Dbfetch

ID   M27161; SV 1; linear; genomic DNA; STD; HUM; 7319 BP.
XX
AC   M27161;
XX
DT   23-APR-1990 (Rel. 23, Created)
DT   14-NOV-2006 (Rel. 89, Last updated, Version 8)
XX
DE   Human MHC class I CD8 alpha-chain (Leu-2/T8) gene, complete cds.
XX
KW   cell surface antigen; cell surface glycoprotein; class I gene;
KW   integral membrane protein; major histocompatibility complex.
XX
OS   Homo sapiens (human)
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
XX
RN   [1]
RP   1-7319
RX   DOI; 10.1007/BF02425282.
RX   PUBMED; 2509342.
RA   Nakayama K., Tokito S., Okumura K., Nakauchi H.;
RT   "Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8)";
RL   Immunogenetics 30(5):393-397(1989).
XX
DR   MD5; 571f4baee43f7bc8506145547ebcff4a.
DR   Ensembl-Gn; ENSG00000153563; homo_sapiens.
DR   Ensembl-Tr; ENST00000283635; homo_sapiens.
DR   Ensembl-Tr; ENST00000352580; homo_sapiens.
DR   Ensembl-Tr; ENST00000409511; homo_sapiens.
DR   IMGT/LIGM; M27161.
XX
CC   Draft entry and computer-readable sequence for [1] kindly submitted
CC   by K.-i.Nakayama, 31-AUG-1989.
XX
FH   Key             Location/Qualifiers
FH
FT   source          1..7319
FT                   /organism="Homo sapiens"
FT                   /map="2p12"
FT                   /mol_type="genomic DNA"
FT                   /db_xref="taxon:9606"
FT   prim_transcript <1..>7319
FT                   /note="MHC CD8 alpha-chain mRNA and introns"
FT   misc_feature    238..256
FT                   /note="initiator-like sequence"
FT   misc_feature    476..485
FT                   /note="Tcr v-beta decamer-like sequence"
FT   CDS             join(619..667,763..1116,1700..1810,2017..2127,2890..2920,
FT                   5504..5555)
FT                   /partial
FT                   /codon_start=1
FT                   /note="MHC CD8 alpha-chain (Leu-2/T8)"
FT                   /db_xref="GOA:P01732"
FT                   /db_xref="HGNC:HGNC:1706"
FT                   /db_xref="InterPro:IPR003599"
FT                   /db_xref="InterPro:IPR007110"
FT                   /db_xref="InterPro:IPR013106"
FT                   /db_xref="InterPro:IPR013783"
FT                   /db_xref="InterPro:IPR015468"
FT                   /db_xref="InterPro:IPR036179"
FT                   /db_xref="PDB:1AKJ"
FT                   /db_xref="PDB:1CD8"
FT                   /db_xref="PDB:1Q69"
FT                   /db_xref="PDB:2HP4"
FT                   /db_xref="PDB:3QZW"
FT                   /db_xref="UniProtKB/Swiss-Prot:P01732"
FT                   /protein_id="AAA59674.1"
FT                   /translation="MALPVTALLLPLALLLHAARPSQFRVSPLDRTWNLGETVELKCQV
FT                   LLSNPTSGCSWLFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSGKRLGDTFVLTLSD
FT                   FRRENEGYYFCSALSNSIMYFSHFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRPEA
FT                   CRPAAGGAVHTRGLDFACDIYIWAPLAGTCGVLLLSLVITLYCNHRNRRRVCKCPRPVV
FT                   KSGDKPSLSARYV"
FT   exon            <619..667
FT                   /gene="CD8A"
FT                   /number=1
FT                   /note="MHC CD8 alpha-chain (Leu-2/T8); G00-120-581"
FT   intron          668..762
FT                   /note="CD8 alpha-chain intron A"
FT   exon            763..1116
FT                   /number=2
FT   intron          1117..1699
FT                   /note="CD8 alpha-chain intron B"
FT   exon            1700..1810
FT                   /number=3
FT   intron          1811..2016
