ID AF039204; SV 1; linear; genomic RNA; STD; VRL; 15000 BP. XX AC AF039204; XX DT 11-MAY-1998 (Rel. 55, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 4) XX DE Grapevine leafroll-associated virus 2 methyltransferase/helicase DE polyprotein gene, partial cds; and RNA-dependent RNA polymerase, putative DE transmembrane small hydrophobic protein, 65 kDa chaperone protein, 63 kDa DE protein, 25 kDa diverged coat protein, 22 kDa coat protein, 19 kDa protein, DE and 24 kDa protein genes, complete cds. XX KW . XX OS Grapevine leafroll-associated virus 2 OC Viruses; Riboviria; Closteroviridae; Closterovirus. XX RN [1] RP 1-15000 RX PUBMED; 9603345. RA Zhu H.Y., Ling K.S., Goszczynski D.E., McFerson J.R., Gonsalves D.; RT "Nucleotide sequence and genome organization of grapevine RT leafroll-associated virus-2 are similar to beet yellows virus, the RT closterovirus type member"; RL J. Gen. Virol. 79(Pt 5):1289-1298(1998). XX RN [2] RP 1-15000 RA Zhu H.Y., Ling K.S., Gonsalves D.; RT ; RL Submitted (18-DEC-1997) to the INSDC. RL Plant Pathology, Cornell University, New York State Agricultural Experiment RL Station, Geneva, NY 14456, USA XX DR MD5; 52a4aaf40ec0826df20424760d85627e. DR EuropePMC; PMC3588190; 23467405. XX FH Key Location/Qualifiers FH FT source 1..15000 FT /organism="Grapevine leafroll-associated virus 2" FT /isolate="Pinot Noir" FT /mol_type="genomic RNA" FT /db_xref="taxon:64003" FT CDS <1..7423 FT /codon_start=2 FT /product="methyltransferase/helicase polyprotein" FT /function="replication and unknown functions" FT /note="larger than 277 kDa; ORF1a; contains domains for two FT papain-like leader proteases, a methyltransferase and a FT helicase; identified by sequence comparison" FT /db_xref="GOA:O71209" FT /db_xref="InterPro:IPR002588" FT /db_xref="InterPro:IPR008749" FT /db_xref="InterPro:IPR027351" FT /db_xref="InterPro:IPR027417" FT /db_xref="UniProtKB/TrEMBL:O71209" FT /protein_id="AAC40855.1" FT /translation="ADYVAMLRYVCGGKFPLVLMSRVIYPDGRCYLAHMRYLCAFYCRP FT FRESDYALGMWPTVARLRACVEKNFGVEACGIALRGYYTSRNVYHCDYDSAYVKYFRNL FT SGRIGGGSFDPTSLTSVITVKISGLPGGLPKNIAFGAFLCDIRYVEPVDSGGIQSSVKT FT KREDAHRTVEERAAGGSVEQPRQKRIDEKGCGRVPSGGFSHLLVGNLNEVRRKVAAGLL FT RFRVGGDMDFHRSFSTQAGHRLLVWRRSSRSVCLELYSPSKNFLRYDVLPCSGDYAAMF FT SFAAGGRFPLVLMTRIRYPNGFCYLAHCRYACAFLLRGFDPKRFDIGAFPTAAKLRNRM FT VSELGERSLGLNLYGAYTSRGVFHCDYDAKFIKDLRLMSAVIAGKDGVEEVVPSDITPA FT MKQKTIEAVYDRLYGGTDSLLKLSIEKDLIDFKNDVQSLKKDRPIVKVPFYMSEATQNS FT LTRFYPQFELKFSHSSHSDHPAAAASRLLENETLVRLCGNSVSDIGGCPLFHLHSKTQR FT RVHVCRPVLDGKDAQRRVVRDLQYSNVRLGDDDKILEGPRNIDICHYPLGACDHESSAM FT MMVQVYDASLYEICGAMIKKKSRITYLTMVTPGEFLDGRECVYMESLDCEIEVDVHADV FT VMYKFGSSCYSHKLSIIKDIMTTPYLTLGGFLFSVEMYEVRMGVNYFKITKSEVSPSIS FT CTKLLRYRRANSDVVKVKLPRFDKKRRMCLPGYDTIYLDSKFVSRVFDYVVCNCSAVNS FT KTFEWVWSFIKSSKSRVIISGKIIHKDVNLDLKYVESFAAVMLASGVRSRLASEYLAKN FT LSHFSGDCSFIEATSFVLREKIRNMTLNFNERLLQLVKRVAFATLDVSFLDLDSTLESI FT TDFAECKVAIELDELGCLRAEAENEKIRNLAGDSIAAKLASEIVVDIDSKPSPKQVGNS FT SSENADKREVQRPGLRGGSRNGVVGEFLHFVVDSALRLFKYATDQQRIKSYVRFLDSAV FT SFLDYNYDNLSFILRVLSEGYSCMFAFLANRGDLSSRVRSAVCAVKEVATSCANASVSK FT AKVMITFAAAVCAMMFNSCGFSGDGREYKSYIHRYTQVLFDTIFFEDSSYLPIEVLSSA FT ICGAIVTLFSSGSSISLNAFLLQITKGFSLEVVVRNVVRVTHGLSTTATDGVIRGVFSQ FT IVSHLLVGNTGNVAYQSAFIAGVVPLLVKKCVSLIFILREDTYSGFIKHGISEFSFLSS FT ILKFLKGKLVDELKSIIQGVFDSNKHVFKEATQEAIRTTVMQVPVAVVDALKSAAGKIY FT NNFTSRRTFGKDEGSSSDGACEEYFSCDEGEGPGLKGGSSYGFSILAFFSRIMWGARRL FT IVKVKHECFGKLFEFLSLKLHEFRTRVFGKNRTDVGVYDFLPTGIVETLSSIEECDQIE