What can I do with GO?

 What can I do with GO?

One of the most popular uses of GO is to find significant shared GO terms (or parents of those GO terms) that are annotated to genes in a particular query set (e.g. a set of genes that are overexpressed in a microarray experiment). This process helps you to find out what those genes may have in common and is known as a GO enrichment analysis.

GO is also used for purposes as diverse as:

  • integrating proteomic information from different organisms;
  • assigning functions to protein domains;
  • finding functional similarities in genes that are overexpressed or underexpressed in diseases and as we age;
  • analysing groups of genes that are co-expressed during development;
  • developing automated ways of deriving information about gene function from the literature;
  • verifying models of genetic, metabolic and product interaction networks.

The GO tools web page lists the tools that you can use to analyse the data from GO.