FT                   /note="CD8 intron C"
FT   exon            2017..2127
FT                   /number=4
FT   intron          2128..2889
FT                   /note="CD8 intron D"
FT   exon            2890..2920
FT                   /number=5
FT   intron          2921..5503
FT                   /note="CD8 intron E"
FT   exon            5504..>5555
FT                   /number=6
FT                   /note="MHC CD8 alpha-chain (Leu-2/T8)"
XX
SQ   Sequence 7319 BP; 1690 A; 1933 C; 1837 G; 1856 T; 3 other;
     aagcttcggc tgctgccgcc ctcatggaaa tctcctgggg gaagggagag ggtccttcct        60
     cggtgaaaac tggggctgct ctagcgagtt cctcagaagc gggcaggtcg ctagctcctc       120
     ttccttttca gccctcagtg cccattttgc caataaaaag tcccaaggtg acagtacaag       180
     agacgccttt agtgaaggca aaggaaggga cactcccctc ctttgctgcc tactctcgcc       240
     ctcacttctt gaaatctttg gtctcccttc acccactctg tcactctcac aagacaacca       300
     tttccaagga ctatttccaa gcccttttcc tcatccccaa acccgcagtt ttcagctgcc       360
     cccagttgcc tggccaggct gcctcgacgg ccctattcac gggccccagc ctcctcgccg       420
     ggctggaagg cgacaaccgc gaaaaggagg gtgactctcc tcggcggggg cttcgggtga       480
     catcacatcc tccaaatgcg aaatcaggct ccgggccggc cgaagggcgc aactttcccc       540
     cctcggcgcc ccaccggctc ccgcgcgcct cccctcgcgc ccgagcttcg agccaagcag       600
     cgtcctgggg agcgcgtcat ggccttacca gtgaccgcct tgctcctgcc gctggccttg       660
     ctgctccgtg agtttgagac gcccgggaag gcaggggatg gggcgggcgg ggggcggggg       720
     gctcgggact gcttgctcag cctcgctgct tgcctcctgc agacgccgcc aggccgagcc       780
     agttccgggt gtcgccgctg gatcggacct ggaacctggg cgagacagtg gagctgaagt       840
     gccaggtgct gctgtccaac ccgacgtcgg gctgctcgtg gctcttccag ccgcgcggcg       900
     ccgccgccag tcccaccttc ctcctatacc tctcccaaaa caagcccaag gcggccgagg       960
     ggctggacac ccagcggttc tcgggcaaga ggttggggga caccttcgtc ctcaccctga      1020
     gcgacttccg ccgagagaac gagggctact atttctgctc ggccctgagc aactccatca      1080
     tgtacttcag ccacttcgtg ccggtcttcc tgccaggtcc gcgcgccggg ttgcnncacc      1140
     tctccgcgtg gggcttgggg ttcacctcaa cctgttttcc acacctgggc cctgctttca      1200
     agcctcttag cgcacctgga agcgacttag atactgttcc catttcacag acacagcaaa      1260
     ctgaggctaa cgcgaggctg agtagggact ggggatggct ttttacgtcc ggccgatctg      1320
     gactcgagtt cggattcttg tgtgattctg ggcaaatgac ttaaattatc tgcgcctccg      1380
     tttgctcgtg ggtaaaatgc ggacagcaat caacccgcgc tccagggttg ctggttcagc      1440
     ccgggagaga ggccaggtgc aggggagctg gctcctgcgc tccggctctg ggcgccgcgt      1500
     gcgctgggct gagccgaggc ccgagcacag ggctccgcgc gcatcccggg gtccccatcc      1560
     tgtctcctct gctatccctt ctcccaggaa aaccgggaaa aagcatcccc gtagggaaag      1620
     gtgcgcgagg ccagggctag ggcaagaaca cctccataac cccagcctgg cccccaacca      1680
     cgctctgttg ctcttgcagc gaagcccacc acgacgccag cgccgcgacc accaacaccg      1740
     gcgcccacca tcgcgtcgca gcccctgtcc ctgcgcccag aggcgtgccg gccagcggcg      1800
     gggggcgcag gtgaggcgtg cgggggcccg gggcgggggc ggcacgcacc gcggggagag      1860
     cccatgccag ggacagccct gatactgtag gtagagtcaa gggctgtcca agtggtggga      1920
     aaccgagatc tgaggcggag agacgttccc gggacggtgg ggcggttggg aggtcccggg      1980
     ccctctccta aatgtcggcg tctttggtgt cgtcagtgca cacgaggggg ctggacttcg      2040
     cctgtgatat ctacatctgg gcgcccctgg ccgggacttg tggggtcctt ctcctgtcac      2100
     tggttatcac cctttactgc aaccacagta agtcccgagg aatcgcggcg ggaaggagtc      2160
     ggccccgctc ctgcccttgg ctctgctagc tccaggcgga ccttgcgagg ggggagcttg      2220
