ID AF046869; SV 1; linear; genomic RNA; STD; VRL; 15428 BP. XX AC AF046869; XX DT 21-OCT-1998 (Rel. 57, Created) DT 24-FEB-2018 (Rel. 135, Last updated, Version 5) XX DE Porcine reproductive and respiratory syndrome virus 1 isolate 16244B, DE 2/18/97(Nebraska)pass.3, complete genome. XX KW . XX OS Porcine reproductive and respiratory syndrome virus 1 OC Viruses; Riboviria; Nidovirales; Arnidovirineae; Arteriviridae; OC Variarterivirinae; Betaarterivirus; Eurpobartevirus; OC Betaarterivirus suid 1. XX RN [1] RP 1-15428 RX PUBMED; 10073689. RA Allende R., Lewis T.L., Lu Z., Rock D.L., Kutish G.F., Ali A., Doster A.R., RA Osorio F.A.; RT "North American and European porcine reproductive and respiratory syndrome RT viruses differ in non-structural protein coding regions"; RL J. Gen. Virol. 80(Pt 2):307-315(1999). XX RN [2] RP 1-15428 RA Allende R., Lewis T.L., Lu Z., Rock D.L., Ali A., Kutish G.F., Osorio F.A.; RT ; RL Submitted (04-FEB-1998) to the INSDC. RL Microbiology, Plum Island Animal Disease Center, U.S. Dept. Agriculture, RL Agricultural Research Service, P.O. Box 848, Greenport, New York RL 11944-0848, USA XX DR MD5; 2fe6b50854745976d3385bdc5a8a1520. DR EuropePMC; PMC110963; 11044133. DR EuropePMC; PMC149535; 12610145. DR EuropePMC; PMC155073; 11932389. DR EuropePMC; PMC2738230; 19587037. DR EuropePMC; PMC371078; 15016889. DR EuropePMC; PMC3835772; 24298557. DR EuropePMC; PMC3957927; 24371078. DR EuropePMC; PMC4645332; 26401031. DR EuropePMC; PMC4828316; 26872419. DR RFAM; RF01076; RF_site2. XX FH Key Location/Qualifiers FH FT source 1..15428 FT /organism="Porcine reproductive and respiratory syndrome FT virus 1" FT /host="Sus scrofa" FT /isolate="16244B, 2/18/97(Nebraska)pass.3" FT /mol_type="genomic RNA" FT /note="Pathogenic pig isolate" FT /db_xref="taxon:1965066" FT 5'UTR 1..189 FT CDS 190..7701 FT /codon_start=1 FT /product="ORF1a polyprotein" FT /note="cysteine protease/serine protease; ORF1a" FT /db_xref="GOA:Q9YN02" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR008741" FT /db_xref="InterPro:IPR008743" FT /db_xref="InterPro:IPR008760" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR023183" FT /db_xref="InterPro:IPR023338" FT /db_xref="InterPro:IPR025773" FT /db_xref="InterPro:IPR027351" FT /db_xref="InterPro:IPR027355" FT /db_xref="InterPro:IPR027417" FT /db_xref="InterPro:IPR031932" FT /db_xref="InterPro:IPR032785" FT /db_xref="InterPro:IPR032855" FT /db_xref="InterPro:IPR037227" FT /db_xref="InterPro:IPR038154" FT /db_xref="InterPro:IPR038155" FT /db_xref="InterPro:IPR038451" FT /db_xref="PDB:5EYI" FT /db_xref="PDB:5YLX" FT /db_xref="UniProtKB/Swiss-Prot:Q9YN02" FT /protein_id="AAC64691.1" FT /translation="MSGILDRCTCTPNARVFVAEGQVYCTRCLSARSLLPLNLQVSELG FT VLGLFYRPEEPLRWTLPRAFPTVECSPAGACWLSAIFPIARMTSGNLNFQQRMVRVAAE FT IYRAGQLTPAVLKALQVYERGCRWYPIVGPVPGVAVFANSLHVSDKPFPGATHVLTNLP FT LPQRPKPEDFCPFECAMATVYDIGHDAVMYVAEGKISWAPRGGDEVKFEAVPGELKLIA FT NRLRTSFPPHHAVDMSKFAFTAPGCGVSMRVERQHGCLPADTVPEGNCWWSLFDLLPLE FT VQDKEIRHANQFGYQTKHGVSGKYLQRRLQVNGLRAVTDSNGPIVVQYFSVKESWIRHL FT KLAGEPSYSGFEDLLRIRVEPNTSPLANTEGKIFRFGSHKWYGAGKRARKARSCATATV FT AGRALSVRETRQAKEHEVAGADKAEHLKHYSPPAEGNCGWHCISAIANRMVNSIFETTL FT PERVRPPDDWATDDDLANAIQILRLPAALDRNGACTSAKYVLKLEGEHWTVTVTPGMSP FT SLLPLECVQGCCEHKGGLGSPDAIEVSGFDPACLDWLAEVMHLPSSAIPAALAEMSGDS FT DRSASPVTTVWTVSQFFARHSGGNHPDQVRLGKIISLCQVIEDCCCSQNKTNRVTPEEV FT AAKIDLYLRGATNLEECLARLEKARPPRVIDTSFDWDVVLPGVEAATQTNKLPQVNQCR FT ALVPVVTQKSLDNNSVPLTAFSLANYYYRAQGDEVRHRERLTAVLSKLEEVVREEYGLM FT PTEPGPRPTLPRGLDELKDQMEEDLLRLANAQATSDMMAWAVEQVDLKTWVKNYPRWTP FT PPPPPKVQPRKTKPVKSLPERKPVPAPRRKVGPDCGSPVSLGGDVPNSWEDLAVSSPLD FT