ID D00538; SV 1; linear; genomic RNA; STD; VRL; 7401 BP. XX AC D00538; XX DT 28-MAY-1990 (Rel. 24, Created) DT 22-APR-2005 (Rel. 83, Last updated, Version 9) XX DE Human coxsackievirus A21 (strain Coe) genomic RNA, complete genome. XX KW . XX OS Human coxsackievirus A21 Coe OC Viruses; Riboviria; Picornavirales; Picornaviridae; Enterovirus; OC Enterovirus C. XX RN [1] RP 1-7401 RX PUBMED; 2584950. RA Hughes P.J., North C., Minor P.D., Stanway G.; RT "The complete nucleotide sequence of coxsackievirus A21"; RL J. Gen. Virol. 70:2943-2952(1989). XX RN [2] RX DOI; 10.1016/0955-2235(94)90020-5. RX PUBMED; 8199356. RA Burt D., Law A.; RT "Evolution of the transforming growth factor-beta superfamily"; RL Prog. Growth Factor Res. 5(1):99-118(1994). XX DR MD5; 74dcf827908ec8a65a0cf4c6c4c03eed. DR EuropePMC; PMC104435; 9971773. DR EuropePMC; PMC112895; 10482628. DR EuropePMC; PMC114071; 11160660. DR EuropePMC; PMC116354; 10954543. DR EuropePMC; PMC121380; 9457433. DR EuropePMC; PMC167246; 12885914. DR EuropePMC; PMC1951248; 17537940. DR EuropePMC; PMC225006; 14512548. DR EuropePMC; PMC2669712; 19412342. DR EuropePMC; PMC3421820; 22740708. DR EuropePMC; PMC387693; 15078968. DR EuropePMC; PMC4809597; 27019095. DR EuropePMC; PMC5633025; 29018627. DR EuropePMC; PMC5749474; 29260690. DR EuropePMC; PMC84788; 10203496. DR RFAM; RF00048; Entero_CRE. DR RFAM; RF00229; IRES_Picorna. DR RFAM; RF00386; Entero_5_CRE. XX CC Protein boundaries are predicted by alignment with those of other CC enteroviruses. XX FH Key Location/Qualifiers FH FT source 1..7401 FT /organism="Human coxsackievirus A21 Coe" FT /strain="Coe" FT /mol_type="genomic RNA" FT /db_xref="taxon:12070" FT CDS 712..7332 FT /codon_start=1 FT /product="polyprotein precursor" FT /db_xref="GOA:P22055" FT /db_xref="InterPro:IPR000081" FT /db_xref="InterPro:IPR000199" FT /db_xref="InterPro:IPR000605" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR001676" FT /db_xref="InterPro:IPR002527" FT /db_xref="InterPro:IPR003138" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR014759" FT /db_xref="InterPro:IPR014838" FT /db_xref="InterPro:IPR029053" FT /db_xref="InterPro:IPR033703" FT /db_xref="InterPro:IPR036203" FT /db_xref="PDB:1Z7S" FT /db_xref="PDB:1Z7Z" FT /db_xref="UniProtKB/Swiss-Prot:P22055" FT /protein_id="BAA00426.1" FT /translation="MGAQVSTQKTGAHENQNVAANGSTINYTTINYYKDSASNSATRQD FT LSQDPSKFTEPVKDLMLKTAPALNSPNVEACGYSDRVRQITLGNSTITTQEAANAIVAY FT GEWPTYINDSEANPVDAPTEPDVSSNRFYTLESVSWKTTSRGWWWKLPDCLKDMGMFGQ FT NMYYHYLGRSGYTIHVQCNASKFHQGALGVFLIPEFVMACNTESKTSYVSYINANPGER FT GGEFTNTYNPSNTDVSEGRQFAALDYLLGSGVLAGNAFVYPHQIINLRTNNSATIVVPY FT VNSLVIDCMAKHNNWGIVILPLAPLAFAATSSPQVPITVTIAPMCTEFNGLRNITIPVH FT QGLPTMNTPGSNQFLTSDDFQSPCALPNFDVTPPIHIPGEVKNMMELAEIDTLIPMNAV FT DGKVNTMEMYQIPLNDNLSKAPIFCLSLSPASDKRLSHTMLGEILNYYTHWTGSIRFTF FT