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What is the IMPC?

The International Mouse Phenotyping Consortium (IMPC) is an international effort of more than 21 research institutions (Figure 1) working together to build a comprehensive catalogue of mammalian gene function, using the mouse as a model. 

The IMPC members are distributed worldwide, with participating insititutions in North America, Europe, Africa, Asia and Australia. You can find further details on the participating institutes here: https://www.mousephenotype.org/about-impc/consortium-members/
Figure 1 The IMPC is a transnational consortium.

The IMPC aims to create and characterise 20,000 knockout mouse lines – one for every protein-coding gene – to determine the function of all genes in the mammalian genome and their role in disease (Figure 2). Determining the physiological systems that are disrupted when a gene is disabled allows to establish gene-phenotype associations.

The IMPC database is continuously growing as data is being generated. The IMPC dataset is publicly available under the Creative Commons Attribution 4.0 International license (CC-BY 4.0). All data and images are available to use, free of charge.

The IMPC main goals are: 1. Create mutant mice (one strain for every protein-codig gene, for about 20,000 genes), 2. Characterise the mice (by systematically phenotyping them), 3. Catalogue the data (and make it publicly available through our website), and 4. Connect the information (by linking the phenotypic data to known biology, including rare diseases).
Figure 2 The main goals of the International Mouse Phenotyping Consortium.