ID D00627; SV 1; linear; genomic RNA; STD; VRL; 7452 BP. XX AC D00627; XX DT 12-MAR-1991 (Rel. 27, Created) DT 14-DEC-2007 (Rel. 94, Last updated, Version 7) XX DE Human coxsackievirus A9 genomic RNA, complete genome, strain: Griggs. XX KW . XX OS Coxsackievirus A9 OC Viruses; Riboviria; Picornavirales; Picornaviridae; Enterovirus; OC Enterovirus B. XX RN [1] RP 1-7452 RX PUBMED; 2558158. RA Chang K., Auvinen P., Hyypia T., Stanway G.; RT "The nucleotide sequence of Coxsackievirus A9; implications for receptor RT binding and enterovirus classification"; RL J. Gen. Virol. 70:3269-3280(1989). XX DR MD5; 47aa98fdce813f0783d25a116ed66b4d. DR EuropePMC; PMC104435; 9971773. DR EuropePMC; PMC112895; 10482628. DR EuropePMC; PMC114636; 11581430. DR EuropePMC; PMC121380; 9457433. DR EuropePMC; PMC1392672; 16455897. DR EuropePMC; PMC1951248; 17537940. DR EuropePMC; PMC225006; 14512548. DR EuropePMC; PMC228507; 12970427. DR EuropePMC; PMC2907575; 20367886. DR EuropePMC; PMC2919010; 20554778. DR EuropePMC; PMC3290945; 17176588. DR EuropePMC; PMC3358056; 22516379. DR EuropePMC; PMC3620579; 23521862. DR EuropePMC; PMC368751; 14694117. DR EuropePMC; PMC3889841; 24426171. DR EuropePMC; PMC3931826; 24587020. DR EuropePMC; PMC4692522; 26709514. DR EuropePMC; PMC4766141; 27026855. DR EuropePMC; PMC5110190; 27630238. DR EuropePMC; PMC5328557; 27993855. DR EuropePMC; PMC544264; 15640172. DR RFAM; RF00041; Entero_OriR. DR RFAM; RF00048; Entero_CRE. DR RFAM; RF00229; IRES_Picorna. DR RFAM; RF00386; Entero_5_CRE. XX CC These data kindly submitted in computer readable form by: CC Glyn Stanway CC Biology Department, CC Essex University CC Wivenhoe Park CC Colchester CO4 3SQ CC United Kingdom XX FH Key Location/Qualifiers FH FT source 1..7452 FT /organism="Coxsackievirus A9" FT /strain="Griggs" FT /mol_type="genomic RNA" FT /note="obtained from the American Type Culture Collection" FT /note="synonym: Coxsackievirus A9" FT /db_xref="taxon:12067" FT stem_loop 10..36 FT stem_loop 591..620 FT CDS 744..7349 FT /codon_start=1 FT /product="polyprotein" FT /note="polyprotein precursor" FT /db_xref="GOA:P21404" FT /db_xref="InterPro:IPR000081" FT /db_xref="InterPro:IPR000199" FT /db_xref="InterPro:IPR000605" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR001676" FT /db_xref="InterPro:IPR002527" FT /db_xref="InterPro:IPR003138" FT /db_xref="InterPro:IPR003593" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR014759" FT /db_xref="InterPro:IPR014838" FT /db_xref="InterPro:IPR027417" FT /db_xref="InterPro:IPR029053" FT /db_xref="InterPro:IPR033703" FT /db_xref="InterPro:IPR036203" FT /db_xref="InterPro:IPR036988" FT /db_xref="PDB:1D4M" FT /db_xref="PDB:3J2J" FT /db_xref="UniProtKB/Swiss-Prot:P21404" FT /protein_id="BAA00518.1" FT /translation="MGAQVSTQKTGAHETSLSAAGNSIIHYTNINYYKDAASNSANRQD FT FTQDPSKFTEPVKDVMIKSLPALNSPTVEECGYSDRVRSITLGNSTITTQECANVVVGY FT GRWPTYLRDDEATAEDQPTQPDVATCRFYTLDSIKWEKGSVGWWWKFPEALSDMGLFGQ FT NMQYHYLGRAGYTIHLQCNASKFHQGCLLVVCVPEAEMGGAVVGQAFSATAMANGDKAY FT EFTSATQSDQTKVQTAIHNAGMGVGVGNLTIYPHQWINLRTNNSATIVMPYINSVPMDN FT MFRHYNFTLMVIPFVKLDYADTASTYVPITVTVAPMCAEYNGLRLAQAQGLPTMNTPGS FT TQFLTSDDFQSPCALPQFDVTPSMNIPGEVKNLMEIAEVDSVVPVNNVQDTTDQMEMFR FT IPVTINAPLQQQVFGLRLQPGLDSVFKHTLLGEILNYYAHWSGSMKLTFVFCGSAMATG FT KFLIAYSPPGANPPKTRKDAMLGTHIIWDIGLQSSCVLCVPWISQTHYRLVQQDEYTSA FT GYVTCWYQTGMIVPPGTPNSSSIMCFASACNDFSVRMLRDTPFISQDNKLQGDVEEAIE FT RARCTVADTMRTGPSNSASVPALTAVETGHTSQVTPSDTMQTRHVKNYHSRSESTVENF FT LGRSACVYMEEYKTTDKHVNKKFVAWPINTKQMVQMRRKLEMFTYLRFDMEVTFVITSR FT QDPGTTLAQDMPVLTRQIMYVPPGGPIPAKVDDYAWQTSTNPSIFWTEGNAPARMSIPF FT ISIGNAYSNFYDGWSNFDQRGSYGYNTLNNLGHIYVRHVSGSSPHPITSTIRVYFKPKH FT TRAWVPRPPRLCQYKKAFSVDFTPTPITDTRKDINTVTTVAQSRRRGDMSTLNTHGAFG FT QQSGAVYVGNYRVINRHLATHTDWQNCVWEDYNRDLLVSTTTAHGCDVIARCQCTTGVY FT FCASKNKHYPVSFEGPGLVEVQESEYYPKRYQSHVLLAAGFSEPGDCGGILRCEHGVIG FT IVTMGGEGVVGFADVRDLLWLEDDAMEQGVKDYVEQLGNAFGSGFTNQICEQVNLLKES FT LVGQDSILEKSLKALVKIISALVIVVRNHDDLITVTAILALIGCTSSPWRWLKQKVSQY FT YGIPMAERQNDSWLKKFTEMTNACKRMEWIAIKIQKFIEWLKVKILPEVREKHEFLNRL FT KQLPLLESQIATIEQSAPSQSDQEQLFSNVQYFAHYCRKYAPLYAAEAKRVFSLEKKMS FT NYIQFKSKCRIEPVCLLLHGSPGAGKSVATNLIGRSLAEKLNSSVYSLPPDPDHFDGYK FT QQAVVIMDDLCQNPDGKDVSLFCQMVSSVDFVPPMAALEEKGILFTSPFVLASTNAGSI FT NAPTVSDSRALARRFHFDMNIEVISMYSQNGKINMPMSVKTCDEECCPVNFKKCCPLVC FT GKAIQFIDRRTQVRYSLDMLVTEMFREYNHRHSVGATLEALFQGPPIYREIKISVAPET FT PPPPVIADLLKSVDSEDVREYCKEKGWLIPEVNSTLQIEKYVSRAFICLQAITTFVSVA FT GIIYIIYKLFAGFQGAYTGIPNQKPKVPTLRQAKVQGPAFEFAVAMMKRNSSTVKTEYG FT EFTMLGIYDRWAVLPRHAKPGPTILMNDQEVGVMDAKELVDKDGTNLELTLLKLNRNEK FT FRDIRGFLAKEEMEVNEAVLAINTSKFPNMYIPVGQVTDYGFLNLGGTPTKRMLMYNFP FT TRAGQCGGVLMSTGKVLGIHVGGNGHQGFSAALLKHYFNDEQGEIEFIESSKDAGFPII FT NTPSKTKLEPSVFHQVFEGVKEPAVLRNGDPRLKANFEEAIFSKYIGNVNTHVDEYMLE FT AVDHYAGQLATLDISTEPMKLEDAVYGTEGLEALDLTTSAGYPYVALGIKKRDILSKKT FT RDLTKLKECMDKYGLNLPMITYVKDQLRSAEKVAKGKSRLIEASSLNDSVAMRQTFGNL FT YKTFHLNPGIVTGSAVGCDPDLFWSKIPVMLNGHLIAFDYSGYDASLSPVWFACLKLLL FT