Small Molecule Bioactivity Resources At The EBI
Is it right for me?
- This highly interdisciplinary course in next-generation publicly available chemoinformatics tools is ideal for academics or industrial researchers interested in drug discovery or for researchers looking to progress from basic functional genomics to translational research.
- Participants should have a degree in a biomedical discipline. No previous training in bioinformatics is required.
- The course will be highly interactive and will include problem solving sessions each day. Attendees are strongly encouraged to bring ideas for particular pieces of work to the addressed during these sessions.
What will I learn?
- Hands on training on searching public databases such as ChEMBL and PubChem, for small molecules of biological interest.
- Using related bioinformatics databases and services (including Ensembl, Uniprot, ArrayExpress and Zinc), that cross-reference small molecule data.
- How to find out about the structure-activity relationships of small bioactive molecules using ChEMBL.
- Selecting compounds to screen against novel targets and reference standards.
- Optimising compound structures for target validation.
What will it cover?
- Overview of public domain chemical structure resources.
- The role of open science in drug discovery.
- Analysis and modulation of disease linked pathways.
- Tools and strategies to get the best from chemical and small molecule databases.
- Target analysis and prioritisation of genomic data for drug discovery.
Guest Speakers
- Jeremy Besnard - University Of Dundee, Scotland
- Noel O'Boyle - University College Cork, Ireland
| Time | Topic |
|---|---|
| Day 1 - Mon 25 January 2010 | |
| 09:00 - 09:30 | Welcome Coffee and Safety Briefing |
| 09:30 - 12:00 | Introduction to EMBL-EBI bioactivity resources (John Overington) |
| 12:00 - 13:00 | Lunch |
| 13:00 - 15:00 | Overview of uses of bioactivity data (John Overington) |
| 15:00 - 15:30 | Tea Break |
| 15:30 - 17:30 | Review and discussion of student problems (Anna Gaulton/John Overington/Anne Hersey) |
| Day 2 - Tue 26 January 2010 | |
| 09:00 - 10:30 | Biology led querying (Anna Gaulton/John Overington) |
| 10:30 - 11:00 | Coffee break |
| 11:00 - 12:30 | Biology led querying (Anna Gaulton/John Overington) |
| 12:30 - 13:30 | Lunch |
| 13:30 - 15:00 | Problem solving in workgroups - biology use cases |
| 15:00 - 15:30 | Tea break |
| 15:30 - 17:30 | Problem solving in workgroups - biology use cases |
| Day 3 - Wed 27 January 2010 | |
| 09:00 - 10:30 | Chemistry led querying (Anne Hersey/Louisa Bellis) |
| 10:30 - 11:00 | Coffee break |
| 11:00 - 12:30 | Chemistry led querying (Anne Hersey/Louisa Bellis) |
| 12:30 - 13:30 | Lunch |
| 13:30 - 15:00 | Problem solving in workgroups - chemistry use cases |
| 15:00 - 15:30 | Tea break |
| 15:30 - 17:30 | Problem solving in workgroups - chemistry use cases |
| Day 4 - Thu 28 January 2010 | |
| 09:00 - 10:30 | Data integration and complex querying (SQL, etc.) (Bissan Al-Lazikani) |
| 10:30 - 11:00 | Coffee break |
| 11:00 - 12:30 | Data integration and complex querying (SQL, etc.) (Bissan Al-Lazikani) |
| 12:30 - 13:30 | Lunch |
| 13:30 - 15:00 | Patent querying (Trainer to be confirmed) |
| 15:00 - 15:30 | Tea break |
| 15:30 - 17:30 | Prediction of bioactivity from chemical structure (Jeremy Besnard) |
| Day 5 - Fri 29 January 2010 | |
| 09:00 - 10:00 | Recap of material (John Overington) |
| 10:00 - 10:30 | Coffee break |
| 10:30 - 12:30 | Advanced applications: Use of protein structures - docking (Noel O'Boyle) |
| 12:30 - 13:30 | Lunch |
| 13:30 - 15:00 | Advanced applications continued: Use of protein structures - docking (Noel O'Boyle) |
| 15:00 - 15:30 | Course Close and Survey |
Please complete the registration form indicating the type of registration you require. Items marked * are mandatory. Incomplete registrations will not be processed. Payment is required online during the registration process. Please do not begin the registration process unless you can pay.
Costs:
Academic and SME (What’s this?) Registration = £325.00
Members of EBI-Industry Programme (What’s this?) Registration = £325.00 (included in subscription)
Other Commercial Registration = £675.00
Accommodation and subsistence is included in the registration fee for commercial, academic and SME registrants. There is an optional accommodation package available to Industry programme members.
Bursary Applications:
Bursary Application Deadline: 6 November 2009 - 12 noon (GMT)
There are a limited number of bursaries available for academic participants only. These are awarded by the selection committee according to merit. The bursary will cover the entire course fees (including accommodation and subsistence) and a percentage of travel costs (up to a reasonable maximum set by the selection committee) - please indicate in your application a rough estimate of likely travel costs.
All bursary applicants must complete the bursary registration below and also provide a CV and a completed bursary application form bursary application form [Word 232KB] [click here for PDF version]. This must be completed and signed by your scientific sponsor (supervisor or head of department) and include justification for the bursary.
Applicants will be notified of a bursary award along with their place on the course, usually within one month of the application deadline.
We will reject incomplete applications. Both the application form and sponsor’s letter must be received before the application deadline. The decision of the selection committee is final.
Types of registration:
Registration Closed.
The course materials are available to download from the following link:
/training/sites/ebi.ac.uk.training/files/materials/2010/course_100125_smallmolecules.zip