{"nodes":[{"id":"_ROOT_AER_","usage":"The Mother Of All Annotation_Extension Relations","domain":"None defined","range":"None defined","subsets":[]},{"id":"adjacent_to","usage":"x adjacent to y if and only if x and y share a boundary.","domain":"GO:0005575 (cellular_component)","range":"CL:0000000 (cell) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"causally_upstream_of","usage":"Process A is causally_upstream of process B if process A occurs first, and process A causes process B to happen. Processes A and B do not overlap.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"GO:0003674 (molecular function) or GO:0003824 (catalytic activity) or GO:0008150 (biological process)","subsets":["biological_process","molecular_function"]},{"id":"coincident_with","usage":"Use this relation to link a region of chromosome or chromatin to the sequence region that it contains.  The sequence region may be a specific gene or some generic region referred to by a SO term.","domain":"GO:0005575 (cellular_component)","range":"CHEBI:24431 (chemical entity) or SO:0000001 (region) or SO:0000110 (sequence feature) or SO:0000704 (gene)","subsets":["cellular_component"]},{"id":"directly_negatively_regulates","usage":"p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"GO:0003674 (molecular function) or GO:0008150 (biological process)","subsets":["biological_process","molecular_function"]},{"id":"directly_positively_regulates","usage":"p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"GO:0003674 (molecular function) or GO:0008150 (biological process)","subsets":["biological_process","molecular_function"]},{"id":"directly_regulates","usage":"p directly regulates q iff p is immediately causally upstream of q and p regulates q.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"GO:0003674 (molecular function) or GO:0008150 (biological process)","subsets":["biological_process","molecular_function"]},{"id":"existence_overlaps","usage":"Identifies a process or life stage during which a cellular component is present","domain":"GO:0005575 (cellular_component)","range":"FBdv:00007012 (life cycle stage) or GO:0008150 (biological process) or UBERON:0000105 (anatomical entity) or WBls:0000075 (nematoda life stage)","subsets":["biological_process","developmental_stages"]},{"id":"existence_starts_and_ends_during","usage":"Identifies a process or life stage during which a cellular component is present","domain":"GO:0005575 (cellular_component)","range":"FBdv:00007012 (life cycle stage) or GO:0008150 (biological process) or UBERON:0000105 (anatomical entity) or WBls:0000075 (nematoda life stage)","subsets":["biological_process","developmental_stages"]},{"id":"exists_during","usage":"Identifies a process or life stage during which a cellular component is present","domain":"GO:0005575 (cellular_component)","range":"FBdv:00007012 (life cycle stage) or GO:0008150 (biological process) or UBERON:0000105 (anatomical entity) or WBls:0000075 (nematoda life stage)","subsets":["biological_process","developmental_stages"]},{"id":"happens_during","usage":"Identifies a process or life stage during which a molecular function or biological process occurs. This is weaker than parthood. So, for example, various processes occur during gastrulation without being part of it.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"FBdv:00007012 (life cycle stage) or GO:0008150 (biological process) or UBERON:0000105 (anatomical entity) or WBls:0000075 (nematoda life stage)","subsets":["biological_process","developmental_stages"]},{"id":"has_end_location","usage":"Use this relation to relate a biological process to the location (cell component, cell type, anatomical location) in which the process ends. Examples include recording the cell-type or cellular compartment in which a cell-cell signalling process ends. To record a location in which the entire process occurs, please use 'occurs in'.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or NCBITaxon:1 (root) or PO:0025131 (plant anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"has_input","usage":"Use this relation to relate a biological process or molecular function to an entity that participates in the process/function, is present at the start of the process/function and whose state is affected by that process/function.  Change of state includes being transported, modified, consumed or destroyed.  An input may be any continuant: chemical; gene product; cell component;  cells type; organism.  For inputs to MFs that are bound by the gene product that executes the MF, the more specific relation 'has_direct_input' may be used.