ID AF052755; SV 1; linear; viral cRNA; STD; VRL; 15246 BP. XX AC AF052755; XX DT 23-MAR-1998 (Rel. 55, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Parainfluenza virus 5 strain W3A nucleocapsid protein (NP) gene, complete DE cds; V protein and phosphoprotein transcript (V/P) gene, phosphoprotein DE (V/P) and V protein (V/P) genes, complete cds; and membrane protein (M), DE fusion protein (F), small hydrophobic protein (SH), DE hemagglutinin-neuraminidase protein (HN), and L protein (L) genes, complete DE cds. XX KW . XX OS parainfluenza virus 5 OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae; OC Orthorubulavirus; Orthorubulavirus mammalis. XX RN [1] RP 4475-6209 RX DOI; 10.1073/pnas.81.21.6706. RX PUBMED; 6093114. RA Paterson R.G., Harris T.J., Lamb R.A.; RT "Fusion protein of the paramyxovirus simian virus 5: nucleotide sequence of RT mRNA predicts a highly hydrophobic glycoprotein"; RL Proc. Natl. Acad. Sci. U.S.A. 81(21):6706-6710(1984). XX RN [2] RP 6224-8387 RX PUBMED; 3973974. RA Hiebert S.W., Paterson R.G., Lamb R.A.; RT "Hemagglutinin-neuraminidase protein of the paramyxovirus simian virus 5: RT nucleotide sequence of the mRNA predicts an N-terminal membrane anchor"; RL J. Virol. 54(1):1-6(1985). XX RN [3] RP 1793-3087 RX DOI; 10.1016/S0092-8674(88)91285-8. RX PUBMED; 3044614. RA Thomas S.M., Lamb R.A., Paterson R.G.; RT "Two mRNAs that differ by two nontemplated nucleotides encode the amino RT coterminal proteins P and V of the paramyxovirus SV5"; RL Cell 54(6):891-902(1988). XX RN [4] RP 3093-4474 RX PUBMED; 2330672. RX DOI; 10.1016/0042-6822(90)90248-P. RA Sheshberadaran H., Lamb R.A.; RT "Sequence characterization of the membrane protein gene of paramyxovirus RT simian virus 5"; RL Virology 176(1):234-243(1990). XX RN [5] RP 1-1787, 8388-15246 RX DOI; 10.1016/0168-1702(92)90057-G. RX PUBMED; 1320792. RA Parks G.D., Ward C.D., Lamb R.A.; RT "Molecular cloning of the NP and L genes of simian virus 5: identification RT of highly conserved domains in paramyxovirus NP and L proteins"; RL Virus Res. 22(3):259-279(1992). XX RN [6] RP 1-15246 RX DOI; 10.1006/viro.1997.8801. RX PUBMED; 9356337. RA He B., Paterson R.G., Ward C.D., Lamb R.A.; RT "Recovery of infectious SV5 from cloned DNA and expression of a foreign RT gene"; RL Virology 237(2):249-260(1997). XX RN [7] RP 1-15246 RA Lamb R.A.; RT ; RL Submitted (05-MAR-1998) to the INSDC. RL Biochemistry, Molecular Biology and Cell Biology, Northwestern University RL and Howard Hughes Medical Institute, 2153 North Campus Drive, Evanston, IL RL 60208-3500, USA XX DR MD5; 8cc180d7922f0049d4b9401030cc2e67. DR EuropePMC; PMC102035; 11024125. DR EuropePMC; PMC112699; 10400712. DR EuropePMC; PMC112891; 10482624. DR EuropePMC; PMC114129; 11238862. DR EuropePMC; PMC1182632; 16051861. DR EuropePMC; PMC136107; 11907235. DR EuropePMC; PMC140631; 12477832. DR EuropePMC; PMC2937824; 20631121. DR EuropePMC; PMC3004301; 20943976. DR EuropePMC; PMC3067794; 21147917. DR EuropePMC; PMC3410871; 22879820. DR EuropePMC; PMC3901491; 24447466. DR EuropePMC; PMC3993540; 24453358. DR EuropePMC; PMC4794684; 26792745. DR EuropePMC; PMC5068328; 27671656. DR EuropePMC; PMC522361; 15472304. DR EuropePMC; PMC533953; 15564482. XX FH Key Location/Qualifiers FH FT source 1..15246 FT /organism="parainfluenza virus 5" FT /strain="W3A" FT /mol_type="viral cRNA" FT /note="infectious clone constructed from cDNAs in FT references 1-5; infectious clone yields infectious virus in FT rescue assays (see reference 6); the genome length is FT divisible by six and fulfills 'rule of six' criteria as FT described by Kolakofsky, et. al. (J. Virol. 