Investigating a regulatory feature

The regulation tab: investigating the regulatory feature ENSR00000054736

To access the regulation tab, click on any ENSR ID on the Ensembl website.

The regulation tab

Figure 36. Regulatory features are annotated according to cell line (the multi-cell summary is shown in the graphic). Evidence supporting the regulatory feature, e.g. DNase I hypersensitivity, is shown for multiple cell types in the graphic.

 

Notes

Regulatory features. [A] At the top of the regulation tab, positions of regulatory features and associated cell types are listed (Figure 36). In CD4 cells, the feature type is 'promoter associated'. This indicates that the region has histone modification profiling that suggests the sequence is a promoter.

Details by cell line. This section [B] shows the evidence for the existence of the regulatory feature in different cell lines. In this example, DNase I hypersensitive sites are found in this region in several cell lines. The strongest signal (peak) for DNase I hypersensitivity is marked by a black arrow for each study.

 

The details by cell line section (Figure 37) separates the regulatory features across the cell lines, and allows you to view the supporting evidence.


A zoomed-in view to regulatory evidence for CD4 cells

Figure 37. Above is a zoomed-in view to regulatory evidence for CD4 cells, specifically. Clicking on the yellow bar in the Core Evidence track for CD4 cells shows a DNase 1 hypersensitive site on chromosome 13. The yellow plot shows the peak signals for DNase 1 hypersensitivity. Other evidence supporting a regulatory feature at this position in CD4 cells are Pol1 binding (tan bar), and H3K4me3 histone modification (pink bar).

HelpFor detailed information about the data used in determining the regulatory features, go to the Ensembl regulation documentation.