gtggtggttc tagaaacggg gttgttgggg agttccttca cttcgtcgtg 4380 gattctgcct tgcgtctttt caaatacgcg acggatcaac aacggatcaa gtcttacgtg 4440 cgtttcttgg actcggcggt ctcattcttg gattacaact acgataatct atcgtttata 4500 ctgcgagtgc tttcggaagg ttattcgtgt atgttcgcgt ttttggcgaa tcgcggcgac 4560 ttatctagtc gtgtccgtag cgcggtgcgt gctgtgaaag aagttgctac ctcatgcgcg 4620 aacgcgagcg tttctaaagc caaggttatg attaccttcg cagcggccgt gtgtgctatg 4680 atgtttaata gctgcggttt ttcaggcgac ggtcgggagt ataaatcgta tatacatcgt 4740 tacacgcaag tattgtttga cactatcttt tttgaggaca gcagttacct acccatagaa 4800 gttctgagtt cggcgatatg cggtgctatc gtcacacttt tctcctcggg ctcgtccata 4860 agtttaaacg ccttcttact tcaaattacc aaaggattct ccctagaggt tgtcgtccgg 4920 aatgttgtgc gagtcacgca tggtttgagc accacagcga ccgacggcgt catacgtggg 4980 gttttctccc aaattgtgtc tcacttactt gttggaaata ccggtaatgt ggcttaccag 5040 tcagctttca ttgccggggt ggtgcctctt ttagttaaaa agtgtgtgag cttaatcttc 5100 atcttgcgtg aagatactta ttccggtttt attaagcacg gaatcagtga attctctttc 5160 cttagtagta ttctgaagtt cttgaagggt aagcttgtgg acgagttgaa atcgattatt 5220 caaggggttt ttgattccaa caagcacgtg tttaaagaag ctactcagga agcgattcgt 5280 acgacggtca tgcaagtgcc tgtcgctgta gtggatgccc ttaagagcgc cgcgggaaaa 5340 atttataaca attttactag tcgacgtacc tttggtaagg atgaaggctc ctctagcgac 5400 ggcgcatgtg aagagtattt ctcatgcgac gaaggtgaag gtccgggtct gaaagggggt 5460 tccagctatg gcttctcaat tttagcgttc ttttcacgca ttatgtgggg agctcgtcgg 5520 cttattgtta aagtgaagca tgagtgtttt gggaaacttt ttgaatttct atcgctcaag 5580 cttcacgaat tcaggactcg cgtttttggg atgaatagaa cggacgtggg agtttacgat 5640 tttttgccca cggacatcgt ggaaacgctc tcatcgatag aagagtgcga ccaaattgaa 5700 gaacttctcg gcgacgacct gaaaggtgac aaggatgctt cgttgaccga tatgaattac 5760 tttgagttct cagaagactt cttagcctct gtcgaggagc cgcctttcgc tggattgcga 5820 ggaggtagca agaacgtcgc gattttggcg attttggaat acgcgcataa tttgtttcgc 5880 attgtcgcaa gcaagtgttc gaaacgacct ttatttcttg ctttcgccga actctcaagc 5940 gcccttatcg agaaatttaa ggaggttttc cctcgtaaga gccagctcgt cgctatcgtg 6000 cgcgagtata ctcagagatt cctccgaagt cgcatgcgtg cgttgggttt gaataacgag 6060 ttcgtggtaa aatctttcgc cgatttgcta cccgcattaa tgaagcggaa ggtttcaggt 6120 tcgttcttag ctagtgttta tcgcccactt agaggtttct catatatgtg tgtttcagcg 6180 gagcgacgtg aaaagttttt tgctctcgtg tgtttaatcg ggttaagtct ccctttcttc 6240 gtgcgcatcg taggagcgaa agcgtgcgaa gaactcgtgt cctcagcgcg tcgcttttat 6300 gagcgtatta aaatttttct caggcagaag tatgtctctc tttctaattt cttttgtcac 6360 ttgtttagct ctgacgttga tgacagttcc gcatcagcag ggttgaaagg tggtgcgtcg 6420 cgaatgacgc tcttccacct tctggttcgc cttgctagtg ccctcctatc gttagggtgg 6480 gaagggttaa agctactctt atcgcaccac aacttgttat ttttgtgttt tgcattggtt 6540 gacgatgtga acgtccttat caaagttctt gggggtcttt ctttctttgt gcaaccagtc 6600 ttttccttgt ttgcggcgat gcttttacaa ccggacaggt ttgtggggta ttccgagaaa 6660 cttgttacag cgtttgaatt tttcttaaaa tgttcgcctc gcgcgcctgc actactcaaa 6720 gggttttttg agtgcgtggc gaacagcact gtgtcaaaaa ccgttcgaag acttcttcgc 6780 tatttcgtga ggatgctcaa acttcgaaaa gggcgagggt tgcgtgcgga tggtaggggt 6840 ctccatcggc agaaagccgt acccgtcata ccttctaatc gggtcgtgac cgacggggtt 6900 gaaagacttt cggtaaagat gcaaggagtt gaagcgttgc gtaccgaatt gagaatctta 6960 gaagatttag attctgccgt gatcgaaaaa ctcaatagac gcagaaatcg tgacactaat 7020 gacgacgaat ttacgcgccc tgctcatgag cagatgcaag aagtcaccac tttctgttcg 7080 aaagccaact ctgctggttt ggccctggaa agggcagtgc ttgtggaaga cgctataaag 7140 tcggagaaac tttctaagac ggttaatgag atggtgagga aagggagtac caccagcgaa 7200 gaagtggccg tcgctttgtc ggacgatgaa gccgtggaag aaatctctgt tgctgacgag 7260 cgagacgatt cgcctaagac agtcaggata agcgaatacc taaataggtt aaactcaagc 7320 ttcgaattcc cgaagcctat tgttgtggac gacaacaagg ataccggggg tctaacgaac 7380 gccgtgaggg agttttatta tatgcaagaa cttgctcttt tcgaaatcca cagcaaactg 7440 tgcgcctact acgatcaact gcgcatagtc aacttcgatc gttccgtagc accatgcagc 7500 gaagatgctc agctgtacgt acggaagagc ggctcaacga tagtgcaggg taaagaggta 7560 cgtttgcaca ttaaggattt ccacgatcac gatttcctgt ttgacgggaa aatttctatt 7620 aacaagcggc ggcgaggcgg aaacgtttta tatcacgaca acctcgcgtt cttggcgagt 7680 aatttgttct tagccggcta ccccttttca aggagcttcg tcttcacgaa ttcgtcggtc 7740 gatattctcc tctacgaagc tccacccgga ggtggtaaga cgacgacgct gattgactcg 7800 ttcttgaagg tcttcaagaa aggtgaggtt tccaccatga tcttaaccgc caacaaaagt 7860 tcgcaggttg agatcctaaa gaaagtggag aaggaagtgt ctaacattga atgccagaaa 7920 cgtaaagaca agagatctcc gaaaaagagc atttacacca tcgacgctta tttaatgcat 7980 caccgtggtt gtgatgcaga cgttcttttc atcgatgagt gtttcatggt tcatgcgggt 8040 agcgtactag cttgcattga gttcacgagg tgtcataaag taatgatctt cggggatagc 8100 cggcagattc actacattga aaggaacgaa ttggacaagt gtttgtatgg ggatctcgat 8160 aggttcgtgg acctgcagtg tcgggtttat ggtaatattt cgtaccgttg tccatgggat 8220 gtgtgcgctt ggttaagcac agtgtatggc aacctaatcg ccaccgtgaa gggtgaaagc 8280 gaaggtaaga gcagcatgcg cattaacgaa attaattcag tcgacgattt agtccccgac 8340 gtgggttcca cgtttctgtg tatgcttcag tcggagaagt tggaaatcag caagcacttt 8400 attcgcaagg