72, 891-899, FT 1998)" FT /db_xref="taxon:2905673" FT misc_feature 1..55 FT /note="SV5 leader sequence" FT mRNA 56..1787 FT /gene="NP" FT /product="nucleocapsid protein" FT gene 56..1787 FT misc_feature 56..68 FT /gene="NP" FT /note="NP transcription initiation site" FT CDS 152..1681 FT /codon_start=1 FT /gene="NP" FT /product="nucleocapsid protein" FT /db_xref="GOA:Q88435" FT /db_xref="InterPro:IPR002021" FT /db_xref="PDB:4XJN" FT /db_xref="PDB:5WKN" FT /db_xref="UniProtKB/Swiss-Prot:Q88435" FT /protein_id="AAC95511.1" FT /translation="MSSVLKAYERFTLTQELQDQSEEGTIPPTTLKPVIRVFILTSNNP FT ELRSRLLLFCLRIVLSNGARDSHRFGALLTMFSLPSATMLNHVKLADQSPEADIERVEI FT DGFEEGSFRLIPNARSGMSRGEINAYAALAEDLPDTLNHATPFVDSEVEGTAWDEIETF FT LDMCYSVLMQAWIVTCKCMTAPDQPAASIEKRLQKYRQQGRINPRYLLQPEARRIIQNV FT IRKGMVVRHFLTFELQLARAQSLVSNRYYAMVGDVGKYIENCGMGGFFLTLKYALGTRW FT PTLALAAFSGELTKLKSLMALYQTLGEQARYLALLESPHLMDFAAANYPLLYSYAMGIG FT YVLDVNMRNYAFSRSYMNKTYFQLGMETARKQQGAVDMRMAEDLGLTQAERTEMANTLA FT KLTTANRGADTRGGVNPFSSVTGTTQVPAAATGDTLESYMAADRLRQRYADAGTHDDEM FT PPLEEEEEDDTSAGPRTGPTLEQVALDIQNAAVGAPIHTDDLNAALGDLDI" FT misc_feature 1774..1787 FT /gene="NP" FT /note="NP transcription termination site" FT mRNA 1789..3092 FT /gene="V/P" FT /product="V protein and phosphoprotein transcript" FT gene 1789..3092 FT misc_feature 1789..1802 FT /gene="V/P" FT /note="V/P transcription initiation site" FT CDS join(1850..2340,2339..3026) FT /codon_start=1 FT /gene="V/P" FT /product="phosphoprotein" FT /note="editing process yields phosphoprotein via a FT stuttering mechanism, resulting in frameshift" FT /db_xref="InterPro:IPR004897" FT /db_xref="InterPro:IPR025909" FT /db_xref="PDB:5WKN" FT /db_xref="UniProtKB/Swiss-Prot:P11208" FT /protein_id="AAC95513.1" FT /translation="MDPTDLSFSPDEINKLIETGLNTVEYFTSQQVTGTSSLGKNTIPP FT GVTGLLTNAAEAKIQESTNHQKGSVGGGAKPKKPRPKIAIVPADDKTVPGKPIPNPLLG FT LDSTPSTQTVLDLSGKTLPSGSYKGVKLAKFGKENLMTRFIEEPRENPIATSSPIDFKR FT GAGIPAGSIEGSTQSDGWEMKSRSLSGAIHPVLQSPLQQGDLNALVTSVQSLALNVNEI FT LNTVRNLDSRMNQLETKVDRILSSQSLIQTIKNDIVGLKAGMATLEGMITTVKIMDPGV FT PSNVTVEDVRKTLSNHAVVVPESFNDSFLTQSEDVISLDELARPTATSVKKIVRKVPPQ FT KDLTGLKITLEQLAKDCISKPKMREEYLLKINQASSEAQLIDLKKAIIRSAI" FT CDS 1850..2518 FT /codon_start=1 FT /gene="V/P" FT /product="V protein" FT /db_xref="GOA:P11207" FT /db_xref="InterPro:IPR024279" FT /db_xref="InterPro:IPR025909" FT /db_xref="PDB:2B5L" FT /db_xref="PDB:2HYE" FT /db_xref="PDB:2K48" FT /db_xref="PDB:4I1S" FT /db_xref="UniProtKB/Swiss-Prot:P11207" FT /protein_id="AAC95512.1" FT /translation="MDPTDLSFSPDEINKLIETGLNTVEYFTSQQVTGTSSLGKNTIPP FT GVTGLLTNAAEAKIQESTNHQKGSVGGGAKPKKPRPKIAIVPADDKTVPGKPIPNPLLG FT LDSTPSTQTVLDLSGKTLPSGSYKGVKLAKFGKENLMTRFIEEPRENPIATSSPIDFKR FT GRDTGGFHRREYSIGWVGDEVKVTEWCNPSCSPITAAARRFECTCHQCPVTCSECERDT" FT misc_feature 3081..3092 FT /gene="V/P" FT /note="V/P transcription termination site" FT mRNA 3109..4478 FT /gene="M" FT /product="membrane protein" FT gene 3109..4478 FT misc_feature 3109..3120 FT /gene="M" FT /note="M transcription initiation site" FT CDS 3141..4274 FT /codon_start=1 FT /gene="M" FT /product="membrane protein" FT /db_xref="GOA:P16629" FT /db_xref="InterPro:IPR000982" FT /db_xref="InterPro:IPR042539" FT /db_xref="InterPro:IPR042540" FT /db_xref="UniProtKB/Swiss-Prot:P16629" FT /protein_id="AAC95514.1" FT /translation="MPSISIPADPTNPRQSIKAFPIVINSDGGEKGRLVKQLRTTYLND FT LDTHEPLVTFINTYGFIYEQDRGNTIVGEDQLGKKREAVTAAMVTLGCGPNLPSLGNVL FT GQLREFQVTVRKTSSKAEEMVFEIVKYPRIFRGHTLIQKGLVCVSAEKFVKSPGKIQSG FT MDYLFIPTFLSVTYCPAAIKFQVPGPMLKMRSRYTQSLQLELMIRILCKPDSPLMKVHT FT PDKEGRGCLVSVWLHVCNIFKSGNKNGSEWQEYWMRKCANMQLEVSIADMWGPTIIIHA FT RGHIPKSAKLFFGKGGWSCHPLHEVVPSVTKTLWSVGCEITKAKAIIQESSISLLVETT FT DIISPKVKISSKHRRFVKSNWGLFKKTKSLPNLTELE" FT misc_feature 4468..4478 FT /gene="M" FT /note="M transcription termination site" FT mRNA 4502..6219 FT /gene="F" FT /product="fusion protein" FT gene 4502..6219 FT misc_feature 4502..4514 FT /gene="F" FT /note="F transcription initiation site" FT CDS 4530..6119 FT /codon_start=1 FT /gene="F" FT /product="fusion protein" FT /db_xref="GOA:P04849" FT /db_xref="InterPro:IPR000776" FT /db_xref="PDB:1SVF" FT /db_xref="PDB:2B9B" FT /db_xref="PDB:4GIP" FT /db_xref="PDB:4WSG" FT /db_xref="UniProtKB/Swiss-Prot:P04849" FT /protein_id="AAC95515.1" FT /translation="MGTIIQFLVVSCLLAGAGSLDPAALMQIGVIPTNVRQLMYYTEAS