EKLGYSHKETNYIDYLCNSHHLYRDKHYFVRGGMPSGCSGTSIFNSMINNIIIRTLMLK FT VYKGIDLDQFRMIAYGDDVIASYPWPIDASLLAEAGKDYGLIMTPADKGECFNEVTWTN FT VTFLKRYFRADEQYPFLVHPVMPMKDIHESIRWTKDPKNTQDHVRSLCLLAWHNGEHEY FT EEFIRKIRSVPVGRCLTLPAFSTLRRKWLDSF" FT mat_peptide 747..950 FT /product="VP4 protein" FT /note="1A" FT mat_peptide 951..1733 FT /product="VP2 protein" FT /note="1B" FT mat_peptide 1734..2447 FT /product="VP3 protein" FT /note="1C" FT mat_peptide 2448..3353 FT /product="VP1 protein" FT /note="1D" FT misc_feature 3315..3323 FT /note="RGD sequence" FT mat_peptide 3354..3794 FT /product="2A protein" FT /note="protease" FT mat_peptide 3795..4091 FT /product="2B protein" FT mat_peptide 4092..5078 FT /product="2C protein" FT /note="helicase" FT mat_peptide 5079..5345 FT /product="3A protein" FT mat_peptide 5346..5411 FT /product="3B protein" FT /note="VPg" FT mat_peptide 5412..5960 FT /product="3C protein" FT /note="protease" FT mat_peptide 5961..7346 FT /product="3D protein" FT /note="polymerase" XX SQ Sequence 7452 BP; 2128 A; 1708 C; 1828 G; 1788 T; 0 other; tttaaaacag cctgtgggtt gttcccaccc acaggcgcca ccgggcgtta gcacactggt 60 atcacggtac ccttgtgcgc ctgttttata accccacccc gagtaaacct tagaagcaat 120 gcacctctgg tcaatagtag gtgtgacaca ccagtcacat cgtgaccaag cacttctgtc 180 tccccggact gagtatcaat aggctgctcg cgcggctgaa ggagaaagcg ttcgttaccc 240 ggccagctac ttcgagaagc ctagtaacac catgaaggtt gcagagtgtt tcgctcagca 300 cttcccctgt gtagatcagg ccgatgagtc accgcgttcc tcacgggcga ccgtggcggt 360 cgctgcgctg gtggcctgcc tatggggcaa cccataggac gctctaatgc tgacatggtg 420 cgaagagtct attgagctag ctggtagtcc tccggcccct gaatgcggct aatcccaact 480 gcggagcacg caccctcaaa ccagggggca gcgtgtcgta acgggcaact ctgcagcgga 540 accgactact ttgggtgtcc gtgtttcttt ttattcctat attggctgct tatggtgaca 600 attgagagat tgttaccata tagctattgg attggccatc cggtgagcaa cagagctatt 660 gtgtatctgt ttactggttt catacccctt aattacaaag aagtcaaaac ccttcacttg 720 atcttgttat tcaatacaac aaaatgggag ctcaagtgtc aacacagaaa actggagctc 780 atgaaaccag tttaagtgcg gcaggtaatt caattataca ttatacgaac atcaactact 840 ataaagatgc tgcgtctaat tcggctaatc ggcaagactt tacacaagac ccgagtaagt 900 ttacagagcc tgttaaagat gttatgatta agtctttacc tgccctcaac tcaccaacag 960 tagaagagtg cgggtacagc gatcgggtta ggtccatcac ccttggaaac tccacgataa 1020 ccacgcagga gtgtgctaac gtggtggtgg ggtatggtag atggcccact tacctcaggg 1080 acgacgaggc gactgccgag gatcaaccca cacagcctga cgtagcaaca tgccgctttt 1140 atactttaga ttcaatcaag tgggaaaagg gatcggtggg gtggtggtgg aagttcccag 1200 aagcgcttag tgatatggga ttattcggtc