To search Reactome enter your query into the Search box located on the right side of the menu bar, at the top of most Reactome web pages (boxed by a red dashed line in Figure 16). You can also use text descriptions or accession numbers/identifiers for many external gene, proteins or compound databases, e.g. UniProt or ChEBI.
Figure 16. The text search box highlighted in the menu bar.
For example, to search Reactome for content related to protein kinases, type protein kinase in the search box and click on the Search button.
The results will appear as shown in Figure 17. The total number of hits is indicated top left. Results are sorted into categories, e.g. Reaction, Pathway, Protein, each displayed in its own section, with an indication of the number of hits in that section.
You can filter the results by selecting the appropriate check boxes from the panel on the left side (see Figure 18 below). This includes a count of the hits by category. Select check boxes for the categories you want to see. For example, if you only want results of type 'Proteins', check the Protein box.
Figure 17. Results table displaying hits for the search term protein kinase. Results aer grouped by type, e.g. Protein or Reaction.The checkboxes on the left side apply filters to your search results.
Most results have descriptive text details. Your search terms will be highlighted if they appear within the title or descriptive text.
Select the title of a hit to open a page of details. This will include a section titled Locations in the Pathway Browser, which will have one or more names with plus symbols (figure 18). The name indicates the top-level pathway, i.e. major topic that contains the hit. To see more precisely where your hit occurs in the hierarchy of Reactome pathways, click on the plus symbols to open the pathway hierarchy. Molecules, reactions and even pathways may be re-used in more than one pathway location, hence there may be mutiple plus symbols.
Figure 18. Locations in the Pathway Browser section of search results. The Signal Transduction hierarchy has been revealed (indicated by a minus symbol), the Disease hierarchy (indicated by a plus symbol) has not been selected and is hidden.
Select any of the revealed names to select and open it in the Reactome Pathway Browser.