FT SAFIVVKLMPTIDSPISGCNITSISSYNATVTKLLQPIGENLETIRNQLIPTRRRRRFA FT GVVIGLAALGVATAAQVTAAVALVKANENAAAILNLKNAIQKTNAAVADVVQATQSLGT FT AVQAVQDHINSVVSPAITAANCKAQDAIIGSILNLYLTELTTIFHNQITNPALSPITIQ FT ALRILLGSTLPTVVEKSFNTQISAAELLSSGLLTGQIVGLDLTYMQMVIKIELPTLTVQ FT PATQIIDLATISAFINNQEVMAQLPTRVMVTGSLIQAYPASQCTITPNTVYCRYNDAQV FT LSDDTMACLQGNLTRCTFSPVVGSFLTRFVLFDGIVYANCRSMLCKCMQPAAVILQPSS FT SPVTVIDMYKCVSLQLDNLRFTITQLANVTYNSTIKLESSQILSIDPLDISQNLAAVNK FT SLSDALQHLAQSDTYLSAITSATTTSVLSIIAICLGSLGLILIILLSVVVWKLLTIVVA FT NRNRMENFVYHK" FT misc_feature 6205..6219 FT /gene="F" FT /note="F transcription termination site" FT mRNA 6224..6515 FT /gene="SH" FT /product="small hydrophobic protein" FT gene 6224..6515 FT misc_feature 6224..6236 FT /gene="SH" FT /note="SH transcription initiation site" FT CDS 6303..6437 FT /codon_start=1 FT /gene="SH" FT /product="small hydrophobic protein" FT /db_xref="GOA:P07577" FT /db_xref="UniProtKB/Swiss-Prot:P07577" FT /protein_id="AAC95516.1" FT /translation="MLPDPEDPESKKATRRAGNLIICFLFIFFLFVTFIVPTLRHLLS" FT misc_feature 6502..6515 FT /gene="SH" FT /note="SH transcription termination site" FT mRNA 6517..8392 FT /gene="HN" FT /product="hemagglutinin-neuraminidase protein" FT gene 6517..8392 FT misc_feature 6517..6529 FT /gene="HN" FT /note="HN transcription initiation site" FT CDS 6584..8281 FT /codon_start=1 FT /gene="HN" FT /product="hemagglutinin-neuraminidase protein" FT /db_xref="GOA:P04850" FT /db_xref="InterPro:IPR000665" FT /db_xref="InterPro:IPR016285" FT /db_xref="InterPro:IPR036278" FT /db_xref="PDB:1Z4V" FT /db_xref="PDB:1Z4W" FT /db_xref="PDB:1Z4X" FT /db_xref="PDB:1Z4Y" FT /db_xref="PDB:1Z4Z" FT /db_xref="PDB:1Z50" FT /db_xref="PDB:3TSI" FT /db_xref="PDB:4JF7" FT /db_xref="UniProtKB/Swiss-Prot:P04850" FT /protein_id="AAC95517.1" FT /translation="MVAEDAPVRATCRVLFRTTTLIFLCTLLALSISILYESLITQKQI FT MSQAGSTGSNSGLGSITDLLNNILSVANQIIYNSAVALPLQLDTLESTLLTAIKSLQTS FT DKLEQNCSWSAALINDNRYINGINQFYFSIAEGRNLTLGPLLNMPSFIPTATTPEGCTR FT IPSFSLTKTHWCYTHNVILNGCQDHVSSNQFVSMGIIEPTSAGFPFFRTLKTLYLSDGV FT NRKSCSISTVPGGCMMYCFVSTQPERDDYFSAAPPEQRIIIMYYNDTIVERIINPPGVL FT DVWATLNPGTGSGVYYLGWVLFPIYGGVIKGTSLWNNQANKYFIPQMVAALCSQNQATQ FT VQNAKSSYYSSWFGNRMIQSGILACPLRQDLTNECLVLPFSNDQVLMGAEGRLYMYGDS FT VYYYQRSNSWWPMTMLYKVTITFTNGQPSAISAQNVPTQQVPRPGTGDCSATNRCPGFC FT LTGVYADAWLLTNPSSTSTFGSEATFTGSYLNTATQRINPTMYIANNTQIISSQQFGSS FT GQEAAYGHTTCFRDTGSVMVYCIYIIELSSSLLGQFQIVPFIRQVTLS" FT misc_feature 8381..8392 FT /gene="HN" FT /note="HN transcription termination site" FT mRNA 8406..15215 FT /gene="L" FT /product="L protein" FT gene 8406..15215 FT misc_feature 8406..8416 FT /gene="L" FT /note="L transcription initiation site" FT CDS 8414..15181 FT /codon_start=1 FT /gene="L" FT /product="L protein" FT /db_xref="GOA:Q88434" FT /db_xref="InterPro:IPR014023" FT /db_xref="InterPro:IPR016269" FT /db_xref="InterPro:IPR024352" FT /db_xref="InterPro:IPR025786" FT /db_xref="InterPro:IPR026890" FT /db_xref="InterPro:IPR039736" FT /db_xref="UniProtKB/Swiss-Prot:Q88434" FT /protein_id="AAC95518.1" FT /translation="MAGSREILLPEVHLNSPIVKHKLYYYILLGNLPNEIDLDDLGPLH FT NQNWNQIAHEESNLAQRLVNVRNFLITHIPDLRKGHWQEYVNVILWPRILPLIPDFKIN FT DQLPLLKNWDKLVKESCSVINAGTSQCIQNLSYGLTGRGNLFTRSRELSGDRRDIDLKT FT VVAAWHDSDWKRISDFWIMIKFQMRQLIVRQTDHNDSDLITYIENREGIIIITPELVAL FT FNTENHTLTYMTFEIVLMVSDMYEGRHNILSLCTVSTYLNPLKKRITYLLSLVDNLAFQ FT IGDAVYNIIALLESFVYAQLQMSDPIPELRGQFHAFVCSEILDALRGTNSFTQDELRTV FT TTNLISPFQDLTPDLTAELLCIMRLWGHPMLTASQAAGKVRESMCAGKVLDFPTIMKTL FT AFFHTILINGYRRKHHGVWPPLNLPGNASKGLTELMNDNTEISYEFTLKHWKEVSLIKF FT KKCFDADAGEELSIFMKDKAISAPKQDWMSVFRRSLIKQRHQHHQVPLPNPFNRRLLLN FT FLGDDKFDPNVELQYVTSGEYLHDDTFCASYSLKEKEIKPDGRIFAKLTKRMRSCQVIA FT ESLLANHAGKLMKENGVVMNQLSLTKSLLTMSQIGIISEKARKSTRDNINQPGFQNIQR FT NKSHHSKQVNQRDPSDDFELAASFLTTDLKKYCLQWRYQTIIPFAQSLNRMYGYPHLFE FT WIHLRLMRSTLYVGDPFNPPADTSQFDLDKVINGDIFIVSPRGGIEGLCQKAWTMISIA FT VIILSATESGTRVMSMVQGDNQAIAVTTRVPRSLPTLEKKTIAFRSCNLFFERLKCNNF FT GLGHHLKEQETIISSHFFVYSKRIFYQGRILTQALKNASKLCLTADVLGECTQSSCSNL