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|Annotation||The process of attaching additional information to biological entities. Annotation can be structural (i.e. identification of the elements from a sequence, such as protein coding regions or the location of regulatory motifs) or functional (i.e. adding biological information to the identified elements, such as the biological function of a protein domain or an entire protein, or the molecular interactions or regulatory role of a nucleotide sequence). Annotation can either be applied automatically or can be manually added (in a process called 'curation') from various sources, such as the scientific literature. At EMBL-EBI, we use a combination of automatic and manual annotation to enrich our databases. Annotation can either be applied automatically or it can be curated (manually) from the scientific literature. At EMBL-EBI, we use a combination of automatic and manual annotation to enrich our databases. |
|ArrayExpress||ArrayExpress is a database of functional genomics experiments that can be queried and the data downloaded. www.ebi.ac.uk/arrayexpress/ |
|ArrayExpress Archive||The ArrayExpress Archive is a database of functional genomics data supported by scientific publications. |
|Gene Expression Atlas||The Expression Atlas provides information about which gene products are found under different biological conditions, via baseline and differential expression analysis. www.ebi.ac.uk/gxa/ |
MAGE-ML (Microarray Gene Expression - Markup Language) is the file format used to load experiment and array design information into AE. After loading into AE, the original MAGE-ML file is made available for download so that it can be used for loading into other databases. |
|NHGRI||National Human Genome Research Institute. An NIH institution developing research and technology to understand the structure and function of the human genome, promoting genomic research and applications to human health.
Transcriptomics is the global analysis of gene expression using high-throughput technologies such as microarrays and high-throughput sequencing (HTS). |
|high throughput sequencing||Next generation sequencing or high-throughput sequencing technologies parallelise the sequencing process, producing thousands or millions of sequences at once.
You can find out more about NGS /HTS on the Wikipedia page: http://en.wikipedia.org/wiki/Next-generation_sequencing#High-throughput_sequencing |