gtttgcctaa acttaacgtt ctaactgtgc atgaggcgca aggtgagacg 8460 tatgcgcgtg tgaaccttgt gcgacttaag tttcaggagg atgaaccctt taaatctatc 8520 aggcacataa ccgtcgctct ttctcgtcac accgacagct taacttataa cgtcttagct 8580 gctcgtcgag gtgacgccac ttgcgatgcc atccagaagg ctgcggaatt ggtgaacaag 8640 tttcgcgttt ttcctacatc ttttggtggt agtgttatca atctcaacgt gaaaaaggac 8700 gtggaagata acagtaggtg caaggcttcg tcggcaccat tgagcgtaat caacgacttt 8760 ttgaacgaag ttaatcccgg tactgcggtg attgattttg gtgatttgtc cgcggacttc 8820 agtactgggc cttttgagtg cggtgccagc ggtattgtgg tgcgggacaa catctcctcc 8880 agcaacatca ctgatcacga taagcagcgt gtttagcgta gttcggtcgc aggcgattcc 8940 gcgtagaaaa ccttctctac aagaaaattt gtattcgttt gaagcgcgga attataactt 9000 ctcgacttgc gaccgttaca catctgcttc aatgttcgga gaggctatgg cgatgaactg 9060 tcttcgtcgt tgcttcgacc tagatgcctt ttcgtccctg cgtaatgatg tgattagtat 9120 cacacgttca ggcatcgaac aatggctgga gaaacgtact cctagtcaga ttaaagcatt 9180 aatgaaggat gttgaatcgc ctttggaaat tgacgatgaa atttgtcgtt ttaagttgat 9240 ggtgaagcgt gacgctaagg tgaagttaga ctcttcttgt ttaactaaac acagcgccgc 9300 tcaaaatatc atgtttcatc gcaagagcat taatgctatc ttctctccta tctttaacga 9360 ggtgaaaaac cgaataatgt gctgtcttaa gcctaacata aagtttttta cggagatgac 9420 taacagggat tttgcttctg ttgtcagcaa catgcttggt gacgacgatg tgtaccatat 9480 aggtgaagtt gatttctcaa agtacgacaa gtctcaagat gctttcgtga aggcttttga 9540 agaagtgatg tataaggaac tcggtgttga tgaagagttg ctggctatct ggatgtgcgg 9600 cgagcggtta tcgatagcta acactctcga tggtcagttg tccttcacga tcgagaatca 9660 aaggaagtcg ggagcttcga acacttggat tggtaactct ctcgtcactt tgggtatttt 9720 aagtctttac tacgacgtta gaaatttcga ggcgttgtac atctcgggcg atgattcttt 9780 aattttttct cgcagcgaga tttcgaatta tgccgacgac atatgcactg acatgggttt 9840 tgagacaaaa tttatgtccc caagtgtccc gtacttttgt tctaaatttg ttgttatgtg 9900 tggtcataag acgttttttg ttcccgaccc gtacaagctt tttgtcaagt tgggagcagt 9960 caaagaggat gtttcaatgg atttcctttt cgaaactttt acctccttta aagacttaac 10020 ctccgatttt aacgacgagc gcttaattca aaagctcgct gaacttgtgg ctttaaaata 10080 tgaggttcaa accggcaaca ccaccttggc gttaagtgtg atacattgtt tgcgttcgaa 10140 tttcctctcg tttagcaagt tgtatcctcg cgtgaaggga tggcaggttt tttacacgtc 10200 ggttaagaaa gcgcttctca agagtgggtg ttctctcttc gacagtttca tgaccccttt 10260 tggtcaggct gtcatggttt gggatgatga gtagcgctaa cttgtgcgca gtttctttgt 10320 tcgtgacata caccttgtgt gtcaccgtgc gtttataatg aatcaggttt tgcagtttga 10380 atgtttattt ctgctgaatc tcgcggtttt tgctgtgact ttcattttca ttcttctggt 10440 cttccgcgtg