ID AF268396; SV 1; linear; genomic RNA; STD; VRL; 7468 BP. XX AC AF268396; XX DT 05-JUL-2000 (Rel. 64, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 2) XX DE Hepatitis A virus polyprotein precursor, gene, complete cds. XX KW . XX OS Hepatovirus A OC Viruses; Riboviria; Picornavirales; Picornaviridae; Hepatovirus. XX RN [1] RP 1-7468 RA Baptista M.L., Silva M., de Lima M.A., Yoshida C.F., Gaspar A.M., RA Pires Lopes M.Q., Galler R.; RT "Nucleotide sequence of the HAF-203 hepatitis A virus strain isolated in RT Brazil and expression of the VP1 gene in a bacterial system"; RL Unpublished. XX RN [2] RP 1-7468 RA Baptista M.L., Silva M., de Lima M.A., Yoshida C.F., Gaspar A.M., RA Pires Lopes M.Q., Galler R.; RT ; RL Submitted (16-MAY-2000) to the INSDC. RL Virology, Oswaldo Cruz Foundation, Av. Brasil 4365, Rio de Janeiro, RJ RL 21040-900, Brazil XX DR MD5; 7446d5baca221f187099a40f75ef9cb7. DR EuropePMC; PMC140588; 12477850. DR EuropePMC; PMC3087699; 21496278. DR EuropePMC; PMC3127839; 21612660. DR EuropePMC; PMC3318560; 22238447. DR EuropePMC; PMC4258257; 25420941. DR EuropePMC; PMC427829; 15184483. DR EuropePMC; PMC444796; 15240322. DR EuropePMC; PMC4501425; 25993400. DR EuropePMC; PMC4830115; 27074255. DR EuropePMC; PMC5513050; 28705178. DR EuropePMC; PMC6462791; 30968822. DR RFAM; RF00228; IRES_HepA. DR RFAM; RF01096; PK-HAV. XX FH Key Location/Qualifiers FH FT source 1..7468 FT /organism="Hepatovirus A" FT /strain="HAF-203" FT /mol_type="genomic RNA" FT /country="Brazil" FT /note="isolated in 1992, adapted in cell culture, fourth FT passage" FT /db_xref="taxon:12092" FT CDS 725..7408 FT /codon_start=1 FT /product="polyprotein precursor" FT /db_xref="GOA:Q9IFH5" FT /db_xref="InterPro:IPR000199" FT /db_xref="InterPro:IPR000605" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR001676" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR014759" FT /db_xref="InterPro:IPR024354" FT /db_xref="InterPro:IPR029053" FT /db_xref="InterPro:IPR033703" FT /db_xref="UniProtKB/TrEMBL:Q9IFH5" FT /protein_id="AAF80114.1" FT /translation="MNMSRQGIFQTVGSGLDHILSLADIEEEQMIQSVDRTAVTGASYF FT TSVDQSSVHTAEVGSHQVEPLRTSVDKPGSKKTQGEKFFLIHSADWLTTHALFHEVAKL FT DVVKLLYNEQFAVQGLLRYHTYARFGIEIQVQINPTPFQQGGLICAMVPGDQSYGSIAS FT LTVYPHGLLNCNINNVVRIKVPFIYTRGAYHFKDPQYPVWELTIRVWSELNIGTGTSAY FT TSLNVLARFTDLELHGLTPLSTQMMRNEFRVSTTENVVNLSNYEDARAKMSFALVQEDW FT KSDPSQGGGIKITHFTTWTSIPTLAAQFPFNASDSVGQQIKVIPVDPYFFQMTNTNPDQ FT KCITALASICQMFCFWRGDLVFDFQVFPTKYHSGRLLFCFVPGNELIDVSGITLKQATT FT APCAVMDITGVQSTLRFRVPWISDTPYRVNRYTKSAHQKGEYTAIGKLIVYCYNRLTSP FT SNVASHVRVNVYLSAINLECFAPLYHAMDVTTQVGDDSGGFSTTVSTEQNVPDPQVGMT FT TMKDLKGKANRGKMDVSGVQAPVGAITTIEDPVLAKKVPETFPELKPGESRHTSDHMSI