agaacatgca ataccactac ctgggtcgtg 1260 cagggtacac tattcaccta caatgtaacg cttccaagtt ccatcaaggg tgtttgctag 1320 tagtgtgtgt gcccgaggct gagatgggag gagctgtggt tggacaagca ttttccgcca 1380 ccgcgatggc aaatggtgat aaagcatatg agttcactag cgcaacccaa agtgatcaga 1440 caaaagttca aactgctata cacaatgcag ggatgggcgt aggtgtaggg aacctcacta 1500 tctacccgca ccagtggata aatttgcgca ccaacaacag tgccaccata gtgatgccat 1560 atattaatag tgtgcccatg gacaacatgt tcagacatta taattttacc ctgatggtga 1620 taccttttgt gaaactggac tatgccgaca ccgcatccac gtacgtgcca attacagtga 1680 cggtggcccc aatgtgtgcg gagtataacg gcttacgtct ggcacaagcg caaggtttgc 1740 caactatgaa cacaccagga agcacgcaat tcctaacatc agatgacttt caatcgccgt 1800 gcgctttgcc acaatttgat gtgacgccta gtatgaacat cccaggagaa gtgaagaacc 1860 taatggaaat agcagaagtg gactcggtcg tgcccgtgaa caatgtccaa gacaccactg 1920 accaaatgga gatgttcagg ataccagtga ccataaatgc ccctctacaa caacaggttt 1980 ttggcctcag attgcaacca ggcttagata gtgtgtttaa gcacactctg ttgggagaaa 2040 ttctaaacta ctatgcgcac tggtcaggca gcatgaagct gacatttgtg ttttgcgggt 2100 ctgcaatggc aacagggaaa tttttaatag catattcacc acctggggcc aaccccccga 2160 aaacacgaaa ggatgcaatg ctgggaacac atatcatatg ggacattggt ttacaatcta 2220 gctgtgtgtt gtgtgtgcca tggatcagtc aaacacatta taggcttgta cagcaggatg 2280 agtacaccag cgctggttac gtgacgtgtt ggtatcagac tggtatgatt gtcccaccag 2340 gaaccccaaa ttctagctct attatgtgct ttgcatcagc gtgcaacgac ttctcagtaa 2400 gaatgttgag ggacacacca ttcatatccc aggataataa gctgcaaggg gatgtggaag 2460 aagccattga gagggcacgt tgtacagttg ctgacaccat gcgtacgggg cctagcaatt 2520 ccgcgagcgt acctgcactc actgcagttg agacagggca cacctcgcaa gttactccaa 2580 gtgacactat gcagacaaga catgtgaaaa actatcattc gcgctctgag tcgactgtgg 2640 agaatttcct cggtcggtcg gcatgcgtgt acatggaaga gtacaagacc actgataagc 2700 atgttaacaa gaaattcgtc gcctggccaa tcaacacaaa acaaatggtt cagatgcgga 2760 ggaagctgga aatgttcact tatcttaggt ttgatatgga ggtaactttt gtgatcacaa 2820 gtcgacaaga ccccggaaca accctagctc aggacatgcc cgtgttgacg cgccaaatca 2880 tgtatgtgcc acctggcggt ccgattccag caaaagttga tgattatgcc tggcagacgt 2940 ctacaaaccc cagcattttc tggacggaag gaaacgcacc agcgcgcatg tccatcccat 3000 ttatcagcat aggaaatgca tacagcaatt tttatgacgg gtggtcaaat tttgatcaga 3060 ggggctcata cgggtacaat accctgaata acttaggtca catatatgtg agacacgtga 3120 gtggaagtag tcctcaccca atcacgagca ctattagagt gtatttcaag ccaaaacata 3180 ccagagcttg ggtgccgcgc cctccaaggc tatgccaata caagaaggca tttagcgtgg 3240 atttcacgcc aactcccatt acagacacca ggaaagacat caacactgta accaccgtgg 3300 