FT ELLGDDLKGDKDASLTDMNYFEFSEDFLASIEEPPFAGLRGGSKNIAILAILEYAHNLF FT RIVASKCSKRPLFLAFAELSSALIEKFKEVFPRKSQLVAIVREYTQRFLRSRMRALGLN FT NEFVVKSFADLLPALMKRKVSGSFLASVYRPLRGFSYMCVSAERREKFFALVCLIGLSL FT PFFVRIVGAKACEELVSSARRFYERIKIFLRQKYVSLSNFFCHLFSSDVDDSSASAGLK FT GGASRMTLFHLLVRLASALLSLGWEGLKLLLSHHNLLFLCFALVDDVNVLIKVLGGLSF FT FVQPIFSLFAAMLLQPDRFVEYSEKLVTAFEFFLKCSPRAPALLKGFFECVANSTVSKT FT VRRLLRCFVKMLKLRKGRGLRADGRGLHRQKAVPVIPSNRVVTDGVERLSVKMQGVEAL FT RTELRILEDLDSAVIEKLNRRRNRDTNDDEFTRPAHEQMQEVTTFCSKANSAGLALERA FT VLVEDAIKSEKLSKTVNEMVRKGSTTSEEVAVALSDDEAVEEISVADERDDSPKTVRIS FT EYLNRLNSSFEFPKPIVVDDNKDTGGLTNAVREFYYMQELALFEIHSKLCTYYDQLRIV FT NFDRSVAPCSEDAQLYVRKNGSTIVQGKEVRLHIKDFHDHDFLFDGKISINKRRRGGNV FT LYHDNLAFLASNLFLAGYPFSRSFVFTNSSVDILLYEAPPGGGKTTTLIDSFLKVFKKG FT EVSTMILTANKSSQVEILKKVEKEVSNIECQKRKDKRSPKKSIYTIDAYLMHHRGCDAD FT VLFIDECFMVHAGSVLACIEFTRCHKVMIFGDSRQIHYIERNELDKCLYGDLDRFVDLQ FT CRVYGNISYRCPWDVCAWLSTVYGNLIATVKGESEGKSSMRINEINSVDDLVPDVGSTF FT LCMLQSEKLEISKHFIRKGLTKLNVLTVHEAQGETYARVNLVRLKFQEDEPFKSIRHIT FT VALSRHTDSLTYNVLAARRGDATCDAIQKAAELVNKFRVFPTSFGGSVINLNVKKDVED FT NSRCKASSAPLSVINDFLNEVNPGTAVIDFGDLSADFSTGPFECGASGIVVRDNISSSN FT ITDHDKQRV" FT CDS <7422..8801 FT /codon_start=1 FT /product="RNA-dependent RNA polymerase" FT /function="replication" FT /note="RdRp; 52 kDa; similar to RNA polymerases of other FT closteroviruses; presumably expressed via +1 ribosomal FT frameshift" FT /db_xref="GOA:O71210" FT /db_xref="InterPro:IPR001788" FT /db_xref="InterPro:IPR007094" FT /db_xref="UniProtKB/TrEMBL:O71210" FT /protein_id="AAC40856.1" FT /translation="SVVRSQAIPRRKPSLQENLYSFEARNYNFSTCDRNTSASMFGEAM FT AMNCLRRCFDLDAFSSLRDDVISITRSGIEQWLEKRTPSQIKALMKDVESPLEIDDEIC FT RFKLMVKRDAKVKLDSSCLTKHSAAQNIMFHRKSINAIFSPIFNEVKNRIMCCLKPNIK FT FFTEMTNRDFASVVSNMLGDDDVYHIGEVDFSKYDKSQDAFVKAFEEVMYKELGVDEEL FT LAIWMCGERLSIANTLDGQLSFTIENQRKSGASNTWIGNSLVTLGILSLYYDVRNFEAL FT YISGDDSLIFSRSEISNYADDICTDMGFETKFMSPSVPYFCSKFVVMCGHKTFFVPDPY FT KLFVKLGAVKEDVSMDFLFETFTSFKDLTSDFNDERLIQKLAELVALKYEVQTGNTTLA FT LSVIHCLRSNFLSFSKLYPRVKGWQVFYTSVKKALLKSGCSLFDSFMTPFGQAVMVWDD FT E" FT CDS 8865..9035 FT /codon_start=1 FT /product="putative transmembrane small hydrophobic protein" FT /note="6 kDa; probably membrane-associated; similar to FT small hydrophobic proteins of other closteroviruses" FT /db_xref="GOA:O39853" FT /db_xref="UniProtKB/TrEMBL:O39853" FT /protein_id="AAC40857.1" FT /translation="MNQVLQFECLFLLNLAVFAVTFIFILLVFRVIKSFRQKGHEAPVP FT VVRGGGFSTVV" FT CDS 9051..10850 FT /codon_start=1 FT /product="65 kDa chaperone protein" FT /note="p65; HSP70; similar to heat shock 70 proteins; FT identified by sequence comparison" FT /db_xref="GOA:O71211" FT /db_xref="InterPro:IPR013126" FT /db_xref="InterPro:IPR018181" FT /db_xref="InterPro:IPR029047" FT /db_xref="UniProtKB/TrEMBL:O71211" FT /protein_id="AAC40858.1" FT /translation="MVVFGLDFGTTFSTVCVYKDGRVFSFKQNNSAYIPTYLYLFSDSN FT HMTFGYEAESLMSNLKVKGSFYRDLKRWVGCDSSNLDAYLDRLKPHYSVRLVKIGSGLN FT ETVSIGNFGGTVKSEAHLPGLIALFIKAVISCAEGAFACTCTGVICSVPANYDSVQRNF FT TDQCVSLSGYQCVYMINEPSAAALSACNSIGKKSANLAVYDFGGGTFDVSIISYRNNTF FT VVRASGGDLNLGGRDVDRAFLTHLFSLTSLEPDLTLDISNLKESLSKTDAEIVYTLRGV FT DGRKEDVRVNKNILTSVMLPYVNRTLKILESTLKSYAKSMNESARVKCDLVLIGGSSYL FT PGLADVLTKHQSVDRILRVSDPRAAVAVGCALYSSCLSGSGGLLLIDCAAHTVAIADRS FT CHQIICAPAGAPIPFSGSMPLYLARVNKNSQREVAVFEGEYVKCPKNRKICGANIRFFD FT IGVTGDSYAPVTFYMDFSISSVGAVSFVVRGPEGKQVSLTGTPAYNFSSVALGSRSVRE FT LHISLNNKVFLGLLLHRKADRRILFTKDEAIRYADSIDIADVLKEYKSYAASALPPDED