MARS is a gene finding program designed to predict alternatively spliced transcripts de novo. MARS is based on Twinscan (see below for more information).
For further information please contact Paul Flicek: flicek (AT) ebi.ac.uk.
MARS is an extension to the Twinscan algorithm for dual-genome conservation-based gene prediction. MARS extends Twinscan version 1.X and participated in the EGASP (the ENCODE Genome Annotation Assessment Project) in 2005.
MARS is a contraction of "Multiple Informants: Alternative Splics" and, described briefly, predicts multi-transcript genes using pair-wise evolutionary conservation models from a number of informant sequences. Details of the algorithm and its performance are described in Flicek & Brent, 2006.
Supplementary material for Flicek & Brent, 2006: