ID AF013254; SV 1; linear; genomic RNA; STD; VRL; 15225 BP. XX AC AF013254; XX DT 06-NOV-1997 (Rel. 53, Created) DT 15-APR-2005 (Rel. 83, Last updated, Version 3) XX DE Human respiratory syncytial virus wildtype strain B1, complete genome. XX KW . XX OS Human orthopneumovirus OC Viruses; Riboviria; Negarnaviricota; Haploviricotina; Monjiviricetes; OC Mononegavirales; Pneumoviridae; Orthopneumovirus. XX RN [1] RP 1-15225 RX DOI; 10.1073/pnas.94.25.13961. RX PUBMED; 9391135. RA Karron R.A., Buonagurio D.A., Georgiu A.F., Whitehead S.S., Adamus J.E., RA Clements-Mann M.L., Harris D.O., Randolph V.B., Udem S.A., Murphy B.R., RA Sidhu M.S.; RT "Respiratory syncytial virus (RSV) SH and G proteins are not essential for RT viral replication in vitro: clinical evaluation and molecular RT characterization of a cold-passaged, attenuated RSV subgroup B mutant"; RL Proc. Natl. Acad. Sci. U.S.A. 94(25):13961-13966(1997). XX RN [2] RP 1-15225 RA Sidhu M.S., Udem S.A., Murphy B.R.; RT ; RL Submitted (09-JUL-1997) to the INSDC. RL Viral Vaccine Research, Wyeth-Lederle Vaccines and Pediatrics, 401 N. RL Middletown Rd., Pearl River, NY 10965, USA XX DR MD5; 3e20c242438b416f2f3eed278f9b4450. DR EuropePMC; PMC113024; 10559287. DR EuropePMC; PMC1168771; 15994810. DR EuropePMC; PMC1182632; 16051861. DR EuropePMC; PMC135799; 11773385. DR EuropePMC; PMC140824; 12502814. DR EuropePMC; PMC154614; 12454129. DR EuropePMC; PMC2045289; 17609323. DR EuropePMC; PMC21170; 9671772. DR EuropePMC; PMC212764; 10835365. DR EuropePMC; PMC2668480; 19224988. DR EuropePMC; PMC2700353; 18603323. DR EuropePMC; PMC2737834; 19506055. DR EuropePMC; PMC28415; 9391135. DR EuropePMC; PMC3168431; 21915262. DR EuropePMC; PMC3188560; 21998661. DR EuropePMC; PMC3618235; 23577109. DR EuropePMC; PMC3667090; 23734183. DR EuropePMC; PMC3700225; 23698290. DR EuropePMC; PMC3996061; 24564922. DR EuropePMC; PMC4240712; 25415360. DR EuropePMC; PMC4368745; 25793751. DR EuropePMC; PMC4804761; 26407694. DR EuropePMC; PMC525014; 15542640. DR EuropePMC; PMC5625381; 28747373. DR EuropePMC; PMC5661434; 29085762. DR EuropePMC; PMC5694888; 28948867. DR EuropePMC; PMC6423049; 30886248. DR EuropePMC; PMC6464112; 27062995. DR EuropePMC; PMC6466036; 30717190. DR EuropePMC; PMC6519394; 31139579. XX FH Key Location/Qualifiers FH FT source 1..15225 FT /organism="Human orthopneumovirus" FT /strain="B1" FT /mol_type="genomic RNA" FT /note="wildtype" FT /db_xref="taxon:11250" FT CDS 99..518 FT /codon_start=1 FT /gene="NS1" FT /product="non-structural protein 1" FT /db_xref="GOA:O42083" FT /db_xref="InterPro:IPR005099" FT /db_xref="UniProtKB/Swiss-Prot:O42083" FT /protein_id="AAB82429.1" FT /translation="MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAA FT IHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGL FT MDDNCEIKFSKRLSDSVMTNYMNQISDLLGLDLNS" FT CDS 626..1000 FT /codon_start=1 FT /gene="NS2" FT /product="non-structural protein 2" FT /db_xref="GOA:O42038" FT /db_xref="InterPro:IPR004336" FT /db_xref="UniProtKB/Swiss-Prot:O42038" FT /protein_id="AAB82430.1" FT /translation="MSTTNDNTTMQRLMITDMRPLSMDSIITSLTKEIITHKFIYLINN FT ECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHGGFLE FT CIGIKPTKHTPIIYKYDLNP" FT CDS 1140..2315 FT /codon_start=1 FT /gene="N" FT /product="nucleocapsid protein" FT /db_xref="GOA:O42053" FT /db_xref="InterPro:IPR004930" FT /db_xref="UniProtKB/Swiss-Prot:O42053" FT /protein_id="AAB82431.1" FT /translation="MALSKVKLNDTLNKDQLLSSSKYTIQRSTGDNIDTPNYDVQKHLN FT KLCGMLLITEDANHKFTGLIGMLYAMSRLGREDTIKILKDAGYHVKANGVDITTYRQDI