LPTPPEPATLSSELVIVSSPQCIFRPATPLSEPAPIPAPRGTVSRPVTPLSEPIPVPAP FT RRKFQQVKRLSSAAAVPLHQNEPLDLSASSQTEYEASPSAPPQSGGVLGVEGHEAEETL FT SEISDMSGNIKPASVSSSSSLSSVEITRPKYSAQAIIDSGGPCSGHLQGVKETCLSVMR FT EACDATKLDDPATQEWLSRMWDRVDMLTWRNTSVCQAIRTLDGRLKFLPKMILETPPPY FT PCEFVMMPHTPAPSVGAESDLTIGSVATEDVPRILEKIENVGEMANQEPSAFSEDKPVD FT DQLVNDPRISSRRPDESTAAPSAGTGGAGSFTDLPSSDGADADGGGPFRTAKRKAERLF FT DQLSRQVFDLVSHLPVFFSRLFHPGGGYSTGDWGFAAFTLLCLFLCYSYPAFGIAPLLG FT VFSGTSRRVRMGVFGCWLAFAVGLFKPVSDPVGAACEFDSPECRNILLSFELLKPWDPV FT RSLVVGPVGLGLAILGRLLGGARCIWHFLLRLGIVADCILAGAYVLSQGRCKKCWGSCI FT RTAPNEVAFNVFPFTRATRSSLIDLCDRFCAPKGMDPIFLATGWRGCWAGRSPIEQPSE FT KPIAFAQLDEKKITARTVVAQPYDPNQAVKCLRVLQAGGAMVAEAVPKVVKVSAVPFRA FT PFFPTGVKVDPDCRVVVDPDTFTAALRSGYSTTNLVLGVGDFAQLNGLKIRQISKPSGG FT GPHLMAALHVACSMALHMLTGIYVTAVGSCGTGTNDPWCANPFAVPGYGPGSLCTSRLC FT ISQHGLTLPLTALVAGFGIQEIALVVLIFVSIGGMAHRLSCKADMLCILLAIASYVWVP FT LTWLLCVFPCWLRCFSLHPLTILWLVFFLISVNMPSGILAMVLLVSLWLLGRYTNVAGL FT VTPYDIHHYTSGPRGVAALATAPDGTYLAAVRRAALTGRTMLFTPSQLGSLLEGAFRTR FT KPSLNTVNVIGSSMGSGGVFTIDGKVKCVTAAHVLTGNSARVSGVGFNQMLDFDVKGDF FT AIADCPNWQGAAPKAQFCADGWTGRAYWLTSSGVEPGVIGKGFAFCFTACGDSGSPVIT FT EAGELVGVHTGSNKQGGGIVTRPSGQFCNVAPIKLSELSEFFAGPKVPLGDVKVGSHII FT KDISEVPSDLCALLAAKPELEGGLSTVQLLCVFFLLWRMMGHAWTPLVAVSFFILNEVL FT PAVLVRSVFSFGMFVLSWLTPWSAQILMIRLLTAALNRNRWSLAFFSLGAVTGFVADLA FT ATQGHPLQAVMNLSTYAFLPRMMVVTSPVPVITCGVVHLLAIILYLFKYRGLHQILVGD FT GVFSAAFFLRYFAEGKLREGVSQSCGMNHESLTGALAMRLNDEDLDFLMKWTDFKCFVS FT ASNMRNAAGQFIEAAYAKALRVELAQLVQVDKVRGVLAKLEAFADTVAPQLSPGDIVVA FT LGHTPVGSIFDLKVGSTKHTLQAIETRVLAGSKMTVARVVDPTPTPPPAPVPIPLPPKV FT LENGPNAWGDEDRLNKKKRRRMEALGIYVMGGKKYQKFWDKNSGDVFYEEVHNNTDEWE FT CLRVGDPADFDPEKGTLCGHVTIENKAYHVYISPSGKKFLVPVNPENGRVQWEAAKLSM FT EQALGMMNVDGELTAKELEKLKRIIDKLQGLTKEQCLNC" FT CDS <7680..12071 FT /codon_start=1 FT /product="ORF1b polyprotein" FT /note="RNA dependent RNA polymerase/zinc-finger/helicase; FT ORF1b" FT /db_xref="GOA:Q9YN02" FT /db_xref="InterPro:IPR001205" FT /db_xref="InterPro:IPR007094" FT /db_xref="InterPro:IPR008741" FT /db_xref="InterPro:IPR008743" FT /db_xref="InterPro:IPR008760" FT /db_xref="InterPro:IPR009003" FT /db_xref="InterPro:IPR023183" FT /db_xref="InterPro:IPR023338" FT /db_xref="InterPro:IPR025773" FT /db_xref="InterPro:IPR027351" FT /db_xref="InterPro:IPR027355" FT /db_xref="InterPro:IPR027417" FT /db_xref="InterPro:IPR031932" FT /db_xref="InterPro:IPR032785" FT /db_xref="InterPro:IPR032855" FT /db_xref="InterPro:IPR037227" FT /db_xref="InterPro:IPR038154" FT /db_xref="InterPro:IPR038155" FT /db_xref="InterPro:IPR038451" FT /db_xref="PDB:5EYI" FT /db_xref="PDB:5YLX" FT /db_xref="UniProtKB/Swiss-Prot:Q9YN02" FT /protein_id="AAC64692.1" FT /translation="GAVFKLLAASGLTRCGRGGLVVTETAVKIVKFHNRTFTLGPVNLK FT VASEVELKDAVEHNQHPVARPIDGGVVLLRSAVPSLIDVLISGADASPKLLAHHGPGNT FT GIDGTLWDFESEATKEEVALSAQIIQACDIRRGDAPKIGLPYKLYPVRGNPERVKGVLQ FT NTRFGDIPYKTPSDTGSPVHAAACLTPNATPVTDGRSVLATTMPPGFELYVPTIPASVL FT DYLDSRPDCPKQLTEHGCEDAALKDLSKYDLSTQGFVLPGVLRLVRKYLFAHVGKCPPV FT HRPSTYPAKNSMAGINGNRFPTKDIQSVPEIDVLCAQAVRENWQTVTPCTLKKQYCGKK FT KTRTILGTNNFIALAHRAALSGVTQGFMKKAFNSPIALGKNKFKELQTSVLGRCLEADL FT ASCDRSTPAIVRWFAANLLYELACAEEHLPSYVLNCCHDLLVTQSGAVTKRGGLSSGDP FT ITSVSNTIYSLVIYAQHMVLSYFKSGHPHGLLFLQDQLKFEDMLKVQPLIVYSDDLVLY FT AESPTMPNYHWWVEHLNLMLGFQTDPKKTAITDSPSFLGCRIINGRQLVPNRDRILAAL FT AYHMKASNVSEYYASAAAILMDSCACLEYDPEWFEELVVGIAQCARKDGYSFPGTPFFM FT SMWEKLRSNYEGKKSRVCGYCGAPAPYATACGLDVCIYHTHFHQHCPVTIWCGHPAGSG FT SCSECKSPVGKGTSPLDEVLEQVPYKPPRTVIMHVEQGLTPLDPGRYQTRRGLVSVRRG FT IRGNEVELPDGDYASTALLPTCKEINMVAVASNVLRSRFIIGPPGAGKTYWLLQQVQDG FT DVIYTPTHQTMLDMIRALGTCRFNVPAGTTLQFPVPSRTGPWVRILAGGWCPGKNSFLD FT EAAYCNHLDVLRLLSKTTLTCLGDFKQLHPVGFDSHCYVFDIMPQTQLKTIWRFGQNIC FT