attaagtctt ttcgccagaa gggtcacgaa gcgcctgttc ccgttgttcg 10500 tggcgggggt ttttcaaccg tagtgtagtc aaaagacgcg catatggtag ttttcggttt 10560 ggactttggc accacattct ctacggtgtg tgtgtacaag gatggacgag ttttttcatt 10620 caagcagaat aattcggcgt acatccccac ttacctctat ctcttctccg attctaacca 10680 catgactttt ggttacgagg ccgaatcact gatgagtaat ctgaaagtta aaggttcgtt 10740 ttatagagat ttaaaacgtt gggtgggttg cgattcgagt aacctcgacg cgtaccttga 10800 ccgtttaaaa cctcattact cggtccgctt ggttaagatc ggctctggct tgaacgaaac 10860 tgtttcaatt ggaaactttg ggggcactgt taagtctgag gctcatctgc cagggttgat 10920 agctctcttt attaaggctg tcattagttg cgcggagggc gcgtttgcgt gcacttgcac 10980 cggggttatt tgttcagtac ctgccaatta tgatagcgtt caaaggaatt tcactgatca 11040 gtgtgtttca ctcagcggtt atcaatgcgt atatatgatc aatgaacctt cagcggctgc 11100 gctatctgcg tgtaattcgg ttggaaagaa gtccgcaaat ttggctgttt acgatttcgg 11160 tggtgggacc ttcgacgtgt ctatcatttc ataccgcaac aatacttttg ttgtgcgagc 11220 ttctggaggc gatctaaatc tcggtggaag ggatgttgat cgtgcgtttc tcacgcacct 11280 cttctcttta acatcgctgg aacctgacct cactttggat atctcgaatc tgaaagaatc 11340 tttatcaaaa acggacgcag agatagttta cactttgaga ggtgtcgatg gaagaaaaga 11400 agacgttaga gtaaacaaaa acattcttac gtcggtgatg ctcccctacg tgaacagaac 11460 gcttaagata ttagagtcaa ccttaaaaac gtatgctaag agtatgaatg agagtgcgcg 11520 agttaagtgc gatttagtgc tgataggagg atcttcatat cttcctggcc tggcagacgt 11580 actaacgaag catcagagcg ttgatcgtat cttaagagtt tcggatcctc gggctgccgt 11640 ggccgtcggt tgcgcactat attcttcatg cctctcagga tctggggggt tgctactgat 11700 cgactgtgca gctcacactg tcgctatagc ggacagaagt tgtcagcaaa tcatttgcgc 11760 tccagcgggg gcaccgatcc ccttttcagg aagcatgcct ttgtacttag ccagggtcaa 11820 caagaactcg cagcgtgaaa tcgccgtgtt tgaaggggag tacgttaagt gccctaagaa 11880 cagaaagatc tgtggagcaa atataagatt ttttgatata ggagtgacgg gtgattcgta 11940 cgcacccgtt accttctata tggatttctc catttcaagc gtaggagccg tttcattcgt 12000 ggtgagaggt cctgagggta agcaagtgtc actcactgga actccagcgt ataacttttc 12060 gtctgtggct ctcggatcac gcagtgtccg agaattgcat attagtttaa ataataaagt 12120 ttttctcggt ttgcttctac atagaaaggc ggatcgacga atacttttca ctaaggatga 12180 agcgattcga tacgccgatt caattgatat cgcggatgtg ctaaaggaat ataaaagtta 12240 cgcggccagt gccttaccac cagacgagga tgtcgaatta ctcctgggaa agtctgttca 12300 aaaagtttta cggggaagca gactggaaga aatacctctc taggagcata gcagcacact 12360 caagtgaaat taaaactcta ccagacattc gattgtacgg cggtagggtt gtaaagaagt 12420 ccgatttcga atcagcactt cctaattctt ttgaacagga attaggactg