FT NGKEMKFEVLTLSSLTSEIQVNIEIESRKSYKKMLKEMGEVAPEYRHDSPDCGMIILCI FT AALVITKLAAGDRSGLTAVIRRANNVLKNEIKRYKGLIPKDIANSFYEVFEKHPHLIDV FT FVHFGIAQSSTRGGSRVEGIFAGLFMNAYGSGQVMLRWGVLAKSVKNIMLGHASVQAEM FT EQVVEVYEYAQKLGGEAGFYHILNNPKASLLSLTQFPNFSSVVLGNAAGLGIMGEYRGT FT PRNQDLYDAAKAYAEQLKENGVINYSVLDLTAEELEAIKNQLNPKEDDVEL" FT CDS 2348..3073 FT /codon_start=1 FT /gene="P" FT /product="phosphoprotein" FT /db_xref="GOA:O42062" FT /db_xref="InterPro:IPR003487" FT /db_xref="InterPro:IPR018247" FT /db_xref="UniProtKB/Swiss-Prot:O42062" FT /protein_id="AAB82432.1" FT /translation="MEKFAPEFHGEDANNKATKFLESIKGKFASSKDPKKKDSIISVNS FT IDIEVTKESPITSGTNIINPTSEADSTPETKANYPRKPLVSFKEDLTPSDNPFSKLYKE FT TIETFDNNEEESSYSYEEINDQTNDNITARLDRIDEKLSEILGMLHTLVVASAGPTSAR FT DGIRDAMVGLREEMIEKIRAEALMTNDRLEAMARLRNEESEKMAKDTSDEVPLNPTSKK FT LSDLLEDNDSDNDLSLDDF" FT CDS 3263..4033 FT /codon_start=1 FT /gene="M" FT /product="matrix protein" FT /db_xref="GOA:O42049" FT /db_xref="InterPro:IPR005056" FT /db_xref="UniProtKB/Swiss-Prot:O42049" FT /protein_id="AAB82433.1" FT /translation="METYVNKLHEGSTYTAAVQYNVLEKDDDPASLTIWVPMFQSSVPA FT DLLIKELASINILVKQISTPKGPSLRVTINSRSAVLAQMPSNFIISANVSLDERSKLAY FT DVTTPCEIKACSLTCLKVKSMLTTVKDLTMKTFNPTHEIIALCEFENIMTSKRVIIPTY FT LRPISVKNKDLNSLENIATTEFKNAITNAKIIPYAGLVLVITVTDNKGAFKYIKPQSQF FT IVDLGAYLEKESIYYVTTNWKHTATRFSIKPLED" FT CDS 4303..4500 FT /codon_start=1 FT /gene="SH" FT /product="small hydrophobic protein" FT /db_xref="GOA:O36632" FT /db_xref="InterPro:IPR005327" FT /db_xref="UniProtKB/Swiss-Prot:O36632" FT /protein_id="AAB82434.1" FT /translation="MGNTSITIEFTSKFWPYFTLIHMILTLISLLIIITIMIAILNKLS FT EHKTFCNNTLELGQMHQINT" FT CDS 4690..5589 FT /codon_start=1 FT /gene="G" FT /product="attachment glycoprotein" FT /db_xref="GOA:O36633" FT /db_xref="InterPro:IPR000925" FT /db_xref="UniProtKB/Swiss-Prot:O36633" FT /protein_id="AAB82435.1" FT /translation="MSKHKNQRTARTLEKTWDTLNHLIVISSCLYRLNLKSIAQIALSV FT LAMIISTSLIIAAIIFIISANHKVTLTTVTVQTIKNHTEKNITTYLTQVPPERVSSSKQ FT PTTTSPIHTNSATTSPNTKSETHHTTAQTKGRTTTSTQTNKPSTKPRLKNPPKKPKDDY FT HFEVFNFVPCSICGNNQLCKSICKTIPSNKPKKKPTIKPTNKPTTKTTNKRDPKTPAKT FT TKKETTTNPTKKPTLTTTERDTSTSQSTVLDTTTLEHTIQQQSLHSTTPENTPNSTQTP FT TASEPSTSNSTQNTQSHA" FT CDS 5666..7390 FT /codon_start=1 FT /gene="F" FT /product="fusion protein" FT /db_xref="GOA:O36634" FT /db_xref="InterPro:IPR000776" FT /db_xref="UniProtKB/Swiss-Prot:O36634" FT /protein_id="AAB82436.1" FT /translation="MELLIHRLSAIFLTLAINALYLTSSQNITEEFYQSTCSAVSRGYF FT SALRTGWYTSVITIELSNIKETKCNGTDTKVKLIKQELDKYKNAVTELQLLMQNTPAAN FT NRARREAPQYMNYTINTTKNLNVSISKKRKRRFLGFLLGVGSAIASGIAVSKVLHLEGE FT VNKIKNALLSTNKAVVSLSNGVSVLTSKVLDLKNYINNQLLPIVNQQSCRISNIETVIE FT FQQKNSRLLEINREFSVNAGVTTPLSTYMLTNSELLSLINDMPITNDQKKLMSSNVQIV FT RQQSYSIMSIIKEEVLAYVVQLPIYGVIDTPCWKLHTSPLCTTNIKEGSNICLTRTDRG FT WYCDNAGSVSFFPQADTCKVQSNRVFCDTMNSLTLPSEVSLCNTDIFNSKYDCKIMTSK FT TDISSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYY FT VNKLEGKNLYVKGEPIINYYDPLVFPSDEFDASISQVNEKINQSLAFIRRSDELLHNVN FT TGKSTTNIMITTIIIVIIVVLLSLIAIGLLLYCKAKNTPVTLSKDQLSGINNIAFSK" FT CDS 7618..8205 FT /codon_start=1 FT /gene="M2" FT /product="matrix protein 2" FT /note="Orf 1" FT /db_xref="GOA:O42050" FT /db_xref="InterPro:IPR000571" FT /db_xref="InterPro:IPR009452" FT /db_xref="InterPro:IPR036855" FT /db_xref="UniProtKB/Swiss-Prot:O42050" FT /protein_id="AAB82437.1" FT /translation="MSRRNPCKFEIRGHCLNGRRCHYSHNYFEWPPHALLVRQNFMLNK FT ILKSMDKSIDTLSEISGAAELDRTEEYALGIVGVLESYIGSINNITKQSACVAMSKLLI FT EINSDDIKKLRDNEEPNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKN FT