{"numberOfHits":1,"results":[{"id":"GO:0032602","isObsolete":false,"name":"chemokine production","definition":{"text":"The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.","xrefs":[{"dbCode":"ISBN","dbId":"0198506732"},{"dbCode":"PMID","dbId":"12183377"},{"dbCode":"Wikipedia","dbId":"Chemokine"}]},"synonyms":[{"name":"chemokine biosynthesis","type":"exact"},{"name":"chemokine synthesis","type":"exact"},{"name":"chemokine metabolic process","type":"narrow"},{"name":"chemokine secretion","type":"narrow"},{"name":"chemokine anabolism","type":"exact"},{"name":"chemokine biosynthetic process","type":"narrow"},{"name":"chemokine formation","type":"exact"}],"children":[{"id":"GO:0071610","relation":"is_a"},{"id":"GO:0044809","relation":"is_a"},{"id":"GO:0071924","relation":"is_a"},{"id":"GO:0071925","relation":"is_a"},{"id":"GO:0071612","relation":"is_a"},{"id":"GO:0097388","relation":"is_a"},{"id":"GO:0036392","relation":"is_a"},{"id":"GO:0097389","relation":"is_a"},{"id":"GO:0035530","relation":"is_a"},{"id":"GO:0071606","relation":"is_a"},{"id":"GO:0071954","relation":"is_a"},{"id":"GO:0072567","relation":"is_a"},{"id":"GO:0071607","relation":"is_a"},{"id":"GO:0072566","relation":"is_a"},{"id":"GO:0032642","relation":"regulates"},{"id":"GO:0071605","relation":"is_a"},{"id":"GO:0071608","relation":"is_a"},{"id":"GO:0071609","relation":"is_a"},{"id":"GO:0035393","relation":"is_a"},{"id":"GO:0032722","relation":"positively_regulates"},{"id":"GO:0032603","relation":"is_a"},{"id":"GO:0032682","relation":"negatively_regulates"},{"id":"GO:0097391","relation":"is_a"},{"id":"GO:0097390","relation":"is_a"},{"id":"GO:0097392","relation":"is_a"}],"secondaryIds":["GO:0042033","GO:0050755","GO:0090195"],"history":[{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"never_in_taxon NCBITaxon:4932 (Saccharomyces cerevisiae)"},{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe)"},{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"never_in_taxon NCBITaxon:2157 (Archaea)"},{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"never_in_taxon NCBITaxon:2 (Bacteria)"},{"timestamp":"2020-10-22","action":"Added","category":"SYNONYM","text":"chemokine metabolic process"},{"timestamp":"2020-10-22","action":"Added","category":"SUBSET","text":"gocheck_do_not_annotate"},{"timestamp":"2020-10-22","action":"Added","category":"SECONDARY","text":"GO:0050755 (chemokine metabolic process)"},{"timestamp":"2020-10-22","action":"Deleted","category":"RELATION","text":"is a GO:0050755 (chemokine metabolic process)"},{"timestamp":"2020-10-16","action":"Added","category":"RELATION","text":"is a GO:0050755 (chemokine metabolic process)"},{"timestamp":"2020-10-16","action":"Added","category":"DEFINITION","text":"The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria."},{"timestamp":"2020-10-16","action":"Added","category":"SYNONYM","text":"chemokine synthesis"},{"timestamp":"2020-10-16","action":"Deleted","category":"DEFINITION","text":"The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels."},{"timestamp":"2020-10-16","action":"Added","category":"SYNONYM","text":"chemokine formation"},{"timestamp":"2020-10-16","action":"Added","category":"SECONDARY","text":"GO:0042033 (chemokine biosynthetic process)"},{"timestamp":"2020-10-16","action":"Added","category":"SYNONYM","text":"chemokine biosynthetic process"},{"timestamp":"2020-10-16","action":"Added","category":"SYNONYM","text":"chemokine biosynthesis"},{"timestamp":"2020-10-16","action":"Added","category":"SYNONYM","text":"chemokine anabolism"},{"timestamp":"2020-08-27","action":"Added","category":"SECONDARY","text":"GO:0090195 (chemokine secretion)"},{"timestamp":"2020-08-27","action":"Added","category":"SYNONYM","text":"chemokine secretion"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0001816 (cytokine production)"},{"timestamp":"2006-12-06","action":"Added","category":"TERM","text":"chemokine production"},{"timestamp":"2006-12-06","action":"Added","category":"DEFINITION","text":"The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels."}],"annotationGuidelines":[{"description":"Annotating to terms describing protein or chemical production","url":"http://wiki.geneontology.org/index.php/Usage_of_terms_describing_protein_or_chemical_production"}],"taxonConstraints":[{"ancestorId":"GO:0032602","ancestorName":"chemokine production","relationship":"never_in_taxon","taxId":"2","taxIdType":"NCBITaxon","taxName":"Bacteria"},{"ancestorId":"GO:0032602","ancestorName":"chemokine production","relationship":"never_in_taxon","taxId":"2157","taxIdType":"NCBITaxon","taxName":"Archaea"},{"ancestorId":"GO:0032602","ancestorName":"chemokine production","relationship":"never_in_taxon","taxId":"4896","taxIdType":"NCBITaxon","taxName":"Schizosaccharomyces pombe"},{"ancestorId":"GO:0032602","ancestorName":"chemokine production","relationship":"never_in_taxon","taxId":"4932","taxIdType":"NCBITaxon","taxName":"Saccharomyces cerevisiae"}],"credits":[{"code":"BHF","url":"https://www.ucl.ac.uk/functional-gene-annotation/cardiovascular"}],"aspect":"biological_process","usage":"None"}],"pageInfo":null}