ttcatactga 12480 gcgaacggga agtgggatgg agcaaattat gcggaataac ggtggaagaa gcagcatacg 12540 atcttacgaa tcccaaggct tataaattca ctgccgagac atgtagcccg gatgtaaaag 12600 gtgaaggaca aaaatactct atggaagacg tgatgaattt catgcgttta tcaaatctgg 12660 atgttaacga caagatgctg gcggaacagt gttggtcgct gtccaattca tgcggtgaat 12720 tgatcaaccc agacgacaaa gggcgattcg tggctctcac ctttaaggac agagacacag 12780 ctgatgacac gggtgccgcc aacgtggaat gtcgcgtggg cgactatcta gtttacgcta 12840 tgtccctgtt tgagcagagg acccaaaaat cgcagtctgg caacatctct ctgtacgaaa 12900 agtactgcga atacatcagg acctacttag ggagtacaga cctgtttttc acagcgccgg 12960 acaggattcc gttacttacg ggcatcctat acgatttttg taaggaatac aacattttct 13020 actcgtcata taagagaaac gtcgataatt tcagattctt cttggcgaat tatatgcctt 13080 tgatatctga cgtctttgtc ttccagtggg taaaacccgc gccggatgtt cggctgcttt 13140 ttgagttaag tgcagcggaa ctaacgctgg aggttcccac actgagtttg atagattctc 13200 aagttgtggt aggtcatatc ttaagatacg tagaatccta cacatcagat ccagccatcg 13260 acgcgttaga agacaaactg gaagcgatac tgaaaagtag caatccccgt ctatcgacag 13320 cgcaactatg ggttggtttc ttttgttact atggtgagtt tcgtacggct caaagtagag 13380 tagtgcaaag accaggcgta tacaaaacac ctgactcagt gggtggattt gaaataaaca 13440 tgaaagatgt tgagaaattc ttcgataaac ttcagagaga attgcctaat gtatctttgc 13500 ggcgtcagtt taacggagct agagcgcatg aggctttcaa aatatttaaa aacggaaata 13560 taagtttcaa acctatatcg cgtttaaacg tgcctagaga gttctggtat ctgaacatag 13620 actacttcag gcacgcgaat aggtccgggt taaccgaaga agaaatactc atcctaaaca 13680 acataagcgt tgatgttagg aagttatgcg ctgagagagc gtgcaatacc ctacctagcg 13740 cgaagcgctt tagtaaaaat cataagagta atatacaatc atcacgccaa gagcggagga 13800 ttaaagaccc attggtagtc ctgaaagaca ctttatatga gttccaacgc aagcgtgccg 13860 gttgggggtc tcgaagcact cgagacctcg ggagtcgtgc tgaccacgcg aaaggaagcg 13920 gttgataagt tttttaatga actaaaaaac gaaaattact catcagttga cagcagccga 13980 ttaagcgatt cggaagtaaa agaagtgtta gagaaaagta aagaaagttt caaaagcgaa 14040 ctggcctcca ctgacgagca cttcgtctac cacattatat ttttcttaat ccgatgtgct 14100 aagatatcga cgagtgaaaa agtgaagtac gttggtagtc atacgtacgt ggtcgacgga 14160 aaaacgtaca ccgttcttga cgcttgggta ttcaacatga tgaaaagtct cacgaagaag 14220 tacaaacgag tgaatggtct gcgtgcgttc tgttgcgcgt gcgaagatct atatctaacc 14280 gtcgcaccaa taatgtcaga acgctttaag actaaagccg tagggatgaa aggtttgcct 14340 gttggaaagg aatacttagg cgccgacttt ctttcgggaa ctagcaaact gatgagcgat 14400 cacgacaggg cggtctccat cgttgcagcg aaaaacgctg tcgatcgtag cgctttcacg 14460 ggtggggaga gaaagatagt