TLDIHKSIIISNPKESTVNDQNDQTKNNDITG" FT CDS 8171..8443 FT /codon_start=1 FT /gene="M2" FT /product="matrix protein 2" FT /note="Orf 2" FT /db_xref="InterPro:IPR009969" FT /db_xref="UniProtKB/Swiss-Prot:O42047" FT /protein_id="AAB82438.1" FT /translation="MTKPKIMILPDKYPCSISSILISSESMIATFNHKNILQFNHNHLD FT NHQRLLNNIFDEIHWTPKNLLDATQQFLQHLNIPEDIYTIYILVS" FT CDS 8509..15009 FT /codon_start=1 FT /gene="L" FT /product="polymerase" FT /db_xref="GOA:O36635" FT /db_xref="InterPro:IPR003006" FT /db_xref="InterPro:IPR014023" FT /db_xref="InterPro:IPR025786" FT /db_xref="InterPro:IPR026890" FT /db_xref="InterPro:IPR039736" FT /db_xref="UniProtKB/Swiss-Prot:O36635" FT /protein_id="AAB82439.1" FT /translation="MDPIINGNSANVYLTDSYLKGVISFSECNALGSYLFNGPYLKNDY FT TNLISRQSPLLEHMNLKKLTITQSLISRYHKGELKLEEPTYFQSLLMTYKSMSSSEQIA FT TTNLLKKIIRRAIEISDVKVYAILNKLGLKEKDRVKPNNNSGDENSVLTTIIKDDILSA FT VESNQSYTNSDKNHSVNQNITIKTTLLKKLMCSMQHPPSWLIHWFNLYTKLNNILTQYR FT SNEVKSHGFILIDNQTLSGFQFILNQYGCIVYHKGLKKITTTTYNQFLTWKDISLSRLN FT VCLITWISNCLNTLNKSLGLRCGFNNVVLSQLFLYGDCILKLFHNEGFYIIKEVEGFIM FT SLILNITEEDQFRKRFYNSMLNNITDAAIKAQKNLLSRVCHTLLDKTVSDNIINGKWII FT LLSKFLKLIKLAGDNNLNNLSELYFLFRIFGHPMVDERQAMDAVRINCNETKFYLLSSL FT STLRGAFIYRIIKGFVNTYNRWPTLRNAIVLPLRWLNYYKLNTYPSLLEITENDLIILS FT GLRFYREFHLPKKVDLEMIINDKAISPPKDLIWTSFPRNYMPSHIQNYIEHEKLKFSES FT DRSRRVLEYYLRDNKFNECDLYNCVVNQSYLNNSNHVVSLTGKERELSVGRMFAMQPGM FT FRQIQILAEKMIAENILQFFPESLTRYGDLELQKILELKAGISNKSNRYNDNYNNYISK FT CSIITDLSKFNQAFRYETSCICSDVLDELHGVQSLFSWLHLTIPLVTIICTYRHAPPFI FT KDHVVNLNEVDEQSGLYRYHMGGIEGWCQKLWTIEAISLLDLISLKGKFSITALINGDN FT QSIDISKPVRLIEGQTHAQADYLLALNSLKLLYKEYAGIGHKLKGTETYISRDMQFMSK FT TIQHNGVYYPASIKKVLRVGPWINTILDDFKVSLESIGSLTQELEYRGESLLCSLIFRN FT IWLYNQIALQLRNHALCNNKLYLDILKVLKHLKTFFNLDSIDMALSLYMNLPMLFGGGD FT PNLLYRSFYRRTPDFLTEAIVHSVFVLSYYTGHDLQDKLQDLPDDRLNKFLTCVITFDK FT NPNAEFVTLMRDPQALGSERQAKITSEINRLAVTEVLSIAPNKIFSKSAQHYTTTEIDL FT NDIMQNIEPTYPHGLRVVYESLPFYKAEKIVNLISGTKSITNILEKTSAIDTTDINRAT FT DMMRKNITLLIRILPLDCNKDKRELLSLENLSITELSKYVRERSWSLSNIVGVTSPSIM FT FTMDIKYTTSTIASGIIIEKYNVNSLTRGERGPTKPWVGSSTQEKKTMPVYNRQVLTKK FT QRDQIDLLAKLDWVYASIDNKDEFMEELSTGTLGLSYEKAKKLFPQYLSVNYLHRLTVS FT SRPCEFPASIPAYRTTNYHFDTSPINHVLTEKYGDEDIDIVFQNCISFGLSLMSVVEQF FT TNICPNRIILIPKLNEIHLMKPPIFTGDVDIIKLKQVIQKQHMFLPDKISLTQYVELFL FT SNKALKSGSNINSNLILVHKMSDYFHNAYILSTNLAGHWILIIQLMKDSKGIFEKDWGE FT GYITDHMFINLNVFFNAYKTYLLCFHKGYGKAKLECDMNTSDLLCVLELIDSSYWKSMS FT KVFLEQKVIKYIVNQDTSLHRIKGCHSFKLWFLKRLNNAKFTVCPWVVNIDYHPTHMKA FT ILSYIDLVRMGLINVDKLTIKNKNKFNDEFYTSNLFYISYNFSDNTHLLTKQIRIANSE FT LEDNYNKLYHPTPETLENISLIPVKSNNSNKPKFCISGNTESIMMSTFSNKMHIKSSTV FT TTRFNYSKQDLYNLFPNVVIDRIIDHSGNTAKSNQLYITTSHQTSLVRNSASLYCMLPW FT HHVNRFNFVFSSTGCKISIEYILKDLKIKDPSCIAFIGEGAGNLLLRTVVELHPDIRYI FT YRSLKDCNDHSLPIEFLRLYNGHINIDYGENLTIPATDATNNIHWSYLHIKFAEPISIF FT VCDAELPVTANWSKIIIEWSKHVRKCKYCSSVNRCILIAKYHAQDDIDFKLDNITILKT FT YVCLGSKLKGSEVYLVLTIGPANILPVFDVVQNAKLIFSRTKNFIMPKKTDKESIDANI FT KSLIPFLCYPITKKGIKTSLSKLKSVVNGDILSYSIAGRNEVFSNKLINHKHMNILKWL FT DHVLNFRSAELNYNHLYMIESTYPYLSELLNSLTTNELKKLIKITGSVLYNLPNEQ" XX SQ Sequence 15225 BP; 5903 A; 2710 C; 2399 G; 4213 T; 0 other; acgcgaaaaa atgcgtacta caaacttgca cattcggaaa aaatggggca aataagaatt 60 tgataagtgc tatttaagtc taaccttttc aatcagaaat ggggtgcaat tcactgagca 120 tgataaaggt tagattacaa aatttatttg acaatgacga agtagcattg ttaaaaataa 180 catgttatac tgacaaatta attcttctga ccaatgcatt agccaaagca gcaatacata 240 caattaaatt aaacggtata gtttttatac atgttataac aagcagtgaa gtgtgccctg 300 ataacaacat tgtagtaaaa tctaacttta caacaatgcc aatattacaa aacggaggat 360 acatatggga attgattgag ttgacacact