LFCGSMMATGKLLLSYSPPGAKPPTNRKDAMLGTHIIWDLGLQSSCSMVAPWISNTVYR FT RCARDDFTEGGFITCFYQTRIVVPASTPTSMFMLGFVSACPDFSVRLLRDTSHISQSKL FT IARTQGIEDLIDTAIKNALRVSQPLRPSQLKQPNGVNSQEVPALTAVETGASGQAIPSD FT VVETRHVINYKTRSESCLESFFGRAACVTILSLTNSSKSGEEKKHFNIWNITYTDTVQL FT RRKLEFFTYSRFDLEMTFVFTENYPSTASGEVRNQCDQIMYIPPGAPRPSSWDDYTWQS FT SSNPSIFYMYGNAPPRMSIPYVGIANAYSHFYDGFARVPLEGENTDAGDTFYGLVSIND FT FGVLAVRAVNRSNPHTIHTSVRVYMKPKHIRCWCPRPPRAVLYRGEGVDMISSAIQPLT FT KVDSITTFGFGHQNKAVYVAGYKICNYHLATPSDHLNAISVLWDRDLMVVESRAQGTDT FT IARCSCRCGVYYCESRRKYYLVTFTGPTFRFMEANDYYPARYQSHMLIGCGFAEPGDCG FT GILRCTHGVIGIITAGGEGIVAFADIRDLWVYEEEAMEQGITSYIESLGTAFGAGFTHT FT ISEKVTELTTMVTSTITEKLLKNLVKIVSALVIVVRNYEDTTTILATLALLGCDISPWQ FT WLKKKACDLLEIPHVMRQGDGWMKKFTEACNAAKGLRWVSNKISKFVDWLKCKIIPEAK FT DKVEFLTKLKQLDMLENQIATIHQSCPSQEQQEILFNNVRWLAVQSRRFAPLYAVEARR FT ISKMESTINNYIQFKSKHRIEPVCMLVHGSPGTGKGIASSLIGRAIAERETTSVYSVPL FT APSHFDGYKQQGYDMDDLNQNPDGMDMKLFCQMVSTVEFIPPMASLEEKGILFTSDYVL FT ASTNSHSIAPPTVAHSDALTRRFAFDVEVYTMSEHSVKGKLNMATATQLCKDCPTPANF FT KKCCPLVCGKALQLMDRYTRQRFTVDEITTLIMNEKNRRANIGNCMEALFQGPLRYKDL FT KIDVKTVPPPECISDLLQAVDSQEVRDYCEKKGWIVNVTSQIQLERNINRAMTILQAVT FT TFAAVAGVVYVMYKLFAGQQGAYTGLPNKKPNVPTIRIAKVQGPGFDYAVAMAKRNIVT FT ATTTKGEFTMLGVHDNVAILPTHAAPGETIIVDGKEVEILDARALEDQAGTNLEITIIT FT LKRNEKFRDIRPHIPTQITETNDGVLIVNTSKYPNMYVPVGAVTEQGYLNLSGRQTART FT LMYNFPTRAGQCGGIITCTGKVIGMHVGGNGSHGFAAALKRSYFTQNQGEIQWMRSSKE FT VGYPIINAPSKTKLEPSAFHYVFEGVKEPAVLTKNDPRLKTDFEEAIFSKYVGNKITEV FT DEYMKEAVDHYAGQLMSLDINTEQMCLEDAMYGTDGLEALDLSTSAGYPYVAMGKKKRD FT ILDKQTRDTKEMQRLLDTYGINLPLVTYVKDELRSKTKVEQGKSRLIEASSLNDSVAMR FT MAFGNLYAAFHKNPGVVTGSAVGCDPDLFWSKIPVLMEEKLFAFDYTGYDASLSPAWFE FT ALKMVLEKIGFGNRVDYIDYLNHSHHLYKNKTYCVKGGMPSGCSGTSIFNSMINNLIIR FT TLLLRTYKGIDLDHLKMIAYGDDVIASYPHEVDASLLAQSGKDYGLTMTPADKSATFET FT VTWENVTFLKRFFRADEKYPFLVHPVMPMKEIHESIRWTKDPRNTQDHVRSLCLLAWHN FT GEEEYNKFLAKIRSVPIGRALLLPEYSTLYRRWLDSF" FT mat_peptide 712..918 FT /product="VP4 protein" FT mat_peptide 919..1734 FT /product="VP2 protein" FT mat_peptide 1735..2454 FT /product="VP3 protein" FT mat_peptide 2455..3348 FT /product="VP1 protein" FT mat_peptide 3349..3795 FT /product="2A protein" FT mat_peptide 3796..4086 FT /product="2B protein" FT mat_peptide 4087..5070 FT /product="2C protein" FT mat_peptide 5071..5331 FT /product="3A protein" FT mat_peptide 5332..5397 FT /product="VPg (3B) protein" FT mat_peptide 5398..5946 FT /product="protease (3C) protein" FT mat_peptide 5947..7329 FT /product="polymerase (3D) protein" XX SQ Sequence 7401 BP; 2194 A; 1647 C; 1694 G; 1866 T; 0 other; ttaaaacagc tctggggttg ctcccacccc agaggcccac gtggcggcta gtaatctggt 60 atcaggtacc tttgtacgcc tgttttatat cccttccccc gtaactttag aagcttatca 120 aaagttcaat agcaggggta caagccagta cctctacgaa caagcacttc tgtttccccg 180 gtgaaatcat atagactgta cccacggtca aaagtgattg atccgttatc cgcttgagta 240 cttcgagaag cctagtatcg