tagtttgtat gatctaggga ggtactaagc acggtgtgct 14520 atagtgcgtg ctataataat aaacactagt gcttaagtcg cgcagaagaa aacgctatgg 14580 agttgatgtc cgacagcaac cttagcaacc tggtgataac cgacgcctct agtctaaatg 14640 gtgtcgacaa gaagctttta tctgctgaag ttgtaaaaat gctggtgcag aaaggggctc 14700 ctaacgaggg tatagaagtg gtgttcggtc tactccttta cgcactcgcg gcaagaacca 14760 cgtctcctaa ggttcagcgc gcagattcag acgttatatt ttcaaatagt ttcggagaga 14820 ggaatgtggt agtaacagag ggtgacctta agaaggtact cgacgggtgt gcgcctctca 14880 ctaggttcac taataaactt agaacgttcg gtcgtacttt cactgaggct tacgttgact 14940 tttgtatcgc gtataagcac aaattacccc aactcaacgc cgcggcggaa ttggggattc 15000 cagctgaaga ttcgtactta gctgcagatt ttctgggtac ttgcccgaag ctctctgaat 15060 tacagcaaag taggaagatg ttcgcgagta tgtacgctct aaaaactgaa ggtggagtgg 15120 taaatacacc agtgagcaat ctgcgtcagc taggtagaag ggaagttatg taatggaaga 15180 ttacgaagaa aaatccgaat cgctcatact gctacgcacg aatctgaaca ctatgctttt 15240 agtggtcaag tccgatgcta gtgtagagct gcctaaacta ctaatttgcg gttacttacg 15300 agtgtcagga cgtggggagg tgacgtgttg caaccgtgag gaattaacaa gagattttga 15360 gggcaatcat catacggtga tccgttctag aatcatacaa tatgacagcg agtctgcttt 15420 tgaggaattc aacaactctg attgcgtagt gaagtttttc ctagagactg gtagtgtctt 15480 ttggtttttc cttcgaagtg aaaccaaagg tagagcggtg cgacatttgc gcaccttctt 15540 cgaagctaac aatttcttct ttggatcgca ttgcggtacc atggagtatt gtttgaagca 15600 ggtactatct gaaactgaat ctataatcga ttctttttgc gaagaaagaa atcgttaaga 15660 tgagggttat agtgtctcct tatgaagctg aagacattct gaaaagatcg actgacatgt 15720 tacgaaacat agacagtggg gtcttgagca ctaaagaatg tatcaaggca ttctcgacga 15780 taacgcgaga cctacattgt gcgaaggctt cctaccagtg gggtgttgac actgggttat 15840 atcagcgtaa ttgcgctgaa aaacatttaa ttgacacggt ggagtcaaac atacggttgg 15900 ctcaacctct cgtgcgtgaa aaagtggcgg ttcatttttg taaggatgaa ccaaaagagc 15960 tagtagcatt catcacgcga aagtacgtgg aactcacggg cgtgggagtg agagaagcgg 16020 tgaagaggga aatgcgctct cttaccaaaa cagttttaaa taaaatgtct ttggaaatgg 16080 cgttttacat gtcaccacga gcgtggaaaa acgctgaatg gttagaacta aaattttcac 16140 ctgtgaaaat ctttagagat cttttattag acgtggaaac gctcaacgaa ttgtgcgccg 16200 aagatgatgt tcacgtcgac aaagtaaatg agaatgggga cgaaaatcac gacctcgaac 16260 tccaagacga atgttaaaca ttggttaagt ttaacgaaaa tgattagtaa ataataaatc 16320 gaacgtgggt gtatctacct gacgtatcaa cttaagctgt tactgagtaa ttaaaccaac 16380 aagtgttggt gtaatgtgta tgttgatgta gagaaaaatc cgtttgtaga acggtgtttt 16440 tctcttcttt atttttaaaa aaaaataaaa aaaaaaaaaa agaagc 16486 //