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CHEBI:24431 (chemical entity) or CHEBI:33697 (ribonucleic acid) or GO:0032991 (macromolecular complex) or GO:0043234 (null) or MI:0315 (null) or NCBITaxon:1 (root) or PR:000000001 (protein) or SO:0000110 (sequence feature) or SO:0000673 (transcript) or SO:0000704 (gene) or SO:0000839 (polypeptide region) or SO:0001683 (sequence motif)","subsets":["chemical","sequence_or_complex"]},{"id":"has_output","usage":"Identifies an entity that is changed or created after participation in a molecular function or biological process","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CHEBI:24431 (chemical entity) or CHEBI:33697 (ribonucleic acid) or GO:0032991 (macromolecular complex) or GO:0043234 (null) or MI:0315 (null) or PR:000000001 (protein) or SO:0000673 (transcript) or SO:0000704 (gene)","subsets":["chemical","sequence_or_complex"]},{"id":"has_participant","usage":"Identifies an entity affected by the gene product's participation in a molecular function or biological process","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CHEBI:24431 (chemical entity) or GO:0032991 (macromolecular complex) or GO:0043234 (null) or MI:0315 (null) or PR:000000001 (protein) or SO:0000673 (transcript) or SO:0000704 (gene)","subsets":[]},{"id":"has_start_location","usage":"Use this relation to relate a biological process to its start location.   Examples include recording the cell-type in which a cell-cell signaling process starts and recording a cellular compartment (such as post-synapse, presynapse or cilium) in which a signal transduction process starts.  Note, if the entire process occurs in a particular location, use 'occurs in' instead.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or FBbt:00007002 (cell) or FBbt:10000000 (metazoan anatomical entity) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or NCBITaxon:1 (root) or PO:0025131 (plant anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"has_target_end_location","usage":"Use to relate a transport or localization process to the end location of the transported or localized cargo.","domain":"None defined","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or UBERON:0001062 (anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"has_target_start_location","usage":"Use to relate a transport or localization process to the starting location of the cargo.","domain":"None defined","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or UBERON:0001062 (anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"negatively_regulates","usage":"p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"GO:0003674 (molecular function) or GO:0008150 (biological process)","subsets":["biological_process","molecular_function"]},{"id":"occurs_in","usage":"Identifies the cell, tissue, cellular component or anatomical entity within which all parts of the molecular function or biological process occurs","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or FBbt:00007002 (cell) or FBbt:10000000 (metazoan anatomical entity) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or NCBITaxon:1 (root) or PO:0025131 (plant anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity) or ZFA:0100000 (metazoan anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"part_of","usage":"This relation has two uses in annotation extension.  It may be used to relate a cellular component to some cellular component, cell or anatomical structure that it is part of.  It may also be used to relate a molecular function or biological process to a biological process or developmental stage of which it is a part.  It may not be used to relate cellular components to functions, processes or stages, or to relate processes or functions to cellular components, cells or anatomical structures.","domain":"GO:0003674 (molecular_function) or GO:0005575 (cellular_component) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or EMAPA:0 (metazoan anatomical entity) or FBbt:00007002 (cell) or FBbt:10000000 (metazoan anatomical entity) or FBdv:00007012 (life cycle stage) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0008150 (biological process) or GO:0032991 (macromolecular complex) or NCBITaxon:1 (root) or PO:0009012 (plant structure development stage) or PO:0025131 (plant anatomical entity) or UBERON:0000105 (anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity) or WBls:0000075 (nematoda life stage) or ZFA:0100000 (metazoan anatomical entity)","subsets":["biological_process","cell_or_anatomical","cellular_component","developmental_stages"]},{"id":"positively_regulates","usage":"p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"GO:0003674 (molecular function) or GO:0008150 (biological process)","subsets":["biological_process","molecular_function"]},{"id":"produced_by","usage":"Use this relation to link a cell component that is the product of a cell, to the cell-type that produced it. Examples include recording the cell type that produces an exosome, an LDL, or a secreted ECM component.","domain":"GO:0005575 (cellular_component)","range":"CL:0000000 (cell) or GO:0005623 (cell)","subsets":["cell_or_anatomical"]},{"id":"regulates","usage":"p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"GO:0003674 (molecular function) or GO:0008150 (biological process)","subsets":["biological_process","molecular_function"]},{"id":"results_in_acquisition_of_features_of","usage":"Use this relation to link a cell differentiation process to the cell type that the process results in the differentiation of.","domain":"GO:0030154 (cell differentiation)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or EMAPA:0 (metazoan anatomical entity) or FBbt:00007002 (cell) or GO:0005623 (cell) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell)","subsets":["cell_or_anatomical"]},{"id":"results_in_commitment_to","usage":"The relationship linking a cell and its participation in a process that results in the transition of a cell such that is can only develop into a single cell type.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CL:0000000 (cell) or FBbt:00007002 (cell) or GO:0005623 (cell) or WBbt:0004017 (cell)","subsets":["cell_or_anatomical"]},{"id":"results_in_determination_of","usage":"The relationship linking a cell and its participation in a process that results in the transition of a cell such that it can only develop into a single cell type independent of its environment.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CL:0000000 (cell) or FBbt:00007002 (cell) or GO:0005623 (cell) or WBbt:0004017 (cell)","subsets":["cell_or_anatomical"]},{"id":"results_in_development_of","usage":"The relationship linking an entity and its participation in a process that changes it through time from the formation of the entity to the resultant mature state.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or EMAPA:0 (metazoan anatomical entity) or FBbt:00007002 (cell) or FBbt:10000000 (metazoan anatomical entity) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or PO:0025131 (plant anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity) or ZFA:0100000 (metazoan anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"results_in_division_of","usage":"The relationship linking a entity and its participation in a process that results in the division of the entity into two entities of the same type.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CL:0000000 (cell) or FBbt:00007002 (cell) or GO:0005623 (cell) or WBbt:0004017 (cell)","subsets":["cell_or_anatomical"]},{"id":"results_in_formation_of","usage":"The relationship linking a entity and its participation in a process whereby at the beginning of the process the entity does not exist and at the end of the process the entity exists.","domain":"GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or EMAPA:0 (metazoan anatomical entity) or FBbt:00007002 (cell) or FBbt:10000000 (metazoan anatomical entity) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or PO:0025131 (plant anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity) or ZFA:0100000 (metazoan anatomical entity)","subsets":["cell_or_anatomical"]},{"id":"results_in_maturation_of","usage":"The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or EMAPA:0 (metazoan anatomical entity) or FBbt:00007002 (cell) or FBbt:10000000 (metazoan anatomical entity) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or PO:0009012 (plant structure development stage) or PO:0025131 (plant anatomical entity) or UBERON:0000105 (anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity) or ZFA:0100000 (metazoan anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"results_in_morphogenesis_of","usage":"The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or EMAPA:0 (metazoan anatomical entity) or FBbt:00007002 (cell) or FBbt:10000000 (metazoan anatomical entity) or GO:0005575 (cellular component) or GO:0005623 (cell) or GO:0032991 (macromolecular complex) or PO:0025131 (plant anatomical entity) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell) or WBbt:0005766 (metazoan anatomical entity) or ZFA:0100000 (metazoan anatomical entity)","subsets":["cell_or_anatomical","cellular_component"]},{"id":"results_in_movement_of","usage":"Use this relation to link a locomotion process to the type of cell or anatomical structure or organism that the process results in locomotion of.","domain":"GO:0008150 (biological_process)","range":"CARO:0000000 (anatomical entity) or CL:0000000 (cell) or EMAPA:0 (metazoan anatomical entity) or FBbt:00007002 (cell) or GO:0005623 (cell) or UBERON:0001062 (anatomical entity) or WBbt:0004017 (cell)","subsets":["cell_or_anatomical"]},{"id":"results_in_specification_of","usage":"The relationship linking a cell and its participation in a process that results in the transition of a cell such that is can only develop into a single cell type when left in its environment.","domain":"GO:0008150 (biological_process)","range":"CL:0000000 (cell) or FBbt:00007002 (cell) or GO:0005623 (cell) or WBbt:0004017 (cell)","subsets":["cell_or_anatomical"]},{"id":"transports_or_maintains_localization_of","usage":"Use to relate a process or molecular function to a substance that is transported, localized or whose localization is maintained by that process or function.  