ccttggaatc ttcgacgcgt tgcgctcaac actctgcccc 300 gagtgtagct taggctgatg agtctgggca ctccccaccg gcgacggtgg cccaggctgc 360 gttggcggcc tacccatggc tgatgccgtg ggacgctagt tgtgaacaag gtgtgaagag 420 cctattgagc tactcaagag tcctccggcc cctgaatgcg gctaatccta accacggagc 480 aatcgctcac gacccagtga gtaggttgtc gtaatgcgta agtctgtggc ggaaccgact 540 actttgggtg tccgtgtttc cctttatatt catactggct gcttatggtg acaatttacg 600 aattgttacc atatagctat tggattggcc acccagtgct gtgcaatata tttgagtgct 660 tctttcatag gtgttaccaa catcacattt aaaccacaat agtcagtgca aatgggggct 720 caagtttcaa cccaaaagac cggtgcacac gagaatcaaa acgtggcagc caatggatcc 780 accattaatt atactaccat caactactac aaagacagcg cgagtaactc cgctactaga 840 caagacctct cccaagatcc atcaaaattc acagaaccgg ttaaggactt aatgttgaaa 900 acagcaccag ctttaaactc gcccaacgtg gaagcatgtg ggtacagtga ccgtgtgagg 960 caaatcactt taggtaactc gaccattacc acacaggaag cagctaatgc tattgttgct 1020 tatggtgagt ggcccactta cataaatgac tcagaagcta atccggtaga tgcacccact 1080 gaaccagacg ttagtagcaa ccgtttttac accctggaat cggtgtcttg gaagaccact 1140 tcaaggggat ggtggtggaa gctaccagat tgtctaaaag atatgggaat gtttggtcag 1200 aatatgtact atcactactt aggacgctct ggttacacca ttcatgtcca gtgcaacgct 1260 tctaagtttc accaaggggc gttaggagtt ttcctgatac cagagtttgt catggcttgc 1320 aacactgaga gtaaaacatc atatgtttca tacatcaacg caaatcctgg tgaaaggggc 1380 ggtgagttca cgaacaccta caacccatca aacactgatg tcagtgaggg cagacagttc 1440 gcagcactgg attatctgct gggttctggt gtcctagcag gaaacgcttt cgtatacccg 1500 caccagatca tcaatttgcg caccaacaac agtgcaacaa ttgtggtacc atatgtgaac 1560 tcgctcgtga ttgattgtat ggcaaaacac aataactggg gtattgtcat attaccactg 1620 gcacccttgg cctttgccgc aacatcgtca ccacaggtgc ctattacagt gaccatcgca 1680 cccatgtgta cagaatttaa tgggttgaga aatattacca tcccagtaca tcaagggttg 1740 ccaacaatga acacacctgg ttccaatcaa ttccttacat ctgatgactt ccagtcgccc 1800 tgtgccttac ctaattttga tgttactcca ccgatacaca tacccgggga agtgaagaat 1860 atgatggaac tagctgaaat tgacacactg atcccaatga acgcagtgga cgggaaggtg 1920 aacacaatgg aaatgtatca aataccattg aatgacaatt tgagcaaggc acctatattc 1980 tgtctatctt tatcacctgc ttctgacaaa cgactgagtc acaccatgtt gggtgaaatt 2040 ctaaattatt acactcattg gacggggtcc atcaggttca cctttctatt ttgtggtagt 2100 atgatggcca ctggtaaact gctcctcagc tattccccac caggagctaa accaccaacc 2160 aatcgcaagg atgcaatgct aggtacacac atcatctggg acctagggtt acaatccagt 2220 tgttccatgg ttgcaccgtg gatctctaac acagtgtaca ggcggtgtgc acgtgatgac 2280 ttcactgagg gcgggtttat aacttgcttt tatcaaacta gaattgttgt gcctgcttca 2340 acccccacca gtatgttcat gttaggcttt gttagtgcgt gtccagattt cagtgtcaga 2400 ctgcttaggg acacttccca tattagtcaa tcaaaactaa tagcacgcac acaaggcatt 2460 gaagacctca ttgacacagc gataaagaat gccttaagag tgtcccaacc acttcggccc 2520 agtcaactga agcaacccaa tggagtaaat agccaggagg tgccagctct aactgctgtg 2580 gaaacaggag catctggtca agcgatcccc agtgatgtgg tggaaactag acacgtgata 2640 aattacaaaa