gctctcaatt aaacggtcta atggatgata 420 attgtgaaat caaattttct aaaagactaa gtgactcagt aatgactaat tatatgaatc 480 aaatatctga tttacttggg cttgatctca attcatgaat tatgtttagt ctaactcaat 540 agacatgtgt ttattaccat tttagttaat ataaaaactc atcaaaggga aatggggcaa 600 ataaactcac ctaatcaatc aaactatgag cactacaaat gacaacacta ctatgcaaag 660 attaatgatc acggacatga gacccctgtc gatggattca ataataacat ctctcaccaa 720 agaaatcatc acacacaaat tcatatactt gataaacaat gaatgtattg taagaaaact 780 tgatgaaaga caagctacat ttacattctt agtcaattat gagatgaagc tactgcacaa 840 agtagggagt accaaataca agaaatacac tgaatataat acaaaatatg gcactttccc 900 catgcctata tttatcaatc atggcgggtt tctagaatgt attggcatta agcctacaaa 960 acacactcct ataatataca aatatgacct caacccgtaa attccaacaa aaaaaaccaa 1020 cccaaccaaa ccaagctatt cctcaaacaa caatgctcaa tagttaagaa ggagctaatc 1080 cgttttagta attaaaaata aaagtaaagc caataacata aattggggca aatacaaaga 1140 tggctcttag caaagtcaag ttaaatgata cattaaataa ggatcagctg ctgtcatcca 1200 gcaaatacac tattcaacgt agtacaggag ataatattga cactcccaat tatgatgtgc 1260 aaaaacacct aaacaaacta tgtggtatgc tattaatcac tgaagatgca aatcataaat 1320 tcacaggatt aataggtatg ttatatgcta tgtccaggtt aggaagggaa gacactataa 1380 agatacttaa agatgctgga tatcatgtta aagctaatgg agtagatata acaacatatc 1440 gtcaagatat aaatggaaag gaaatgaaat tcgaagtatt aacattatca agcttgacat 1500 cagaaataca agtcaatatt gagatagaat ctagaaaatc ctacaaaaaa atgctaaaag 1560 agatgggaga agtggctcca gaatataggc atgattctcc agactgtggg atgataatac 1620 tgtgtatagc agcacttgta ataaccaaat tagcagcagg agacagatca ggtcttacag 1680 cagtaattag gagggcaaac aatgtcttaa aaaatgaaat aaaacgctac aagggtctca 1740 taccaaagga tatagctaac agtttttatg aagtgtttga aaaacaccct catcttatag 1800 atgtttttgt gcactttggc attgcacaat catcaacaag agggggtagt agagttgaag 1860 gaatctttgc aggattgttt atgaatgcct atggttcagg gcaagtaatg ctaagatggg 1920 gagttttagc caaatctgta aaaaatatca tgctaggtca tgctagtgtc caggcagaaa 1980 tggagcaagt tgtggaagtc tatgagtatg cacagaagtt gggaggagaa gctggattct 2040 accatatatt gaacaatcca aaagcatcat tgctgtcatt aactcaattt cctaacttct 2100 caagtgtggt cctaggcaat gcagcaggtc taggcataat gggagagtat agaggtacgc 2160 caagaaacca ggatctttat gatgcagcca aagcatatgc agagcaactc aaagaaaatg 2220 gagtaataaa ctacagtgta ttagacttaa cagcagaaga attggaagcc ataaagaatc 2280 aactcaaccc taaagaagat gatgtagagc tttaagttaa caaaaaatac ggggcaaata 2340 agtcaacatg gagaagtttg cacctgaatt tcatggagaa gatgcaaata acaaagctac 2400 caaattccta gaatcaataa agggcaagtt cgcatcatcc aaagatccta agaagaaaga 2460 tagcataata tctgttaact caatagatat agaagtaacc aaagagagcc cgataacatc 2520 tggcaccaac atcatcaatc caacaagtga agccgacagt accccagaaa ccaaagccaa 2580 ctacccaaga aaacccctag taagcttcaa agaagatctc accccaagtg acaacccttt 2640 ttctaagttg tacaaagaaa caatagaaac atttgataac aatgaagaag aatctagcta 2700 ctcatatgaa gagataaatg atcaaacaaa tgacaacatt acagcaagac tagatagaat 2760 tgatgaaaaa ttaagtgaaa tattaggaat gctccataca ttagtagttg caagtgcagg 2820 acccacttca gctcgcgatg gaataagaga tgctatggtt ggtctgagag aagaaatgat 2880 agaaaaaata agagcggaag cattaatgac caatgatagg ttagaggcta tggcaagact 2940 taggaatgag gaaagcgaaa aaatggcaaa agacacctca gatgaagtgc ctcttaatcc 3000 aacttccaaa aaattgagtg acttgttgga agacaacgat agtgacaatg atctgtcact 3060 tgatgatttt tgatcagtga tcaactcact cagcaatcaa caacatcaat aaaacagaca 3120 tcaatccatt gaatcaactg ccagaccgaa caaacaaatg tccgtcagcg gaaccaccaa 3180 ccaatcaatc aaccaactga tccatcagca acctgacgaa attaacaata tagtaacaaa 3240 aaaagaacaa gatggggcaa atatggaaac atacgtgaac aagcttcacg aaggctccac 3300 atacacagca gctgttcagt acaatgttct agaaaaagat gatgatcctg catcactaac 3360 aatatgggtg cctatgttcc