FT YKFMGRSHFLCTFTFNSNNKEYTFPITLSSTSNPPHGLPSTLRWFFNLFQLYRGPLDLT FT IIITGATDVDGMAWFTPVGLAVDTPWVEKQSALSIDYKTALGAVRFNTRRTGNIQIRLP FT WYSYLYAVSGALDGLGDKTDSTFGLVSIQIANYNHSDKYLSFSCYLSVTEQSEFYFPRA FT PLNSNAMLPTESMMSRIAAGDLESSVDDPRSEEDKRFESHIECRKPYKELRLEVGKQRL FT KYAQEELSNEVLPPPRKMKGLFSQAKISLFYTEEHEMMKFSWRGVTADTRALRRFGFSL FT AAGRSVWTLEMDAGVLTGRLIRLNDEKWTEMKDDKIVSLIEKFTSNKYWSKVNFPHGML FT DLEEIAANSKDFPNMSETDLCFLLHWLNPKKINLADRMLGLSGVQEIKEQGVGLIAECR FT TFLHSIAGTLKSMMFGFHHSVTVEIINTVLCLVKSGILLYVIQQLNQDEHSHIIGLLRV FT MNYVDIGCSVISCGKVFSKMLETVFNWQMDSRMMELRTQSFSNWLRDICSGITIFKNFK FT DAIYWLYTKLKDFYEVNYGKKKDILNILKDNQQKIEKAIEEADEFCILQIQDVEKFEQY FT QKGVDLIQKLRTVHSMAQVDPNLMVHLSPLRDCIARVHQKLKNLGSINQAMVTRCEPVV FT CYLYGTRGGGKSLTSIALATKICKHYGVEPEKNIYTKPVASDYWDGYSGQLVCIIDDIG FT QNTTDEDWSDFCQLVSGCPMRLNMASLEEKGRHFSSPFIIATSNWSNPSPKTVYVKEAI FT DRRLHFKVEVKPASFFKNPHNDMLNVNLAKTSDAIKDMSCVDLIMDGHNVSLMDLLSSL FT VMTVEIRKQNMTEFMELWSQGISDDDNDSAVAEFFQSFPSGEPSNSKLSGFFQSVTNHK FT WVAVGAAVGILGVLVGGWFVYKHFSRKEEEPIPAEGVYHGVTKPKHVIKLDADPVESQS FT TLEIAGLVRKNLVQFGVGEKNGCVRWVMNALGVKDDWLLVPSHAYKFEKDYEMMEFYFN FT RGGTYYSISAGNVVIQSLDVGFQDVVLMKVPTIPKFRDITQHFIKKGDVPRALNRLATL FT VTTVNGTPMLISEGPLKMEEKATYVHKKNDGTTVDLTVDQAWRGKGEGLPGMCGGALVS FT SNQSIQNAILGIHVAGGNSILVAKLVTQEMFQNIDKKIESQRIMKVEFTQCSMNVVSKT FT LFRKSPIYHHIDKTMINFPAAMPFSKAEIDPMAVMLSKYSLPIVEEPEGYKEASIFYQN FT KIVGKTQLVDDFLDLDMAITGAPGIDAINMDSSPGFPYVQEKLTKRDLIWLDENGLLLG FT VHPRLAQRILFNTVMMENCSDLDVVFTTCPKDELRPLEKVLESKTRAIDACPLDYTILC FT RMYWGPAISYFHLNPGFHTGVAIGIDPDRQWDELFKTMIRFGDVGLDLDFSAFDASLSP FT FMIREAGRIMSELSGTPSHFGTALINTIIYSKHLLYNCCYHVCGSMPSGSPCTALLNSI FT INNVNLYYVFSKIFGKSPVFFCQALKILCYGDDVLIVFSRDVQIDNLDLIGQKIVDEFK FT KLGMAATSADKNVPQLKPVSELTFLKRSFNLVEDRIRPAISEKTIWSLIAWQRSNAEFE FT QNLENAQWFAFMHGYEFYQKFYYFVQSCLEKEMIEYRLKSYDWWRMRFYDQCFICDLS" XX SQ Sequence 7468 BP; 2179 A; 1207 C; 1629 G; 2453 T; 0 other; gtctccggga atttccggag tccctcttgg aagtccatgg tgaggggact tgatacctca 60 ccgccgtttg cctaggctat aggctaaatt ttccctttcc cttttccctt tcctattccc 120 tttgttttgc ttgtaaatat tgattcctgc aggttcaggg ttcttaaatc tgtttctcta 180 taagaacact catttttcac gctttctgtc ttctttcttc cagggctctc cccttgccct 240 aggctctggc cgttgcgccc ggcggggtca actccatgat tagcatggag ctgtaggagt 300 ctaaattggg gacacagatg tttggaacgt caccttgcag tgttaacttg gctttcatga 360 atctctttga tcttccacaa ggggtaggct acgggtgaaa cctcttaggc taatacttct 420 atgaagagat gccttggata gggtaacagc ggcggatatt ggtgagttgt taagacaaaa 480 accattcaac gccggaggac tgactctcat ccagtggatg cattgagtgg attgactgtc 540 agggctgtct ttaggcttaa ttccagacct ctctgtgctt agggcaaaca tcatttggcc 600 ttaaatggga ttctgtgaga ggggatccct ccattgacag ctggactgtt ctttggggcc 660 ttatgtggtg tttgccgctg aggtactcag gggcatttag gtttttcctc