DAIQPDYRDKLMSMVNTTRVTYVEKPVRYGQVLTPYHRDREDDAITIDSSQGATFDVVT FT LHLPTKDSLNRQRALVAITRARHAIFVYDPHRQLQGLFDLPAKGTPVNLAVHRDGQLIV FT LDRNNKECTVAQALGNGDKFRATDKRVVDSLRAICADLEGSSSPLPKVAHNLGFYFSPD FT LTQFAKLPVELAPHWPVVTTQNNEKWPDRLVASLRPIHKYSRACIGAGYMVGPSVFLGT FT PGVVSYYLTKFVKGEAQLLPETVFSTGRIEVDCREYLDDREREVAASLPHAFIGDVKGT FT TVGGCHHVTSRYLPRVLPKESVAVVGVSSPGKAAKALCTLTDVYLPDLEAYLHPETQSK FT CWKMMLDFKEVRLMVWRDKTAYFQLEGRYFTWYQLASYASYIRVPVNSTVYLDPCMGPA FT LCNRRVVGSTHWGADLAVTPYDYGAKIILSSAYHGEMPPGYKILACAEFSLDDPVRYKH FT TWGFESDTAYLYEFTGNGEDWEDYNDAFRARQEGKIYKATATSLKFHFPPGPVIEPTLG FT LN" FT misc_feature 7689..7760 FT /standard_name="ribosomal frameshift region" FT /function="frameshift [minus 1] at ORF1a/1b junction" FT CDS 12073..12843 FT /codon_start=1 FT /product="GP2 glycosylated envelope protein" FT /note="ORF2" FT /db_xref="GOA:Q9YN00" FT /db_xref="InterPro:IPR003434" FT /db_xref="UniProtKB/TrEMBL:Q9YN00" FT /protein_id="AAC64685.1" FT /translation="MKWGPCKAFLTKLANFLWMLSRSSWCPLLISLYFWPFCLASPSPV FT GWWSFASDWFAPRYSVRALPFTLSNYRRSYEAFLSQCQVDIPTWGTKHPLGMLWHHKVS FT TLIDEMVSRRMYRIMEKSGQAAWKQVVSEATLSRISSLDVVAHFQHLAAIEAETCKYLA FT SRLPMLHNLRMTGSNVTIVYNSTLNQVFAIFPTPGSRPKLHDFQQWLIAVHSSIFSSVA FT ASCTLFVVLWLRVPILRTVFGFRWLGAIFHSNSQ" FT CDS 12696..13460 FT /codon_start=1 FT /product="GP3 envelope protein" FT /note="ORF3" FT /db_xref="GOA:Q9YMZ9" FT /db_xref="InterPro:IPR002556" FT /db_xref="UniProtKB/TrEMBL:Q9YMZ9" FT /protein_id="AAC64686.1" FT /translation="MVNSCTFLHIFLCCSFLYSFCCAVVAGSNSTYCFWFPLVRGNFSF FT ELTVNYTVCPPCLTRQAATEIYEPGRSLWCRIGHDRCGEDDHDELGFMVPPGLSSEGHL FT TSVYAWLAFLSFSYTAQFHPEIFGIGNVSRVYVDIKHQLICAEHDGQNATLSRHDNISA FT VFQTYYQHQVDGGNWFHLEWLRPFFSSWLVLNVSWFLRRSPANHVSVRVLQILRPTPPQ FT RQALLSSKTSVALGIATRPLRRFAKSLSAVRR" FT CDS 13241..13777 FT /codon_start=1 FT /product="GP4" FT /note="ORF4" FT /db_xref="GOA:Q9YMZ8" FT /db_xref="InterPro:IPR003412" FT /db_xref="UniProtKB/TrEMBL:Q9YMZ8" FT /protein_id="AAC64687.1" FT /translation="MASSLLFLVVGFKCLLVSQAFACKPCFSSSLADIETNTTAAAGFA FT VLQDISCLRHRDSASEAIRKIPQCRTAIGTPVYVTITANVTDENYLHSSDLLMLSSCLF FT YASEMSEKGFKVVFGNVSGIVAVCVNFTSYVQHVKEFTQRSLVVDHVRLLHFMTPETMR FT WATVLACLFAILLAI" FT CDS 13788..14390 FT /codon_start=1 FT /product="GP5 glycosylated envelope protein" FT /note="ORF5" FT /db_xref="GOA:Q9YMZ7" FT /db_xref="InterPro:IPR001332" FT /db_xref="UniProtKB/TrEMBL:Q9YMZ7" FT /protein_id="AAC64688.1" FT /translation="MLEKCLTAGCCSRLLSLWCIVPFCFAVLANASNSSSSHLQLIYNL FT TLCELNGTDWLANRFDWAVESFVIFPVLTHIVSYGALTTSHFLDTVALVTVSTAGFVHG FT RYVLSSIYAVCALAALTCFVIRFAKNCMSWRYACTRYTNFLLDTKGRLYRWRSPVIIEK FT RGKVEVEGHLIDLKRVVLDGSVATPITRVSAEQWGRP" FT CDS 14375..14899 FT /codon_start=1 FT /product="membrane protein M" FT /note="ORF6" FT /db_xref="GOA:Q9YMZ6" FT /db_xref="InterPro:IPR001332" FT /db_xref="UniProtKB/TrEMBL:Q9YMZ6" FT /protein_id="AAC64689.1" FT /translation="MGSSLDDFCHDSTAPQKVLLAFSITYTPVMIYALKVSRGRLLGLL FT HLLIFLNCAFTFGYMTFTHFQSTNKVALTMGAVVALLWGVYSAIETWKFITSRCRLCLL FT GRKYILAPAHHVESAAGFHPIAANDNHAFVVRRPGSTTVNGTLVPGLKSLVLGGRKAVK FT QGVVNLVKYAK" FT CDS 14889..15260 FT /codon_start=1 FT /product="nucleocapsid protein N" FT /note="ORF7" FT /db_xref="GOA:Q77XR2" FT /db_xref="InterPro:IPR002484" FT /db_xref="InterPro:IPR037179" FT /db_xref="UniProtKB/TrEMBL:Q77XR2" FT /protein_id="AAC64690.1" FT /translation="MPNNNGKQQKRKKGDGQPVNQLCQMLGKIIAQQNQSRGKGPGKKN FT KKKNPEKPHFPLATEDDVRHHFTPSERQLCLSSIQTAFNQGAGTCTLSDSGRISYTVEF FT SLPTHHTVRLIRVTASPSA" FT 3'UTR 15261..15411 FT polyA_site 15412 XX SQ Sequence 15428 BP; 3353 A; 4125 C; 4047 G; 3903 T; 0 other; cgcccgggca ggtgttggct ctatgcctcg gcatttgtat tgtcaggagc tgtgaccatt 60 ggcacagccc aaaacttgct gcacagaaac acccttctgt gacagcctcc ttcaggggag 120 