agtcatctgt accagcagac ttgctcataa aagaacttgc 3420 aagcatcaac atactagtga agcagatctc tacgcccaaa ggaccttcac tacgagtcac 3480 gattaactca agaagtgctg tgctggctca aatgcctagt aatttcatca taagcgcaaa 3540 tgtatcatta gatgaaagaa gcaaattagc atatgatgta actacacctt gtgaaatcaa 3600 agcatgcagt ctaacatgct taaaagtgaa aagtatgtta actacagtca aagatcttac 3660 catgaagaca ttcaacccca ctcatgagat cattgctcta tgtgaatttg aaaatattat 3720 gacatcaaaa agagtaataa taccaaccta tctaagacca attagtgtca aaaacaagga 3780 tctgaactca ctagaaaaca tagcaaccac cgaattcaaa aatgctatca ccaatgcgaa 3840 aattattccc tatgctggat tagtattagt tatcacagtt actgacaata aaggagcatt 3900 caaatatatc aagccacaga gtcaatttat agtagatctt ggtgcctacc tagaaaaaga 3960 gagcatatat tatgtgacta ctaattggaa gcatacagct acacgttttt caatcaaacc 4020 actagaggat taaatttaat tatcaacact gaatgacagg tccacatata tcctcaaact 4080 acacactata tccaaacatc atgaacatct acactacaca cttcatcaca caaaccaatc 4140 ccactcaaaa tccaaaatca ctaccagcca ctatctgcta gacctagagt gcgaataggt 4200 aaataaaacc aaaatatggg gtaaatagac attagttaga gttcaatcaa tctcaacaac 4260 catttatacc gccaattcaa tacatatact ataaatctta aaatgggaaa tacatccatc 4320 acaatagaat tcacaagcaa attttggccc tattttacac taatacatat gatcttaact 4380 ctaatctctt tactaattat aatcactatt atgattgcaa tactaaataa gctaagtgaa 4440 cataaaacat tctgtaacaa tactcttgaa ctaggacaga tgcatcaaat caacacatag 4500 tgctctacca tcatgctgtg tcaaattata atcctgtata tataaacaaa caaatccaat 4560 cttctcacag agtcatggtg tcgcaaaacc acgccaacta tcatggtagc atagagtagt 4620 tatttaaaaa ttaacataat gatgaattat tagtatggga tcaaaaacaa cattggggca 4680 aatgcaacca tgtccaaaca caagaatcaa cgcactgcca ggactctaga aaagacctgg 4740 gatactctca atcatctaat tgtaatatcc tcttgtttat acagattaaa tttaaaatct 4800 atagcacaaa tagcactatc agttctggca atgataatct caacctctct cataattgca 4860 gccataatat tcatcatctc tgccaatcac aaagttacac taacaacggt cacagttcaa 4920 acaataaaaa accacactga aaaaaacatc accacctacc ttactcaagt cccaccagaa 4980 agggttagct catccaaaca acctacaacc acatcaccaa tccacacaaa ttcagccaca 5040 acatcaccca acacaaagtc agaaacacac cacacaacag cacaaaccaa aggcagaacc 5100 accacctcaa cacagaccaa caagccgagc acaaaaccac gcctaaaaaa tccaccaaaa 5160 aaaccaaaag atgattacca ttttgaagtg ttcaacttcg ttccctgtag tatatgtggc 5220 aacaatcaac tttgcaaatc catctgtaaa acaataccaa gcaacaaacc aaagaagaaa 5280 ccaaccatca aacccacaaa caaaccaacc accaaaacca caaacaaaag agacccaaaa 5340 acaccagcca aaacgacgaa aaaagaaact accaccaacc caacaaaaaa accaaccctc 5400 acgaccacag aaagagacac cagcacctca caatccactg tgctcgacac aaccacatta 5460 gaacacacaa tccaacagca atccctccac tcaaccaccc ccgaaaacac acccaactcc 5520 acacaaacac ccacagcatc cgagccctct acatcaaatt ccacccaaaa tacccaatca 5580 catgcttagt tattcaaaaa ctacatctta gcagaaaacc gtgacctatc aagcaagaac 5640 gaaattaaac ctggggcaaa taaccatgga gctgctgatc cacaggttaa gtgcaatctt 5700 cctaactctt gctattaatg cattgtacct cacctcaagt cagaacataa ctgaggagtt 5760 ttaccaatcg acatgtagtg cagttagcag aggttatttt agtgctttaa gaacaggttg 5820 gtataccagt gtcataacaa tagaattaag taatataaaa gaaaccaaat gcaatggaac 5880 tgacactaaa gtaaaactta taaaacaaga attagataag tataagaatg cagtgacaga 5940 attacagcta cttatgcaaa acacaccagc tgccaacaac cgggccagaa gagaagcacc 6000 acagtatatg aactatacaa tcaataccac taaaaaccta aatgtatcaa taagcaagaa 6060 gaggaaacga agatttctgg gcttcttgtt aggtgtagga tctgcaatag caagtggtat 6120 agctgtatcc aaagttctac accttgaagg agaagtgaac aagatcaaaa atgctttgtt 6180 atctacaaac aaagctgtag tcagtctatc aaatggggtc agtgttttaa ccagcaaagt 6240 gttagatctc aagaattaca taaataacca attattaccc atagtaaatc aacagagctg 6300 tcgcatctcc aacattgaaa cagttataga attccagcag aagaacagca gattgttgga 6360 aatcaacaga gaattcagtg tcaatgcagg tgtaacaaca cctttaagca cttacatgtt 6420 aacaaacagt gagttactat cattgatcaa tgatatgcct ataacaaatg atcagaaaaa 6480 attaatgtca agcaatgttc agatagtaag gcaacaaagt tattctatca tgtctataat 6540 aaaggaagaa gtccttgcat atgttgtaca gctacctatc tatggtgtaa tagatacacc 6600 ttgctggaaa ttacacacat cacctctatg caccaccaac atcaaagaag gatcaaatat 6660 ttgtttaaca aggactgata gaggatggta ttgtgataat gcaggatcag tatccttctt 6720 tccacaggct gacacttgta aagtacagtc caatcgagta ttttgtgaca ctatgaacag 6780 tttgacatta ccaagtgaag tcagcctttg taacactgac atattcaatt ccaagtatga 6840 ctgcaaaatt atgacatcaa aaacagacat aagcagctca gtaattactt ctcttggagc 6900 tatagtgtca tgctatggta aaactaaatg cactgcatcc aacaaaaatc gtgggattat 6960 aaagacattt tctaatggtt gtgactatgt gtcaaacaaa ggagtagata ctgtgtcagt 7020 gggcaacact ttatactatg taaacaagct ggaaggcaag aacctttatg taaaagggga 7080 acctataata aattactatg accctctagt gtttccttct gatgagtttg atgcatcaat 7140 atctcaagtc aatgaaaaaa tcaatcaaag tttagctttt attcgtagat ctgatgaatt 7200 actacataat gtaaatactg gcaaatctac tacaaatatt atgataacta caattattat 7260 agtaatcatt gtagtattgt tatcattaat agctattggt ttgctgttgt attgcaaagc 7320 caaaaacaca ccagttacac taagcaaaga ccaactaagt ggaatcaata atattgcatt 7380 cagcaaatag acaaaaaacc acctgatcat gtttcaacaa cagtctgctg atcaccaatc 7440 ccaaatcaac ccataacaaa cacttcaaca tcacagtaca ggctgaatca tttcttcaca 7500 tcatgctacc cacacaacta agctagatcc ttaactcata gttacataaa aacctcaagt 7560 atcacaatca aacactaaat caacacatca ttcacaaaat taacagctgg ggcaaatatg 7620 tcgcgaagaa atccttgtaa atttgagatt agaggtcatt gcttgaatgg tagaagatgt 7680 cactacagtc ataattactt tgaatggcct cctcatgcct tactagtgag gcaaaacttc 7740 atgttaaaca agatactcaa gtcaatggac aaaagcatag acactttgtc tgaaataagt 7800 ggagctgctg aactggacag aacagaagaa tatgctcttg gtatagttgg agtgctagag 7860 agttacatag gatctataaa caacataaca aaacaatcag catgtgttgc tatgagtaaa 7920 cttcttattg agatcaatag tgatgacatt aaaaagctga gagataatga agaacccaat 7980 tcacctaaga taagagtgta caatactgtt atatcataca ttgagagcaa tagaaaaaac 8040 aacaagcaaa caatccatct gctcaaaaga ctaccagcag acgtgctgaa gaagacaata 8100 aaaaacacat tagatatcca caaaagcata atcataagca acccaaaaga gtcaaccgtg 8160 aatgatcaaa atgaccaaac caaaaataat gatattaccg gataaatatc cttgtagtat 8220 atcatccata ttgatttcaa gtgaaagcat gattgctaca ttcaatcata aaaacatatt 8280 acaatttaac cataaccatt tggataacca ccagcgttta ttaaataata tatttgatga 8340 aattcattgg acacctaaaa acttattaga tgccactcaa caatttctcc aacatcttaa 8400 catccctgaa gatatatata caatatatat attagtgtca taatgcttgg ccataacgat 8460 tctatatcat ccaaccataa aactatctta ataaggttat gggacaaaat ggatcccatt 8520 attaatggaa actctgctaa tgtgtatcta actgatagtt atttaaaagg tgttatctct 8580 ttttcagaat gtaatgcttt agggagttac ctttttaacg gcccttatct caaaaatgat 8640 tacaccaact taattagtag acaaagtcca ctactagagc atatgaatct taaaaaacta 8700 actataacac agtcattaat atctagatat cataaaggtg aactgaaatt agaagaacca 8760 acttatttcc agtcattact tatgacatat aaaagcatgt cctcgtctga acaaattgct 8820 acaactaact tacttaaaaa aataatacga agagctatag aaataagtga tgtaaaggtg 8880 tacgccatct tgaataaact aggactaaag gaaaaggaca gagttaagcc caacaataat 8940 tcaggtgatg aaaactcagt acttacaact ataattaaag atgatatact ttcggctgtg 9000 gaaagcaatc aatcatatac aaattcagac aaaaatcact cagtaaatca aaatatcact 9060 atcaaaacaa cactcttgaa aaaattgatg tgttcaatgc aacatcctcc atcatggtta 9120 atacactggt tcaatttata tacaaaatta aataacatat taacacaata tcgatcaaat 9180 gaggtaaaaa gtcatgggtt tatattaata gataatcaaa ctttaagtgg ttttcagttt 9240 attttaaatc aatatggttg tatcgtttat cataaaggac tcaaaaaaat cacaactact 9300 acttacaatc aatttttaac atggaaagac atcagcctta