attcttaaat 720 aataatgaac atgtctagac aaggtatttt ccagactgtt gggagtggtc ttgaccacat 780 cctgtctttg gcagacattg aggaagagca aatgattcaa tcagttgata ggactgcagt 840 gactggtgct tcttatttta cttctgtgga tcaatcttca gttcatacag ctgaggttgg 900 atcacaccag gttgaacctt tgagaacctc tgttgataaa cccggttcaa agaagactca 960 gggagagaaa tttttcttga ttcattctgc agattggctt actacacatg ctcttttcca 1020 tgaagttgca aaattggatg tggtgaaatt attatacaat gagcagtttg ctgttcaagg 1080 gttgttgaga taccatacat atgcaagatt tggcattgaa attcaagttc agataaaccc 1140 tacacctttc caacaggggg gattgatctg tgctatggtt cctggtgacc agagctatgg 1200 ttctatagca tcattgactg tttatcctca tggtttgtta aattgcaata ttaacaatgt 1260 ggttagaata aaggttccat ttatttacac aagaggtgct taccacttta aagatccaca 1320 atacccagtt tgggaattga caattagagt ttggtcagaa ttaaatattg ggacaggaac 1380 ttcagcttat acttcactca atgttttagc tagatttaca gatttggagt tgcatggatt 1440 aactcctctt tctacacaaa tgatgagaaa tgaatttagg gtcagtacta ctgagaatgt 1500 ggtgaatctg tcaaattatg aagatgcaag agcaaagatg tcttttgctt tggttcagga 1560 agattggaaa tctgatccgt cccagggtgg tgggatcaaa attactcatt ttactacttg 1620 gacatctatt ccaactttgg ctgctcagtt tccatttaat gcttcagact cagttggtca 1680 acaaattaaa gttattccag ttgacccata ttttttccaa atgacaaata caaatcctga 1740 ccaaaaatgt ataactgctt tggcttctat ttgtcagatg ttttgttttt ggagaggaga 1800 tcttgtcttt gattttcaag tttttcccac caaatatcat tcaggtagat tactgttttg 1860 ttttgttcct ggcaatgagc taatagatgt ttctggaatc acattaaagc aagcaactac 1920 tgctccttgt gcagtaatgg atattacagg agtgcagtca actttgagat ttcgtgttcc 1980 ctggatttct gacactcctt acagagtgaa caggtataca aagtcagcac atcagaaagg 2040 tgagtacact gccattggga agcttattgt gtattgttat aacagattga cctctccttc 2100 taacgttgct tcccatgtca gagtgaatgt ttatctttca gcaattaact tggaatgttt 2160 tgctcctctt tatcatgcta tggatgttac tacacaagtt ggagatgatt ctggaggttt 2220 ttcaacaaca gtttctacag aacagaatgt tccagatccc caagttggta tgacaaccat 2280 gaaagatttg aaaggaaaag ctaacagagg gaaaatggat gtttcaggag tacaagcacc 2340 tgtgggagct atcacaacaa ttgaggatcc agttttagca aagaaagtac ctgagacatt 2400 tcctgaattg aaacctggag aatccagaca tacatcagat catatgtcca tctacaagtt 2460 tatgggaagg tctcatttct tgtgcacttt tacattcaat tcaaataata aagagtacac 2520 atttcctata accttgtctt caacctctaa tcctcctcat ggtttgccat caacactgag 2580 gtggtttttc aacttgtttc agttgtatag agggccttta gatctgacaa ttattattac 2640 aggagcaact gatgtagatg gcatggcctg gttcactcca gtaggtcttg ccgttgatac 2700 tccttgggta gagaagcagt cagctttgtc tattgactac aaaactgctc ttggagctgt 2760 cagatttaac acaaggagaa cagggaacat tcagattaga ttaccatggt attcttattt 2820 atatgctgtg tctggagcac tggatggttt gggagacaag acagattcta catttggatt 2880 ggtttctatt cagattgcaa attacaatca ttctgataaa tacttgtctt ttagttgtta 2940 tttgtctgtc acagaacaat cagagtttta