cttagggttt gtccctagca ccttgcttcc ggagttgcac tgctttacgg tctctccacc 180 cctttaacca tgtctgggat acttgatcgg tgcacgtgta cccccaatgc cagggtgttt 240 gtggcggagg gccaagtcta ctgcacacga tgtctcagtg cacggtctct ccttcccctg 300 aacctccaag tttctgagct cggggtgcta ggcctgttct acaggcccga agagccactc 360 cggtggacgt tgccacgtgc attccccact gttgagtgct cccccgctgg ggcctgctgg 420 ctttctgcaa tctttccaat cgcacgaatg accagtggaa acctgaactt ccaacaaaga 480 atggtacggg tcgcagctga gatttacaga gccggccagc tcacccctgc agtcttgaag 540 gctctacaag tttatgaacg gggttgccgc tggtacccca ttgttggacc tgtccctgga 600 gtggccgttt tcgccaattc cctacatgtg agtgataaac ctttcccggg agcaactcac 660 gtgttgacca acctgccgct cccgcagaga cccaagcctg aggacttttg cccctttgag 720 tgtgctatgg ctactgtcta tgacattggt catgacgccg tcatgtatgt ggccgaaggg 780 aaaatctcct gggcccctcg tggcggggat gaagtgaaat ttgaagctgt ccccggggag 840 ttgaagttga ttgcgaaccg gctccgcacc tccttcccgc cccaccacgc agtggacatg 900 tctaagttcg ccttcacagc ccctgggtgt ggtgtttcta tgcgggtcga acgccaacac 960 ggctgccttc ccgctgacac tgtccctgaa ggcaactgct ggtggagctt gtttgacttg 1020 ctcccactgg aagttcagga caaagaaatt cgccatgcta accaatttgg ctaccagacc 1080 aagcatggtg tctctggcaa gtacctacag cggaggctgc aagttaatgg tctccgagca 1140 gtaactgact caaacggacc tatcgtcgtg caatacttct ccgtcaagga gagttggatc 1200 cgccatttga aactggcggg agaacccagc tactctgggt ttgaggacct cctcagaata 1260 agggttgagc ctaacacatc gccattggct aacacggaag gaaagatttt ccggtttggc 1320 agtcacaagt ggtacggcgc tggaaagaga gcaagaaaag cacgctcttg tgcgactgct 1380 acagtcgctg gccgcgcttt gtccgttcgt gaaacccggc aggccaagga gcatgaggtt 1440 gccggcgccg acaaggctga gcacctcaaa cactactccc cgcctgccga agggaattgt 1500 ggttggcact gcatttccgc catcgccaac cggatggtga attccatctt tgaaaccacc 1560 cttcccgaaa gagtgaggcc cccagatgac tgggctactg acgatgatct tgcgaatgcc 1620 atccaaatcc tcagactccc tgcagcctta gacaggaacg gtgcttgtac aagcgccaag 1680 tacgtactta agctagaagg tgagcattgg actgtcactg tgacccctgg gatgtcccct 1740 tctttgctcc ctcttgaatg tgttcagggc tgttgtgagc acaagggcgg tcttggttcc 1800 ccagatgcaa tcgaggtctc tggatttgac cctgcctgcc ttgactggct ggctgaggtg 1860 atgcacctgc ctagcagtgc tatcccagcc gctctggccg aaatgtctgg cgattccgat 1920 cgttcggctt ctccggtcac caccgtgtgg actgtttcgc agttctttgc ccgtcacagc 1980 ggagggaatc accctgacca agtgcgctta gggaaaatta tcagtctctg tcaggtgatt 2040 gaggactgct gctgttccca gaacaaaacc aaccgggtca ccccggagga ggtcgcagca 2100 aagattgacc tgtacctccg tggcgcaaca aatcttgaag aatgcttggc caggcttgag 2160 aaagcgcgcc cgccgcgcgt aatcgacacc tcctttgatt gggatgttgt gctccctggg 2220 gttgaggcgg caacccaaac aaacaagctg ccccaggtca accagtgtcg tgctctggtc 2280 cctgttgtga ctcaaaagtc cttggacaac aactcggtcc ccctgaccgc cttttcactg 2340 gctaactact actaccgtgc gcaaggtgac gaagttcgtc accgtgaaag actaaccgcc 2400 gtgctctcca agttggaaga ggttgttcga gaagaatatg ggctcatgcc aaccgagcct 2460 ggtccacggc ccacactgcc acgcgggctc gacgaactca aagaccagat ggaggaggac 2520 ttgctgagac tggctaacgc ccaggcgact tcggacatga tggcatgggc agtcgagcag 2580 gttgacctaa aaacttgggt caagaactac ccgcggtgga caccaccacc ccctccgcca 2640 aaagttcagc ctcgaaaaac gaagcctgtc aagagcttgc cggagagaaa gcctgtcccc 2700 gctccgcgca ggaaggttgg gcccgattgt ggcagcccgg tttcattagg cggcgatgtc 2760 cctaacagtt gggaagattt ggctgttagt agccccttgg atctcccgac cccacctgag 2820 ccggcaacac tttcaagtga gctagtgatt gtgtcctcac cgcaatgcat ctttaggccg 2880 gcgacaccct tgagtgagcc ggctccaatt cccgcacctc gcggaactgt gtctcgaccg 2940 gtgacaccct tgagtgagcc gatccctgtg cccgcaccgc ggcgtaagtt tcagcaggtg 3000 aaaagattga gttcggcggc ggcagtccca ctgcaccaga acgagcccct ggatttgtct 3060 gcttcctcac agactgaata tgaggcctcc ccctcagcgc cgccgcagag cgggggcgtt 3120 ctgggagtag aggggcatga agctgaggaa accctgagtg aaatctcgga catgtcgggt 3180 aacattaaac ctgcgtccgt gtcatcaagc