FT ATTVMRLTENGVEKDICFYLNIYMTIKQLSYDIIFPQVSIPGDQITLEYINNPHLVSRL FT ALLPSQLGGLNYLSCSRLFNRNIGDPVVSAVADLKRLIKSGCMDYWILYNLLGRKPGNG FT SWATLAADPYSINIEYQYPPTTALKRHTQQALMELSTNPMLRGIFSDNAQAEENNLARF FT LLDREVIFPRVAHIIIEQTSVGRRKQIQGYLDSTRSIMRKSLEIKPLSNRKLNEILDYN FT INYLAYNLALLKNAIEPPTYLKAMTLETCSIDIARNLRKLSWAPLLGGRNLEGLETPDP FT IEITAGALIVGSGYCEQCAAGDNRFTWFFLPSGIEIGGDPRDNPPIRVPYIGSRTDERR FT VASMAYIRGASSSLKAVLRLAGVYIWAFGDTLENWIDALDLSHTRVNITLEQLQSLTPL FT PTSANLTHRLDDGTTTLKFTPASSYTFSSFTHISNDEQYLTINDKTADSNIIYQQLMIT FT GLGILETWNNPPINRTFEESTLHLHTGASCCVRPVDSCILSEALTVKPHITVPYSNKFV FT FDEDPLSEYETAKLESLSFQAQLGNIDAVDMTGKLTLLSQFTARQIINAITGLDESVSL FT TNDAIVASDYVSNWISECMYTKLDELFMYCGWELLLELSYQMYYLRVVGWSNIVDYSYM FT ILRRIPGAALNNLASTLSHPKLFRRAINLDIVAPLNAPHFASLDYIKMSVDAILWGCKR FT VINVLSNGGDLELVVTSEDSLILSDRSMNLIARKLTLLSLIHHNGLELPKIKGFSPDEK FT CFALTEFLRKVVNSGLSSIENLSNFMYNVENPRLAAFASNNYYLTRKLLNSIRDTESGQ FT VAVTSYYESLEYIDSLKLTPHVPGTSCIEDDSLCTNDYIIWIIESNANLEKYPIPNSPE FT DDSNFHNFKLNAPSHHTLRPLGLSSTAWYKGISCCRYLERLKLPQGDHLYIAEGSGASM FT TIIEYLFPGRKIYYNSLFSSGDNPPQRNYAPMPTQFIESVPYKLWQAHTDQYPEIFEDF FT IPLWNGNAAMTDIGMTACVEFIINRVGPRTCSLVHVDLESSASLNQQCLSKPIINAIIT FT ATTVLCPHGVLILKYSWLPFTRFSTLITFLWCYFERITVLRSTYSDPANHEVYLICILA FT NNFAFQTVSQATGMAMTLTDQGFTLISPERINQYWDGHLKQERIVAEAIDKVVLGENAL FT FNSSDNELILKCGGTPNARNLIDIEPVATFIEFEQLICTMLTTHLKEIIDITRSGTQDY FT ESLLLTPYNLGLLGKISTIVRLLTERILNHTIRNWLILPPSLRMIVKQDLEFGIFRITS FT ILNSDRFLKLSPNRKYLIAQLTAGYIRKLIEGDCNIDLTRPIQKQIWKALGCVVYCHDP FT MDQRESTEFIDININEEIDRGIDGEEI" FT misc_feature 15204..15215 FT /gene="L" FT /note="L transcription termination site" FT misc_feature 15216..15246 FT /note="SV5 trailer sequence" XX SQ Sequence 15246 BP; 4732 A; 3289 C; 3155 G; 4070 T; 0 other; accaagggga aaatgaagtg gtgactcaaa tcatcgaaga ccctcgagat tacataggtc 60 cggaacctat ggccttcgtg accgacctcg agtcagagta gttcaataag gacctatcaa 120 gtttgggcaa tttttcgtcc ccgacacaaa aatgtcatcc gtgcttaaag catatgagcg 180 attcacgctc actcaagaac tgcaagatca gagtgaggaa ggtacaatcc cacctacaac 240 actaaaaccg gtaatcaggg tatttatact aacctctaat aacccagagc taagatcccg 300 gcttcttcta ttctgcctac ggattgttct cagtaatggt gcaagggatt cccatcgctt 360 tggagcatta ctcacaatgt tttcgctacc atcagccaca atgctcaatc atgtcaaatt 420 agctgaccag tcaccagaag ctgatatcga aagggtagag atcgatggct ttgaggaggg 480 atcattccgc ttaatcccca atgcacgttc aggtatgagc cgtggagaga tcaatgccta 540 tgctgcactt gcagaagatc tacctgacac actaaaccat gcaacacctt tcgttgattc 600 cgaagtcgag ggaactgcat gggatgagat tgagactttc ttagatatgt gttacagtgt 660 cctaatgcag gcatggatag tgacttgcaa gtgcatgact gcgccagacc aacctgctgc 720 ttctattgag aaacgcctgc aaaaatatcg tcagcaaggc aggatcaacc cgagatatct 780 cctgcaaccg gaggctcgac gaataatcca gaatgtaatc cggaagggaa tggtggtcag 840 acatttcctc acctttgaac tgcagcttgc ccgagcacaa agccttgtat caaataggta 900 ttatgctatg gtaggggatg ttggaaagta tatagagaat tgtggaatgg gaggcttctt 960 tttgacacta aaatatgcat taggaactag atggcccaca cttgctttag ctgcattttc 1020 aggagagcta acaaagctaa agtccctcat ggcattatac cagacccttg gtgagcaggc 1080 ccgatatttg gccctattgg agtcaccaca tttgatggat tttgctgcag caaactaccc 1140 actgctatat agctatgcta tgggaatagg ctatgtgtta gatgtcaaca tgaggaacta 1200 cgctttctcc agatcataca tgaacaagac atatttccaa ttgggaatgg aaactgcaag 1260 aaaacaacag ggtgcagttg acatgaggat ggcagaagat ctcggtctaa ctcaagccga 1320 acgcaccgag atggcaaata cacttgccaa attgaccaca gcaaatcgag gggcagacac 1380 caggggagga gtcaacccgt tctcatctgt cactgggaca actcaggtgc ccgctgcagc 1440 aacaggtgac acactcgaga gttacatggc agcggatcga ctgaggcaga gatatgctga 1500 tgcaggcacc catgatgatg agatgccacc attggaagag gaggaagagg acgacacatc 1560 tgcaggtcca cgcactggac caactcttga acaagtggcc ttggacatcc agaacgcagc 1620 agttggagct cccatccata cagatgacct gaatgccgca ctgggtgatc ttgacatcta 1680 gacaattcag atcccaatct aaaattgaca tacctaattg attagttaga tggaactaca 1740 gtggattcca taaggttcct gcctaccatc ggctttaaag aaaaaaatag gcccggacgg 1800 gttagcaaca agcgactgcc ggtgccaaca gcgcaatcca caatctacaa tggatcccac 1860 tgatctgagc ttctccccag atgagatcaa taagctcata gagacaggcc tgaatactgt 1920 agagtatttt