ttttcccaga gctccattga actcaaatgc 3000 catgttaccc actgaatcaa tgatgagcag aattgcagct ggagacttgg agtcatcagt 3060 ggatgatcct agatcagagg aagataaaag atttgagagt catatagaat gcaggaagcc 3120 atataaagaa ctgagattag aagttgggaa acaaagactc aagtatgctc aggaagaatt 3180 gtcaaatgaa gtacttccac cccctaggaa aatgaaggga ctgttttcac aagccaaaat 3240 ttctcttttt tatactgagg agcatgaaat gatgaagttt tcctggagag gtgtgactgc 3300 tgatactaga gctttaagga ggtttggatt ctctttggcc gcaggcagaa gtgtgtggac 3360 tcttgaaatg gatgctgggg ttcttactgg gagactgatt agattgaatg atgagaaatg 3420 gacagaaatg aaggatgaca agattgtttc attgattgaa aagtttacaa gtaacaaata 3480 ttggtccaaa gtgaatttcc cacatgggat gttggatctt gaagaaattg ctgccaattc 3540 taaggatttt cctaacatgt ctgaaacgga tttgtgtttc ttgctgcatt ggttaaatcc 3600 aaagaaaatt aatttagcag atagaatgct tggattgtct ggagttcagg aaattaaaga 3660 acaaggtgtt ggattaatag cagagtgtag aactttctta cattctattg ctggaacttt 3720 aaaatctatg atgtttggat ttcatcattc tgtgactgtt gaaattataa acactgtgct 3780 ctgtcttgtt aagagtggaa ttttgcttta tgtaatacaa caattgaatc aggatgaaca 3840 ttctcacata attggtctgt tgagagtcat gaattatgta gatattggtt gttcagttat 3900 ttcatgtggc aaagtttttt ccaaaatgct ggaaacagtc tttaattggc aaatggactc 3960 cagaatgatg gagttaagga ctcagagttt ttccaactgg ttaagagata tttgttctgg 4020 gatcaccatt tttaaaaact tcaaggatgc aatttattgg ctttatacaa aattaaagga 4080 cttttatgaa gtgaattatg gcaagaagaa ggacatttta aatattctta aagataacca 4140 acaaaaaata gagaaagcca ttgaggaagc cgatgaattt tgcattttgc aaatccaaga 4200 tgtggaaaaa tttgaacagt atcagaaagg ggttgacttg atacaaaaat tgagaactgt 4260 tcattcaatg gctcaggttg atccaaattt aatggttcat ttgtcacctt tgagagattg 4320 tatagcaaga gttcatcaga aacttaaaaa ccttggatct ataaatcagg caatggtaac 4380 gagatgtgag ccagttgttt gttatttata tggcacaaga gggggaggaa agagcttaac 4440 atcaattgca ttggcaacca aaatttgtaa acattatggt gttgagcctg aaaagaatat 4500 ctatactaaa cctgtggctt cagattactg ggatggatat agtggacaat tagtttgcat 4560 cattgatgat attggccaaa acacaacaga tgaggattgg tcagattttt gtcagttagt 4620 gtcaggatgt ccaatgagat taaacatggc ctctcttgag gagaagggta ggcatttttc 4680 ttctcctttt ataatagcaa cttcaaattg gtcaaatcca agtccaaaaa cagtttatgt 4740 taaggaagca attgaccgca gactccattt caaggttgaa gttaaacctg cttcattttt 4800 caaaaatcct cacaatgata tgttgaatgt taatttagct aaaacaagtg atgcaatcaa 4860 agatatgtct tgtgttgatt tgataatgga tggacataat gtttcattga tggatttgct 4920 cagttcttta gtcatgacag ttgaaattag aaaacaaaac atgactgaat tcatggagtt 4980 gtggtctcag ggaatttcag atgatgataa tgatagtgca gtagctgagt ttttccagtc 5040 ttttccatct ggtgaaccat cgaactctaa attatctggc tttttccaat ctgttactaa 5100 tcacaagtgg gttgctgtgg gagctgcagt tggcattctt ggagtgctcg ttggaggatg 5160 gtttgtgtat aagcatttct cccgcaaaga ggaggaacca atcccagctg aaggggtata 5220 