How is data stored in IntAct?

To learn how to use IntAct effectively, you need to understand how the resource is structured (Figure 8).

Schema of how interaction data is stored in IntAct

Figure 8. Schema of how interaction data is stored in IntAct.

[A]  Each entry in the database corresponds to a publication – a scientific article that is curated by the IntAct team.

[B]  The information in the paper is analysed and those experiments that contain molecular interactions are represented in the database (experiment level). Each experiment corresponds to one or more interactions identified in the same organism using the same techniques.

[C]  The interactions in each experiment are then listed in the interaction level, adding information such as kinetic binding parameters if they were given by the authors.

[D]  Each participant in an interaction is identified using cross-references to existing resources such as UniProt or ChEBI, if possible, and represented at the participant level.

[E]  Finally, features of each participant, such as binding sites, tags, mutations affecting the interaction or post-translational modifications, can be depicted in detail at the feature level.

 

Next, we will explain how the interactions are represented in IntAct.