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Hands-on training at EBI - A two-day dip into the EBI’s data resources: Understanding your data
Course Summary
Title: A two-day dip into the EBI’s data resources: Understanding your data
Date: 10-11 September 2007
Venue: Hinxton, Cambridge, UK
Organisers: IT-Training EBI
Registration Deadline: T.B.A.
About this Course
As we move towards understanding biology at the systems level, access to
large data sets of many different types has become crucial. Technologies
such as genome-sequencing, microarrays, proteomics and structural
genomics have provided ‘parts lists’ for many living organisms.
The EMBL-EBI maintains the world’s most comprehensive range of molecular
databases. This course provides a broad introduction to EBI core
resources and practical, trainer-guided demonstration of when, why and
how to use them. Several resources will be covered spanning genomics to
systems biology.
In addition to presenting practical information on the range of EBI
resources and how to use these tools, this course aims to illustrate
their applicability to research by using a range of case studies. In
this way, use of the resources is presented with reference to biological
questions.
Topics include
- EB-eye search engine:
The EB-eye search system is a high-performance, full-featured text
search engine that provides rapid access to the EBI's data resources.
Users can search globally across all EBI databases or narrow their
selection to individually in selected resources by using the advance
search option.
- EBI Literature resources
CiteXplore is the EBI’s portal to the scientific literature, directing
users to full text articles as well as relevant biological databases. It
provides access to MEDLINE (NLM), Agricola (NAL), patent abstracts
(EPO), Chinese Biological Abstracts (CBA) and CiteSeer (UPenn).
- Ensembl (genomes):
A genomic sequence database providing a comprehensive and integrated
source of annotation of mainly vertebrate genome sequences.
- ArrayExpress (microarray data):
EMBL-EBI’s MIAME-compliant repository for gene expression data from
microarray and transcriptomics experiments (MIAME - Minimum Information
About a Microarray Experiment).
- UniProt (protein sequences):
UniProt is a collaboratively maintained central repository of protein
sequence and function. Users can access curated protein information
through a central access point, the UniProt Knowledgebase (UniProtKB).
- PDBe (macromolecular structures):
The EBI’s Protein Databank in Europe (PDBe) is Europe’s
representative in the worldwide Protein Data Bank (http://www.wwpdb.org/). It
contains structural data from crystallography, nuclear magnetic
resonance spectroscopy and electron microscopy experiments, in addition
to derived information linking structure to biochemical function,
protein sequence and taxonomy.
- IntAct (protein–protein interactions):
IntAct is a molecular interaction database and analysis system. The
project is a member of the International Molecular Exchange (IMEx)
consortium for exchanging molecular interaction data and supports the
development of the Human Proteome Organisation (HUPO) community standard
data model.
- PRIDE (proteomics):
The Proteomics Identifications Database is a public data repository for
proteomic identifications and associated mass spectra, linked to
supporting publications.
- Reactome (pathways):
Reactome is a curated knowledgebase of biological processes, containing
reactions, pathways, proteins, DNA, small molecules and complexes.
Reactome encompasses metabolism, signalling, cell cycle, apoptosis, gene
expression, pathogen–host interactions and much more.
Course requirements
A basic understanding of bioinformatics and a familiarity with the use of biological databases would be an advantage.
The training is free, however we need to charge participants an administration fee of £25 per day.
Registration closed
Trainers
- David Croft is a bioinformatician and has been giving talks and training
for the Reactome project since 2005. He is also involved in maintaining
and updating the Reactome website. Prior to joining the EBI, he spent
seven years in industry, designing bioinformatics and cheminformatics
applications.
- Phil Jones is the technical lead software engineer for the PRIDE project. He has a background in both biological sciences and software
engineering, and holds a Post-Graduate Certificate in Education. He has
held positions in software engineering and in science education. He has
given courses and talks on various software development projects in
numerous locations worldwide.
- Sandra Orchard is a Senior Scientific Database Curator working across
the Sequence Database, InterPro and Proteomics Services teams. She is
responsible for the curation standards within the IntAct Molecular
Interaction database as well as contributing to the annotation of the
UniProtKB, InterPro and GOA databases and applies her experience to
provide hand-on training in several resources including UniProtKB, IPI,
InterPro and IntAct.
- Gabriella Rustici is a research scientist in the Microarray Informatics
group at the EBI and her research focuses on meta-analysis of microarray
datasets. She is also involved in training activities and applies her
experience to provide hands-on training in several resources including ArrayExpress and Expression Profiler.
- Vicky Schneider is the EBI’s Scientific Training Officer and responsible
for developing and coordinating the in-house and external training
activities of the EBI. She has an academic background in behavioural
ecology and adaptive evolution. Prior to joining the EBI, Vicky held an
Assistant Professor position at the University of Bern, Switzerland.
- Giulietta Spudich is an outreach and training officer for Ensembl. She
is also involved in providing technical support for the genome browser.
She has a background in academic research (structural biology and
biochemistry) and has taught lecture-style classes and day-long
workshops for University of California, Berkeley (USA), University of
Cambridge (UK) and gives world-wide workshops on Ensembl.
Program Contents
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