FT VELLLGKSVQKVLRGSRLEEIPL" FT CDS 10777..12432 FT /codon_start=1 FT /product="63 kDa protein" FT /note="p63; putative heat shock protein 90 homolog" FT /db_xref="InterPro:IPR004909" FT /db_xref="UniProtKB/TrEMBL:O71212" FT /protein_id="AAC40859.1" FT /translation="MSNYSWESLFKKFYGEADWKKYLSRSIAAHSSEIKTLPDIRLYGG FT RVVKKSEFESALPNSFEQELGLFILSEREVGWSKLCGITVEEAAYDLTNPKAYKFTAET FT CSPDVKGEGQKYSMEDVMNFMRLSNLDVNDKMLTEQCWSLSNSCGELINPDDKGRFVAL FT TFKDRDTADDTGAANVECRVGDYLVYAMSLFEQRTQKSQSGNISLYEKYCEYIRTYLGS FT TDLFFTAPDRIPLLTGILYDFCKEYNVFYSSYKRNVDNFRFFLANYMPLISDVFVFQWV FT KPAPDVRLLFELSAAELTLEVPTLSLIDSQVVVGHILRYVESYTSDPAIDALEDKLEAI FT LKSSNPRLSTAQLWVGFFCYYGEFRTAQSRVVQRPGVYKTPDSVGGFEINMKDVEKFFD FT KLQRELPNVSLRRQFNGARAHEAFKIFKNGNISFRPISRLNVPREFWYLNIDYFRHANR FT SGLTEEEILILNNISVDVRKLCAERACNTLPSAKRFSKNHKSNIQSSRQERRIKDPLVV FT LKDTLYEFQHKRAGWGSRSTRDLGSRADHAKGSG" FT CDS 12344..13015 FT /codon_start=1 FT /product="25 kDa diverged coat protein" FT /note="p25; CPd; coat protein duplicate" FT /db_xref="GOA:O39856" FT /db_xref="InterPro:IPR002679" FT /db_xref="UniProtKB/TrEMBL:O39856" FT /protein_id="AAC40860.1" FT /translation="MSSNTSVPVGGLEALETSGVVLTTRKEAVDKFFNELKNENYSSVD FT SSRLSDSEVKEVLEKSKESFKSELASTDEHFVYHIIFFLIRCAKISTSEKVKYVGSHTY FT VVDGKTYTVLDAWVFNMMKSLTKKYKRVNGLRAFCCACEDLYLTVAPIMSERFKTKAVG FT MKGLPVGKEYLGADFLSGTSKLMSDHDRAVSIVAAKNAVDRSAFTGGERKIVSLYDLGR FT Y" FT CDS 13084..13680 FT /codon_start=1 FT /product="22 kDa coat protein" FT /note="p22" FT /db_xref="GOA:O71213" FT /db_xref="InterPro:IPR002679" FT /db_xref="UniProtKB/TrEMBL:O71213" FT /experiment="experimental evidence, no additional details FT recorded" FT /protein_id="AAC40861.1" FT /translation="MELMSDSNLSNLVITDASSLNGVDKKLLSAEVEKMLVQKGAPNEG FT IEVVFGLLLYALAARTTSPKVQRADSDVIFSNSFGERNVVVTEGDLKKVLDGCAPLTRF FT TNKLRTFGRTFTEAYVDFCIAYKHKLPQLNAAAELGIPAEDSYLAADFLGTCPKLSELQ FT QSRKMFASMYALKTEGGVVNTPVSNLRQLGRREVM" FT CDS 13680..14165 FT /codon_start=1 FT /product="19 kDa protein" FT /note="p19" FT /db_xref="UniProtKB/TrEMBL:O39858" FT /protein_id="AAC40862.1" FT /translation="MEDYEEKSESLILLRTNLNTMLLVVKSDASVELPKLLICGYLRVS FT GRGEVTCCNREELTRDFEGNHHTVIRSRIIQYDSESAFEEFNNSDCVVKFFLETGSVFW FT FFLRSETKGRAVRHLRTFFEANNFFFGSHCGTMEYCLKQVLTETESIIDSFCEERNR" FT CDS 14167..14784 FT /codon_start=1 FT /product="24 kDa protein" FT /note="p24" FT /db_xref="InterPro:IPR021575" FT /db_xref="InterPro:IPR021742" FT /db_xref="UniProtKB/TrEMBL:O71214" FT /protein_id="AAC40863.1" FT /translation="MRVIVSPYEAEDILKRSTDMLRNIDSGVLSTKECIKAFSTITRDL FT HCAKASYQWGVDTGLYQRNCAEKRLIDTVESNIRLAQPLVREKVAVHFCKDEPKELVAF FT ITRKYVELTGVGVREAVKREMRSLTKTVLNKMSLEMAFYMSPRAWKNAEWLELKFSPVK FT IFRDLLLDVETLNELCAEDDVHVDKVNENGDENHDLELQDEC" FT 3'UTR 14785..15000 FT /note="similar to 3'UTRs of other monopartite FT closteroviruses" XX SQ Sequence 15000 BP; 3877 A; 3050 C; 3820 G; 4253 T; 0 other; ggcggattac gtggcgatgc tgcgttatgt gtgtggcggg aaatttccac tcgtcctcat 60 gagtagagtt atttacccgg atgggcgctg ttacttggcc catatgaggt atttgtgcgc 120 cttttactgt cgcccgttta gagagtcgga ttatgccctc ggaatgtggc ctacggtggc 180 gcgtctcagg gcatgcgttg agaagaactt cggtgtcgaa gcttgtggca tagctcttcg 240 tggctattac acctctcgca atgtttatca ctgtgattat gactctgctt atgtaaaata 300 ttttagaaac ctttccggcc gcattggcgg tggttcgttc gatccgacat ctttaacctc 360 cgtaataacg gtgaagatta gcggtcttcc aggtggtctt cctaaaaata tagcgtttgg 420 tgccttcctg tgcgatatac gttacgtcga accggtagac tcgggcggca ttcaatcgag 480 cgttaagacg aaacgtgaag atgcgcaccg aaccgtagag gaacgggcgg