acttcccaac aagtcacagg aacatcctct cttggaaaga atacaatacc 1980 accaggggtc acaggactac taaccaatgc tgcagaggca aagatccaag agtcaactaa 2040 ccatcagaag ggctcagttg gtgggggtgc aaaaccaaag aaaccgcgac caaaaattgc 2100 cattgtgcca gcagatgaca aaacagtgcc cggaaagccg atcccaaacc ctctattagg 2160 tctggactcc accccgagca cccaaactgt gcttgatcta agtgggaaaa cattaccatc 2220 aggatcctat aagggggtta agcttgcgaa atttggaaaa gaaaatctga tgacacggtt 2280 catcgaggaa cccagagaga atcctatcgc aaccagttcc cccatcgatt ttaagagggg 2340 cagggatacc ggcgggttcc atagaaggga gtactcaatc ggatgggtgg gagatgaagt 2400 caaggtcact gagtggtgca atccatcctg ttctccaatc accgctgcag caaggcgatt 2460 tgaatgcact tgtcaccagt gtccagtcac ttgctctgaa tgtgaacgag atacttaata 2520 cagtgagaaa tttggactct cggatgaatc aactggagac aaaagtagat cgcattctct 2580 catctcagtc tctaatccag accatcaaga atgacatagt tggacttaaa gcagggatgg 2640 ctactttaga aggaatgatt acaactgtga aaatcatgga cccgggagtt cccagtaatg 2700 ttactgtgga agatgtacgc aagacactaa gtaaccatgc tgttgttgtg ccagaatcat 2760 tcaatgatag tttcttgact caatctgaag atgtaatttc acttgatgag ttggctcgac 2820 caactgcaac aagtgttaag aagattgtca ggaaggttcc tcctcagaag gatctgactg 2880 gattgaagat tacactagag caattggcaa aggattgcat cagcaaaccg aagatgaggg 2940 aagagtatct cctcaaaatc aaccaggctt ccagtgaggc tcagctaatt gacctcaaga 3000 aagcaatcat ccgcagtgca atttgatcaa gaaacaccca attacactac actggtatga 3060 cactgtacta accctgaggg ttttagaaaa aacgattaac gataaataag cccgaacact 3120 acacactacc tgaggcagcc atgccatcca tcagcattcc cgcagacccc accaatccac 3180 gtcaatcaat aaaagcgttc ccaattgtga tcaacagtga tgggggtgag aaaggccgct 3240 tggttaaaca actacgcaca acctacttga atgacctaga tactcatgag ccactggtga 3300 cattcataaa tacctatgga ttcatctacg aacaggatcg ggggaatacc attgtcggag 3360 aggatcaact tgggaagaaa agagaggctg tgaccgctgc aatggttacc cttggatgtg 3420 ggcctaatct accatcatta gggaatgtcc tgggacaact gagggaattc caggtcactg 3480 ttaggaagac atccagcaaa gcggaagaga tggtctttga aattgttaag tatccgagaa 3540 tatttcgggg tcatacatta atccagaaag gactagtctg tgtctccgca gaaaaatttg 3600 ttaagtcacc agggaaaata caatctggaa tggactatct cttcattccg acatttctgt 3660 cagtgactta ctgtccagct gcaatcaaat ttcaggtacc tggccccatg ttgaaaatga 3720 gatcaagata cactcagagc ttacaacttg aactaatgat aagaatcctg tgtaagcccg 3780 attcgccact tatgaaggtc catacccctg acaaggaggg aagaggatgt cttgtatcag 3840 tatggctgca tgtatgcaac atcttcaaat caggaaacaa gaatggcagt gagtggcagg 3900 aatactggat gagaaagtgt gctaacatgc aacttgaagt gtcgattgca gatatgtggg 3960 gaccaactat cataattcat gccagaggtc acattcccaa aagtgctaag ttgttttttg 4020 gaaagggtgg atggagctgc catccacttc acgaagttgt tccaagtgtc actaaaacac 4080 tatggtccgt gggctgtgag attacaaagg cgaaggcaat aatacaagag agtagcatct 4140 ctcttctcgt ggagactact gacatcataa gtccaaaagt caaaatttca tctaagcatc 4200 gccgctttgt gaaatcaaat tggggtctgt tcaagaaaac taaatcactg cctaacctga 4260 cggagctgga atgactgacc tctaatcgag actacaccgc cgcaaactat aggtgggtgg 4320 tacctcagtg attaatcttg taagcactga tcgtaggcta caacacacta atattatcca 4380 gattagagag cttaattagc tctgtattaa taataacact actattccaa taactggaat 4440 caccagcttg atttatctcc aaaatgattc aaagaaaaca aatcatatta agactatcct 4500 aagcacgaac ccatatcgtc cttcaaatca tgggtactat aattcaattt ctggtggtct 4560 cctgtctatt ggcaggagca ggcagccttg atccagcagc cctcatgcaa atcggtgtca 4620 ttccaacaaa tgtccggcaa cttatgtatt atactgaggc ctcatcagca ttcattgttg 4680 tgaagttaat gcctacaatt gactcgccga ttagtggatg taatataaca tcaatttcaa 4740 gctataatgc aacagtgaca aaactcctac agccgatcgg tgagaatttg gagacgatta 4800 ggaaccagtt gattccaact cggaggagac gccggtttgc aggggtggtg attggattag 4860 ctgcattagg agtagctact gccgcacagg tcactgccgc agtggcacta gtaaaggcaa 4920 atgaaaatgc tgcggctata ctcaatctca aaaatgcaat ccaaaaaaca aatgcagcag 4980 ttgcagatgt ggtccaggcc acacaatcac taggaacggc agttcaagca gttcaagatc 5040 acataaacag tgtggtaagt ccagcaatta cagcagccaa ttgtaaggcc caagatgcta 5100 tcattggctc aatcctcaat ctctatttga ccgagttgac aaccatcttc cacaatcaaa 5160 ttacaaaccc tgcattgagt cccattacaa ttcaagcttt aaggatccta ctggggagta 5220 ccttgccgac tgtggtcgaa aaatctttca atacccagat aagtgcagct gagcttctct 5280 