tcatggtgta actaagccca agcatgtgat taaattagat gcagatccag tagaatctca 5280 gtcaactttg gaaatagcag gactggttag gaagaacttg gttcagtttg gagttggaga 5340 gaagaatgga tgtgtgagat gggttatgaa tgccttggga gtgaaagatg attggctgct 5400 tgtgccttcc catgcttata aatttgagaa agattatgaa atgatggagt tttattttaa 5460 tagaggtgga acttactatt caatttcagc tggtaatgtt gttattcaat ctttggatgt 5520 gggattccag gatgttgttc tgatgaaggt tcctacaatt cctaagttta gagatattac 5580 tcagcatttt attaagaaag gggatgtgcc tagagctttg aatcgcctgg caacattagt 5640 gacaactgta aatggaaccc ctatgttaat ttctgagggc ccactaaaga tggaagagaa 5700 agctacttat gttcataaga aaaatgatgg tacaacagtt gatttaactg tggatcaggc 5760 atggagagga aaaggcgaag gtcttcctgg aatgtgtggt ggggccttgg tttcatcgaa 5820 tcaatctata cagaatgcaa tcttgggcat ccatgttgct ggaggaaatt caattcttgt 5880 tgcaaaattg gttactcaag aaatgttcca aaatattgat aagaaaattg aaagtcagag 5940 aattatgaaa gtggagttta ctcagtgttc aatgaatgtg gtctccaaaa cgctttttag 6000 aaagagtccc atttatcatc acattgataa aaccatgatt aattttcctg cagctatgcc 6060 cttttctaaa gctgaaattg atccaatggc tgtgatgtta tctaagtatt cattacctat 6120 tgtagaagaa ccagagggtt ataaagaggc ttcaattttt tatcaaaata aaatagtggg 6180 taagactcag ttagttgatg attttctaga tcttgatatg gccattacag gggccccagg 6240 aattgatgct atcaacatgg attcatctcc tggatttcct tatgtccagg agaagttgac 6300 caaaagagat ttaatttggt tggatgaaaa tggtttattg ctgggagttc atccaagatt 6360 ggctcagaga atcttattca atactgtcat gatggaaaat tgttctgatt tggatgttgt 6420 ttttacaacc tgtccaaaag atgaattgag accattagag aaagtgttgg aatcaaaaac 6480 aagagctatt gatgcttgtc ctctggatta cacaattttg tgccgaatgt attggggtcc 6540 agctattagt tattttcatt tgaatccagg tttccataca ggtgttgcta ttggcataga 6600 tcctgataga cagtgggatg aattatttaa aacaatgata agattcggag atgttggtct 6660 tgatttagat ttctctgctt ttgatgctag tcttagtcca tttatgatta gagaagcagg 6720 tagaatcatg agtgaactat ctggaactcc atcccatttt ggcacagctc ttatcaatac 6780 tatcatttat tccaagcatt tgctgtataa ctgttgttac catgtctgtg gttcaatgcc 6840 ctctgggtct ccttgtacag ctttgctaaa ttcaattatt aataatgtca atttgtatta 6900 tgtgttttcc aagatatttg gaaagtctcc agttttcttt tgtcaggctt tgaagattct 6960 ctgttatgga gatgatgttt taatagtttt ctctcgagat gttcagattg ataatcttga 7020 tttgattgga caaaaaattg tagatgagtt taagaaactt ggcatggcag ctacttctgc 7080 tgacaagaat gtacctcagc tgaaaccagt ttcggaattg acttttctca aaagatcttt 7140 caatttggta gaggatagaa ttagacctgc aatttcggag aaaacaattt ggtctttaat 7200 agcatggcag agaagtaacg ctgagtttga gcagaattta gaaaatgctc agtggtttgc 7260 ttttatgcat ggctatgagt tttatcagaa attttattat tttgttcagt cctgtttgga 7320 gaaagagatg atagaataca gacttaaatc ttatgattgg tggagaatga gattttatga 7380 ccagtgtttc atttgtgacc tttcatgatt tgtttaaaca aattttctta aaatttctga 7440 ggtttgttta tttcttttat cagtaaat 7468 //