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|Annotation||The process of attaching additional information to biological entities. Annotation can be structural (i.e. identification of the elements from a sequence, such as protein coding regions or the location of regulatory motifs) or functional (i.e. adding biological information to the identified elements, such as the biological function of a protein domain or an entire protein, or the molecular interactions or regulatory role of a nucleotide sequence). Annotation can either be applied automatically or can be manually added (in a process called 'curation') from various sources, such as the scientific literature. At EMBL-EBI, we use a combination of automatic and manual annotation to enrich our databases. Annotation can either be applied automatically or it can be curated (manually) from the scientific literature. At EMBL-EBI, we use a combination of automatic and manual annotation to enrich our databases. |
|ArrayExpress||ArrayExpress is a database of functional genomics experiments that can be queried and the data downloaded. www.ebi.ac.uk/arrayexpress/ |
|ArrayExpress Archive||The ArrayExpress Archive is a database of functional genomics data supported by scientific publications. |
|Gene Expression Atlas||The Expression Atlas provides information about which gene products are found under different biological conditions, via baseline and differential expression analysis. www.ebi.ac.uk/gxa/ |
MAGE-ML (Microarray Gene Expression - Markup Language) is the file format used to load experiment and array design information into AE. After loading into AE, the original MAGE-ML file is made available for download so that it can be used for loading into other databases. |
|NHGRI||National Human Genome Research Institute. An NIH institution developing research and technology to understand the structure and function of the human genome, promoting genomic research and applications to human health.
|high throughput sequencing||Next generation sequencing or high-throughput sequencing technologies parallelise the sequencing process, producing thousands or millions of sequences at once.
You can find out more about NGS /HTS on the Wikipedia page: http://en.wikipedia.org/wiki/Next-generation_sequencing#High-throughput_sequencing |