gcagattaaa tgtttgctta 9360 attacttgga taagtaattg tttgaataca ttaaataaaa gcttagggct gagatgtgga 9420 ttcaataatg ttgtgttatc acaattattt ctttatggag attgtatact gaaattattt 9480 cataatgaag gcttctacat aataaaagaa gtagagggat ttattatgtc tttaattcta 9540 aacataacag aagaagatca atttaggaaa cgattttata atagcatgct aaataacatc 9600 acagatgcag ctattaaggc tcaaaagaac ctactatcaa gggtatgtca cactttatta 9660 gacaagacag tgtctgataa tatcataaat ggtaaatgga taatcctatt aagtaaattt 9720 cttaaattga ttaagcttgc aggtgataat aatctcaata atttgagtga gctatatttt 9780 ctcttcagaa tctttggaca tccaatggtt gatgaaagac aagcaatgga tgctgtaaga 9840 attaactgta atgaaactaa gttctactta ttaagtagtc taagtacgtt aagaggtgct 9900 ttcatttata gaatcataaa agggtttgta aatacctaca acagatggcc cactttaagg 9960 aatgctattg tcctacctct aagatggtta aactattata aacttaatac ttatccatct 10020 ctacttgaaa tcacagaaaa tgatttgatt attttatcag gattgcggtt ctatcgtgaa 10080 tttcatctgc ctaaaaaagt ggatcttgaa atgataataa atgacaaagc catttcacct 10140 ccaaaagatc taatatggac tagttttcct agaaattaca tgccatcaca tatacaaaat 10200 tatatagaac atgaaaagtt gaagttctct gaaagcgaca gatcaagaag agtactagag 10260 tattacttga gagataataa attcaatgaa tgcgatctat acaattgtgt agtcaatcaa 10320 agctatctca acaactctaa tcacgtggta tcactaactg gtaaagaaag agagctcagt 10380 gtaggtagaa tgtttgctat gcaaccaggt atgtttaggc aaatccaaat cttagcagag 10440 aaaatgatag ccgaaaatat tttacaattc ttccctgaga gtttgacaag atatggtgat 10500 ctagagcttc aaaagatatt agaattaaaa gcaggaataa gcaacaagtc aaatcgttat 10560 aatgataact acaacaatta tatcagtaaa tgttctatca ttacagatct tagcaaattc 10620 aatcaagcat ttagatatga aacatcatgt atctgcagtg atgtattaga tgaactgcat 10680 ggagtacaat ctctgttctc ttggttgcat ttaacaatac ctcttgtcac aataatatgt 10740 acatatagac atgcacctcc tttcataaag gatcatgttg ttaatcttaa tgaagttgat 10800 gaacaaagtg gattatacag atatcatatg ggtggtattg agggctggtg tcaaaaactg 10860 tggaccattg aagctatatc attattagat ctaatatctc tcaaagggaa attctctatc 10920 acagctctga taaatggtga taatcagtca attgatataa gtaaaccagt tagacttata 10980 gagggtcaga cccatgctca agcagattat ttgttagcat taaatagcct taaattgcta 11040 tataaagagt atgcaggtat aggccataag cttaagggaa cagagaccta tatatcccga 11100 gatatgcagt tcatgagcaa aacaatccag cacaatggag tgtactatcc agccagtatc 11160 aaaaaagtcc tgagagtagg tccatggata aatacaatac ttgatgattt taaagttagt 11220 ttagaatcta taggtagctt aacacaggag ttagaataca gaggggaaag cttattatgc 11280 agtttaatat ttaggaacat ttggttatac aatcaaattg ctttgcaact ccgaaatcat 11340 gcattatgta acaataagct atatttagat atattgaaag tattaaaaca cttaaaaact 11400 ttttttaatc ttgatagtat cgatatggcg ttatcattgt atatgaattt gcctatgctg 11460 tttggtggtg gtgatcctaa tttgttatat cgaagctttt ataggagaac tccagacttc 11520 cttacagaag ctatagtaca ttcagtgttt gtgttgagct attatactgg tcacgattta 11580 caagataagc tccaggatct tccagatgat agactgaaca aattcttgac atgtgtcatc 11640 acattcgata aaaatcccaa tgccgagttt gtaacattga tgagggatcc acaggcgtta 11700 gggtctgaaa ggcaagctaa aattactagt gagattaata gattagcagt aacagaagtc 11760 ttaagtatag ctccaaacaa aatattttct aaaagtgcac aacattatac taccactgag 11820 attgatctaa atgacattat gcaaaatata gaaccaactt accctcatgg attaagagtt 11880 gtttatgaaa gtctaccttt ttataaagca gaaaaaatag ttaatcttat atcaggaaca 11940 aaatccataa ctaatatact tgaaaaaaca tcagcaatag atacaactga tattaatagg 12000 gctactgata tgatgaggaa aaatataact ttacttataa ggatacttcc actagattgt 12060 aacaaagaca aaagagagtt attaagttta gaaaatctta gtataactga attaagcaag 12120 tatgtaagag aaagatcttg gtcattatcc aatatagtag gagtaacatc gccaagtatt 12180 atgttcacaa tggacattaa atatacaact agcactatag ccagtggtat aattatagaa 12240 aaatataatg ttaatagttt aactcgtggt gaaagaggac ctactaagcc