ccggcggatc 540 cgtcgagcaa ccgcgacaaa agaggataga tgagaaaggt tgcggcagag ttcctagtgg 600 aggtttttcg catctcctgg tcggcaacct taacgaagtt aggaggaagg tagctgccgg 660 acttctacgc tttcgcgttg gcggtgatat ggattttcat cgctcgttct ccacccaagc 720 gggccaccgc ttgctggtgt ggcgccgctc gagccggagc gtgtgccttg aactttactc 780 accatctaaa aactttttgc gttacgatgt cttgccctgt tctggagact atgcagcgat 840 gttttctttc gcggcgggcg gccgtttccc tttagttttg atgactagaa ttagataccc 900 gaacgggttt tgttacttgg ctcactgccg gtacgcgtgc gcgtttctct taaggggttt 960 tgatccgaag cgtttcgaca tcggtgcttt ccccaccgcg gccaagctca gaaaccgtat 1020 ggtttcggag cttggtgaaa gaagtttagg tttgaacttg tacggcgcat atacgtcacg 1080 cggcgtcttt cactgcgatt atgacgctaa gtttataaag gatttgcgtc ttatgtcagc 1140 agttatagct ggaaaggacg gggtggaaga ggtggtacct tctgacataa ctcctgccat 1200 gaagcagaaa acgatcgaag ccgtgtatga tagattatat ggcggcactg actcgttgct 1260 gaaactgagc atcgagaaag acttaatcga tttcaaaaat gacgtgcaga gtttgaagaa 1320 agatcggccg attgtcaaag tgccctttta catgtcggaa gcaacacaga attcgctgac 1380 gcgtttctac cctcagttcg aacttaagtt ttcgcactcc tcgcattcag atcatcccgc 1440 cgccgccgct tctagactgc tggaaaatga aacgttagtg cgcttatgtg gtaatagcgt 1500 ttcagatatt ggaggttgtc ctcttttcca tttgcattcc aagacgcaaa gacgggttca 1560 cgtatgtagg cctgtgttgg atggcaagga tgcgcagcgt cgcgtggtgc gtgatttgca 1620 gtattccaac gtgcgtttgg gagacgatga taaaattttg gaagggccac gcaatatcga 1680 catttgccac tatcctctgg gcgcgtgtga ccacgaaagt agtgctatga tgatggtgca 1740 ggtgtatgac gcgtcccttt atgagatatg tggcgccatg atcaagaaga aaagccgcat 1800 aacgtactta accatggtca cgcccggcga gtttcttgac ggacgcgaat gcgtctacat 1860 ggagtcgtta gactgtgaga ttgaagttga tgtgcacgcg gacgtcgtaa tgtacaaatt 1920 cggtagttct tgctattcgc acaagctttc aatcatcaag gacatcatga ccactccgta 1980 cttgacacta ggtggttttc tattcagcgt ggagatgtat gaggtgcgta tgggcgtgaa 2040 ttacttcaag attacgaagt ccgaagtatc gcctagcatt agctgcacca agctcctgag 2100 ataccgaaga gctaatagtg acgtggttaa agttaaactt ccacgtttcg ataagaaacg 2160 tcgcatgtgt ctgcctgggt atgacaccat atacctagat tcgaagtttg tgagtcgcgt 2220 tttcgattat gtcgtgtgta attgctctgc cgtgaactca aaaactttcg agtgggtgtg 2280 gagtttcatt aagtctagta agtcgagggt gattattagc ggtaaaataa ttcacaagga 2340 tgtgaatttg gacctcaagt acgtcgagag tttcgccgcg gttatgttgg cctctggcgt 2400 gcgcagtaga ctagcgtccg agtaccttgc taagaacctt agtcattttt cgggagattg 2460 ctcctttatt gaagccacgt ctttcgtgtt gcgtgagaaa atcagaaaca tgactctgaa 2520 ttttaacgaa agacttttac agttagtgaa gcgcgttgcc tttgcgacct tggacgtgag 2580 ttttctagat ttagattcaa ctcttgaatc aataactgat tttgccgagt gtaaggtagc 2640 gattgaactc gacgagttgg gttgcttgag agcggaggcc gagaatgaaa aaatcaggaa 2700 tctggcggga gattcgattg cggctaaact cgcgagcgag atagtggtcg atattgactc 2760 taagccttca ccgaagcagg tgggtaattc gtcatccgaa aacgccgata agcgggaagt 2820 tcagaggccc ggtttgcgtg gtggttctag aaacggggtt gttggggagt tccttcactt 2880 cgtcgtggat tctgccttgc gtcttttcaa atacgcgacg gatcaacaac ggatcaagtc 2940 ttacgtgcgt ttcttggact cggcggtctc attcttggat tacaactacg ataatctatc 3000 gtttatactg cgagtgcttt cggaaggtta ttcgtgtatg ttcgcgtttt tggcgaatcg 3060 cggcgactta tctagtcgtg tccgtagcgc ggtgtgtgct gtgaaagaag ttgctacctc 3120 atgcgcgaac gcgagcgttt ctaaagccaa ggttatgatt accttcgcag cggccgtgtg 3180 tgctatgatg tttaatagct gcggtttttc aggcgacggt cgggagtata aatcgtatat 3240 acatcgttac acgcaagtat tgtttgacac tatctttttt gaggacagca gttacctacc 3300 catagaagtt ctgagttcgg cgatatgcgg tgctatcgtc acacttttct cctcgggctc 3360 gtccataagt ttaaacgcct tcttacttca aattaccaaa ggattctccc tagaggttgt 3420 cgtccggaat gttgtgcgag tcacgcatgg