agctccttgt ccagcgtgga aatcacacgc 3240 ccaaaatact cagctcaagc catcatcgac tcgggcgggc cctgcagtgg gcatctccaa 3300 ggggtaaagg aaacatgcct tagtgtcatg cgcgaggcat gtgatgcgac taagcttgat 3360 gaccctgcta cgcaggaatg gctttctcgc atgtgggatc gggtggacat gctgacttgg 3420 cgcaacacgt ctgtttgcca ggcgattcgc accttagatg gcaggttaaa gttcctccca 3480 aaaatgatac tcgagacacc gccgccctat ccgtgtgagt ttgtgatgat gcctcacacg 3540 cctgcacctt ccgtaggtgc ggagagtgac cttaccattg gctcagttgc tactgaagat 3600 gttccacgca tcctcgagaa aatagaaaat gtcggcgaga tggccaacca ggaaccctcg 3660 gccttctccg aggataaacc ggtagatgac cagcttgtca acgacccccg gatatcgtcg 3720 cggaggcctg acgagagcac agcagctccg tctgcaggca caggtggcgc cggctctttt 3780 accgatttgc cgtcttcaga tggcgcggat gcggacgggg gggggccgtt tcggacggca 3840 aaaagaaaag ctgaaaggct ctttgatcaa ctgagccgtc aggtttttga cctcgtctcc 3900 catctccctg ttttcttctc acgccttttc caccctggcg gtggttattc tacgggtgat 3960 tggggttttg cagcttttac tctattgtgc ctctttttat gttacagtta cccagccttt 4020 ggcattgctc ccctcttggg tgtgttttct gggacttctc ggcgcgttcg aatgggggtt 4080 tttggctgct ggttggcttt tgctgttggt ctgttcaagc ctgtgtccga cccagtcggc 4140 gctgcttgtg agtttgactc gccagagtgt agaaatatcc ttctttcttt tgagcttctc 4200 aaaccttggg accctgttcg cagccttgtt gtgggccccg tcggtctcgg tcttgccatt 4260 cttggcaggt tactgggcgg ggcacgctgc atctggcact ttttgcttag gcttggcatt 4320 gttgcagact gtatcttggc tggagcttac gtgctttctc aaggcaggtg taaaaagtgc 4380 tggggatctt gtataagaac tgctcctaat gaggtcgctt ttaacgtgtt ccctttcaca 4440 cgtgcgacca gatcgtcact tatcgacctg tgcgatcggt tttgtgcgcc aaaaggaatg 4500 gaccccattt ttctcgccac tgggtggcgc ggatgctggg ccggccgaag ccccattgag 4560 caaccctctg aaaaacccat cgcgtttgct caattggatg aaaagaagat tacggctaga 4620 actgtggtcg cccagcctta tgaccccaac caagccgtaa agtgcttgcg ggtattgcag 4680 gcgggtgggg cgatggtggc tgaggcggtc ccaaaagtgg tcaaggtttc cgctgttcca 4740 ttccgagccc ccttctttcc cactggagtg aaagttgacc ctgattgcag ggtcgtagtc 4800 gaccctgaca ctttcactgc agctctccgg tctggctact ccaccacaaa cctcgtcctt 4860 ggtgtagggg actttgccca gctgaatgga ttaaaaatca ggcaaatttc caagccttca 4920 gggggaggcc cacatctcat ggctgccttg catgttgcct gctcgatggc tctgcacatg 4980 cttactggga tttatgtgac tgcggtgggt tcttgcggca ccggcaccaa cgacccgtgg 5040 tgcgctaacc cgtttgccgt ccctggctac ggacctggct ctctgtgcac gtccagattg 5100 tgcatttccc aacacggcct taccctgccc ttgacagcac ttgtggcggg attcggcatt 5160 caagaaattg ccttggtcgt tttgattttt gtttccatcg gaggcatggc tcataggttg 5220 agctgtaagg ctgacatgct gtgcattttg cttgcaattg ccagctatgt ttgggtacct 5280 ctcacctggt tgctttgtgt gtttccttgc tggttgcgct gtttttcttt gcaccccctc 5340 accatcctat ggttggtgtt tttcttgatt tctgtgaata tgccttcagg aatcttggcc 5400 atggtgttgt tggtttctct ttggcttctt ggtcgctata ctaatgttgc tggccttgtc 5460 accccctacg acattcatca ttacaccagt ggcccccgcg gtgttgccgc cttggctacc 5520 gcaccagatg ggacctactt ggccgctgtc cgccgcgctg cgttgactgg ccgcaccatg 5580 ctgtttaccc cgtcccagct tgggtctctt cttgagggtg ctttcagaac tcgaaagccc 5640 tcactgaaca ccgtcaatgt gatcgggtcc tccatgggct ctggcggggt gtttaccatc 5700 gacgggaagg tcaagtgcgt aactgccgca catgtcctta cgggcaattc agctcgggtc 5760 tccggggtcg gcttcaatca aatgcttgac tttgacgtaa agggagattt cgctatagct 5820 gattgcccga attggcaagg ggctgccccc aaggcccaat tctgcgcgga tggatggact 5880 ggccgtgcct attggctaac atcctctggc gtcgaacccg gcgtcattgg aaaaggattc 5940 gccttctgct tcaccgcatg tggcgattcc gggtccccag tgatcaccga ggccggtgag 6000 cttgtcggcg ttcacacggg atcgaataaa caaggggggg gcattgttac gcgcccctca 6060 ggccagtttt gtaatgtggc acccatcaag ctaagcgaat taagtgaatt ctttgctggg 6120 cctaaggtcc cgctcggtga tgtgaaggtc ggcagccaca taattaaaga cataagcgag 6180 gtgccttcag atctttgtgc cttgcttgct gccaaacctg aactggaagg aggcctctcc 6240 accgtccaac ttctttgtgt gttttttctc ctgtggagaa tgatgggaca