atgggtaggt 12300 tcatctacgc aggagaaaaa aacaatgcca gtgtacaata gacaagtttt aaccaaaaag 12360 caaagagacc aaatagattt attagcaaaa ttagactggg tatatgcatc catagacaac 12420 aaagatgaat tcatggaaga actgagtact ggaacacttg gactgtcata tgaaaaagcc 12480 aaaaagttgt ttccacaata tctaagtgtc aattatttac accgtttaac agtcagtagt 12540 agaccatgtg aattccctgc atcaatacca gcttatagaa caacaaatta tcatttcgat 12600 actagtccta tcaatcatgt attaacagaa aagtatggag atgaagatat cgacattgtg 12660 tttcaaaatt gcataagttt tggtcttagc ctgatgtcgg ttgtggaaca attcacaaac 12720 atatgtccta atagaattat tctcataccg aagctgaatg agatacattt gatgaaacct 12780 cctatattta caggagatgt tgatatcatc aagttgaagc aagtgataca aaaacagcat 12840 atgttcctac cagataaaat aagtttaacc caatatgtag aattattcct aagtaacaaa 12900 gcacttaaat ctggatctaa catcaattct aatttaatat tagtacataa aatgtctgat 12960 tattttcata atgcttatat tttaagtact aatttagctg gacattggat tctaattatt 13020 caacttatga aagattcaaa aggtattttt gaaaaagatt ggggagaggg gtacataact 13080 gatcatatgt tcattaattt gaatgttttc tttaatgctt ataagactta tttgctatgt 13140 tttcataaag gttatggtaa agcaaaatta gaatgtgata tgaacacttc agatcttctt 13200 tgtgttttgg agttaataga cagtagctac tggaaatcta tgtctaaagt tttcctagaa 13260 caaaaagtca taaaatacat agtcaatcaa gacacaagtt tgcatagaat aaaaggctgt 13320 cacagtttta agttgtggtt tttaaaacgc cttaataatg ctaaatttac cgtatgccct 13380 tgggttgtta acatagatta tcacccaaca catatgaaag ctatattatc ttacatagat 13440 ttagttagaa tggggttaat aaatgtagat aaattaacca ttaaaaataa aaacaaattc 13500 aatgatgaat tttacacatc aaatctcttt tacattagtt ataacttttc agacaacact 13560 catttgctaa caaaacaaat aagaattgct aattcagaat tagaagataa ttataacaaa 13620 ctatatcacc caaccccaga aactttagaa aatatatcat taattcctgt taaaagtaat 13680 aatagtaaca aacctaaatt ttgtataagt ggaaataccg aatctataat gatgtcaaca 13740 ttctctaata aaatgcatat taaatcttcc actgttacca caagattcaa ttatagcaaa 13800 caagacttgt acaatttatt tccaaatgtt gtgatagaca ggattataga tcattcaggt 13860 aatacagcaa aatctaacca actttacatc accacttcac atcagacatc tttagtaagg 13920 aatagtgcat cactttattg catgcttcct tggcatcatg tcaatagatt taactttgta 13980 tttagttcca caggatgcaa gatcagtata gagtatattt taaaagatct taagattaag 14040 gaccccagtt gtatagcatt cataggtgaa ggagctggta acttattatt acgtacggta 14100 gtagaacttc atccagacat aagatacatt tacagaagtt taaaagattg caatgatcat 14160 agtttaccta ttgaatttct aagattatac aacgggcata taaacataga ttatggtgag 14220 aatttaacca ttcctgctac agatgcaact aataacattc attggtctta tttacatata 14280 aaatttgcag aacctattag catctttgtc tgcgatgctg aattacctgt tacagccaat 14340 tggagtaaaa ttataattga atggagtaag catgtaagaa agtgcaagta ctgttcttct 14400 gtaaatagat gcattttaat cgcaaaatat catgctcaag atgatattga tttcaaatta 14460 gataacatta ctatattaaa aacttacgtg tgcctaggta gcaagttaaa aggatctgaa 14520 gtttacttag tccttacaat aggccctgca aatatacttc ctgtttttga tgttgtgcaa 14580 aatgctaaat tgattttttc aagaactaaa aatttcatta tgcctaaaaa aactgacaag 14640 gaatctatcg atgcaaatat taaaagctta atacctttcc tttgttaccc tataacaaaa 14700 aaaggaatta agacttcatt gtcaaaattg aagagtgtag ttaatgggga tatattatca 14760 tattctatag ctggacgtaa tgaagtattc agcaacaagc ttataaacca caagcatatg 14820 aatatcctaa aatggctaga tcatgtttta aattttagat cagctgaact taattacaat 14880 catttataca tgatagagtc cacatatcct tacttaagtg aattgttaaa tagtttaaca 14940 accaatgagc tcaagaaact gattaaaata acaggtagtg tactatacaa ccttcccaac 15000 gaacagtaac ttaaaatatc attaacaagt ttggtcaaat ttagatgcta acacatcatt 15060 atattatagt tattaaaaaa tatgcaaact tttcaataat ttagcttact gattccaaaa 15120 ttatcatttt atttttaagg ggttgaataa aagtctaaaa ctaacaatga tacatgtgca 15180 tttacaacac aacgagacat tagtttttga cacttttttt ctcgt 15225 //