ccaggtctga atcgtgtctt gagtcattct ttgggagagc tgcgtgtgtc 2700 acaatcctat ctctgaccaa ctcttccaag agcggggagg agaagaagca tttcaacata 2760 tggaacatta catacaccga cactgttcag ttacgcagaa aattggagtt tttcacgtat 2820 tccaggtttg accttgaaat gacttttgtg ttcacagaga attaccctag tacagccagt 2880 ggggaagtgc gtaaccaatg tgaccagatc atgtacattc caccaggggc accccgtcca 2940 tcatcctggg atgactatac atggcaatcc tcctctaacc cttccatctt ttacatgtat 3000 ggaaatgcac ctccacggat gtcaattcct tacgtgggga ttgccaatgc ctattcacac 3060 ttctatgatg gctttgcacg ggtgccactt gagggtgaga ataccgatgc tggtgacacg 3120 ttttacggct tagtgtccat aaatgatttt ggagttttag cagttagagc ggtaaaccgc 3180 agtaacccac acactataca cacatctgtg agagtgtaca tgaaaccaaa acacattcgg 3240 tgttggtgcc ccagacctcc tcgggctgta ttatacaggg gagagggagt ggacatgata 3300 tccagtgcaa ttcaacctct gactaaagta gactcaatta ccacttttgg gtttggccac 3360 cagaacaagg cagtgtacgt tgccggttac aagatttgta actaccacct agcaacccca 3420 agtgatcact tgaatgcaat tagtgtgtta tgggacaggg atttaatggt ggtggaatct 3480 agagcccagg gaactgatac cattgccagg tgtagttgca ggtgtggagt ttactattgt 3540 gaatctagaa ggaagtacta ccttgtcact ttcactggcc caacgtttcg atttatggaa 3600 gcaaatgact actatccagc aagataccag tctcacatgc tgatagggtg cggatttgca 3660 gaacccgggg actgtggtgg gatattaagg tgcactcatg gggtgattgg tatcatcact 3720 gcagggggtg aagggatagt agcctttgct gacattagag acctttgggt gtatgaagag 3780 gaagccatgg aacagggaat aacaagttac atcgaatccc tcggtacagc ttttggtgca 3840 gggttcaccc acacaatcag tgagaaagtg actgagttga caacaatggt caccagtact 3900 atcacagaaa aattactgaa aaatttagtg aaaatagtat cggctctagt gattgttgtg 3960 agaaattatg aggacactac cacgatcctt gcaacactag cattacttgg gtgtgatata 4020 tctccttggc aatggttgaa gaagaaggca tgtgacttac tagagattcc tcatgtgatg 4080 cgccaaggtg atgggtggat gaagaaattc acagaggctt gcaatgcagc taaagggctt 4140 agatgggtca gcaataaaat ttccaagttt gtagattggt tgaagtgtaa aattatccca 4200 gaagctaagg acaaggtgga atttctcacc aagttgaaac agctagacat gctggaaaat 4260 caaattgcaa ccatccacca atcttgcccc agccaagaac aacaagagat ccttttcaac 4320 aacgtaagat ggctagcagt ccagtcccgt cggttcgcgc cattatatgc tgtggaggca 4380 cgccggatta gcaaaatgga gagcacaata aacaattata tacagttcaa gagcaaacac 4440 cgtattgagc cagtatgtat gctcgttcat gggtcaccag ggacgggtaa gggtatagct 4500 agctcattga taggtagagc aatagcagag agggaaacca catcggtcta ctcagtgcca 4560 ctggccccat ctcactttga tggctataaa caacaagggt atgatatgga cgacctaaac 4620 caaaaccccg atggtatgga catgaaactg ttttgccaaa tggtatcaac agtggagttc 4680 attcctccaa tggcctcact agaggagaag ggtattttgt ttacatctga ttatgtcctg 4740 gcttctacca actctcactc aatagcacca cccacagtag ctcatagtga tgccttaacc 4800 agacgatttg catttgatgt ggaggtttac acgatgtctg aacattcagt caaaggcaaa 4860 ctaaacatgg ccacagccac tcagttgtgt aaggattgtc caacacctgc aaatttcaaa 4920 aagtgttgcc ctctcgtctg tggaaaggcc ttgcaattaa tggacaggta caccagacag 4980 aggttcactg tggatgagat taccacatta atcatgaatg agaaaaacag