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Gene regulation
The Ensembl regulatory build (available for human, mouse, pig, chicken and a few fish species) provides a set of regulatory features, sequences that may be implicated in gene regulation (Video 8). These sequences have indicators suggesting they may be promoters, enhancers, or other elements.
The features are based on regions of open chromatin identified using DNase I hypersensitivity assays, transcription factor binding sites, CTCF binding regions and histone modifications. These data come from experiments analysed by mainly ChIP-seq, but also DNase-seq experiments, from the ENCODE (Encyclopedia of DNA elements), Blueprint, Roadmap Epigenomics, GENE-SWiTCH and AQUA-FAANG consortium. Ensembl displays the activity of these features in different cell types, and the evidence used to determine this activity.
 Find out how to view sequences implicated in gene regulation in this section. Read more about the regulatory build here. |