cgcaaagtcg gcgtcggggt gacatgtcca cccttaacac gcatggtgcc ttcggacaac 3360 aatccggggc cgtctatgtg ggcaactaca gagtgatcaa cagacacctg gcaacacaca 3420 cggattggca aaattgcgtg tgggaggatt acaatagaga cctccttgtg agcacgacta 3480 cagcgcacgg gtgtgatgtc atagctagat gccagtgtac aaccggggtg tacttttgtg 3540 catccaagaa caagcactac cctgtttcat tcgaagggcc aggtttagtg gaagtccaag 3600 agagtgaata ctaccctaaa agatatcaat cccatgtact tctggcagca ggattttccg 3660 aaccagggga ctgtggtggc atcttaaggt gtgaacacgg tgtcataggc atcgtaacca 3720 tgggaggcga aggtgttgtg ggttttgctg acgtgcgcga cctcttatgg ttagaggatg 3780 acgctatgga gcagggtgtg aaggactacg tggagcaact tggaaatgca tttggttcag 3840 gcttcaccaa tcagatctgt gagcaagtta accttttaaa agaatcacta gtgggtcaag 3900 actccatctt agagaaatct ctaaaagccc tagtcaagat aatatcagcc ttagtgatcg 3960 tggtgaggaa ccacgatgac ctaattacag tgactgccat actagccctc atcggttgca 4020 cctcgtctcc atggcggtgg cttaaacaga aagtgtcaca gtattatggg atacccatgg 4080 ctgaacgcca aaatgatagc tggctcaaga aattcactga aatgacaaat gcctgcaaac 4140 gaatggagtg gatagccatc aaaattcaga agtttataga gtggctcaaa gttaaaattc 4200 taccagaggt aagggagaag catgagttcc tgaacagact taaacagctt cccctattag 4260 agagtcagat tgccaccatc gagcagagtg caccatccca aagcgaccaa gagcaattgt 4320 tttccaatgt ccagtacttt gcacactatt gcagaaagta tgcccccctc tacgcagcag 4380 aggcaaagag ggtgttctcc cttgagaaaa agatgagcaa ttacatacag ttcaagtcca 4440 aatgccgtat tgagcctgta tgtttgctcc tacatgggag tccaggtgcc ggcaagtcgg 4500 tggcaacaaa cctaattgga aggtcactcg ctgagaaatt aaacagttca gtgtactcat 4560 taccaccaga cccagatcac tttgatggct acaaacaaca ggccgtagtg attatggatg 4620 acctatgcca gaaccctgat ggaaaagatg tctccttgtt ttgccaaatg gtctctagtg 4680 tagattttgt gccgcccatg gctgccttgg aagagaaggg cattttgttc acctctccgt 4740 tcgttctggc atcgactaat gcaggatcca taaatgctcc aactgtgtca gacagcaggg 4800 ccttagcaag gaggtttcac ttcgatatga acattgaagt tatctccatg tatagtcaga 4860 acggcaaaat aaatatgccg atgtcagtga agacgtgtga tgaagagtgc tgtccagtca 4920 actttaagaa gtgttgccct ctagtatgtg gtaaagccat ccagttcata gacagaagaa 4980 cccaagttag atactccctt gacatgctgg taactgagat gtttagagag tataaccata 5040 ggcatagtgt cggggccacc cttgaggcat tattccaggg tccaccgata tatagagaaa 5100 ttaagatcag tgttgcgcca gagacaccac caccacctgt catcgctgat ctactcaagt 5160 cggtggacag tgaggatgtg agagagtact gcaaagaaaa gggatggttg atccctgagg 5220 taaactccac cctccaaatt gaaaaatacg tcagtcgggc tttcatttgc ttgcaggcaa 5280 taaccacatt cgtgtcagta gctgggatca tctacataat atataagctc tttgcaggct 5340 ttcagggtgc atatacagga atacccaatc agaaacctaa