tgcctggacg 6300 cccttggttg ctgtgagttt ctttattttg aatgaggttc tcccagccgt cctggtccgg 6360 agtgttttct cctttggaat gtttgtgctc tcctggctca cgccatggtc tgcgcaaatt 6420 ctgatgatca ggcttctgac agcagccctt aacaggaaca gatggtcact tgcctttttc 6480 agcctcggtg cagtgaccgg ttttgtcgca gatcttgcgg ccactcaggg gcatccgttg 6540 caggcagtga tgaatttgag cacctatgca ttcctgcctc ggatgatggt tgtgacctca 6600 ccagtcccag tgatcacgtg tggtgtcgtg cacctacttg ccatcatttt gtacttgttt 6660 aagtaccgtg gcctgcacca gatccttgtt ggcgatggag tgttctctgc ggctttcttc 6720 ttgagatact ttgccgaggg aaagttgagg gaaggggtgt cgcaatcctg cggaatgaac 6780 catgagtctc tgactggtgc cctcgctatg agactcaatg acgaggactt ggatttcctt 6840 atgaaatgga ctgattttaa gtgctttgtt tctgcgtcca acatgaggaa tgcagcgggt 6900 caatttatcg aggctgccta tgctaaagca cttagagtag aactggccca gttggtgcag 6960 gttgataaag ttcgaggagt tttggccaaa cttgaagctt ttgctgatac cgtggcacct 7020 caactctcgc ccggtgacat tgttgtcgct ctcggccaca cgcctgttgg cagtatcttc 7080 gacctaaagg ttggtagcac caagcatacc ctccaagcca ttgagactag agtccttgct 7140 gggtccaaaa tgaccgtggc gcgcgtcgtc gatccgaccc ccacgccccc acccgcaccc 7200 gtgcccattc ccctcccacc gaaagttctg gagaatggcc ccaacgcttg gggggatgag 7260 gaccgtttga ataagaagaa gaggcgcagg atggaagccc tcggcatcta tgttatgggc 7320 gggaaaaagt accagaaatt ttgggacaag aattccggtg atgtgtttta tgaggaggtc 7380 cataacaaca cagatgagtg ggagtgtctc agagttggcg accctgctga ctttgaccct 7440 gagaagggaa ctctgtgtgg acatgtcacc attgaaaaca aggcttacca tgtttacatc 7500 tccccatctg gtaagaagtt cttggtcccc gtcaacccag agaatggaag agtccaatgg 7560 gaagctgcaa agctttccat ggagcaggcc ctaggtatga tgaatgtcga cggcgaactg 7620 actgccaaag aactggagaa actgaaaaga ataattgaca aactccaggg cctgactaag 7680 gagcagtgtt taaactgcta gccgccagcg gcttgacccg ctgtggtcgc ggcggcttgg 7740 ttgttactga gacagcggta aaaatagtca aatttcacaa ccggaccttc accctgggac 7800 ctgtgaattt aaaagtggcc agtgaggttg agctaaaaga cgcggttgag cacaaccaac 7860 acccggttgc gagaccgatc gatggtggag ttgtgctcct gcgttccgcg gttccttcgc 7920 ttatagacgt cttgatctcc ggtgctgatg catctcccaa gttacttgcc catcatgggc 7980 cgggaaacac tgggatcgat ggcacgctct gggattttga gtccgaagcc actaaagagg 8040 aagtcgcact cagtgcgcaa ataatacagg cttgtgacat caggcgcggc gatgctccta 8100 aaattggtct cccttacaaa ctgtaccctg ttaggggtaa ccctgagcgg gtgaaaggag 8160 ttctgcagaa tacaaggttt ggagacatac cttacaaaac ccccagtgac actggaagcc 8220 cagtgcacgc ggctgcctgc cttacgccca acgccactcc ggtgactgac gggcgctccg 8280 tcttggccac gaccatgccc cccgggtttg agttatatgt accgaccata ccagcgtctg 8340 tccttgatta ccttgactct aggcctgact gcccaaaaca gctgacagag cacggctgcg 8400 aagatgccgc actgaaagac ctctctaaat atgacttgtc cacccaaggc tttgttttac 8460 ctggagtcct tcgccttgtg cggaaatacc tgtttgccca tgtaggtaag tgcccacccg 8520 ttcatcggcc ttctacttac cctgctaaga attctatggc tgggataaat gggaacaggt 8580 tcccaaccaa ggacattcag agcgtccctg aaatcgacgt tctgtgcgca caggctgtgc 8640 gagaaaactg gcaaactgtc accccttgta ctctcaagaa acagtattgc gggaagaaga 8700 agactaggac catactcggc accaataact tcatcgcact agcccaccga gcagcgttga 8760 gtggtgttac ccagggtttc atgaaaaagg cgtttaactc tcccatcgcc ctcggaaaga 8820 acaagttcaa ggagctacag acttcggtcc tgggcaggtg ccttgaagct gatctcgcat 8880 cctgcgatcg atccacgcct gcaattgtcc gctggtttgc cgccaacctt ctttatgaac 8940 ttgcctgtgc tgaagagcat ctaccgtcgt acgtgctgaa ctgctgccac gacttactgg 9000 tcacgcagtc cggcgcggtg actaagagag gtggcctgtc gtctggcgac ccgatcacct 9060 ctgtgtctaa caccatttat agtttggtga tctatgcaca gcatatggtg cttagttact 9120 tcaagagtgg tcacccccat ggcctcctgt tcttacaaga ccagctgaag tttgaggaca 9180 tgctcaaggt ccaacccctg atcgtctatt cggacgacct cgtgctgtat gccgagtctc 9240 ccaccatgcc aaactatcac tggtgggttg aacatctgaa tttgatgctg gggtttcaga 9300 cggacccaaa gaagacagca ataacagact cgccatcatt tctaggctgt agaataataa 9360 