tttgagcacc acagcgaccg acggcgtcat 3480 acgtggggtt ttctcccaaa ttgtgtctca cttacttgtt ggaaatacgg gtaatgtggc 3540 ttaccagtca gctttcattg ccggggtggt gcctctttta gttaaaaagt gtgtgagctt 3600 aatcttcatc ttgcgtgaag atacttattc cggttttatt aagcacggaa tcagtgaatt 3660 ctctttcctt agtagtattc tgaagttctt gaagggtaag cttgtggacg agttgaaatc 3720 gattattcaa ggggtttttg attccaacaa gcacgtgttt aaagaagcta ctcaggaagc 3780 gattcgtacg acggtcatgc aagtgcctgt cgctgtagtg gatgccctta agagcgccgc 3840 gggaaaaatt tataacaatt ttactagtcg acgtaccttt ggtaaggatg aaggctcctc 3900 tagcgacggc gcatgtgaag agtatttctc atgcgacgaa ggtgaaggtc cgggtctgaa 3960 agggggttcc agctatggct tctcaatttt agcgttcttt tcacgcatta tgtggggagc 4020 tcgtcggctt attgttaagg tgaagcatga gtgttttggg aaactttttg aatttctatc 4080 gctcaagctt cacgaattca ggactcgcgt ttttgggaag aatagaacgg acgtgggagt 4140 ttacgatttt ttgcccacgg gcatcgtgga aacgctctca tcgatagaag agtgcgacca 4200 aattgaagaa cttctcggcg acgacctgaa aggtgacaag gatgcttcgt tgaccgatat 4260 gaattacttt gagttctcag aagacttctt agcctctatc gaggagccgc ctttcgctgg 4320 attgcgagga ggtagcaaga acatcgcgat tttggcgatt ttggaatacg cgcataattt 4380 gtttcgcatt gtcgcaagca agtgttcgaa acgaccttta tttcttgctt tcgccgaact 4440 ctcaagcgcc cttatcgaga aatttaagga ggttttccct cgtaagagcc agctcgtcgc 4500 tatcgtgcgc gagtatactc agagattcct ccgaagtcgc atgcgtgcgt tgggtttgaa 4560 taacgagttc gtggtaaaat ctttcgccga tttgctaccc gcattaatga agcggaaggt 4620 ttcaggttcg ttcttagcta gtgtttatcg cccacttaga ggtttctcat atatgtgtgt 4680 ttcagcggag cgacgtgaaa agttttttgc tctcgtgtgt ttaatcgggt taagtctccc 4740 tttcttcgtg cgcatcgtag gagcgaaagc gtgcgaagaa ctcgtgtcct cagcgcgtcg 4800 cttttatgag cgtattaaaa tttttctaag gcagaagtat gtctctcttt ctaatttctt 4860 ttgtcacttg tttagctctg acgttgatga cagttccgca tctgcagggt tgaaaggtgg 4920 tgcgtcgcga atgacgctct tccaccttct ggttcgcctt gctagtgccc tcctatcgtt 4980 agggtgggaa gggttaaagc tactcttatc gcaccacaac ttgttatttt tgtgttttgc 5040 attggttgac gatgtgaacg tccttatcaa agttcttggg ggtctttctt tctttgtgca 5100 accaatcttt tccttgtttg cggcgatgct tctacaaccg gacaggtttg tggagtattc 5160 cgagaaactt gttacagcgt ttgaattttt cttaaaatgt tcgcctcgcg cgcctgcact 5220 actcaaaggg ttttttgagt gcgtggcgaa cagcactgtg tcaaaaaccg ttcgaagact 5280 tcttcgctgt ttcgtgaaga tgctcaaact tcgaaaaggg cgagggttgc gtgcggatgg 5340 taggggtctc catcggcaga aagccgtacc cgtcatacct tctaatcggg tcgtgaccga 5400 cggggttgaa agactttcgg taaagatgca aggagttgaa gcgttgcgta ccgaattgag 5460 aatcttagaa gatttagatt ctgccgtgat cgaaaaactc aatagacgca gaaatcgtga 5520 cactaatgac gacgaattta cgcgccctgc tcatgagcag atgcaagaag tcaccacttt 5580 ctgttcgaaa gccaactctg ctggtttggc cctggaaagg gcagtgcttg tggaagacgc 5640 tataaagtcg gagaaacttt ctaagacggt taatgagatg gtgaggaaag ggagtaccac 5700 cagcgaagaa gtggccgtcg ctttgtcgga cgatgaagcc gtggaagaaa tctctgttgc 5760 tgacgagcga gacgattcgc ctaagacagt caggataagc gaatacctaa ataggttaaa 5820 ctcaagcttc gaattcccga agcctattgt tgtggacgac aacaaggata ccgggggtct 5880 aacgaacgcc gtgagggagt tttattatat gcaagaactt gctcttttcg aaatccacag 5940 caaactgtgc acctactacg atcaactgcg catagtcaac ttcgatcgtt ccgtagcacc 6000 atgcagcgaa gatgctcagc tgtacgtacg gaagaacggc tcaacgatag tgcagggtaa 6060 agaggtacgt ttgcacatta aggatttcca cgatcacgat ttcctgtttg acggaaaaat 6120 ttctattaac aagcggcggc gaggcggaaa tgttttatat cacgacaacc tcgcgttctt 6180 ggcgagtaat ttgttcttag ccggctaccc cttttcaagg agcttcgtct tcacgaattc 6240 gtcggtcgat attctcctct acgaagctcc acccggaggt ggtaagacga cgacgctgat 6300 tgactcgttc ttgaaggtct tcaagaaagg tgaggtttcc accatgatct