catcagggtt attgacaggc cagattgtgg gattagattt gacctatatg cagatggtca 5340 taaaaattga gctgccaact ttaactgtac aacctgcaac ccagatcata gatctggcca 5400 ccatttctgc attcattaac aatcaagaag tcatggccca attaccaaca cgtgttatgg 5460 tgactggcag cttgatccaa gcctatcccg catcgcaatg caccattaca cccaacactg 5520 tgtactgtag gtataatgat gcccaagtac tctcagatga tactatggct tgcctccaag 5580 gtaacttgac aagatgcacc ttctctccag tggttgggag ctttctcact cgattcgtgc 5640 tgttcgatgg aatagtttat gcaaattgca ggtcgatgtt gtgcaagtgc atgcaacctg 5700 ctgctgtgat cctacagccg agttcatccc ctgtaactgt cattgacatg tacaaatgtg 5760 tgagtctgca gcttgacaat ctcagattca ccatcactca attggccaat gtaacctaca 5820 atagcaccat caagcttgaa tcatcccaga tcttgtctat tgatccgttg gatatatccc 5880 aaaatctagc tgcggtgaat aagagtctaa gtgatgcact acaacactta gcacaaagtg 5940 acacatatct ttctgcaatc acatcagcta cgactacaag tgtattatcc ataatagcaa 6000 tctgtcttgg atcgttaggt ttaatattaa taatcttgct cagtgtagtt gtgtggaagt 6060 tattgaccat tgtcgttgct aatcgaaata gaatggagaa ttttgtttat cataaataag 6120 cattccacca ctcacgatct gatctcagtg agaaaaatca acctgcaact cttggaacaa 6180 gataagacag tcatccatta gtaattttta agaaaaaaac gataggaccg aacctagtat 6240 tgaaagaacc gtctcggtca atctaggtaa tcgagctgat accgtctcgg aaagctcaaa 6300 tcatgctgcc tgatccggaa gatccggaaa gcaagaaagc tacaaggaga gcaggaaacc 6360 taattatctg cttcctattc atcttctttc tgtttgtaac cttcattgtt ccaactctaa 6420 gacacttgct gtcctaacac ctgctatagg ctatccactg catcatctct cctgccatac 6480 ttcctactca catcatatct attttaaaga aaaaataggc ccgaacacta atcgtgccgg 6540 cagtgccact gcacacacaa cactacacat acaatacact acaatggttg cagaagatgc 6600 ccctgttagg gccacttgcc gagtattatt tcgaacaaca actttaatct ttctatgcac 6660 actactagca ttaagcatct ctatccttta tgagagttta ataacccaaa agcaaatcat 6720 gagccaagca ggctcaactg gatctaattc tggattagga agtatcactg atcttcttaa 6780 taatattctc tctgtcgcaa atcagattat atataactct gcagtcgctc tacctctaca 6840 attggacact cttgaatcaa cactccttac agccattaag tctcttcaaa ccagtgacaa 6900 gctagaacag aactgctcgt ggagtgctgc actgattaat gataatagat acattaatgg 6960 catcaatcag ttctattttt caattgctga gggtcgcaat ctgacacttg gcccacttct 7020 taatatgcct agtttcattc caactgccac gacaccagag ggctgcacca ggatcccatc 7080 attctcgctc actaagacac actggtgtta tacacacaat gttatcctga atggatgcca 7140 ggatcatgta tcctcaaatc aatttgtttc catgggaatc attgaaccca cttctgccgg 7200 gtttccattc tttcgaaccc taaagactct atatctcagc gatggggtca atcgtaagag 7260 ctgctctatc agtacagttc cggggggttg tatgatgtac tgttttgttt ctactcaacc 7320 agagagggat gactactttt ctgccgctcc tccagaacaa cgaattatta taatgtacta 7380 taatgataca atcgtggagc gcataattaa tccacccggg gtactagatg tatgggcaac 7440 attgaaccca ggaacaggaa gcggggtata ttatttaggt tgggtgctct ttccaatata 7500 tggcggcgtg attaaaggta cgagtttatg gaataatcaa gcaaataaat actttatccc 7560 ccagatggtt gctgctctct gctcacaaaa ccaggcaact caagtccaaa atgctaagtc 7620 atcatactat agcagctggt ttggcaatcg aatgattcag tctgggatcc tggcatgtcc 7680 tcttcgacag gatctaacca atgagtgttt agttctgccc ttttctaatg atcaggtgct 7740 tatgggtgct gaagggagat tatacatgta tggtgactcg gtgtattact atcaaagaag 7800 caatagttgg tggcctatga ccatgctgta taaggtaacc ataacattca ctaatggtca 7860 gccatctgct atatcagctc agaatgtgcc cacacagcag gtccctagac ctgggacagg 7920 agactgctct gcaaccaata gatgtcccgg tttttgcttg acaggagtgt atgccgatgc 7980 ctggttactg accaaccctt cgtctaccag tacatttgga tcagaagcaa ccttcactgg 8040 ttcttatctc aacacagcaa ctcagcgtat caatccgacg atgtatatcg cgaacaacac 8100 acagatcata agctcacagc aatttggatc aagcggtcaa gaagcagcat atggccacac 8160 aacctgtttt agggacacag gctctgttat ggtatactgt atctatatta ttgaattgtc 8220 ctcatctctc ttaggacaat ttcagattgt cccatttatc cgtcaggtga cactatccta 8280 aaggcagaag ccttcaggtc tgacccagcc aatcaaagca ttataccaga ccatggaatg 8340 cataccaaac attattgaca ctaatgacac acaaaattgg ttttaagaaa aaccaagaga 8400 acaataggcc agaatggctg ggtctcggga gatattactc cctgaagtcc atctcaattc 8460 accaattgta aagcataagc tatactatta cattctactt ggaaacctcc caaatgagat 8520 cgaccttgac gatttaggtc cattacataa tcaaaattgg aatcagatag cacatgaaga 8580 gtctaactta gctcaacgct tggtaaatgt aagaaatttt ctaattaccc