atgggcgcca gctagtcccc aaccgtgaca ggatcctcgc ggccctcgcc tatcacatga 9420 aggcgagcaa tgtttctgaa tactatgcct cagcggctgc aatactcatg gacagctgtg 9480 cttgtttgga gtatgatcct gaatggtttg aagaacttgt agtcggaata gcgcagtgcg 9540 cccgcaagga cggctacagc tttcccggca cgccgttctt catgtccatg tgggagaaac 9600 tcaggtccaa ttatgagggg aagaagtcga gagtgtgcgg gtactgcggg gccccggccc 9660 cgtacgctac tgcctgtggc ctcgacgtct gcatttacca cacccacttc caccagcatt 9720 gtccagtcac aatctggtgt ggtcatccag cgggttctgg ttcttgtagt gagtgcaaat 9780 cccctgtagg gaaaggcaca agccctttag acgaagtgct ggaacaagtc ccgtataagc 9840 ccccacggac cgtcatcatg catgtggagc agggtctcac cccccttgat ccaggtagat 9900 accaaactcg ccgcggatta gtctctgtca ggcgtggaat taggggaaat gaagttgaac 9960 taccagacgg tgattatgct agcaccgcct tgctccctac ctgcaaagag atcaacatgg 10020 tcgctgtcgc ttccaatgta ttgcgcagca ggttcatcat cggcccaccc ggtgctggga 10080 aaacatactg gctccttcaa caggtccagg atggtgatgt tatttacaca ccaactcacc 10140 agaccatgct tgacatgatt agggctttgg gaacgtgccg gttcaacgtc ccggctggca 10200 caacgctgca attccccgtc ccctcccgca ccggtccgtg ggttcgcatc ctagccggcg 10260 gttggtgtcc tggcaagaat tccttcctag atgaagcagc gtattgcaac caccttgatg 10320 ttttgaggct tcttagtaaa actaccctca cctgtctagg agacttcaag caactccacc 10380 cagtgggttt tgactctcat tgctatgttt ttgacatcat gcctcaaact caactgaaga 10440 ccatctggag gtttggacag aatatctgtg atgccattca gccagattac agggacaaac 10500 tcatgtctat ggtcaacaca acccgtgtga cctacgtgga aaaacctgtc aggtatgggc 10560 aggtcctcac cccctaccac agggaccgag aggacgacgc catcactatt gattccagtc 10620 aaggtgccac attcgatgtg gttacattgc atttgcccac taaagattca ctcaacaggc 10680 aaagagccct tgttgccatc accagggcaa gacacgctat ctttgtgtat gacccgcaca 10740 ggcagctgca gggcctgttt gatcttcctg caaaaggcac acccgtcaac ctcgcagtgc 10800 accgcgacgg gcagctgatc gtgctggata gaaataacaa agaatgcacg gttgctcagg 10860 ctctaggcaa cggggataaa tttagggcca cagataagcg cgttgtagat tctctccgcg 10920 ccatttgtgc tgacctagaa gggtcgagct ctccgctccc caaggtcgca cacaacttgg 10980 gattttattt ctcacctgat ttaacacagt ttgctaaact cccagtagaa cttgcacctc 11040 actggcccgt ggtgacaacc cagaacaatg aaaagtggcc agatcggctg gttgccagcc 11100 ttcgccctat ccacaaatac agccgcgcgt gcatcggtgc cggctatatg gtgggccctt 11160 cggtgtttct aggcactcct ggggtcgtgt catactatct cacaaaattt gttaagggcg 11220 aggctcaatt gcttccggag acggttttca gcaccggccg aattgaggta gactgccggg 11280 aatatcttga tgatcgggag cgagaagttg ctgcgtccct cccacacgcc ttcattggcg 11340 acgtcaaagg cactaccgtt ggaggatgtc atcatgtcac ctccagatac ctcccgcgcg 11400 tccttcccaa ggaatcagtt gcggtagtcg gggtttcaag ccccggaaaa gccgcgaaag 11460 cattgtgcac actgacagat gtgtacctcc cagatcttga agcctatctc cacccggaga 11520 cccagtccaa gtgctggaaa atgatgttgg acttcaaaga agttcgacta atggtctgga 11580 gagacaaaac agcctatttc caacttgaag gtcgctattt cacctggtat cagcttgcca 11640 gctatgcctc gtacatccgt gttcctgtca actctacggt gtacttggac ccctgcatgg 11700 gccccgccct ttgcaacagg agagtcgtcg ggtccaccca ctggggggct gacctcgcgg 11760 ttacccctta tgattacggc gctaaaatca tcctgtctag cgcgtaccat ggtgaaatgc 11820 cccccggata caaaattctg gcgtgcgcgg agttctcgtt ggatgaccca gttaggtaca 11880 aacacacttg ggggtttgaa tcggatacag cgtatctgta tgagttcacc ggaaacggtg 11940 aggactggga ggattacaat gatgcgtttc gtgcgcgcca ggaagggaaa atttacaagg 12000 ccactgccac cagcttgaag tttcattttc ccccgggccc tgtcattgaa ccaactttag 12060 gcctgaattg aaatgaaatg gggtccatgc aaagcctttt tgacaaaatt ggccaacttt 12120 ttgtggatgc tttcacggag ttcttggtgt ccattgttga tatcattata tttttggcca 12180 ttttgtttgg cttcaccatc gccggttggt tggtggtcct ttgcatcaga ttggtttgct 12240 ccgcgatact ccgtacgcgc cctgccattc actctgagca attacagaag atcttatgag 12300 gcctttcttt cccagtgcca agtggacatt cccacctggg gaactaaaca tcctttgggg 12360 atgctttggc accataaggt gtcaaccttg atagatgaaa tggtgtcgcg tcgaatgtac 12420 cgcatcatgg aaaaatcagg gcaggctgcc tggaaacagg tggtgagcga ggctacactg 12480 tctcgcatta gtagtttgga tgtggtggct cattttcagc atctagccgc cattgaagcc 12540 gagacctgca aatatttggc ctcccggctg cccatgctac acaacctgcg catgacaggt 12600 tcaaatgtaa ccatagtgta taatagcact ttgaatcagg tgtttgctat ttttccaacc 12660 cctggttccc gaccaaagct tcatgatttt cagcaatggt taatagctgt acattcctcc 12720 atattttcct ctgttgcagc ttcttgtact ctttttgttg tgctgtggtt gcgggttcca 12780 attctacgta ctgtttttgg tttccgctgg ttaggggcaa tttttcattc gaactcacag 12840 tgaattacac ggtgtgtcca ccttgcctca cccggcaagc agccacagag atctacgaac 12900 ccggtaggtc tctttggtgc aggatagggc atgaccgatg tggggaggat gatcatgacg 12960 agctggggtt tatggtaccg cctggcctct ccagcgaagg ccacttgact agtgtttacg 13020 cctggttggc gttcttgtcc ttcagctaca cggcccagtt ccatcccgag atattcggga 13080 tagggaatgt gagtcgagtt tatgtcgaca tcaaacatca actcatctgc gccgaacatg 13140 acgggcagaa cgccaccttg tctcgtcatg acaatatttc agccgtgttt cagacctatt 13200 accaacatca agtcgacggc ggcaattggt ttcacctaga atggcttcgt cccttctttt 13260 cctcgtggtt ggttttaaat gtctcttggt ttctcaggcg ttcgcctgca aaccatgttt 13320 cagttcgagt cttgcagata ttgagaccaa caccaccgca gcggcaggct ttgctgtcct 13380 ccaagacatc agttgcctta ggcatcgcga ctcggcctct gaggcgattc gcaaaatccc 13440 tcagtgccgt acggcgatag ggacacccgt gtatgttacc atcacagcca atgtgacaga 13500 tgagaattat ttacattctt ctgatctcct catgctttct tcttgccttt tctatgcttc 13560 tgagatgagt gaaaagggat ttaaggtggt atttggcaat gtgtcaggca tcgtggctgt 13620 gtgtgtcaac tttaccagct atgtccaaca tgtcaaggag tttacccaac gctccctggt 13680 ggtcgaccat gtgcggttgc tccatttcat gacacctgag accatgaggt gggcaactgt 13740 tttagcctgt ctttttgcca ttctgttggc aatttgaatg tttaagtatg ttggagaaat 13800 gcttgaccgc gggctgttgc tcgcgattgc tttctttgtg gtgtatcgtg ccgttctgtt 13860 ttgctgtgct cgccaacgcc agcaacagca gcagctccca tctacagctg atttacaact 13920 tgacgttatg tgagctgaat ggcacagatt ggctagccaa cagatttgat tgggcagtgg 13980 agagttttgt catttttccc gttttgactc acattgtctc ctatggtgcc ctcaccacca 14040 gccattttct tgacacagtc gctttagtca ctgtgtctac cgccgggttt gttcacgggc 14100 ggtatgtcct aagtagcatc tacgcggtct gtgccctggc tgcgttgact tgctttgtca 14160 ttaggtttgc aaagaattgc atgtcctggc gctatgcgtg caccagatat accaactttc 14220 ttttggacac taagggcaga ctctatcgtt ggcggtcgcc cgtcatcata gagaaaaggg 14280 gcaaagttga ggtcgaaggt catctgatcg acctcaaaag agttgtgctt gatggttccg 14340 tggcaacccc tataaccaga gtttcagcgg aacaatgggg tcgtccttag atgacttctg 14400 tcatgatagc acggctccac aaaaggtgct cttggcgttc tctattacct acacgccagt 14460 gatgatatat gccctgaagg tgagtcgcgg ccgactgcta gggcttttgc accttttgat 14520 cttcctgaat tgtgctttca ccttcgggta catgactttc acgcactttc agagtacaaa 14580 taaggtcgcg ctcactatgg gagcagtagt tgcactcctt tggggggtgt actcagccat 14640 agaaacctgg aaattcatca cctccagatg ccgtttgtgc ttgctaggcc gcaagtacat 14700 tctggcccct gcccaccacg ttgaaagtgc cgcaggcttt catccgattg cggcaaatga 14760 taaccacgca tttgtcgtcc ggcgtcccgg ctccactacg gtcaacggca cattggtgcc 14820 cgggttgaaa agcctcgtgt tgggtggcag aaaagctgtt aagcagggag tggtaaacct 14880 tgtcaaatat gccaaataac aacggcaagc agcagaagag aaagaagggg gatggccagc 14940 cagtcaatca gctgtgccag atgctgggta agatcatcgc tcagcaaaac cagtccagag 15000 gcaagggacc gggaaagaaa aataagaaga aaaacccgga gaagccccat tttcctctag 15060 cgactgaaga tgatgtcaga catcacttta cccccagtga gcggcaattg tgtctgtcgt 15120 caatccagac cgcctttaat caaggcgctg ggacttgcac cctgtcagat tcagggagga 15180 taagttacac tgtggagttt agtttgccta cgcatcatac tgtgcgcctg atccgcgtca 15240 cagcatcacc ctcagcatga tgggctggca ttcttgaggc atctcagtgt ttgaattgga 15300 agaatgtgtg gtgaatggca ctgattgaca ttgtgcctct aagtcaccta ttcaattagg 15360 gcgaccgtgt gggggtgaga tttaattggc gagaaccatg cggccgaaat taaaaaaaaa 15420 aaaaaaaa 15428 //