taaccgccaa 6360 caaaagttcg caggttgaga tcctaaagaa agtggagaag gaagtgtcta acattgaatg 6420 ccagaaacgt aaagacaaaa gatctccgaa aaagagcatt tacaccatcg acgcttattt 6480 aatgcatcac cgtggttgtg atgcagacgt tcttttcatc gatgagtgtt tcatggttca 6540 tgcgggtagc gtactagctt gcattgagtt cacgaggtgt cataaagtaa tgatcttcgg 6600 ggatagccgg cagattcact acattgaaag gaacgaattg gacaagtgtt tgtatgggga 6660 tctcgacagg ttcgtggacc tgcagtgtcg ggtttatggt aatatttcgt accgttgtcc 6720 atgggatgtg tgcgcttggt taagcacagt gtatggcaac ctaatcgcca ccgtgaaggg 6780 tgaaagcgaa ggtaagagca gcatgcgcat taacgaaatt aattcagtcg acgatttagt 6840 ccccgacgtg ggttccacgt ttctgtgtat gcttcagtcg gagaagttgg aaatcagcaa 6900 gcactttatt cgcaagggtt tgactaaact taacgttcta acggtgcatg aggcgcaagg 6960 tgagacgtat gcgcgtgtga accttgtgcg acttaagttt caggaggatg aaccctttaa 7020 atctatcagg cacataaccg tcgctctttc tcgtcacacc gacagcttaa cttataacgt 7080 cttagctgct cgtcgaggtg acgccacttg cgatgccatc cagaaggctg cggaattggt 7140 gaacaagttt cgcgtttttc ctacatcttt tggtggtagt gttatcaatc tcaacgtgaa 7200 gaaggacgtg gaagataaca gtaggtgcaa ggcttcgtcg gcaccattga gcgtaatcaa 7260 cgactttttg aacgaagtta atcccggtac tgcggtgatt gattttggtg atttgtccgc 7320 ggacttcagt actgggcctt ttgagtgcgg tgccagcggt attgtggtgc gggacaacat 7380 ctcctccagc aacatcactg atcacgataa gcagcgtgtt tagcgtagtt cggtcgcagg 7440 cgattccgcg tagaaaacct tctctacaag aaaatttgta ttcgtttgaa gcgcggaatt 7500 ataacttctc gacttgcgac cgtaacacat ctgcttcaat gttcggagag gctatggcga 7560 tgaactgtct tcgtcgttgc ttcgacctag atgccttttc gtccctgcgt gatgatgtga 7620 ttagtatcac acgttcaggc atcgaacaat ggctggagaa acgtactcct agtcagatta 7680 aagcattaat gaaggatgtt gaatcgcctt tggaaattga cgatgaaatt tgtcgtttta 7740 agttgatggt gaagcgtgac gctaaggtga agttagactc ttcttgttta actaaacaca 7800 gcgccgctca aaatatcatg tttcatcgca agagcattaa tgctatcttc tctcctatct 7860 ttaatgaggt gaaaaaccga ataatgtgct gtcttaagcc taacataaag ttttttacgg 7920 agatgactaa cagggatttt gcttctgttg tcagcaacat gcttggtgac gacgatgtgt 7980 accatatagg tgaagttgat ttctcaaagt acgacaagtc tcaagatgct ttcgtgaagg 8040 cttttgaaga agtaatgtat aaggaactcg gtgttgatga agagttgctg gctatctgga 8100 tgtgcggcga gcggttatcg atagctaaca ctctcgatgg tcagttgtcc ttcacgatcg 8160 agaatcaaag gaagtcggga gcttcgaaca cttggattgg taactctctc gtcactttgg 8220 gtattttaag tctttactac gacgttagaa atttcgaggc gttgtacatc tcgggcgatg 8280 attctttaat tttttctcgc agcgagattt cgaattatgc cgacgacata tgcactgaca 8340 tgggttttga gacaaaattt atgtccccaa gtgtcccgta cttttgttct aaatttgttg 8400 ttatgtgtgg tcataagacg ttttttgttc ccgacccgta caagcttttt gtcaagttgg 8460 gagcagtcaa agaggatgtt tcaatggatt tccttttcga gacttttacc tcctttaaag 8520 acttaacctc cgattttaac gacgagcgct taattcaaaa gctcgctgaa cttgtggctt 8580 taaaatatga ggttcaaacc ggcaacacca ccttggcgtt aagtgtgata cattgtttgc 8640 gttcgaattt cctctcgttt agcaagttat atcctcgcgt gaagggatgg caggtttttt 8700 acacgtcggt taagaaagcg cttctcaaga gtgggtgttc tctcttcgac agtttcatga 8760 ccccttttgg tcaggctgtc atggtttggg atgatgagta gcgctaactt gtgcgcagtt 8820 tctttgttcg tgacatacac cttgtgtgtc accgtgcgtt tataatgaat caggttttgc 8880 agtttgaatg tttgtttctg ctgaatctcg cggtttttgc tgtgactttc attttcattc 8940 ttctggtctt ccgcgtgatt aagtcttttc gccagaaggg tcacgaagca cctgttcccg 9000 ttgttcgtgg cgggggtttt tcaaccgtag tgtagtcaaa agacgcgcat atggtagttt 9060 tcggtttgga ctttggcacc acattctcta cggtgtgtgt gtacaaggat ggacgagttt 9120 tttcattcaa gcagaataat tcggcgtaca tccccactta cctctatctc ttctccgatt 9180 ctaaccacat gacttttggt tacgaggccg aatcactgat gagtaatctg aaagttaaag 9240 gttcgtttta tagagattta