     gggttgagtt ttctgggact cccgagctgc cccgcaggta caggcacttc tttctgggag      2280
     atagaatgcg agaaagccct tcccgctcct tgcgctctcg gagaggtttt gggagacaaa      2340
     gccgcgttcc cagagccgct gcagcgggtg tgttccgtcg acgaagctcg cagcgcgcgc      2400
     gcacatgtct ggacacatga caaacgcccg ccgggagggg gccgctgtgg ccgagtcaag      2460
     tgcccaggag ggttagtcaa aaccaccatc agtttgaggt tcgtccttgg ccctcttcgg      2520
     cgaaccgccc accctgcttt gggtcccatg caagagaggt gccggatcag gtctgcaggc      2580
     tccccgcttt cgcccgcgtc tgtagttgca atttttttta attgatgctt gagacgaagg      2640
     atggataaga agcccttacc cggctctcaa gagttataat cctcaaagaa ataggggaaa      2700
     ggaaggagaa ttcgtagagg caattcccta tttgcctcat ccaatttcag cccatgatcg      2760
     ttctgaaatg attttttgta aaaccaaaaa acagcagcaa caacaacagc aacaacaaaa      2820
     aatacactgt ctttggggac tattgatgga taggggcact cactttttcc cttctttttc      2880
     cttatccagg gaaccgaaga cgtgtttgca aatgtccccg gtgagtctct tttgaactct      2940
     cagcctgctc accttggcca gccctggggt ggggtcctgg tttccccagc agcaaatagt      3000
     gggaactttt cccagagaga ggtcatggcc gtgaaatcct ggggcaggga gtcagccagt      3060
     tcctgagcaa agagaggcca aggctggcat ctggcctgtg tctttgagaa aaaggaggcc      3120
     cgggttaggc gggtgccaac agcagtgtga ctccagtaaa tctccatctt atttgacctg      3180
     gcacttccaa aaaaaaaaaa aaaaaacctg agggattccc ccaatttatc ctagctcctc      3240
     gtaggacctg acctcctctt tattctgatt attccatctg ggttttgttg ttttcttaag      3300
     aaaacaattt tttttcctac ttggctggtc tagttttttg agggagagcc aatcttttat      3360
     cagctgaacc aaaataataa tggctttggt tgctaacttc tctgtgtcat gtaggacctt      3420
     ggtttgctgc caaggactgg agtagaaaaa aggggaacga gatgcaggga caattggcta      3480
     tctggcagct caagtgactg cctcatccag tttcagccca tgatcacaca cacacacaca      3540
     cacacacaca cactctctct ctctctctcc ctctctgtta aaaacctctc tccacccgtt      3600
     ggctgaggca tccctgtggt agcatctaac aagtgcctgc tctagtcagg cactgtgata      3660
     ggggtaatac tccccatctc tcttaatcct cacagcaact ttgtgccatc tcatggctca      3720
     gggattagta aagtggcaaa ggcacattaa actcagatta tcaatagtaa taaccatttg      3780
     atgaaagcct acaacgcacg ttacttgctt tatagatttt ttttaatttt aagttttatg      3840
     acaactttta aagtagtcat gattacctgc atttacagat aaggaaactg aggcttagaa      3900
     catttagtga tttgtccaag gtcatactgc ccgggagctg caacttccat ccaaagctca      3960
     gacaccttcc ccatggctgc aggctgaagt gttaaggata accgactgtg tacaccagtt      4020
     cttttcagta gatgaaatat tttacatttt atacctggag tttgcatttt atactccttt      4080
     acatttttct gagggaatcc aagttcagga ctttacacat tgttgttttt agcaatggaa      4140
     atgcaatgga tttccaatgc atatgttaca ggtgatatac caaggggata aagactttaa      4200
     aaatgagccg ggtattgtgg tgcatgccta taatccgggc tactcaggag gctgaggcag      4260
     gagaatcgct tgaacgtggg aggcggaggt tgcagtgagc tgagatcgta ccactgcact      4320
     ccagcctggg taacagagca agattccatc tcacaaaaaa aaaaaaaagt ggggggggaa      4380
     gtttttagct tttcttttct tttcttttct tttttttttt tttttttttt tgagacggag      4440
     tctcgctatc tcgcccaggc tggagtgcag tggtgcgatc tcggctcact gcaagctccg      4500
     cctcccgggt tcacgccatt ctcctgcctc aacctcccaa gtagctggga ctacaggcac      4560
     ccgcccagct gggactacag gcacccgcca caacacccgg ctaatttttt gtatttttag      4620
     tagagacggg gtttcaccgt gttagccagg atggtctcga tctcctgacc tcgtgatccg      4680
     cccgccttgg cctcccaaag tgctgggatt ataggcgtga gctaccgcac ccggccagtt      4740