acatccctga 8640 tcttagaaag ggccattggc aagagtatgt caatgtaata ctgtggccgc gaattcttcc 8700 cttgatcccg gattttaaaa tcaatgacca attgcctctg ctcaaaaatt gggacaagtt 8760 agttaaagaa tcatgttcag taatcaatgc aggtacttcc cagtgcattc agaatctcag 8820 ctatggactg acaggtcgtg ggaacctctt tacacgatca cgtgaactct ctggtgaccg 8880 cagggatatt gatcttaaga cagttgtggc agcatggcat gactcagact ggaaaagaat 8940 aagtgatttt tggattatga tcaaattcca gatgagacaa ttaattgtta ggcaaacaga 9000 tcataatgat tctgatttaa tcacgtatat cgaaaataga gaaggcataa tcatcataac 9060 ccctgaactg gtagcattat ttaacactga gaatcataca ctaacataca tgacctttga 9120 aattgtactg atggtttcag atatgtacga aggtcgtcac aacattttat cactatgcac 9180 agttagcact tacctgaatc ctctgaagaa aagaataaca tatttattga gccttgtaga 9240 taacttagct tttcagatag gtgatgctgt atataacata attgctttgc tagaatcctt 9300 tgtatatgca cagttgcaaa tgtcagatcc catcccagaa ctcagaggac aattccatgc 9360 attcgtatgt tctgagattc ttgatgcact aagaggaact aatagtttca cccaggatga 9420 attaagaact gtgacaacta atttgatatc cccattccaa gatctgaccc cagatcttac 9480 ggctgaattg ctctgtataa tgaggctttg gggacacccc atgctcactg ccagtcaagc 9540 tgcaggaaag gtacgcgagt ctatgtgtgc tggaaaagta ttagactttc ccaccattat 9600 gaaaacacta gcctttttcc atactattct gatcaatgga tacaggagga agcatcatgg 9660 agtatggcca cccttaaact taccgggtaa tgcttcaaag ggtctcacgg aacttatgaa 9720 tgacaatact gaaataagct atgaattcac acttaagcat tggaaggaag tctctcttat 9780 aaaattcaag aaatgttttg atgcagacgc aggtgaggaa ctcagtatat ttatgaaaga 9840 taaggcaatt agtgccccaa aacaagactg gatgagtgtg tttagaagaa gcctaatcaa 9900 acagcgccat cagcatcatc aggtccccct accaaatcca ttcaatcgac ggctgttgct 9960 aaactttctc ggagatgaca aattcgaccc gaatgtggag ctacagtatg taacatcagg 10020 tgagtatcta catgatgaca cgttttgtgc atcatattca ctaaaagaga aggaaattaa 10080 acctgatggt cgaatttttg caaagttgac taagagaatg agatcatgtc aagttatagc 10140 agaatctctt ttagcgaacc atgctgggaa gttaatgaaa gagaatggtg ttgtgatgaa 10200 tcagctatca ttaacaaaat cactattaac aatgagtcag attggaataa tatccgagaa 10260 agctagaaag tcaactcgag ataacataaa tcaacctggt ttccagaata tccagagaaa 10320 taaatcacat cactccaagc aagtcaatca gcgagatcca agtgatgact ttgaattggc 10380 agcatctttt ttaactactg atctcaaaaa atattgttta caatggaggt accagacaat 10440 tatcccattt gctcaatcat taaacagaat gtatggttat cctcatctct ttgagtggat 10500 tcacttacgg ctaatgcgta gtacacttta cgtgggggat cccttcaacc caccagcaga 10560 taccagtcaa tttgatctag ataaagtaat taatggagat atcttcattg tatcacccag 10620 aggtggaatt gaagggctgt gtcaaaaggc ttggacaatg atatctatcg ctgtgataat 10680 tctatctgcc acagagtctg gcacacgagt aatgagtatg gtgcagggag ataatcaagc 10740 aattgctgtc accacacgag taccaaggag cctgccgact cttgagaaaa agactattgc 10800 ttttagatct tgtaatctat tctttgagag gttaaaatgt aataattttg gattaggtca 10860 ccatttgaaa gaacaagaga ctatcattag ttctcacttc tttgtttata gcaagagaat 10920 attctatcag gggaggattc taacgcaagc cttaaaaaat gctagtaagc tctgcttgac 10980 agctgatgtc ctaggagaat gcacccaatc atcatgttct aatcttgcaa ctactgtcat 11040 gaggttaact gagaatggtg ttgaaaaaga tatctgtttc tacttgaata tctatatgac 11100 catcaaacag ctctcctatg atatcatctt ccctcaagtg tcaattcctg gagatcagat 11160 cacattagaa tacataaata atccacacct ggtatcacga ttggctcttt tgccatccca 11220 gttaggaggt ctaaactacc tgtcatgcag taggctgttc aatcgaaaca taggcgaccc 11280 ggtggtttcc gcagttgcag atcttaagag attaattaaa tcaggatgta tggattactg 11340 gatcctttat aacttattag ggagaaaacc gggaaacggc tcatgggcta ctttagcagc 11400 tgacccgtac tcaatcaata tagagtatca ataccctcca actacagctc ttaagaggca 11460 cacccaacaa gctctgatgg aactcagtac gaatccaatg ttacgtggca tattctctga 11520 caatgcacag gcagaagaaa ataaccttgc taggtttctc ctggataggg aggtgatctt 11580 tccgcgtgta gctcacatca tcattgagca aaccagtgtc gggaggagaa aacagattca 11640 aggatatttg gattcaacta gatcgataat gaggaaatca ctagaaatta agcccttatc 11700 caataggaag cttaatgaaa tactggatta caacatcaat tacctagctt acaatttggc 11760 attactcaag aatgctattg aacctccgac ttatttgaag gcaatgacac ttgaaacatg 11820 tagcatcgac attgcaagga acctccggaa gctctcctgg gccccactct tgggtgggag 11880 aaatcttgaa ggattagaga cgccagatcc cattgaaatt actgcaggag cattaattgt 11940 tggatcgggc