aaacgttggg tgggttgcga ttcgagtaac ctcgacgcgt 9300 accttgaccg tttaaaacct cattactcgg tccgcttggt taagatcggc tctggcttga 9360 acgaaactgt ttcaattgga aacttcgggg gcactgttaa gtctgaggct catctgccag 9420 ggttgatagc tctctttatt aaggctgtca ttagttgcgc ggagggcgcg tttgcgtgca 9480 cttgcaccgg ggttatttgt tcagtacctg ccaattatga tagcgttcaa aggaatttca 9540 ctgatcagtg tgtttcactc agcggttatc agtgcgtata tatgatcaat gaaccttcag 9600 cggctgcgct atctgcgtgt aattcgattg gaaagaagtc cgcaaatttg gctgtttacg 9660 atttcggtgg tgggaccttc gacgtgtcta tcatttcata ccgcaacaat acttttgttg 9720 tgcgagcttc tggaggcgat ctaaatctcg gtggaaggga tgttgatcgt gcgtttctca 9780 cgcacctctt ctctttaaca tcgctggaac ctgacctcac tttggatatc tcgaatctga 9840 aagaatcttt atcaaaaacg gacgcagaga tagtttacac tttgagaggt gtcgatggaa 9900 gaaaagaaga cgttagagta aacaaaaaca ttcttacgtc ggtgatgctc ccctacgtga 9960 acagaacgct taagatatta gagtcaacct taaaatcgta tgctaagagt atgaatgaga 10020 gtgcgcgagt taagtgcgat ttagtgctga taggaggatc ttcatatctt cctggcctgg 10080 cagacgtact aacgaagcat cagagcgttg atcgtatctt aagagtttcg gatcctcggg 10140 ctgccgtggc cgtcggttgc gcattatatt cttcatgcct ctcaggatct ggggggttgc 10200 tactgatcga ctgtgcagct cacactgtcg ctatagcgga cagaagttgt catcaaatca 10260 tttgcgctcc agcgggggca ccgatcccct tttcaggaag catgcctttg tacttagcca 10320 gggtcaacaa gaactcgcag cgtgaagtcg ccgtgtttga aggggagtac gttaagtgcc 10380 ctaagaacag aaagatctgt ggagcaaata taagattttt tgatatagga gtgacgggtg 10440 attcgtacgc acccgttacc ttctatatgg atttctccat ttcaagcgta ggagccgttt 10500 cattcgtggt gagaggtcct gagggtaagc aagtgtcact cactggaact ccagcgtata 10560 acttttcgtc tgtggctctc ggatcacgca gtgtccgaga attgcatatt agtttaaata 10620 ataaagtttt tctcggtttg cttctacata gaaaggcgga tcgacgaata cttttcacta 10680 aggatgaagc gattcgatac gccgattcaa ttgatatcgc ggatgtgcta aaggaatata 10740 aaagttacgc ggccagtgcc ttaccaccag acgaggatgt cgaattactc ctgggaaagt 10800 ctgttcaaaa agttttacgg ggaagcagac tggaagaaat acctctctag gagcatagca 10860 gcacactcaa gtgaaattaa aactctacca gacattcgat tgtacggcgg tagggttgta 10920 aagaagtccg aattcgaatc agcacttcct aattcttttg aacaggaatt aggactgttc 10980 atactgagcg aacgggaagt gggatggagc aaattatgcg gaataacggt ggaagaagca 11040 gcatacgatc ttacgaatcc caaggcttat aaattcactg ccgagacatg tagcccggat 11100 gtaaaaggtg aaggacaaaa atactctatg gaagacgtga tgaatttcat gcgtttatca 11160 aatctggatg ttaacgacaa gatgctgacg gaacagtgtt ggtcgctgtc caattcatgc 11220 ggtgaattga tcaacccaga cgacaaaggg cgattcgtgg ctctcacctt taaggacaga 11280 gacacagctg atgacacggg tgccgccaac gtggaatgtc gcgtgggcga ctatctagtt 11340 tacgctatgt ccctgtttga gcagaggacc caaaaatcgc agtctggcaa catctctctg 11400 tacgaaaagt actgtgaata catcaggacc tacttaggga gtacagacct gttcttcaca 11460 gcgccggaca ggattccgtt acttacgggc atcctatacg atttttgtaa ggaatacaac 11520 gttttctact cgtcatataa gagaaacgtc gataatttca gattcttctt ggcgaattat 11580 atgcctttga tatctgacgt ctttgtcttc cagtgggtaa aacccgcgcc ggatgttcgg 11640 ctgctttttg agttaagtgc agcggaacta acgctggagg ttcccacact gagtttgata 11700 gattctcaag ttgtggtagg tcatatctta agatacgtag aatcctacac atcagatcca 11760 gccatcgacg cgttagaaga caaactggaa gcgatactga aaagtagcaa tccccgtcta 11820 tcgacagcgc aactatgggt tggtttcttt tgttactatg gtgagtttcg tacggctcaa 11880 agtagagtag tgcaaagacc aggcgtatac aaaacacctg actcagtggg tggatttgaa 11940 ataaacatga aagatgttga gaaattcttc gataaacttc agagagaatt gcctaatgta 12000 tctttgcggc gtcagtttaa cggagctaga gcgcatgagg ctttcaaaat atttaaaaac 12060 ggaaatataa gtttcagacc tatatcgcgt ttaaacgtgc ctagagagtt ctggtatctg 12120 aacatagact acttcaggca