ggtacctacc ttaagacaag 5400 caaaagtgca gggtcccgca tttgaattcg ccgttgcaat gatgaagaga aactcaagca 5460 cggtgaagac tgagtatggc gaattcacca tgctgggcat ctatgacagg tgggccgtct 5520 taccacgcca cgctaagcct ggaccaacca tcctgatgaa tgaccaggaa gtgggcgtga 5580 tggatgctaa ggaattagtg gataaggatg gcacaaacct agaactgaca ttgcttaaat 5640 taaacaggaa tgagaagttc agagacatca gaggcttctt agctaaggag gagatggagg 5700 tcaacgaagc cgtgctagca attaatacca gtaaatttcc caacatgtac attccagtgg 5760 gacaagtcac ggactacggc ttcctaaacc tgggtggtac acccactaag agaatgctca 5820 tgtacaactt ccccacaaga gcaggtcagt gcggcggagt gctcatgtcc actggcaaag 5880 tcttgggaat ccatgttggt ggaaatggtc atcaaggttt ctcagcagca cttctcaagc 5940 actacttcaa tgatgaacaa ggagagatcg agttcattga gagttcaaag gatgcagggt 6000 tcccgattat caatacacct agtaagacca agctggagcc aagtgtcttc catcaagttt 6060 ttgaaggtgt caaagaacca gcggtcctca ggaatggtga tccacgcctc aaagctaatt 6120 ttgaggaagc catattttcc aagtacatcg gaaatgttaa cacgcacgtg gatgaataca 6180 tgctggaagc tgttgatcat tatgccggac aattggccac cctagatatt agcactgaac 6240 caatgaagtt ggaggatgct gtatacggta ctgaaggtct tgaggctctt gacctaacaa 6300 cgagtgcagg ttacccttat gttgctctgg gcatcaagaa gagggacatt ctctcaaaga 6360 agaccaggga cctgaccaag ctgaaggagt gcatggacaa gtatggccta aacttgccaa 6420 tgataaccta tgtgaaagat caactcagat ctgcagagaa ggtggcaaag ggaaagtcta 6480 ggctcattga ggcgtccagt ttgaatgact ccgtggcaat gagacagaca ttcggcaacc 6540 tatacaaaac ttttcaccta aacccaggga ttgtgactgg cagtgccgtc gggtgtgacc 6600 cggatctctt ttggagtaaa ataccagtaa tgttaaacgg tcacctcata gcctttgatt 6660 actctggata tgatgctagc ttgagtcctg tatggtttgc ttgtctaaaa ctactacttg 6720 agaaacttgg ttactcgcac aaggagacca attacattga ttacctgtgc aactcccatc 6780 acctgtacag ggacaagcat tatttcgtgc ggggtggcat gccatcagga tgttctggca 6840 cgagcatctt taactcaatg ataaacaaca tcataattag gacactcatg ttgaaggttt 6900 acaaagggat cgacttggat caattcagga tgattgctta tggtgacgat gtgatcgcat 6960 catacccgtg gcccatagat gcgtctttgc ttgctgaagc tggcaaggac tatggattaa 7020 tcatgacacc agcagacaaa ggggagtgct tcaatgaagt tacttggact aacgtcacat 7080 tcctaaagag gtattttaga gcagatgaac aatacccctt tttagtgcac cctgttatgc 7140 ctatgaaaga catacacgaa tcaatcagat ggaccaagga tccaaagaac acccaagacc 7200 acgtgcgctc gctatgctta ttagcttggc acaacgggga gcacgaatat gaggagttca 7260 ttcgcaaaat caggagcgtc ccagttggac gttgtttgac cctacctgcg ttctcaaccc 7320 tacgcaggaa gtggttggac tctttctaaa ttagagacaa tttgaactga tttgaattgg 7380 ctcaacccta ctgtactaac cgaactagat aacggtgcag taggggtaaa ttctccgcat 7440 tcggtgcgga gg 7452 //