What are protein signatures?
Protein classification resources at the EBI: InterPro
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|Amino acid||Amino Acids are the chemical units or "building blocks" of the body that make up proteins.
You can find out more about amino acids on the Wikipedia page: http://en.wikipedia.org/wiki/Amino_acid |
|Annotation||The process of attaching additional information to biological entities. Annotation can be structural (i.e. identification of the elements from a sequence, such as protein coding regions or the location of regulatory motifs) or functional (i.e. adding biological information to the identified elements, such as the biological function of a protein domain or an entire protein, or the molecular interactions or regulatory role of a nucleotide sequence). Annotation can either be applied automatically or can be manually added (in a process called 'curation') from various sources, such as the scientific literature. At EMBL-EBI, we use a combination of automatic and manual annotation to enrich our databases. Annotation can either be applied automatically or it can be curated (manually) from the scientific literature. At EMBL-EBI, we use a combination of automatic and manual annotation to enrich our databases. |
|Domain||Independently stable tertiary structures of proteins. They are distinct functional and/or structural units and can evolve, exist and function independently. |
|InterPro||The EBI’s integrated resource for protein motifs, families and domains. It provides a single, consistent interface of protein signatures contributed by ten different databases, each of which uses a slightly different method for deriving protein signatures. |
|PRINTS||PRINTS is a compendium of protein fingerprints. A fingerprint is a group of conserved motifs used to characterise a protein family and whose diagnostic power is refined by iterative scanning of the protein sequence database UniProt. They are organised in hierarchical family levels to pinpoint specific functions. PRINTS is developed by the Bioinformatics Group, Faculty of Life Science, School of Computer Sciences, The University of Manchester, Oxford Rd, Manchester, UK. |
|Proteomics||Proteomics is the large-scale study of proteomes. A proteome is a set of proteins produced in an organism, system, or biological context. We may refer to, for instance, the proteome of a species (for example, Homo sapiens) or an organ (for example, the liver). |
|curation||In the context of biological databases, curation is the process of interpreting and representing biological data using standardised annotation, controlled vocabularies and standardised formats, so the data can be stored and made available to the scientific community. |
|curator||A professional scientist who collects, annotates, and validates information that is disseminated by biological and model organism databases. The role of a biocurator encompasses quality control of primary biological research data intended for publication, extracting and organizing data from original scientific literature, and describing the data with standard annotation protocols and vocabularies that enable powerful queries and biological database inter-operability. Curators communicate with researchers to ensure the accuracy of curated information and to foster data exchanges with research laboratories. |