{"numberOfHits":1,"results":[{"id":"GO:0050613","isObsolete":false,"name":"Delta14-sterol reductase activity","definition":{"text":"Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.","xrefs":[{"dbCode":"EC","dbId":"1.3.1.70"}]},"comment":"Note that zymosterol is cholesta-8,24-dien-3-ol.","synonyms":[{"name":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity","type":"related"},{"name":"C-14 sterol reductase activity","type":"exact"},{"name":"D14-sterol reductase activity","type":"exact"},{"name":"sterol C-14 reductase activity","type":"exact"},{"name":"sterol C14-reductase activity","type":"related"}],"secondaryIds":["GO:0000251"],"history":[{"timestamp":"2026-01-29","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2026-01-23","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2026-01-22","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2026-01-18","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2026-01-17","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-12-12","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-12-11","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-12-10","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-12-09","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-12-07","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-12-06","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-12-01","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-11-30","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-11-01","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-10-30","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-10-29","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-10-28","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-10-24","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-10-23","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-10-02","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-09-30","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-09-29","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-09-28","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-09-12","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-09-10","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-25","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-24","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-23","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-19","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-15","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-13","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-08","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-08-05","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-30","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-29","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-24","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-23","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-18","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-17","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-12","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-10","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-09","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-08","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-05","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-07-04","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-06-25","action":"Deleted","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2025-06-24","action":"Added","category":"XREF","text":"Reactome:R-HSA-9946140"},{"timestamp":"2024-11-22","action":"Updated","category":"TERM","text":"Delta14-sterol reductase activity"},{"timestamp":"2023-08-11","action":"Deleted","category":"XREF","text":"MetaCyc:1.3.1.70-RXN"},{"timestamp":"2023-08-11","action":"Added","category":"XREF","text":"MetaCyc:RXN66-14"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"sterol C14-reductase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"sterol C14-reductase activity"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-194698"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-194674"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-194698"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-194674"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-194698"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-194674"},{"timestamp":"2018-07-13","action":"Added","category":"XREF","text":"RHEA:18561"},{"timestamp":"2018-07-13","action":"Deleted","category":"XREF","text":"RHEA:18564"},{"timestamp":"2011-09-16","action":"Added","category":"XREF","text":"RHEA:18564"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0016628 (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"sterol C-14 reductase activity"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol:NADP+ delta14-oxidoreductase activity"},{"timestamp":"2007-11-08","action":"Deleted","category":"SYNONYM","text":"sterol C-14 reductase"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"sterol C14-reductase activity"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"D14-sterol reductase activity"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"C-14 sterol reductase activity"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"sterol C-14 reductase"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"sterol C-14 reductase"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"D14-sterol reductase activity"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"C-14 sterol reductase activity"},{"timestamp":"2004-09-25","action":"Added","category":"SYNONYM","text":"C-14 sterol reductase activity"},{"timestamp":"2004-09-25","action":"Added","category":"SYNONYM","text":"sterol C-14 reductase"},{"timestamp":"2004-09-25","action":"Added","category":"SECONDARY","text":"GO:0000251 (C-14 sterol reductase activity)"},{"timestamp":"2004-04-19","action":"Added","category":"SYNONYM","text":"D14-sterol reductase activity"},{"timestamp":"2004-04-16","action":"Deleted","category":"SYNONYM","text":"D14-sterol reductase activity"},{"timestamp":"2003-10-27","action":"Added","category":"SYNONYM","text":"D14-sterol reductase activity"},{"timestamp":"2003-10-27","action":"Added","category":"XREF","text":"MetaCyc:1.3.1.70-RXN"},{"timestamp":"2003-09-25","action":"Added","category":"XREF","text":"EC:1.3.1.70"},{"timestamp":"2003-09-25","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol."},{"timestamp":"2003-09-25","action":"Added","category":"TERM","text":"delta14-sterol reductase activity"}],"xRefs":[{"dbCode":"EC","dbId":"1.3.1.70"},{"dbCode":"MetaCyc","dbId":"RXN66-14"},{"dbCode":"Reactome","dbId":"R-HSA-194674"},{"dbCode":"Reactome","dbId":"R-HSA-194698"},{"dbCode":"Reactome","dbId":"R-HSA-9946140"},{"dbCode":"RHEA","dbId":"18561"}],"xRelations":[{"id":"CHEBI:58349","term":"NADP(3-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58349","relation":"has_participant"},{"id":"CHEBI:18364","term":"14-demethyllanosterol","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18364","relation":"has_participant"},{"id":"CHEBI:17813","term":"4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17813","relation":"has_participant"},{"id":"CHEBI:57783","term":"NADPH(4-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57783","relation":"has_participant"},{"id":"CHEBI:15378","term":"hydron","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15378","relation":"has_participant"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0050613","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"O63264","taxonId":"4957","entityName":"ZBI1_ZYGBI","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"P03879","taxonId":"559292","entityName":"MBI4_YEAST","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"P03880","taxonId":"162425","entityName":"ANI1_ASPNU","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"P03882","taxonId":"559292","entityName":"SCE1_YEAST","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"Q0H8X2","taxonId":"5270","entityName":"BI1_MYCMD","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"Q35127","taxonId":"367110","entityName":"MBI1_NEUCR","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A0R4IWF9","taxonId":"7955","entityName":"A0A0R4IWF9_DANRE","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A1D8PT92","taxonId":"237561","entityName":"A0A1D8PT92_CANAL","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A2R9YJQ0","taxonId":"7955","entityName":"A0A2R9YJQ0_DANRE","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A8M1P554","taxonId":"7955","entityName":"A0A8M1P554_DANRE","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A8M1PAH1","taxonId":"7955","entityName":"A0A8M1PAH1_DANRE","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163","category":"NOT-qualified manual","entityType":"protein","entityId":"A0MTA1","taxonId":"7955","entityName":"APEX1_DANRE","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"A1Z9T4","taxonId":"7227","entityName":"A1Z9T4_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"A7EKP7","taxonId":"665079","entityName":"A7EKP7_SCLS1","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"P02521","taxonId":"9031","entityName":"ARLY1_CHICK","ancestorGoId":"GO:0003824"},{"goId":"GO:0050613","reason":"2 NOT-qualified manual annotations exist with evidence code ECO:0000304 from these references: PMID:8170369, PMID:9155028","category":"NOT-qualified manual","entityType":"protein","entityId":"P91615","taxonId":"7227","entityName":"ADHR_DROME","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"Q4WKE9","taxonId":"330879","entityName":"Q4WKE9_ASPFU","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"Q5BGM7","taxonId":"227321","entityName":"Q5BGM7_ASPN4","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"Q6C017","taxonId":"284591","entityName":"Q6C017_YARLI","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7SGR1","taxonId":"367110","entityName":"Q7SGR1_NEUCR","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7SIE0","taxonId":"9103","entityName":"ARLY1_MELGA","ancestorGoId":"GO:0003824"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:15054108","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8MLV1","taxonId":"7227","entityName":"LBR_DROME","ancestorGoId":"GO:0016491"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000316 from this reference: PMID:15054108","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8MLV1","taxonId":"7227","entityName":"LBR_DROME","ancestorGoId":"GO:0050613"},{"goId":"GO:0050613","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8MZ84","taxonId":"7227","entityName":"Q8MZ84_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0050613","reason":"2 NOT-qualified manual annotations exist with evidence code ECO:0000304 from these references: PMID:8170369, PMID:9155028","category":"NOT-qualified manual","entityType":"protein","entityId":"X2JAH0","taxonId":"7227","entityName":"X2JAH0_DROME","ancestorGoId":"GO:0016491"}]}],"pageInfo":null}