Training

This course will introduce you to approaches used for finding, analysing and using biological sequences. It will explore how to conduct searches across biological databases using both metadata and sequence data approaches. The course will explain how sequence searching approaches function, and how to effectively find relevant results. Practical elements will develop skills in locating and aligning sequences, and provide guidance on where to go next to learn more about the biological context of the sequences.

The key areas covered by the workshop will include:

• Sequence data resources at EMBL-EBI
• Tools for multiple sequence alignment
• Methods for conducting phylogenetic analysis
• Using sequences to investigate families, function and structure

During this course you will learn about:

• EBI Search interface, ENA and UniProt databases
• Sequence searching tools – BLAST, PSI-SEARCH, HMMER
• Multiple sequence alignment tools – Clustal Omega, MUSCLE.
• Phylogeny tools
• InterPro, PDBe, UniProt

After this course you should be able to:

• Use basic bioinformatics approaches data searching
• Find relevant database entries using sequence searching methods
• Conduct alignments of multiple sequences via a variety of methods
• Construct basic phylogenetic trees
• Perform further analyses on sequences to help examine their potential functions

This prgramme is subject to change.