tactgtgaac agtgtgctgc aggagacaat cgattcacat ggtttttctt 12000 gccatctggt atcgagatag gaggggatcc ccgtgataat cctcctatcc gtgtaccgta 12060 cattggctcc aggactgatg agaggagggt agcctcaatg gcatacatca ggggtgcctc 12120 gagtagctta aaagcagttc ttagactggc gggagtgtac atctgggcat tcggagatac 12180 tctggagaat tggatagatg cactggattt gtctcacact agagttaaca tcacacttga 12240 acagctgcaa tccctcaccc cacttccaac ctctgccaat ctaacccatc ggttggatga 12300 tggcacaact accctaaagt ttactcctgc gagctcttac accttttcaa gtttcactca 12360 tatatcaaat gatgagcaat acctgacaat taatgacaaa actgcagatt caaatataat 12420 ctaccaacag ttaatgatca ctggactcgg aatcttagaa acatggaata atcccccaat 12480 caatagaaca ttcgaagaat ctaccctaca tttgcacact ggtgcatcat gttgtgtccg 12540 acctgtggac tcctgcattc tctcagaagc attaacagtc aagccacata ttacagtacc 12600 gtacagcaat aaatttgtat ttgatgagga cccgctatct gaatatgaaa ctgcaaaact 12660 ggaatcgtta tcattccaag cccaattagg caacattgat gctgtagata tgacaggtaa 12720 attaacatta ttgtcccaat tcactgcaag gcagattatc aatgcaatca ctggactcga 12780 tgagtctgtc tctcttacta atgatgccat tgttgcatca gactatgtct ccaattggat 12840 tagtgaatgc atgtatacca aattagatga attatttatg tattgtgggt gggaactact 12900 attggaacta tcctatcaaa tgtattatct gagggtagtt gggtggagta atatagtgga 12960 ttattcttac atgatcttga gaagaatccc gggtgcagca ttaaacaatc tggcatctac 13020 attaagtcat ccaaaacttt tccgacgagc tatcaaccta gatatagttg cccccttaaa 13080 tgctcctcat tttgcatctc tggactacat caagatgagt gtggatgcaa tactctgggg 13140 ctgtaaaaga gtcatcaatg tgctctccaa tggaggggac ttagaattag ttgtgacatc 13200 tgaagatagc cttattctca gtgaccgatc catgaatctc attgcaagga aattaacttt 13260 attatcactg attcaccata atggtttgga actaccaaag attaaggggt tctctcctga 13320 tgagaagtgt ttcgctttga cagaattttt gaggaaagtg gtgaactcag ggttgagttc 13380 aatagagaac ctatcaaatt ttatgtacaa tgtggagaac ccacggcttg cagcattcgc 13440 cagcaacaat tactacctga ccagaaaatt attgaattca atacgagata ctgagtcggg 13500 tcaagtagca gtcacctcat attatgaatc attagaatat attgatagtc ttaagctaac 13560 cccacatgtg cctggcacct catgcattga ggatgatagt ctatgtacaa atgattacat 13620 aatctggatc atagagtcta atgcaaactt ggagaagtat ccaattccaa atagccctga 13680 ggatgattcc aatttccata actttaagtt gaatgctcca tcgcaccata ccttacgccc 13740 attagggttg tcatcaactg cttggtataa gggtataagc tgctgcaggt accttgagcg 13800 attaaagcta ccacaaggtg atcatttata tattgcagaa ggtagtggtg ccagtatgac 13860 aatcatagaa tacctattcc caggaagaaa gatatattac aattctttat ttagtagtgg 13920 tgacaatccc ccacaaagaa attatgcacc aatgcctact cagttcattg agagtgtccc 13980 atacaagctc tggcaagcac acacagatca atatcccgag atttttgagg acttcatccc 14040 tctatggaac ggaaacgccg ccatgactga cataggaatg acagcttgtg tagaattcat 14100 catcaatcga gtcggcccaa ggacttgcag tttagtacat gtagatttgg aatcaagtgc 14160 aagcttaaat caacaatgcc tgtcaaagcc gataattaat gctatcatca ctgctacaac 14220 tgttttgtgc cctcatgggg tgcttattct gaaatatagt tggttgccat ttactagatt 14280 tagtactttg atcactttct tatggtgcta ctttgagaga atcactgttc ttaggagcac 14340 atattctgat ccagctaatc atgaggttta tttaatttgt atccttgcca acaactttgc 14400 attccagact gtctcgcagg caacaggaat ggcgatgact ttaactgatc aagggtttac 14460 tttgatatca cctgaaagaa taaatcagta ttgggatggt cacttgaagc aagaacgtat 14520 cgtagcagaa gcaattgata aggtggttct aggagaaaat gctctattta attcgagtga 14580 taatgaatta attctcaaat gtggagggac accaaatgca cggaatctca tcgatatcga 14640 gccagtcgca actttcatag aatttgaaca attgatctgc acaatgttga caacccactt 14700 gaaggaaata attgatataa caaggtctgg aacccaggat tatgaaagtt tattactcac 14760 tccttacaat ttaggtcttc ttggtaaaat cagtacgata gtgagattat taacagaaag 14820 gattctaaat catactatca ggaattggtt gatcctccca ccttcgctcc ggatgatcgt 14880 gaagcaggac ttggaattcg gcatattcag gattacttcc atcctcaatt ctgatcggtt 14940 cctgaagctt tctccaaata ggaaatactt gattgcacaa ttaactgcag gctacattag 15000 gaaattgatt gagggggatt gcaatatcga tctaaccaga cctatccaaa agcaaatctg 15060 gaaagcatta ggttgtgtag tctattgtca cgatccaatg gatcaaaggg agtcaacaga 15120 gtttattgat ataaatatta atgaagaaat agaccgcggg atcgatggcg aggaaatcta 15180 aacatatcaa gaatcagaat tagtttaaga aaaaagaaga ggattaatct tggttttccc 15240 cttggt 15246 //