cgcgaatagg tccgggttaa ccgaagaaga aatactcatc 12180 ctaaacaaca taagcgttga tgttaggaag ttatgcgctg agagagcgtg caatacccta 12240 cctagcgcga agcgctttag taaaaatcat aagagtaata tacaatcatc acgccaagag 12300 cggaggatta aagacccatt ggtagtcctg aaagacactt tatatgagtt ccaacacaag 12360 cgtgccggtt gggggtctcg aagcactcga gacctcggga gtcgtgctga ccacgcgaaa 12420 ggaagcggtt gataagtttt ttaatgaact aaaaaacgaa aattactcat cagttgacag 12480 cagccgatta agcgattcgg aagtaaaaga agtgttagag aaaagtaaag aaagtttcaa 12540 aagcgaactg gcctccactg acgagcactt cgtctaccac attatatttt tcttaatccg 12600 atgtgctaag atatcgacaa gtgaaaaggt gaagtacgtt ggtagtcata cgtacgtggt 12660 cgacggaaaa acgtacaccg ttcttgacgc ttgggtattc aacatgatga aaagtctcac 12720 gaagaagtac aaacgagtga atggtctgcg tgcgttctgt tgcgcgtgcg aagatctata 12780 tctaaccgtc gcaccaataa tgtcagaacg ctttaagact aaagccgtag ggatgaaagg 12840 tttgcctgtt ggaaaggaat acttaggcgc cgactttctt tcgggaacta gcaaactgat 12900 gagcgatcac gacagggcgg tctccatcgt tgcagcgaaa aacgctgtcg atcgtagcgc 12960 tttcacgggt ggggagagaa agatagttag tttgtatgat ctagggaggt actaagcacg 13020 gtgtgctata gtgcgtgcta taataataaa cactagtgct taagtcgcgc agaagaaaac 13080 gctatggagt tgatgtccga cagcaacctt agcaacctgg tgataaccga cgcctctagt 13140 ctaaatggtg tcgacaagaa gcttttatct gctgaagttg aaaaaatgtt ggtgcagaaa 13200 ggggctccta acgagggtat agaagtggtg ttcggtctac tcctttacgc actcgcggca 13260 agaaccacgt ctcctaaggt tcagcgcgca gattcagacg ttatattttc aaatagtttc 13320 ggagagagga atgtggtagt aacagagggt gaccttaaga aggtactcga cgggtgtgcg 13380 cctctcacta ggttcactaa taaacttaga acgttcggtc gtactttcac tgaggcttac 13440 gttgactttt gtatcgcgta taagcacaaa ttaccccaac tcaacgccgc ggcggaattg 13500 gggattccag ctgaagattc gtacttagct gcagattttc tgggtacttg cccgaagctc 13560 tctgaattac agcaaagtag gaagatgttc gcgagtatgt acgctctaaa aactgaaggt 13620 ggagtggtaa atacaccagt gagcaatctg cgtcagctag gtagaaggga agttatgtaa 13680 tggaagatta cgaagaaaaa tccgaatcgc tcatactgct acgcacgaat ctgaacacta 13740 tgcttttagt ggtcaagtcc gatgctagtg tagagctgcc taaactacta atttgcggtt 13800 acttacgagt gtcaggacgt ggggaggtga cgtgttgcaa ccgtgaggaa ttaacaagag 13860 attttgaggg caatcatcat acggtgatcc gttctagaat catacaatat gacagcgagt 13920 ctgcttttga ggaattcaac aactctgatt gcgtagtgaa gtttttccta gagactggta 13980 gtgtcttttg gtttttcctt cgaagtgaaa ccaaaggtag agcggtgcga catttgcgca 14040 ccttcttcga agctaacaat ttcttctttg gatcgcattg cggtaccatg gagtattgtt 14100 tgaagcaggt actaactgaa actgaatcta taatcgattc tttttgcgaa gaaagaaatc 14160 gttaagatga gggttatagt gtctccttat gaagctgaag acattctgaa aagatcgact 14220 gacatgttac gaaacataga cagtggggtc ttgagcacta aagaatgtat caaggcattc 14280 tcgacgataa cgcgagacct acattgtgcg aaggcttcct accagtgggg tgttgacact 14340 gggttatatc agcgtaattg cgctgaaaaa cgtttaattg acacggtgga gtcaaacata 14400 cggttggctc aacctctcgt gcgtgaaaaa gtggcggttc atttttgtaa ggatgaacca 14460 aaagagctag tagcattcat cacgcgaaag tacgtggaac tcacgggcgt gggagtgaga 14520 gaagcggtga agagggaaat gcgctctctt accaaaacag ttttaaataa aatgtctttg 14580 gaaatggcgt tttacatgtc accacgagcg tggaaaaacg ctgaatggtt agaactaaaa 14640 ttttcacctg tgaaaatctt tagagatctg ctattagacg tggaaacgct caacgaattg 14700 tgcgccgaag atgatgttca cgtcgacaaa gtaaatgaga atggggacga aaatcacgac 14760 ctcgaactcc aagacgaatg ttaaacattg gttaagttta acgaaaatga ttagtaaata 14820 ataaatcgaa cgtgggtgta tctacctgac gtatcaactt aagctgttac tgagtaatta 14880 aaccaacaag tgttggtgta atgtgtatgt tgatgtagag aaaaatccgt ttgtagaacg 14940 gtgtttttct cttctttatt tttaaaaaaa aaataaaaaa aaaaaaaaaa aagcggccgc 15000 //