     tttagcattt ttattattca gggtgcactt tggaactttt gcagaaggac catccctttt      4800
     ctcgatcttt tctgaaaact ctcattgtga gatgaataac tgagaataaa gttctgcctt      4860
     aaaatacaaa gctatacaga ttaaacacac ctgggaaatt ccaacacccg agttaatata      4920
     ctcagtgatg atggtgggcc gctcagcttc aacagagagg ttttagaggg ctgagagtgc      4980
     agacatgacg ctcatgatga attagcatgt ttacaaggtg ctagcctggt gctgaattaa      5040
     cacgttttta gcgtaacatc atttggctga tggtggtgat ttgctcacat cctcctctct      5100
     ccctgtcatc ctccggggct gagaatcagg tcagctaatg actttggtta tcagtctcac      5160
     tctcacacct ctgtggagac cttgacaggg gctccaggaa gctagactaa ctcggtttag      5220
     atcctggctc agccacctcc tagatgtgtg accttgggca agtttaactt ctcaatctca      5280
     gtgcccaccc ttaaggctgc tgtgaggatt acatgagatg gtgcaagtaa ggcatttagc      5340
     acgggtgctg tgctgacgtc attcacccag tcccatgctg gtgccccagg aacaggttct      5400
     cagacctttc aaaggctggg ggattgggag gctggacgtg gctggatgga tgctgcactg      5460
     gcggggttct ggctacaatg atggtcgctt tcctctcttt caggcctgtg gtcaaatcgg      5520
     gagacaagcc cagcctttcg gcgagatacg tctaaccctg tgcaacagcc actacattac      5580
     ttcaaactga gatccttcct tttgagggag caagtccttc cctttcattt tttccagtct      5640
     tcctccctgt gtattcattc tcatgattat tattttagtg ggggcggggt gggaaagatt      5700
     actttttctt tatgtgtttg acgggaaaca aaactaggta aaatctacag tacaccacaa      5760
     gggtcacaat actgttgtgc gcacatcgcg gtagggcgtg gaaaggggca ggccagagct      5820
     acccgcagag ttctcagaat catgctgaga gagctggagg cacccatgcc atctcaacct      5880
     cttccccgcc cgttttacaa agggggaggc taaagcccag agacagcttg atcaaaggca      5940
     cacagcaagt cagggttgga gcagtagctg gagggacctt gtctcccagc tcagggctct      6000
     ttcctccaca ccattcaggt ctttctttcc gaggcccctg tctcagggtg aggtgcttga      6060
     gtctccaacg gcaagggaac aagtacttct tgatacctgg gatactgtgc ccagagcctc      6120
     gaggaggtaa tgaattaaag aagagaactg cctttggcag agttctataa tgtaaacaat      6180
     atcagacttt ttttttttta taatcaagcc taaaattgta tagacctaaa ataaaatgaa      6240
     gtggtgagct taaccctgga aaatgaancc ctctatctct aaagaaaatc tctgtgaaac      6300
     ccctacgtgg aggcggaatt gctctcccag cccttgcatt gcagaggggc ccatgaaaga      6360
     ggacaggcta cccctttaca aatagaattt gagcatcagt gaggttaaac taaggccctc      6420
     ttgaatctct gaatttgaga tacaaacatg ttcctgggat cactgatgac tttttatact      6480
     ttgtaaagac aattgttgga gagaaaatca cacagccctg gcctccgctc aactagcaga      6540
     tacagggatg aggcagacct gactctctta aggaggctga gagcccaaac tgctgtccca      6600
     aacatgcact tccttgctta aggtatggta caagcaatgc ctgcccattg gagagaaaaa      6660
     acttaagtag ataaggaaat aagaaccact cataattctt caccttagga ataatctcct      6720
     gttaatatgg tgtacattct tcctgattat tttctacaca tacatgtaaa atatgtcttt      6780
     cttttttaaa tagggttgta ctatgctgtt atgagtggct ttaatgaata aacatttgta      6840
     gcatcctctt taatgggtaa acagcatccg attttggttg tgccatcatt tatttaacta      6900
     ttacctgata tttagttgtt tccaaccttt tcctactata acactcttaa aatgttgcat      6960
     atatttttgt ttctttagga taaagaccta aaagtaaaat tattgaatca gtccccacct      7020
     tcacctgagc ctgccatttt cacatcaatc aaaacagatt agcttcatcc tgcattaccc      7080
     ttcttccttt tgttctttct tggtaacaga ggagacgatg ctcctttcat gataaatcac      7140
     taagtcatct tgttgttgag gtaaaatatt cgtactgaaa attgcttaag tcgtaaatgt      7200
     acagctcgat gacatcataa agcaaacaca cccatgtaat cagccctcca gaagtctgtc      7260
     gttagtttta aaaccaagat acttttagag aatggaaagc aagagtggct ttctgttct       7319
//