aagggccaac 5040 attggcaatt gtatggaagc cttgtttcaa ggaccactga ggtacaaaga tctgaagatt 5100 gatgtgaaga cagttccccc ccctgagtgc atcagtgatt tattacaagc agtggattct 5160 caagaggtta gggattactg tgagaagaaa ggctggatcg ttaacgttac tagccagata 5220 caattagaaa ggaacatcaa tagggccatg actatactcc aagctgttac cacatttgca 5280 gcagtcgcag gagtagtgta tgtaatgtac aaactcttcg ctggccagca gggtgcatac 5340 actggcttgc caaacaaaaa gcccaatgtc cctactatca gaattgctaa agtccagggg 5400 ccaggatttg actatgcagt ggcaatggca aaaagaaaca tagttactgc aaccaccact 5460 aagggtgaat ttaccatgtt aggggtgcat gataatgtag caatattgcc aacccatgcc 5520 gctccaggag aaactatcat tgttgatggg aaagaagtgg agatcctaga tgccagagcc 5580 ttagaagatc aagcgggaac caaccttgag attaccatta ttactctaaa aagaaatgag 5640 aaatttagag acatcagacc acatattccc acccaaatta ctgaaactaa cgatggagtg 5700 ttgatcgtga acactagtaa gtaccccaac atgtatgtcc cagttggtgc tgtgactgaa 5760 cagggatatc ttaatctcag tggacgccaa actgctcgta ctttaatgta caactttcca 5820 acacgagcag gccagtgcgg aggaatcatc acttgtactg gcaaagtcat tgggatgcac 5880 gttggcggga acggttcaca tgggtttgca gcagccctta agcgatcata cttcacccaa 5940 aatcagggcg aaattcaatg gatgaggtca tcaaaagaag tggggtaccc cattataaat 6000 gccccatcca agacaaagtt agaacccagt gcttttcact atgtttttga aggtgttaag 6060 gaaccagctg tgctcactaa aaatgacccc agactaaaaa cagattttga agaagccatc 6120 ttttcaaaat acgtggggaa caaaattact gaagtggacg aatacatgaa agaagcagtg 6180 gatcactatg caggacagtt aatgtcactg gatatcaaca cagaacagat gtgcctggag 6240 gatgccatgt acggtactga tggtcttgaa gctctggatc ttagcactag tgctggatac 6300 ccttatgttg caatggggaa aaagaaaaga gacattctag acaaacagac cagggatact 6360 aaagagatgc agagactttt ggacacctat ggaatcaacc taccattagt cacatacgtg 6420 aaagatgaac tcagatcaaa gactaaagtg gaacaaggaa agtcaaggtt gattgaagct 6480 tccagtctta atgattcagt tgcaatgaga atggcctttg gcaatcttta cgcagctttc 6540 cacaagaatc caggcgtggt gacaggatca gcagttggtt gtgacccaga tttgttttgg 6600 agcaagatac cagtgctaat ggaagaaaaa ctcttcgctt ttgactacac agggtatgat 6660 gcctcactca gccctgcttg gtttgaagct cttaaaatgg tgttagaaaa gattggattc 6720 ggcaatagag tagactacat agactacctg aaccactctc accaccttta taaaaacaaa 6780 acttattgtg tcaaaggtgg catgccatcc ggctgctctg gcacatcaat tttcaactca 6840 atgattaata acctgatcat taggacgctt ttactgagaa cctacaaggg catagacttg 6900 gaccacctaa aaatgattgc ctatggtgat gacgtgatag cttcctaccc ccatgaggtt 6960 gacgctagtc tcctagccca atcaggaaaa gactatggac tgaccatgac tccagcagat 7020 aaatcagcaa cctttgaaac agtcacatgg gagaatgtaa cattcctgaa aagatttttc 7080 agagcagatg agaagtatcc attcctggtg catccagtga tgccaatgaa agaaattcac 7140 gaatcaatca gatggaccaa ggaccctaga aacacacagg atcacgtacg ctcattgtgc 7200 ctattggctt ggcataacgg cgaagaagaa tataataaat ttttagctaa aatcagaagt 7260 gtgccaatcg gaagagcttt attgctccca gagtactcca cattgtaccg ccgatggctc 7320 gattcatttt agtaacccta cctcagtcgg attcggattg ggttatactg ttgtaggggt 7380 aaatttttct ttaattcgga g 7401 //