The substance may be a chemical, gene product or cellular component.  For the movement via locomotion of cells and anatomical structure please use results_in_movement_of.","domain":"GO:0003674 (molecular_function) or GO:0008150 (biological_process)","range":"CHEBI:24431 (chemical entity) or CHEBI:33697 (ribonucleic acid) or GO:0005575 (cellular component) or GO:0032991 (macromolecular complex) or PR:000000001 (protein) or SO:0000673 (transcript)","subsets":["cellular_component","chemical"]}],"edges":[{"id":"[adjacent_to -> _ROOT_AER_]","source":"adjacent_to","target":"_ROOT_AER_","type":"is_a"},{"id":"[causally_upstream_of -> _ROOT_AER_]","source":"causally_upstream_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[coincident_with -> _ROOT_AER_]","source":"coincident_with","target":"_ROOT_AER_","type":"is_a"},{"id":"[directly_negatively_regulates -> directly_regulates]","source":"directly_negatively_regulates","target":"directly_regulates","type":"is_a"},{"id":"[directly_negatively_regulates -> negatively_regulates]","source":"directly_negatively_regulates","target":"negatively_regulates","type":"is_a"},{"id":"[directly_positively_regulates -> directly_regulates]","source":"directly_positively_regulates","target":"directly_regulates","type":"is_a"},{"id":"[directly_positively_regulates -> positively_regulates]","source":"directly_positively_regulates","target":"positively_regulates","type":"is_a"},{"id":"[directly_regulates -> regulates]","source":"directly_regulates","target":"regulates","type":"is_a"},{"id":"[existence_overlaps -> _ROOT_AER_]","source":"existence_overlaps","target":"_ROOT_AER_","type":"is_a"},{"id":"[existence_starts_and_ends_during -> _ROOT_AER_]","source":"existence_starts_and_ends_during","target":"_ROOT_AER_","type":"is_a"},{"id":"[exists_during -> _ROOT_AER_]","source":"exists_during","target":"_ROOT_AER_","type":"is_a"},{"id":"[happens_during -> _ROOT_AER_]","source":"happens_during","target":"_ROOT_AER_","type":"is_a"},{"id":"[has_end_location -> _ROOT_AER_]","source":"has_end_location","target":"_ROOT_AER_","type":"is_a"},{"id":"[has_input -> has_participant]","source":"has_input","target":"has_participant","type":"is_a"},{"id":"[has_output -> has_participant]","source":"has_output","target":"has_participant","type":"is_a"},{"id":"[has_participant -> _ROOT_AER_]","source":"has_participant","target":"_ROOT_AER_","type":"is_a"},{"id":"[has_start_location -> _ROOT_AER_]","source":"has_start_location","target":"_ROOT_AER_","type":"is_a"},{"id":"[has_target_end_location -> _ROOT_AER_]","source":"has_target_end_location","target":"_ROOT_AER_","type":"is_a"},{"id":"[has_target_start_location -> _ROOT_AER_]","source":"has_target_start_location","target":"_ROOT_AER_","type":"is_a"},{"id":"[negatively_regulates -> regulates]","source":"negatively_regulates","target":"regulates","type":"is_a"},{"id":"[occurs_in -> _ROOT_AER_]","source":"occurs_in","target":"_ROOT_AER_","type":"is_a"},{"id":"[part_of -> _ROOT_AER_]","source":"part_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[positively_regulates -> regulates]","source":"positively_regulates","target":"regulates","type":"is_a"},{"id":"[produced_by -> _ROOT_AER_]","source":"produced_by","target":"_ROOT_AER_","type":"is_a"},{"id":"[regulates -> causally_upstream_of]","source":"regulates","target":"causally_upstream_of","type":"is_a"},{"id":"[results_in_acquisition_of_features_of -> _ROOT_AER_]","source":"results_in_acquisition_of_features_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[results_in_commitment_to -> _ROOT_AER_]","source":"results_in_commitment_to","target":"_ROOT_AER_","type":"is_a"},{"id":"[results_in_determination_of -> _ROOT_AER_]","source":"results_in_determination_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[results_in_development_of -> _ROOT_AER_]","source":"results_in_development_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[results_in_division_of -> has_participant]","source":"results_in_division_of","target":"has_participant","type":"is_a"},{"id":"[results_in_formation_of -> has_output]","source":"results_in_formation_of","target":"has_output","type":"is_a"},{"id":"[results_in_maturation_of -> _ROOT_AER_]","source":"results_in_maturation_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[results_in_morphogenesis_of -> _ROOT_AER_]","source":"results_in_morphogenesis_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[results_in_movement_of -> _ROOT_AER_]","source":"results_in_movement_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[results_in_specification_of -> _ROOT_AER_]","source":"results_in_specification_of","target":"_ROOT_AER_","type":"is_a"},{"id":"[transports_or_maintains_localization_of -> _ROOT_AER_]","source":"transports_or_maintains_localization_of","target":"_ROOT_AER_","type":"is_a"}]}